The use of neoadjuvant platinum-based chemotherapy in locally advanced breast cancer that is triple negative: retrospective analysis of 144 patients
Abstract
Triple-negative breast cancers comprise about 20 % of breast cancers. They have poor prognosis and have no standard therapy. The aim of this study was to evaluate pathologic complete response (pCR), progression-free survival (PFS), and overall survival (OS) in patients with TNBC treated with neoadjuvant platinum-based chemotherapy. This is a retrospective study of one hundred and forty-four women with TNBC treated with neoadjuvant platinum-containing chemotherapy for locally advanced breast cancer at the University of Miami between January 1, 1999, and January 1, 2011. The medical record was reviewed to obtain data on clinical characteristics, including ethnicity, race, age, clinical stage, treatment regimen, and vital status. This study was approved by the University of Miami IRB. All patients had locally advanced breast cancer with at least one of the following features at presentation: T3, T4, N2, and N3. The mean tumor size by palpation was 9.4 cm. The clinical T-stage at presentation was 1.4 % T1, 8.3 % T2, 52.8 % T3, and 37.5 % T4 (19.4 % T4d). The nodal status by physical exam at presentation was 23 % N0, 37.5 % N1, 34 % N2, and 5.5 % N3. pCR in breast and axilla was seen in 31 %. PFS and OS were 55 and 59 %, respectively, at 7 years. Cisplatin offered a survival advantage over carboplatin in both PFS (P = 0.007) and OS (P = 0.018). Node positivity was the most important predictor of survival. Cisplatin/docetaxel neoadjuvant therapy was well tolerated and an effective therapy in locally advanced TNB.
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Clinical studies indicate that platinum-based therapy can provide enhanced efficacy in triple-negative breast cancer.
“Clinical studies have indicated that platinum-based therapy can provide enhanced efficacy in TNBC (4, 5).”
From Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model (2015) · cites this paper as [5]
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- Authors
- Hurley, J., Reis, I. M., Rodgers, S. E., Gomez-Fernandez, C., Wright, J., Leone, J. P., Larrieu, R., & Pegram, M. D.
- Affiliations
- University of Miami (US)
- The University of Texas at San Antonio Health Science Center (US)
- Stanford Medicine (US)
- Corresponding author
- Hurley, Judith
- ORCID
- Venue
- Breast Cancer Research and Treatment
- Published
- 2013-03-31
- Volume
- 138
- Issue
- 3
- Pages
- 783-794
- ISSN
- 0167-6806 (ISSN-L)
- 1573-7217
- OpenAlex
- W2050933203
- Cited by
- 83
- References
- 42
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 17 · 2014: 11 · 2013: 2
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Breast Cancer Research and Treatment (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Keywords
- triple-negative breast cancer, locally advanced breast cancer, neoadjuvant chemotherapy, platinum-based chemotherapy, cisplatin, carboplatin, docetaxel, pathological complete response, progression-free survival, overall survival, lymph node status, prognostic factors
- MeSH terms
- Docetaxel, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Axilla, Breast Neoplasms, Cisplatin, Female, Humans, Middle Aged, Retrospective Studies, Carboplatin, Treatment Outcome, Disease-Free Survival, Neoadjuvant Therapy, Taxoids
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