Breast cancer oral anti-cancer medication adherence: a systematic review of psychosocial motivators and barriers
Abstract
Purpose In the past decade, there has been an increase in the development and use of oral anti-cancer medications (OAMs), especially for breast cancer-the most prevalent cancer in women. However, adherence rates for OAMs are often suboptimal, leading to lower survival rate, increased risk of recurrence, and higher healthcare costs. Our goal was to identify potentially modifiable psychosocial facilitators and barriers that may be targeted to increase OAM adherence for breast cancer patients.Methods We systematically searched PubMed for studies published in the U.S. by June 15, 2016 that addressed the following: (1) OAMs for breast cancer; (2) medication adherence; and (3) at least one psychosocial aspect of adherence.Results Of the 1752 papers screened, 21 articles were included and analyzed. The most commonly reported motivators for adherence are patient-provider relationships (n = 11 studied, 82% reported significant association) and positive views and beliefs of medication (n = 9 studied, 89% reported significant association). We also identified consistent evidence of the impact of depression and emotions, perception of illness, concern of side effects, self-efficacy in medication management and decision making, knowledge of medication, and social support on OAM adherence.Conclusions Compared to traditional demographic, system, and clinical-related factors that have been well documented in the literature but are not easily changed, these cognitive, psychological, and interpersonal factors are more amendable via intervention and therefore could generate greater benefit in improving patient compliance and health outcomes. As OAMs shift treatment administration responsibility onto patients, continuous provider communication and education on illness and regimen are the keys to supporting patients' medication behavior.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These factors can have negative consequences for the disease course, including increased frequency and duration of hospital stays, lower adherence to treatment recommendations, difficulties coping, reduced quality of life, and increased mortality.
“These factors can have negative consequences for the disease course, including an increase in the frequency and duration of hospital stays, lower adherence to treatment recommendations, difficulties in coping with the disease, reduced quality of life and an increase in mortality [9–14].”
Cites
Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974 · see citing works
A new taxonomy for describing and defining adherence to medications
Vrijens, B., De Geest, S., Hughes, D. A., Przemyslaw, K., Demonceau, J., Ruppar, T., Dobbels, F., Fargher, E., Morrison, V., Lewek, P., et al. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04167.x · Cited by 2,028 · see citing works
Patient preferences for oral versus intravenous palliative chemotherapy.
Liu, G., Franssen, E., Fitch, M. I., & Warner, E. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.1.110 · Cited by 917 · see citing works
Hershman, D. L., Shao, T., Kushi, L. H., Buono, D., Tsai, W. Y., Fehrenbacher, L., Kwan, M., Gomez, S. L., & Neugut, A. I. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1132-4 · Cited by 870 · see citing works
Self-report measures of medication adherence behavior: recommendations on optimal use
Stirratt, M. J., Dunbar-Jacob, J., Crane, H. M., Simoni, J. M., Czajkowski, S., Hilliard, M. E., Aikens, J. E., Hunter, C. M., Velligan, D. I., Huntley, K., et al. (2015) · Translational Behavioral Medicine · doi:10.1007/s13142-015-0315-2 · Cited by 824 · see citing works
Viswanathan, M., Golin, C. E., Jones, C. D., Ashok, M., Blalock, S. J., Wines, R. C. M., Coker-Schwimmer, E. J. L., Rosen, D. L., Sista, P., & Lohr, K. N. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-11-201212040-00538 · Cited by 754 · see citing works
Murphy, C. C., Bartholomew, L. K., Carpentier, M. Y., Bluethmann, S. M., & Vernon, S. W. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2114-5 · Cited by 708 · see citing works
Adherence to Therapy With Oral Antineoplastic Agents
Partridge, A. H. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.9.652 · Cited by 585 · see citing works
Patient adherence and persistence with oral anticancer treatment
Ruddy, K., Mayer, E., & Partridge, A. (2009) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20004 · Cited by 569 · see citing works
NCCN Task Force Report: Oral Chemotherapy
Weingart, S. N., Brown, E., Bach, P. B., Eng, K. J., Johnson, S. A., Kuzel, T. M., Langbaum, T. S., Leedy, R. D., Muller, R. J., Newcomer, L. N., et al. (2008) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2008.2003 · Cited by 438 · see citing works
A Systematic Review of Adherence to Oral Antineoplastic Therapies
Greer, J. A., Amoyal, N. R., Nisotel, L. E., Fishbein, J. N., MacDonald, J. J., Stagl, J. M., Lennes, I. T., Temel, J. S., Safren, S. A., & Pirl, W. F. (2016) · The Oncologist · doi:10.1634/theoncologist.2015-0405 · Cited by 351 · see citing works
