Cited by 83Breast Cancer Treatment StudiesBreast Lesions and CarcinomasMRI in cancer diagnosis

The use of neoadjuvant platinum-based chemotherapy in locally advanced breast cancer that is triple negative: retrospective analysis of 144 patients

Hurley, Judith, Reis, Isildinha M., Rodgers, Steven E., Gomez-Fernandez, Carmen, Wright, Jean, Leone, Jose Pablo, Larrieu, Rene, Pegram, Mark D.·2013·Breast Cancer Research and Treatment

Abstract

Triple-negative breast cancers comprise about 20 % of breast cancers. They have poor prognosis and have no standard therapy. The aim of this study was to evaluate pathologic complete response (pCR), progression-free survival (PFS), and overall survival (OS) in patients with TNBC treated with neoadjuvant platinum-based chemotherapy. This is a retrospective study of one hundred and forty-four women with TNBC treated with neoadjuvant platinum-containing chemotherapy for locally advanced breast cancer at the University of Miami between January 1, 1999, and January 1, 2011. The medical record was reviewed to obtain data on clinical characteristics, including ethnicity, race, age, clinical stage, treatment regimen, and vital status. This study was approved by the University of Miami IRB. All patients had locally advanced breast cancer with at least one of the following features at presentation: T3, T4, N2, and N3. The mean tumor size by palpation was 9.4 cm. The clinical T-stage at presentation was 1.4 % T1, 8.3 % T2, 52.8 % T3, and 37.5 % T4 (19.4 % T4d). The nodal status by physical exam at presentation was 23 % N0, 37.5 % N1, 34 % N2, and 5.5 % N3. pCR in breast and axilla was seen in 31 %. PFS and OS were 55 and 59 %, respectively, at 7 years. Cisplatin offered a survival advantage over carboplatin in both PFS (P = 0.007) and OS (P = 0.018). Node positivity was the most important predictor of survival. Cisplatin/docetaxel neoadjuvant therapy was well tolerated and an effective therapy in locally advanced TNB.

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Crossref · 10.1007/s10549-013-2497-y

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Authors
Hurley, J., Reis, I. M., Rodgers, S. E., Gomez-Fernandez, C., Wright, J., Leone, J. P., Larrieu, R., & Pegram, M. D.
Affiliations
  • University of Miami (US)
  • The University of Texas at San Antonio Health Science Center (US)
  • Stanford Medicine (US)
Corresponding author
Hurley, Judith
Venue
Breast Cancer Research and Treatment
Published
2013-03-31
Volume
138
Issue
3
Pages
783-794
ISSN
  • 0167-6806 (ISSN-L)
  • 1573-7217
OpenAlex
W2050933203
Cited by
83
References
42
Citations by year
2025: 4 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 17 · 2014: 11 · 2013: 2
FWCI
4.20
Type
journal article
Language
en
Open access
closed
Locations
  • Breast Cancer Research and Treatment (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
Keywords
triple-negative breast cancer, locally advanced breast cancer, neoadjuvant chemotherapy, platinum-based chemotherapy, cisplatin, carboplatin, docetaxel, pathological complete response, progression-free survival, overall survival, lymph node status, prognostic factors
MeSH terms
Docetaxel, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Axilla, Breast Neoplasms, Cisplatin, Female, Humans, Middle Aged, Retrospective Studies, Carboplatin, Treatment Outcome, Disease-Free Survival, Neoadjuvant Therapy, Taxoids

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