Molecular mechanisms linking exercise to cancer prevention and treatment

Hojman, Pernille; Gehl, Julie; Christensen, Jesper F.; Pedersen, Bente K.

doi:10.1016/j.cmet.2017.09.015

Cited by 603Metabolism, Diabetes, and CancerExercise and Physiological ResponsesCancer, Hypoxia, and Metabolism

Molecular mechanisms linking exercise to cancer prevention and treatment

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Hojman, Pernille, Gehl, Julie, Christensen, Jesper F., Pedersen, Bente K.·2018·Cell Metabolism

DOI 10.1016/j.cmet.2017.09.015

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Abstract

The benefits of exercise training for cancer patients are becoming increasingly evident. Physical exercise has been shown to reduce cancer incidence and inhibit tumor growth. Here we provide the status of the current molecular understanding of the effect of exercise on cancer. We propose that exercise has a role in controlling cancer progression through a direct effect on tumor-intrinsic factors, interplay with whole-body exercise effects, alleviation of cancer-related adverse events, and improvement of anti-cancer treatment efficacy. These findings have wide-ranging societal implications, as this understanding may lead to changes in cancer treatment strategies.

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Myokines with anticancer effects have been recognized.
“In addition, myokines with anticancer effects have been recognized (41, 42).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [41]
The anti-inflammatory effects of physical training may mediate some of the protective effects of exercise on cancer development.
“Therefore, the anti-inflammatory effects of physical training may mediate some of the protective effects of exercise on cancer development (41).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [41]
Epidemiological studies suggest that physical activity in leisure time reduces the risk of at least 13 different cancer types.
“Epidemiological studies suggest that physical activity in leisure time reduces the risk of at least 13 different cancer types (41, 42, 222, 223).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [41]
A few mechanistic studies have demonstrated a potential role of other myokines, including Oncostatin M, irisin, and SPARC in the suppression of breast and colon cancer growth.
“A few mechanistic studies have demonstrated a potential role of other myokines, including Oncostatin M, irisin, and SPARC in the suppression of breast and colon cancer growth (41, 224-227).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [41]