McCowan, C., Shearer, J., Donnan, P. T., Dewar, J. A., Crilly, M., Thompson, A. M., & Fahey, T. P. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604758 · Cited by 343 · see citing works
Adherence to tamoxifen over the five-year course
Lash, T. L., Fox, M. P., Westrup, J., Fink, A. K., & Silliman, R. A. (2006) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9193-0 · Cited by 321 · see citing works
Waterhouse, D. M., Calzone, K. A., Mele, C., & Brenner, D. E. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.6.1189 · Cited by 313 · see citing works
Adjuvant Tamoxifen: Predictors of Use, Side Effects, and Discontinuation in Older Women
Demissie, S., Silliman, R. A., & Lash, T. L. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.2.322 · Cited by 301 · see citing works
Cohort study of adherence to adjuvant endocrine therapy, breast cancer recurrence and mortality
Makubate, B., Donnan, P. T., Dewar, J. A., Thompson, A. M., & McCowan, C. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.116 · Cited by 298 · see citing works
Fink, A. K., Gurwitz, J. H., Rakowski, W., Guadagnoli, E., & Silliman, R. A. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.11.064 · Cited by 282 · see citing works
Patient Centered Experiences in Breast Cancer: Predicting Long-Term Adherence to Tamoxifen Use
Kahn, K. L., Schneider, E. C., Malin, J. L., Adams, J. L., & Epstein, A. M. (2007) · Medical Care · doi:10.1097/01.mlr.0000257193.10760.7f · Cited by 245 · see citing works
Kanters, S., Park, J. J. H., Chan, K., Socías, M., Ford, N., Forrest, J. I., Thorlund, K., Nachega, J., & Mills, E. (2017) · The Lancet HIV · doi:10.1016/s2352-3018(16)30206-5 · Cited by 245 · see citing works
Verbrugghe, M., Verhaeghe, S., Lauwaert, K., Beeckman, D., & Van Hecke, A. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.12.014 · Cited by 202 · see citing works
Fallowfield, L. J., Atkins, L., Catt, S., Cox, A., Coxon, C. R., Langridge, C., Morris, R., & Price, M. H. (2005) · Annals of Oncology · doi:10.1093/annonc/mdj044 · Cited by 173 · see citing works
Treatment non-adherence in teenage and young adult patients with cancer
Kondryn, H., Edmondson, C. L., Hill, J., & Eden, T. O. B. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70069-3 · Cited by 151 · see citing works
Impact of Fertility Concerns on Tamoxifen Initiation and Persistence
Llarena, N. C., Estevez, S. L., Tucker, S. L., & Jeruss, J. S. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv202 · Cited by 144 · see citing works
Liu, Y., Malin, J. L., Diamant, A. L., Thind, A., & Maly, R. C. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2387-8 · Cited by 140 · see citing works
Bender, C. M., Gentry, A. L., Brufsky, A. M., Casillo, F. E., Cohen, S. M., Dailey, M. M., Donovan, H. S., Dunbar-Jacob, J., Jankowitz, R. C., Rosenzweig, M. Q., et al. (2014) · Oncology Nursing Forum · doi:10.1188/14.onf.274-285 · Cited by 131 · see citing works
Patient adherence to oral anticancer drugs: an emerging issue in modern oncology.
Foulon, V., Schöffski, P., & Wolter, P. (2011) · PubMed · doi:10.2143/acb.66.2.2062525 · Cited by 97 · see citing works
A review on adherence management in patients on oral cancer therapies
Wood, L. (2011) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2011.10.002 · Cited by 90 · see citing works
Insight into Barriers Against Optimal Adherence to Oral Hormonal Therapy in Women with Breast Cancer
Kirk, M. C., & Hudis, C. A. (2008) · Clinical Breast Cancer · doi:10.3816/cbc.2008.n.016 · Cited by 87 · see citing works
Friese, C. R., Pini, T. M., Li, Y., Abrahamse, P. H., Graff, J. J., Hamilton, A. S., Jagsi, R., Janz, N. K., Hawley, S. T., Katz, S. J., et al. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2499-9 · Cited by 85 · see citing works
Black, K. L., Ikezaki, K., Santori, E. M., Becker, D. P., & Vinters, H. V. (1990) · Cancer · doi:10.1002/1097-0142(19900101)65:1 · Cited by 84 · see citing works
Adherence enhancing interventions for oral anticancer agents: A systematic review
Mathes, T., Antoine, S., Pieper, D., & Eikermann, M. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.07.004 · Cited by 83 · see citing works
Manning, M. A., & Bettencourt, B. A. (2011) · Psychology and Health · doi:10.1080/08870446.2010.542815 · Cited by 81 · see citing works
von Mehren, M., & Widmer, N. (2010) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2010.10.001 · Cited by 73 · see citing works
Bestvina, C. M., Zullig, L. L., & Zafar, S. Y. (2014) · Future Oncology · doi:10.2217/fon.14.130 · Cited by 73 · see citing works
Self-citationMedication taking behaviors among breast cancer patients on adjuvant endocrine therapy
Kimmick, G., Edmond, S. N., Bosworth, H. B., Peppercorn, J., Marcom, P. K., Blackwell, K., Keefe, F. J., & Shelby, R. A. (2015) · The Breast · doi:10.1016/j.breast.2015.06.010 · Cited by 72 · see citing works
Self-citationPath model of multidimensional compliance with cancer therapy.
Richardson, J. L., Marks, G. N., Johnson, C. A., Graham, J. A., Chan, K. K., Selser, J. N., Kishbaugh, C., Barranday, Y., & Levine, A. M. (1987) · Health Psychology · doi:10.1037/0278-6133.6.3.183 · Cited by 70 · see citing works
Oral antineoplastic agents: how do we care about adherence?
Barillet, M., Prevost, V., Joly, F., & Clarisse, B. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12734 · Cited by 68 · see citing works
Modifiable risk factors for adherence to adjuvant endocrine therapy among breast cancer patients
Arriola, K. J., Mason, T. A., Bannon, K. A., Holmes, C. E., Powell, C. L., Horne, K., & O'Regan, R. M. (2014) · Patient Education and Counseling · doi:10.1016/j.pec.2013.12.019 · Cited by 63 · see citing works
Hershman, D. L., Kushi, L. H., Hillyer, G. C., Coromilas, E. J., Buono, D. L., Lamerato, L. E., Bovbjerg, D. H., Mandelblatt, J. S., Tsai, W., Zhong, X., et al. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3788-x · Cited by 62 · see citing works
Predictors of Adherence to Behavior Change Interventions in the Elderly
Culos-Reed, S. N., Rejeski, W. J., McAuley, E., Ockene, J. K., & ROTER, D. L. (2000) · Controlled Clinical Trials · doi:10.1016/s0197-2456(00)00079-9 · Cited by 61 · see citing works
Liew, J. R., Christensen, A. J., & de Moor, J. S. (2014) · Journal of Cancer Survivorship · doi:10.1007/s11764-014-0374-2 · Cited by 59 · see citing works
Wells, K. J., Pan, T. M., Vázquez‐Otero, C., Ung, D., Ustjanauskas, A. E., Muñoz, D., Laronga, C., Roetzheim, R. G., Goldenstein, M., Carrizosa, C. M., et al. (2016) · Supportive Care in Cancer · doi:10.1007/s00520-016-3229-8 · Cited by 57 · see citing works
Adolescent Adherence to Oral Therapy for Leukemia: A Focus Group Study
Malbasa, T., Kodish, E. D., & Santacroce, S. J. (2007) · Journal of Pediatric Oncology Nursing · doi:10.1177/1043454206298695 · Cited by 51 · see citing works
Benjamin, L., Cotté, F.-E., Philippe, C., Mercier, F., Bachelot, T., & Vidal-Trecan, G. M. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.09.019 · Cited by 48 · see citing works
Spoelstra, S., Given, C. W., Sikorskii, A. E., Coursaris, C. K., Majumder, A., DeKoekkoek, T., Schueller, M., & Given, B. A. (2015) · Telemedicine Journal and e-Health · doi:10.1089/tmj.2015.0126 · Cited by 47 · see citing works
Adherence to imatinib therapy in patients with gastrointestinal stromal tumors
Blay, J., & Rutkowski, P. L. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.07.005 · Cited by 43 · see citing works
Rust, C. F., Davis, C., & Moore, M. R. (2015) · Social Work in Health Care · doi:10.1080/00981389.2014.964447 · Cited by 39 · see citing works
Perceptions, Attributions, and Emotions Toward Endocrine Therapy in Young Women with Breast Cancer
Walker, H. E., Rosenberg, S. M., Stanton, A. L., Petrie, K. J., & Partridge, A. H. (2015) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2015.0051 · Cited by 38 · see citing works
Medication adherence: A practical measurement selection guide using case studies
Zullig, L. L., Mendys, P., & Bosworth, H. B. (2017) · Patient Education and Counseling · doi:10.1016/j.pec.2017.02.001 · Cited by 35 · see citing works
Self-citationThe role of parent-adolescent concordance in compliance with cancer chemotherapy.
Tebbi, C. K., Richards, M., Cummings, K. M., Zevon, M. A., & Mallon, J. C. (1988) · PubMed · Cited by 34 · see citing works
Londen, G. J. V., Donovan, H. S., Beckjord, E. B., Cardy, A., Bovbjerg, D. H., Davidson, N. E., Morse, J. Q., Switzer, G. E., Leeuw, I. M. V., & Dew, M. A. (2014) · Oncology nursing forum · doi:10.1188/14.onf.660-668 · Cited by 34 · see citing works
Neugut, A. I., Hillyer, G. C., Kushi, L. H., Lamerato, L. E., Buono, D. L., Nathanson, D. S., Bovbjerg, D. H., Mandelblatt, J. S., Tsai, W., Jacobson, J. S., et al. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3855-3 · Cited by 33 · see citing works
Bhatta, S. S., Hou, N., Moton, Z., Polite, B. N., Fleming, G. F., Olopade, O. I., Huo, D., & Hong, S. (2013) · SpringerPlus · doi:10.1186/2193-1801-2-356 · Cited by 29 · see citing works
Rust, C. F., & Davis, C. (2011) · Social Work in Health Care · doi:10.1080/00981389.2011.585703 · Cited by 27 · see citing works
Mazzoni, E., Fedele, P., Orlando, L., Marino, A., D’amico, M., Sponziello, F., Nacci, A., Calvani, N., Schiavone, P., Rizzo, P. C., et al. (2010) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(10)70048-7 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Distress Management, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology
Riba, M. B., Donovan, K. A., Andersen, B., Braun, I., Breitbart, W. S., Brewer, B. W., Buchmann, L. O., Clark, M. M., Collins, M., Corbett, C., et al. (2019) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2019.0048 · Cited by 871 · see citing works
Molecular mechanisms linking exercise to cancer prevention and treatment
Hojman, P., Gehl, J., Christensen, J. F., & Pedersen, B. K. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.015 · Cited by 600 · see citing works
Soundararajan, P., & Kim, J. S. (2018) · Molecules · doi:10.3390/molecules23112983 · Cited by 268 · see citing works
The relationship between acceptance of cancer and distress: A meta-analytic review
Secinti, E., Tometich, D. B., Johns, S. A., & Mosher, C. E. (2019) · Clinical Psychology Review · doi:10.1016/j.cpr.2019.05.001 · Cited by 132 · see citing works
“and associations with important health outcomes (L. F. Brown et al., 2010; Lin et al., 2017; Pinquart & Duberstein, 2010).”