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Schlittler, M., Goiny, M., Agudelo, L. Z., Venckūnas, T., Brazaitis, M., Skurvydas, A., Kamandulis, S., Ruas, J. L., Erhardt, S., Westerblad, H., et al. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00053.2016 · Cited by 173 · see citing works
Type I Interferons and Natural Killer Cell Regulation in Cancer
Müller, L., Aigner, P., & Stoiber, D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00304 · Cited by 165 · see citing works
Breast cancer oral anti-cancer medication adherence: a systematic review of psychosocial motivators and barriers
Lin, C., Clark, R., Tu, P., Bosworth, H. B., & Zullig, L. L. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4317-2 · Cited by 160 · see citing works
Modulation of blood flow, hypoxia, and vascular function in orthotopic prostate tumors during exercise
McCullough, D. J., Stabley, J. N., Siemann, D. W., & Behnke, B. J. (2014) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dju036 · Cited by 159 · see citing works
Oncogenic regulation of tumor metabolic reprogramming
Tarrado‐Castellarnau, M., de Atauri, P., & Cascante, M. (2016) · Oncotarget · doi:10.18632/oncotarget.10911 · Cited by 159 · see citing works
Effects of Exercise on Tumor Physiology and Metabolism
Pedersen, L., Christensen, J. F., & Højman, P. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000096 · Cited by 134 · see citing works
Effect of Exercise on Markers of Inflammation in Breast Cancer Survivors: The Yale Exercise and Survivorship Study
Jones, S. B., Thomas, G. A., Hesselsweet, S. D., Alvarez-Reeves, M., Yu, H., & Irwin, M. L. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0278 · Cited by 124 · see citing works
Regular exercise decreases liver tumors development in hepatocyte-specific PTEN-deficient mice independently of steatosis
Piguet, A., Saran, U., Simillion, C., Keller, I., Terracciano, L., Reeves, H. L., & Dufour, J. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.01.017 · Cited by 121 · see citing works
Exercise regulates breast cancer cell viability: systemic training adaptations versus acute exercise responses
Dethlefsen, C., Lillelund, C., Midtgaard, J., Andersen, C., Pedersen, B. K., Christensen, J. F., & Højman, P. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3970-1 · Cited by 120 · see citing works
Effect of Acute Exercise on Prostate Cancer Cell Growth
Rundqvist, H., Augsten, M., Strömberg, A., Rullman, E., Mijwel, S., Kharaziha, P., Panaretakis, T., Gustafsson, T. P., & Östman, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067579 · Cited by 118 · see citing works
Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer
Gallot, Y. S., Durieux, A., Castells, J., Desgeorges, M. M., Vernus, B., Plantureux, L., Rémond, D., Jahnke, V. E., Lefai, É., Dardevet, D. P., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0057 · Cited by 117 · see citing works
Every exercise bout matters: linking systemic exercise responses to breast cancer control
Dethlefsen, C., Pedersen, K. S., & Højman, P. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4129-4 · Cited by 94 · see citing works
Exercise‐induced lung cancer regression: Mechanistic findings from a mouse model
Higgins, K. A., Park, D., Lee, G. Y., Curran, W. J., & Deng, X. (2014) · Cancer · doi:10.1002/cncr.28878 · Cited by 92 · see citing works
Inflammation‐induced activation of the indoleamine 2,3‐dioxygenase pathway: Relevance to cancer‐related fatigue
Kim, S., Miller, B. J., Stefanek, M. E., & Miller, A. H. (2015) · Cancer · doi:10.1002/cncr.29302 · Cited by 90 · see citing works
Effects of exercise training on tumor hypoxia and vascular function in the rodent preclinical orthotopic prostate cancer model
McCullough, D. J., Nguyen, L. M. ‐., Siemann, D. W., & Behnke, B. J. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00949.2013 · Cited by 89 · see citing works
Exercise Improves V˙O2max and Body Composition in Androgen Deprivation Therapy–treated Prostate Cancer Patients
Wall, B. A., Galvao, D. A., Fatehee, N. N., Taaffe, D. R., Spry, N. A., Joseph, D. J., Hébert, J. J., & Newton, R. U. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001277 · Cited by 82 · see citing works
Autophagy and cardiovascular aging
Nair, S., & Ren, J. T. (2012) · Cell Cycle · doi:10.4161/cc.20317 · Cited by 81 · see citing works
Local hyperthermia in head and neck cancer: mechanism, application and advance
Gao, S., Zheng, M. H., Ren, X., Tang, Y., & Liang, X. (2016) · Oncotarget · doi:10.18632/oncotarget.10350 · Cited by 77 · see citing works
Exercise‐induced changes in tumour LDH‐B and MCT1 expression are modulated by oestrogen‐related receptor alpha in breast cancer‐bearing BALB/c mice
Aveseh, M., Nikooie, R., & Aminaie, M. (2015) · The Journal of Physiology · doi:10.1113/jp270463 · Cited by 67 · see citing works
Impact of Acute Intermittent Exercise on Natural Killer Cells in Breast Cancer Survivors
Evans, E. S., Hackney, A. C., McMurray, R. G., Randell, S. H., Muss, H. B., Deal, A. M., & Battaglini, C. L. (2015) · Integrative Cancer Therapies · doi:10.1177/1534735415580681 · Cited by 65 · see citing works