BackgroundEbrahiminejad, V., Prewett, P. D., Davies, G. J., & Rad, Z. F. (2022) · Advanced Materials Interfaces · doi:10.1002/admi.202101856 · Cited by 81 · see citing works
Zhu, C., Ma, H., He, A., Li, Y., He, C., & Xia, Y. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215814 · Cited by 80 · see citing works
Inotai, A., Ágh, T., van Maris, R. F., Erdősi, D., Kovács, S., Kaló, Z., & Senkus, E. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102264 · Cited by 82 · see citing works
Interventions to Enhance Adherence to Oral Antineoplastic Agents: A Scoping Review
Rosenberg, S. M., Petrie, K. J., Stanton, A. L., Ngo, L. D., Finnerty, E. K., & Partridge, A. H. (2019) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djz244 · Cited by 79 · see citing works
Diagnostic and drug release systems based on microneedle arrays in breast cancer therapy
Khan, S., Hasan, A., Attar, F., Babadaei, M. M. N., Zeinabad, H. A., Salehi, M., Alizadeh, M., Hassan, M., Derakhshankhah, H., Hamblin, M. R., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.036 · Cited by 73 · see citing works
Moreno, P. I., Ramírez, A. G., Miguel‐Majors, S. L. S., Castillo, L., Fox, R. S., Gallion, K. J., Muñoz, E., Estabrook, R., Perez, A., Lad, T. E., et al. (2018) · Supportive Care in Cancer · doi:10.1007/s00520-018-4426-4 · Cited by 72 · see citing works
Ekinci, E., Nathoo, S., Korattyil, T., Vadhariya, A., Zaghloul, H. A., Niravath, P. A., Abughosh, S., & Trivedi, M. V. (2018) · Journal of Cancer Survivorship · doi:10.1007/s11764-017-0674-4 · Cited by 65 · see citing works
Blödt, S., Müller‐Nordhorn, J., Seifert, G., & Holmberg, C. (2021) · Health Expectations · doi:10.1111/hex.13171 · Cited by 49 · see citing works
Talens, A., Guilabert, M., Lumbreras, B., Aznar-Saliente, T., & López-Pintor, E. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18084266 · Cited by 47 · see citing works
Konstantinou, P., Kassianos, A. P., Georgiou, G., Panayides, A., Papageorgiou, A., Almas, I., Wozniak, G., & Karekla, M. (2020) · Translational Behavioral Medicine · doi:10.1093/tbm/ibaa118 · Cited by 89 · see citing works
Park, H. R., Kang, H. S., Kim, S. H., & Singh‐Carlson, S. (2021) · Cancer Nursing · doi:10.1097/ncc.0000000000001030 · Cited by 41 · see citing works
Krok‐Schoen, J. L., Naughton, M. J., Young, G. S., Moon, J., Poi, M. J., Melin, S. A., Wood, M. E., Hopkins, J. O., Paskett, E. D., & Post, D. M. (2019) · Cancer Control · doi:10.1177/1073274819883287 · Cited by 35 · see citing works
Sikorskii, A. E., Given, C. W., Given, B. A., Vachon, E. A., Krauss, J. C., Rosenzweig, M. Q., McCorkle, R. C., Champion, V. L., Banik, A., & Majumder, A. (2018) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2018.07.021 · Cited by 35 · see citing works
Lemogne, C., Bellivier, F., Fakra, É., Yon, L., Limosin, F., Consoli, S. M., Lantieri, L. A., & Hivelin, M. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.02.006 · Cited by 29 · see citing works
Gil-Guillén, V. F., Balsa, A., Bernárdez, B., y Llorca, C. V., Contreras, E. M., de la Haba-Rodríguez, J., Castellano, J. M., & Martínez, J. C. G. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912036 · Cited by 33 · see citing works
Green, S. M. C., French, D., Graham, C. D., Hall, L., Rousseau, N. S., Foy, R., Clark, J., Parbutt, C., Raine, E., Gardner, B., et al. (2022) · BMC Health Services Research · doi:10.1186/s12913-022-08243-4 · Cited by 31 · see citing works
Komatsu, H., Yagasaki, K., Yamaguchi, T., Mori, A., Kawano, H., Minamoto, N., Honma, O., & Tamura, K. (2020) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2020.101780 · Cited by 27 · see citing works
Nguyen, T. Q., Do, M. T., & Pham, T. A. (2021) · Cancer Medicine · doi:10.1002/cam4.4298 · Cited by 27 · see citing works
Factors Associated With Medication Beliefs in Patients With Cancer: An Integrative Review
Marshall, V. K., & Given, B. A. (2018) · Oncology nursing forum · doi:10.1188/18.onf.508-526 · Cited by 26 · see citing works
Impact of anxio-depressive symptoms and cognitive function on oral anticancer therapies adherence
Santos, M. D., Lange, M., Gervais, R., Clarisse, B., Capel, A., Barillet, M., Grellard, J., Heutte, N., Licaj, I., & Joly, F. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-4644-4 · Cited by 26 · see citing works
Yu, J., Wu, J., Huang, O., Chen, X., & Shen, K. (2021) · Journal of Medical Internet Research · doi:10.2196/27576 · Cited by 25 · see citing works
Conley, C. C., McIntyre, M., Pensak, N., Lynce, F., Graham, D., Ismail-Khan, R., Lopez, K., Vadaparampil, S., & O'Neill, S. (2022) · Breast Cancer Research and Treatment · doi:10.1007/s10549-022-06518-2 · Cited by 27 · see citing works
Omari, M., Zarrouq, B., Amaadour, L., Benbrahim, Z., Asri, A. E., Mellas, N., Rhazi, K. E., Ragala, M. E. A., & Halim, K. (2022) · Cancer Control · doi:10.1177/10732748221074735 · Cited by 25 · see citing works
Racial Comparisons in Timeliness of Colon Cancer Treatment in an Equal-Access Health System
Eaglehouse, Y. L., Georg, M. W., Shriver, C. D., & Zhu, K. (2019) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djz135 · Cited by 25 · see citing works
Xiang, G., Xing, N., Wang, S., & Zhang, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1172939 · Cited by 24 · see citing works
Schäfer, A., Jírů-Hillmann, S., Widmann, J., Montellano, F. A., Salmen, J., Pryss, R., Wöckel, A., & Heuschmann, P. U. (2025) · Journal of Cancer Survivorship · doi:10.1007/s11764-023-01470-6 · Cited by 23 · see citing works
Meneveau, M. O., Keim‐Malpass, J., Camacho, T. F., Anderson, R. T., & Showalter, S. L. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05908-8 · Cited by 21 · see citing works
Moon, Z., Moss-Morris, R. E., Hunter, M. S., & Hughes, L. D. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05850-x · Cited by 22 · see citing works
Poelstra, R., Selles, R. W., Slijper, H. P., van der Oest, M. J. W., Feitz, R., Hovius, S. E. R., Porsius, J. T., & the Hand-Wrist Study Group (2018) · Journal of Hand Surgery (European Volume) · doi:10.1177/1753193418780187 · Cited by 21 · see citing works
Lafata, J. E., Nguyen, B., Staresinic, C., Johnson, M., Gratie, D., & Muluneh, B. (2022) · Journal of Oncology Pharmacy Practice · doi:10.1177/10781552211073576 · Cited by 21 · see citing works
Grégoire, C., Marie, N., Sombrun, C., Faymonville, M.-É., Kotsou, I., van Nitsen, V., de Ribaucourt, S., Jérusalem, G., Laureys, S., Vanhaudenhuyse, A., et al. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.807741 · Cited by 21 · see citing works
Nishioka, S., Watanabe, T., Asano, M., YAMAMOTO, T., Kawakami, K., Yada, S., Aramaki, E., Yajima, H., Kizaki, H., & Hori, S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267901 · Cited by 20 · see citing works
Tian, X., Tang, L. L., Yi, L.-J., Qin, X.-P., Chen, G., & Herrera, M. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.857659 · Cited by 17 · see citing works
Tian, X., Liao, Z., Yi, L.-J., Tang, L. L., Chen, G., & Herrera, M. (2022) · Asia-Pacific Journal of Oncology Nursing · doi:10.1016/j.apjon.2022.100151 · Cited by 17 · see citing works
Masiero, M. A., Spada, G. E., Sanchini, V., Munzone, E., Pietrobon, R. S., Teixeira, L., Valencia, M., Machiavelli, A., Fragale, E., Pezzolato, M., et al. (2023) · JMIR Research Protocols · doi:10.2196/48852 · Cited by 17 · see citing works
Le, V. P., Zhong, L., Narsipur, N., Hays, E. A., Tran, D. K., Rosario, K., & Wilson, L. (2021) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2021.27.3.327 · Cited by 18 · see citing works
Price, G. L., Sudharshan, L., Ryan, P. D., Rajkumar, J., Sheffield, K. M., Smyth, E. N., Guimaraes, C. M., Rybowski, S., Carter, G. C., Gathirua‐Mwangi, W. G., et al. (2022) · Current Medical Research and Opinion · doi:10.1080/03007995.2022.2073122 · Cited by 16 · see citing works
PVA-PVP-montmorillonite nanocomposite for efficient delivery of doxorubicin to breast cancer cells
Amini, J., Pourmadadi, M., Abedi, M., Yazdian, F. A., Rahdar, A., & Diez-Pascual, A. M. (2024) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2024.112180 · Cited by 16 · see citing works
Çakmak, H. S. G., & Kapucu, S. (2021) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2021.151140 · Cited by 16 · see citing works
Improvement in adherence to Capecitabine and Lapatinib by way of a therapeutic education program
Vacher, L., Thivat, É., Poirier, C., Mouret‐Reynier, M., Chollet, P. J. M., Devaud, H., Dubray‐Longeras, P., Kwiatkowski, F., Durando, X., Praagh-Doreau, I. V., et al. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-05144-x · Cited by 15 · see citing works
Labonté, M., Guillaumie, L., Dionne, A. R., Dorval, M., Nabi, H., Lemieux, J., Provencher, L., & Lauzier, S. (2020) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2020.02.004 · Cited by 13 · see citing works