Cancer Immunosurveillance and Immunoediting by Natural Killer Cells
Gross, E. T. E., Sunwoo, J. B., & Bui, J. D. (2013) · The Cancer Journal · doi:10.1097/ppo.0000000000000005 · Cited by 65 · see citing works
Exercise and Prognosis on the Basis of Clinicopathologic and Molecular Features in Early-Stage Breast Cancer: The LACE and Pathways Studies
Jones, L. W., Kwan, M. L., Weltzien, E. K., Chandarlapaty, S., Sternfeld, B., Sweeney, C., Bernard, P. S., Castillo, A., Habel, L. A., Kroenke, C. H., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3307 · Cited by 61 · see citing works
Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer
COLBERT, L. H., WESTERLIND, K. C., PERKINS, S. N., HAINES, D. C., BERRIGAN, D., DONEHOWER, L. A., FUCHS-YOUNG, R., & HURSTING, S. D. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31819f1f05 · Cited by 60 · see citing works
Candidate mechanisms accounting for effects of physical activity on breast carcinogenesis
Thompson, H. J., Jiang, W., & Zhu, Z. (2009) · IUBMB Life · doi:10.1002/iub.233 · Cited by 59 · cited 2× · see citing works
“In contrast, the Akt/mTOR pathway has been shown to be deactivatedwith endurance exercise in several models ofmurine tumors (Thompson et al., 2009).”
Background
Inhibition of Human Lung Cancer Cell Proliferation and Survival by Post-Exercise Serum Is Associated with the Inhibition of Akt, mTOR, p70 S6K, and Erk1/2
Kurgan, N., Tsakiridis, E. E., Kouvelioti, R., Moore, J., Klentrou, P., & Tsiani, E. (2017) · Cancers · doi:10.3390/cancers9050046 · Cited by 58 · see citing works
Voluntary Exercise Prevents Cisplatin-Induced Muscle Wasting during Chemotherapy in Mice
Højman, P., Fjelbye, J., Zerahn, B., Christensen, J. F., Dethlefsen, C., Lønkvist, C. K., Brandt, C., Gissel, H., Pedersen, B. K., & Gehl, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109030 · Cited by 57 · see citing works
Blood flow responses to mild-intensity exercise in ectopic vs. orthotopic prostate tumors; dependence upon host tissue hemodynamics and vascular reactivity
Garcia, E., Becker, V. G. C., McCullough, D. J., Stabley, J. N., Gittemeier, E. M., Opoku-Acheampong, A. B., Sieman, D. W., & Behnke, B. J. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00266.2016 · Cited by 57 · see citing works
Interventions that may reduce depressive symptoms among prostate cancer patients: a systematic review and meta‐analysis
Newby, T. A., Graff, J. N., Ganzini, L. K., & McDonagh, M. S. (2015) · Psycho-Oncology · doi:10.1002/pon.3781 · Cited by 50 · see citing works
The Hippo signal transduction network for exercise physiologists
Gabriel, B. M., Hamilton, D. L., Tremblay, A. M., & Wackerhage, H. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01076.2015 · Cited by 48 · cited 1× · see citing works
“Recent studies have demonstrated that this pathway is downregulated by exercise and catecholamines (Gabriel et al., 2016; Yu et al., 2012).”
Background
Effects of strength training on muscle cellular outcomes in prostate cancer patients on androgen deprivation therapy
Nilsen, T. S., Thorsen, L., Fosså, S. D., Wiig, M., Kirkegaard, C., Skovlund, E., Benestad, H. B., & Raastad, T. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12543 · Cited by 46 · see citing works
Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy
Hvid, T., Winding, K. M., Rinnov, A., Dejgaard, T. F., Thomsen, C., Iversen, P., Brasso, K., Mikines, K. J., van Hall, G., Lindegaard, B., et al. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0393 · Cited by 38 · see citing works
Metabolic Approaches to Treatment of Melanoma
Hersey, P., Watts, R. N., Zhang, X. D., & Hackett, J. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0251 · Cited by 36 · see citing works
Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice
Lu, Y., Lou, Y.-R., Nolan, B., Peng, Q., Xie, J., Wagner, G. C., & Conney, A. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607789103 · Cited by 33 · see citing works
Inflammatory Marker Changes in Postmenopausal Women after a Year-long Exercise Intervention Comparing High Versus Moderate Volumes
Friedenreich, C. M., O’Reilly, R., Shaw, E., Stanczyk, F. Z., Yasui, Y., Brenner, D. R., & Courneya, K. S. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0284 · Cited by 33 · see citing works
Association between changes in fat distribution and biomarkers for breast cancer
van Gemert, W. A., Monninkhof, E. M., May, A. M., Elias, S. G., van der Palen, J. A. M., Veldhuis, W. B., Stapper, M., Stellato, R. K., Schuit, A. J., & Peeters, P. H. M. (2017) · Endocrine Related Cancer · doi:10.1530/erc-16-0490 · Cited by 26 · see citing works
Voluntary physical activity abolishes the proliferative tumor growth microenvironment created by adipose tissue in animals fed a high fat diet
Theriau, C. F., Shpilberg, Y., Riddell, M. C., & Connor, M. K. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00862.2015 · Cited by 25 · see citing works
Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas
Jiang, W., Zhu, Z., & Thompson, H. J. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs350 · Cited by 18 · see citing works

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Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226 · see citing works
“com/edrv A few mechanistic studies have demonstrated a potential role of other myokines, including Oncostatin M, irisin, and SPARC in the suppression of breast and colon cancer growth (41, 224-227).”
BackgroundInfluential
American College of Sports Medicine Roundtable Report on Physical Activity, Sedentary Behavior, and Cancer Prevention and Control
PATEL, A. V., FRIEDENREICH, C. M., MOORE, S. C., HAYES, S. C., SILVER, J. K., CAMPBELL, K. L., WINTERS-STONE, K., GERBER, L. H., GEORGE, S. M., FULTON, J. E., et al. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002117 · Cited by 861 · see citing works
American Cancer Society guideline for diet and physical activity for cancer prevention
Rock, C. L., Thomson, C., Gansler, T., Gapstur, S. M., McCullough, M. L., Patel, A. V., Andrews, K. S., Bandera, E. V., Spees, C. K., Robien, K., et al. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21591 · Cited by 789 · see citing works
Physical activity and muscle-brain crosstalk
Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772 · see citing works
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Papadimitriou, N., Dimou, N. L., Tsilidis, K. K., Banbury, B. L., Martin, R. M., Lewis, S. J., Kazmi, N., Robinson, T., Albanes, D., Aleksandrova, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14389-8 · Cited by 655 · see citing works
Exercise-induced oxidative stress: Friend or foe?
Powers, S. K., Deminice, R., Ozdemir, M., Yoshihara, T., Bomkamp, M. P., & Hyatt, H. (2020) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2020.04.001 · Cited by 655 · see citing works
HIFs, angiogenesis, and metabolism: Elusive enemies in breast cancer
de Heer, E. C., Jalving, M., & Harris, A. L. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137552 · Cited by 372 · see citing works
Resistance Exercise Training as a Primary Countermeasure to Age-Related Chronic Disease
Mcleod, J. C., Stokes, T., & Phillips, S. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00645 · Cited by 254 · see citing works
Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer
Liu, S., Zhang, X., Wang, W., Li, X., Sun, X., Zhao, Y., Wang, Q., Li, Y., Hu, F., & Ren, H. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02165-x · Cited by 279 · see citing works
Exercise training in cancer control and treatment
Christensen, J. F., Simonsen, C., & Hojman, P. (2018) · Comprehensive physiology · doi:10.1002/cphy.c180016 · Cited by 203 · see citing works
Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization
Schild, T., Low, V., Blenis, J., & Gomes, A. P. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.02.001 · Cited by 185 · see citing works
The physiology of optimizing health with a focus on exercise as medicine
Pedersen, B. K. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114339 · Cited by 163 · see citing works
Molecular Mechanisms of Exercise on Cancer: A Bibliometrics Study and Visualization Analysis via CiteSpace
Zhong, D., Li, Y., Huang, Y., Hong, X., Li, J., & Jin, R. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.797902 · Cited by 159 · see citing works
Cancer and stress: NextGen strategies
Cui, B., Peng, F., Lu, J., He, B., Su, Q., Luo, H., Deng, Z., Jiang, T., Su, K., Huang, Y., et al. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.005 · Cited by 152 · see citing works
Roles of matrix metalloproteinase-7 (MMP-7) in cancer
Liao, H.-Y., Da, C.-M., Liao, B., & Zhang, H. (2021) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2021.03.003 · Cited by 152 · see citing works
Circadian rhythms and cancers: the intrinsic links and therapeutic potentials
Zhou, L., Zhang, Z., Nice, E. C., Huang, C., Zhang, W., & Tang, Y. C. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01238-y · Cited by 156 · see citing works
Impacts of exercise interventions on different diseases and organ functions in mice
Guo, S., Huang, Y., Yan, Z., Huang, H., Hong, S., & Liu, T. (2019) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2019.07.004 · Cited by 150 · see citing works
Sarcopenia and Cognitive Function: Role of Myokines in Muscle Brain Cross-Talk
Scisciola, L., Fontanella, R. A., Surina, S., Cataldo, V., Paolisso, G., & Barbieri, M. (2021) · Life · doi:10.3390/life11020173 · Cited by 143 · see citing works
Machine Learning: A New Prospect in Multi-Omics Data Analysis of Cancer