Bentley, S., Morgan, L., Exall, E., Arbuckle, R., Rossom, R. C., Roche, N., Khunti, K. K., Higgins, V., & Piercy, J. (2022) · Patient Preference and Adherence · doi:10.2147/ppa.s358046 · Cited by 14 · see citing works
Mortality Prediction of Various Cancer Patients via Relevant Feature Analysis and Machine Learning
Bozkurt, C., & Aşuroğlu, T. (2023) · SN Computer Science · doi:10.1007/s42979-023-01720-5 · Cited by 14 · see citing works
Yang, S., Park, S. W., Bae, S. J., Ahn, S. G., Jeong, J., & Park, K. (2023) · Journal of Breast Cancer · doi:10.4048/jbc.2023.26.e22 · Cited by 15 · see citing works
Yi, F.-C., Zhou, H.-X., Chen, B.-J., Ren, H.-Q., Ma, Z., Zhang, X.-Y., & Duan, J. (2024) · Thoracic Cancer · doi:10.1111/1759-7714.15287 · Cited by 12 · see citing works
Boyne, D. J., O'Sullivan, D. E., Heer, E. V., Hilsden, R. J., Sajobi, T. T., Cheung, W. Y., Brenner, D. R., & Friedenreich, C. M. (2020) · Cancer Medicine · doi:10.1002/cam4.2843 · Cited by 14 · see citing works
Factors influencing psychological wellbeing of early breast cancer patients
DeMiglio, L., Murdoch, V., Ivison, J., Fageria, S., & Voutsadakis, I. A. (2020) · Reports of Practical Oncology & Radiotherapy · doi:10.1016/j.rpor.2020.09.009 · Cited by 14 · see citing works
Initiatives to Improve Safety of Oral Anticancer Agents Delivered by Community Pharmacists
Fricker, J. (2018) · European Medical Journal · doi:10.33590/emj/10310935 · Cited by 14 · see citing works
Anderson, J. N., Paladino, A. J., Blue, R., Dangerfield, D. T., Eggly, S. S., Martin, M. Y., Schwartzberg, L. S., Vidal, G. A., & Graetz, I. (2023) · Journal of Cancer Survivorship · doi:10.1007/s11764-023-01511-0 · Cited by 14 · see citing works
Cancer and Stress: Understanding the Connections and Interventions
D’Andre, S. D., Ellsworth, L. L., Kirsch, J. L., Montane, H. N., Kruger, M. B., Donovan, K. A., Bronars, C. A., Markovic, S. N., & Ehlers, S. L. (2024) · American Journal of Lifestyle Medicine · doi:10.1177/15598276241304373 · Cited by 13 · see citing works
Babcock, A., Ali, A. A., Balkrishnan, R., Montero, A. J., & Diaby, V. (2020) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2020.26.7.826 · Cited by 13 · see citing works
Peerdeman, K. J., Hinnen, C., van Vliet, L. M., & Evers, A. W. M. (2020) · Patient Education and Counseling · doi:10.1016/j.pec.2020.07.021 · Cited by 13 · see citing works
Stephenson, J. J., Gable, J. C., Zincavage, R. M., Price, G. L., Churchill, C., Zhu, E., Stenger, K. B., Singhal, M., Nepal, B., Grabner, M., et al. (2021) · Patient Preference and Adherence · doi:10.2147/ppa.s319239 · Cited by 13 · see citing works
Chang, H. A., Barreto, N. B., Davtyan, A., Beier, E., Cangin, M. A., Salman, J., & Patel, S. K. (2019) · Psycho-Oncology · doi:10.1002/pon.5003 · Cited by 12 · see citing works
Pieters, H. C., Green, E., Khakshooy, S., Sleven, M., & Stanton, A. L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210972 · Cited by 12 · see citing works
Liao, W.-C., Angus, F., Conley, J., & Chen, L. (2025) · JMIR Cancer · doi:10.2196/64208 · Cited by 11 · see citing works
Dang, T. H., O’Callaghan, C. C., Alexander, M., Burbury, K., Jayaraman, P. P., Wickramasinghe, N. S., & Schofield, P. E. (2023) · Supportive Care in Cancer · doi:10.1007/s00520-023-08122-6 · Cited by 12 · see citing works
Beliefs about medicines and adherence in women with breast cancer on adjuvant endocrine therapy
Tan, E. H., Wong, A. L. A., Tan, C. C., Wong, P., Tan, S. H., Ang, L. E. Y., Lim, S. E., Chong, W. Q., Ho, J., Lee, S. C., et al. (2021) · Journal of Health Psychology · doi:10.1177/1359105321990776 · Cited by 10 · see citing works
Villarreal-Garza, C. M., Mesa-Chávez, F., Ferrigno, A. S., la Garza‐Ramos, C. D., Fonseca, A., Villanueva-Tamez, K., Campos-Salgado, J. Y., Cruz‐Ramos, M., Rodriguez-Gomez, D. O., Ruiz-Cruz, S., et al. (2021) · The Breast · doi:10.1016/j.breast.2021.05.013 · Cited by 10 · see citing works
van Helmondt, S. J., Lodder, P., van Woezik, R., de Vries, J., & van der Lee, M. L. (2023) · Annals of Behavioral Medicine · doi:10.1093/abm/kaac078 · Cited by 10 · see citing works
Exploring adherence in patients with advanced breast cancer: focus on CDK4/6 inhibitors
Baković, M., Bago, M., Benić, L., Krajinović, M., Silovski, T., Plavetić, N. D., Turković, L., Sertić, M., & Hadžiabdić, M. O. (2023) · Acta Pharmaceutica · doi:10.2478/acph-2023-0045 · Cited by 9 · see citing works