Arjmand, B., Hamidpour, S. K., Tayanloo-Beik, A., Goodarzi, P., Aghayan, H. R., Adibi, H., & Larijani, B. A. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.824451 · Cited by 141 · see citing works
Physical Activity and Cancer Care—A Review
Misiąg, W., Piszczyk, A., Szymańska–Chabowska, A., & Chabowski, M. (2022) · Cancers · doi:10.3390/cancers14174154 · Cited by 139 · see citing works
The current knowledge concerning solid cancer and therapy
Najafi, M., Majidpoor, J., Toolee, H., & Mortezaee, K. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22900 · Cited by 131 · see citing works
Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development
Safe, S. H., Abbruzzese, J. L., Abdelrahim, M., & Hedrick, E. (2018) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-17-0407 · Cited by 120 · see citing works
Intestinal Microbiota: A Novel Target to Improve Anti-Tumor Treatment?
Villéger, R., Lopès, A., Carrier, G., Véziant, J., Billard, E., Barnich, N., Gagnière, J., Vazeille, E., & Bonnet, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184584 · Cited by 119 · see citing works
Effects of exercise on circadian rhythms in humans
Shen, B., Ma, C., Wu, G., Liu, H., Chen, L., & Yang, G. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1282357 · Cited by 125 · see citing works
Effects of Exercise on Cancer Treatment Efficacy: A Systematic Review of Preclinical and Clinical Studies
Yang, L., Morielli, A. R., Heer, E., Kirkham, A. A., Cheung, W. Y., Usmani, N., Friedenreich, C. M., & Courneya, K. S. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-1258 · Cited by 118 · see citing works
Cancer Cachexia and Related Metabolic Dysfunction
da Fonseca, G. W. P., Farkaš, J., Dora, E., von Haehling, S., & Lainščak, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072321 · Cited by 116 · see citing works
Recent advances in near-infrared light-responsive nanocarriers for cancer therapy
Saneja, A., Kumar, R., Arora, D., Kumar, S., Panda, A. K., & Jaglan, S. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.02.005 · Cited by 111 · see citing works
Metabolic interplays between the tumour and the host shape the tumour macroenvironment
Altea‐Manzano, P., Decker-Farrell, A. R., Janowitz, T., & Erez, A. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-024-00786-4 · Cited by 127 · see citing works
Muscle-Organ Crosstalk: Focus on Immunometabolism
Bay, M. L., & Pedersen, B. K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.567881 · Cited by 110 · see citing works
Effects of Exercise on Cardiorespiratory Fitness and Biochemical Progression in Men With Localized Prostate Cancer Under Active Surveillance
Kang, D., Fairey, A., Boulé, N. G., Field, C. J., Wharton, S. A., & Courneya, K. S. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2021.3067 · Cited by 107 · see citing works
Risk factors for early-onset colorectal cancer: systematic review and meta-analysis
Hua, H., Jiang, Q., Sun, P., & Xu, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1132306 · Cited by 107 · see citing works
Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis
Crudele, L., Piccinin, E., & Moschetta, A. (2021) · Nutrients · doi:10.3390/nu13062101 · Cited by 109 · see citing works
Exercise Interventions for Depression, Anxiety, and Quality of Life in Older Adults With Cancer
Soong, R. Y., Low, C. E., Ong, V., Sim, I., Lee, C. Y. C., Lee, F., Chew, L., Yau, C. E., Lee, A. R. Y. B., & Chen, M. Z. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.57859 · Cited by 116 · see citing works
Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
Sanft, T. B., Harrigan, M., McGowan, C. J., Cartmel, B., Zupa, M., Li, F., Ferrucci, L. M., Puklin, L. S., Cao, A., Nguyen, T. H., et al. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.23.00871 · Cited by 109 · see citing works
Safety and feasibility of preoperative exercise training during neoadjuvant treatment before surgery for adenocarcinoma of the gastro-oesophageal junction
Christensen, J. F., Simonsen, C., Banck-Petersen, A., Thorsen-Streit, S., Herrstedt, A., Djurhuus, S. S., Egeland, C., Mortensen, C. E., Kofoed, S., Kristensen, T. S., et al. (2018) · BJS Open · doi:10.1002/bjs5.50110 · Cited by 86 · see citing works
Exercise prehabilitation during neoadjuvant chemotherapy may enhance tumour regression in oesophageal cancer: results from a prospective non-randomised trial
Zylstra, J., Whyte, G. P., Beckmann, K., Pate, J., Santaolalla, A., Gervais-Andre, L., Russell, B. A., Maisey, N. R., Waters, J. S., Tham, G., et al. (2022) · British Journal of Sports Medicine · doi:10.1136/bjsports-2021-104243 · Cited by 84 · see citing works