Rinder, P., Marcille, T., Sinel-Boucher, P., Cals-Maurette, M., Kanoun, D., Lévy, C., Teixeira, L., Hornus, P., Szeftel, D., & Heudel, P. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.11909 · Cited by 9 · see citing works
He, P., Zhang, B., & Shen, S. (2022) · Journal of Healthcare Engineering · doi:10.1155/2022/9506915 · Cited by 10 · see citing works
Ustaoğlu, G., Bulut, D. G., Üyetürk, Ü., & Uysal, Ö. (2020) · Special Care in Dentistry · doi:10.1111/scd.12538 · Cited by 9 · see citing works
Rzeszutek, M. J., DeFulio, A., & Brown, H. D. (2021) · The Psychological Record · doi:10.1007/s40732-021-00489-4 · Cited by 9 · see citing works
Qi, H., Zhu, L., Chen, L., Zhang, W., Wang, T., Chen, H., Wu, Q., Zhan, Q., Le, T. N., Zhang, L., et al. (2021) · Journal of Oncology Pharmacy Practice · doi:10.1177/10781552211027218 · Cited by 8 · see citing works
Saad, A. H., Rabeea, I. S., & Salih, H. (2022) · Iraqi Journal of Pharmaceutical Sciences · doi:10.31351/vol30isssuppl.pp31-39 · Cited by 9 · see citing works
Villarreal-Garza, C. M., Ferrigno, A. S., la Garza‐Ramos, C. D., Vazquez‐Juarez, D., Moreno‐Jaime, B., Bonilla, Y. A. R., Segura‐González, M., Mariscal‐Ramírez, I., Perazzo, F., Jaliffe, G. G., et al. (2023) · Cancer Medicine · doi:10.1002/cam4.6215 · Cited by 8 · see citing works
Alkan, A., Yaşar, A., Güç, Z. G., Gürbüz, M., Başoğlu, T., Göksu, S. S., Başal, F. B., Türk, H. M., Özdemir, Ö., Çınkır, H. Y., et al. (2020) · European Journal of Cancer Care · doi:10.1111/ecc.13296 · Cited by 8 · see citing works
Vizin, G., Szekeres, T., Juhász, A., Marton, L., Dank, M., Perczel-Forintos, D., & Urbán, R. (2023) · BMC Psychology · doi:10.1186/s40359-023-01355-4 · Cited by 7 · see citing works
Conley, C. C., Wernli, K. J., Knerr, S. A., Li, T., Leppig, K. A., Ehrlich, K. J., Farrell, D., Gao, H., Bowles, E. J. A., Graham, A. L., et al. (2021) · Journal of Cancer Education · doi:10.1007/s13187-021-02114-y · Cited by 7 · see citing works
Anxiety and Depression in Patients with Breast Cancer: A Cross-sectional Study
Podvorica, E., Kraja, J., Rrustemi, N., Dugolli, X., & Hyseni, E. (2022) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2022.8310 · Cited by 7 · see citing works
Adherence to oral hormonal anticancer agents in breast cancer
Gori, S., Modena, A., Foglietta, J., Verzè, M., Inno, A., Casarin, A., Russo, A. D., & Nicolis, F. (2022) · Tumori Journal · doi:10.1177/03008916221096183 · Cited by 7 · see citing works
Sollazzo, F., Nitto, M. D., Rosito, L., Torino, F., Alvaro, R., Lacarbonara, F., Vellone, E., & Durante, Á. (2023) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2023.102327 · Cited by 7 · see citing works
Jayani, R., Hamparsumian, A., Sun, C., Li, D., Chien, L. C., Moreno, J., Katheria, V., Hughes, S. F. D. S., Taylor, W. D., & Dale, W. (2024) · Cancer · doi:10.1002/cncr.35482 · Cited by 7 · see citing works
How do Hematologists Communicate with Patients Suffering from Chronic Lymphocytic Leukemia?
Karamanidou, C., Xochelli, A., Ghia, P., & Σταματόπουλος, Κ. (2021) · European Journal of Health Communication · doi:10.47368/ejhc.2021.306 · Cited by 6 · see citing works
Arch, J. J., Slivjak, E. T., Bright, E. E., Crespi, C. M., Levin, M. E., Genung, S. R., Nealis, M. S., ALBRIGHT, K. J., Mitchell, J. L., Sheth, A. D., et al. (2022) · Journal of Contextual Behavioral Science · doi:10.1016/j.jcbs.2022.07.002 · Cited by 6 · see citing works
Bentley, S., Exall, E., Morgan, L., Roche, N., Khunti, K., Rossom, R., Piercy, J., Arbuckle, R., & Higgins, V. (2024) · Patient Preference and Adherence · doi:10.2147/ppa.s433662 · Cited by 6 · see citing works
Moysés, R. P. C., Amaral, G. D. S., Viana, J., Benzaken, A. S., & Pereira, M. G. (2021) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2021.1963222 · Cited by 6 · see citing works
Green, S. M. C., French, D., Graham, C. D., Hall, L., Rousseau, N. S., Foy, R., Clark, J., Parbutt, C., Raine, E., Gardner, B., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1239166/v1 · Cited by 6 · see citing works
Sadigh, G., Meisel, J. L., Byers, K., Robles, A., Serrano, L., Jung, O., Coleman, D., Yeager, K. A., & Graetz, I. (2023) · Journal of Oncology Pharmacy Practice · doi:10.1177/10781552231161823 · Cited by 5 · see citing works
Baralo, B., Paravathaneni, M., Jain, A., Buragamadagu, B., Khanam, A., Iqbal, S. F., Hossain, S., Mulla, S., Choi, E., & Thirumaran, R. (2022) · BMC Psychology · doi:10.1186/s40359-022-00994-3 · Cited by 5 · see citing works
Koch, E. A. T., Steeb, T., Bender-Säbelkampf, S., Busch, D., Feustel, J., Kaufmann, M. D., Maronna, A., Meder, C. H., Ronicke, M., Toussaint, F., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12113813 · Cited by 5 · see citing works
Grégoire, C., Faymonville, M.-É., Vanhaudenhuyse, A., Jérusalem, G., Monseur, J. J., & Bragard, I. (2023) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207144.2023.2249044 · Cited by 5 · see citing works
Green, S. M. C., Smith, S. G., Collins, L. M., & Strayhorn, J. C. (2024) · Translational Behavioral Medicine · doi:10.1093/tbm/ibae029 · Cited by 5 · see citing works
Okroša, A. D., Silovski, T., Plavetić, N. D., Silovski, H., Kovačić, A., & Mucalo, I. (2023) · Acta Pharmaceutica · doi:10.2478/acph-2023-0043 · Cited by 4 · see citing works
Zhang, C., Wang, V., Sarrami, S. M., Reddy, P. D., & Cruz, C. D. L. (2024) · Aesthetic Surgery Journal · doi:10.1093/asj/sjae155 · Cited by 4 · see citing works
Puspitasari, A. W., Kristina, S. A., Satibi, & Prabandari, Y. S. (2022) · INDONESIAN JOURNAL OF PHARMACY · doi:10.22146/ijp.2284 · Cited by 7 · see citing works
Ward, K. A., Muller, D. A., Dutta, S. W., Malhi, J. K., Sanders, J. C., Luminais, C., Millard, T. A., Showalter, T. N., Showalter, S. L., & Janowski, E. (2023) · Clinical Breast Cancer · doi:10.1016/j.clbc.2023.01.012 · Cited by 4 · see citing works
Varet, F., Fournier, V., & Delouvée, S. (2024) · Applied Psychology Health and Well-Being · doi:10.1111/aphw.12615 · Cited by 4 · see citing works
Castel, O. C., Shadmi, E., Keinan‐Boker, L., Granot, T., Karkabi, K., & Dagan, E. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-04668-6 · Cited by 4 · see citing works
Schäfer, A., Wendel, J., Franke, I., Bauer, A., Baumeister, H., Bendig, E., Brucker, S. Y., Deutsch, T. M., Garatva, P., Haas, K., et al. (2024) · Trials · doi:10.1186/s13063-024-08614-8 · Cited by 3 · see citing works
“These factors can have negative consequences for the disease course, including an increase in the frequency and duration of hospital stays, lower adherence to treatment recommendations, difficulties in coping with the disease, reduced quality of life and an increase in mortality [9–14].”
de Aguiar, Y. P. M., de Souza, A. E. S., Silva, C. D. L. E., & Queiroz, S. O. D. C. (2022) · ecancermedicalscience · doi:10.3332/ecancer.2022.1417 · Cited by 3 · see citing works
Nishioka, S., Asano, M., Yada, S., Aramaki, E., Yajima, H., Yanagisawa, Y., Sayama, K., Kizaki, H., & Hori, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-42496-1 · Cited by 5 · see citing works
Oral Anticancer Therapies: Addressing Nonadherence in Patients With Breast Cancer
Cazzaniga, M. E., Huober, J., Tamma, A. V., Emde, A., Thoele, K., & O’Shaughnessy, J. (2024) · Clinical Breast Cancer · doi:10.1016/j.clbc.2024.12.011 · Cited by 3 · see citing works
Paladino, A. J., Pebley, K., Kocak, M., Krukowski, R. A., Waters, T. M., Vidal, G. A., Schwartzberg, L. S., Curry, A. N., & Graetz, I. (2022) · BMC Health Services Research · doi:10.1186/s12913-022-08705-9 · Cited by 3 · see citing works
- Authors
- Lin, C., Clark, R., Tu, P., Bosworth, H. B., & Zullig, L. L.
- Affiliations
- Duke University (US)
- Corresponding author
- Lin, Cheryl
- Venue
- Breast Cancer Research and Treatment
- Published
- 2017-06-01
- Volume
- 165
- Issue
- 2
- Pages
- 247-260
- ISSN
- 0167-6806 (ISSN-L)
- 1573-7217
- OpenAlex
- W2621337730
- Cited by
- 160
- References
- 55
- Citations by year
- 2026: 15 · 2025: 14 · 2024: 20 · 2023: 22 · 2022: 32 · 2021: 23 · 2020: 14 · 2019: 12 · 2018: 7 · 2017: 1
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Breast Cancer Research and Treatment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- VA Research Career Scientist Award (RCS 08-027)
- VA Health Services Research and Development (HSR&D) Career Development Award (CDA 13-025)
- Duke University Bass Connections
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Health Professions › General Health Professions › Patient-Provider Communication in Healthcare
- Keywords
- breast cancer, medication adherence, psychosocial factors, patient-provider relationship, medication beliefs, depression, adverse effects, self-efficacy, social support, patient education, treatment adherence interventions
- MeSH terms
- Administration, Oral, Antineoplastic Agents, Breast Neoplasms, Female, Humans, Physician-Patient Relations, Quality of Life, Stress, Psychological, Medication Adherence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