Molecular insights of exercise therapy in disease prevention and treatment
Walzik, D., Chirino, T. Y. W., Zimmer, P., & Joisten, N. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01841-0 · Cited by 89 · see citing works
Understanding sex differences in the regulation of cancer-induced muscle wasting
Montalvo, R. N., Counts, B. R., & Carson, J. A. (2018) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000380 · Cited by 80 · see citing works
Piezo-type mechanosensitive ion channel component 1 (Piezo1) in human cancer
Yu, J., & Liao, H.-Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111692 · Cited by 78 · see citing works
Exercise in cancer prevention and anticancer therapy: Efficacy, molecular mechanisms and clinical information
Zhu, C., Ma, H., He, A., Li, Y., He, C., & Xia, Y. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215814 · Cited by 80 · see citing works
Voluntary exercise sensitizes cancer immunotherapy via the collagen inhibition-orchestrated inflammatory tumor immune microenvironment
Luo, Z., Mei, J., Wang, X., Wang, R., He, Z., Geffen, Y., Sun, X., Zhang, X., Xu, J., Wan, R., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114697 · Cited by 83 · see citing works
Using ncRNAs as Tools in Cancer Diagnosis and Treatment—The Way towards Personalized Medicine to Improve Patients’ Health
Piergentili, R., Basile, G., Nocella, C., Carnevale, R., Marinelli, E., Patrone, R., & Zaami, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169353 · Cited by 81 · see citing works
Exercise, redox homeostasis and the epigenetic landscape
Dimauro, I., Paronetto, M. P., & Caporossi, D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101477 · Cited by 76 · see citing works
Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration
Becker, M., Joseph, S. S., García‐Carrizo, F., Tom, R. Z., Opaleva, D., Serr, I., Tschöp, M. H., Schulz, T. J., Hofmann, S. M., & Daniel, C. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.08.010 · Cited by 73 · see citing works
Exercise-Induced Mitohormesis for the Maintenance of Skeletal Muscle and Healthspan Extension
Musci, R., Hamilton, K., & Linden, M. (2019) · Sports · doi:10.3390/sports7070170 · Cited by 73 · see citing works
Does exercise intensity matter for fatigue during (neo‐)adjuvant cancer treatment? The Phys‐Can randomized clinical trial
Demmelmaier, I., Brooke, H. L., Henriksson, A., Mazzoni, A., Bjørke, A. C. H., Igelström, H., Ax, A., Sjövall, K., Hellbom, M., Pingel, R., et al. (2021) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.13930 · Cited by 81 · see citing works
The Gut Microbiota: A Potential Gateway to Improved Health Outcomes in Breast Cancer Treatment and Survivorship
Sampsell, K., Hao, D., & Reimer, R. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239239 · Cited by 70 · see citing works
Performing arts as a health resource? An umbrella review of the health impacts of music and dance participation
McCrary, J. M., Redding, E., & ALTENMÜLLER, E. O. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252956 · Cited by 71 · see citing works
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Authors: Hojman, P., Gehl, J., Christensen, J. F., & Pedersen, B. K.
Affiliations: Herlev Hospital (DK)
University of Copenhagen (DK)
ORCID: Gehl, Julie
Christensen, Jesper F.
Pedersen, Bente K.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2018-01
Volume: 27
Issue: 1
Pages: 10-21
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2017.09.015
OpenAlex: W2765400080
Cited by: 600
References: 112
Citations by year: 2026: 63 · 2025: 78 · 2024: 86 · 2023: 71 · 2022: 90 · 2021: 77 · 2020: 70 · 2019: 38 · 2018: 25 · 2017: 1 · 2013: 1
FWCI: 3.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 374 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Danmarks Grundforskningsfond (DNRF55)
Strategiske ForskningsrÃ¥d (09-067009, 09-075724)
TrygFonden
KrÃ¦ftens BekÃ¦mpelse
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: physical activity, cancer prevention, cancer therapy, tumor growth inhibition, tumor progression, tumor-intrinsic factors, exercise-induced metabolic changes, molecular mechanisms
MeSH terms: Humans, Immunity, Models, Biological, Neoplasms, Exercise, Carcinogenesis

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Molecular mechanisms linking exercise to cancer prevention and treatment

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