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Height at diagnosis and birth-weight as risk factors for osteosarcoma
Open accessAbstract
Objectives Osteosarcoma typically occurs during puberty. Studies of the association between height and/or birth-weight and osteosarcoma are conflicting. Therefore, we conducted a large pooled analysis of height and birth-weight in osteosarcoma.Methods Patient data from seven studies of height and three of birth-weight were obtained, resulting in 1,067 cases with height and 434 cases with birth-weight data. We compared cases to the 2000 US National Center for Health Statistics Growth Charts by simulating 1,000 age- and gender-matched controls per case. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between height or birth-weight and risk of osteosarcoma for each study were estimated using logistic regression. All of the case data were combined for an aggregate analysis.Results Compared to average birth-weight subjects (2,665-4,045 g), individuals with high birth-weight (≥ 4,046 g) had an increased osteosarcoma risk (OR 1.35, 95% CI 1.01-1.79). Taller than average (51st - 89th percentile) and very tall individuals (≥ 90th percentile) had an increased risk of osteosarcoma (OR 1.35, 95% CI 1.18-1.54 and OR 2.60, 95% CI 2.19-3.07, respectively; P (trend) < 0.0001).Conclusions This is the largest analysis of height at diagnosis and birth-weight in relation to osteosarcoma. It suggests that rapid bone growth during puberty and in utero contributes to OS etiology.
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“In addition, polygenic interactions may explain the association between tall stature and risk of osteosarcoma 24 .”
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Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
CDC GROWTH CHARTS FOR THE UNITED STATES: METHODS AND DEVELOPMENT 2000
Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Strawn, L. G., Flegal, K. M., & Mei, Z. (2002) · Cited by 6,426
2000 CDC Growth Charts for the United States: methods and development.
Kuczmarski, R. J., Ogden, C. L., Guo, S. S., Grummer‐Strawn, L. M., Flegal, K. M., Mei, Z., Wei, R. X., Curtin, L. R., Roche, A. F., & Johnson, C. L. (2002) · PubMed · Cited by 3,716
Cancer Epidemiology and Prevention
Schottenfeld, D. (2006) · doi:10.1093/acprof:oso/9780195149616.001.0001 · Cited by 3,376
Effect of Treatment of Gestational Diabetes Mellitus on Pregnancy Outcomes
Crowther, C. A., Hiller, J. E., Moss, J. R., McPhee, A. J., Jeffries, W. S., & Robinson, J. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042973 · Cited by 3,159
Tanner, J. M., Whitehouse, R. H., & Takaishi, M. (1966) · Archives of Disease in Childhood · doi:10.1136/adc.41.220.613 · Cited by 2,549
Mirabello, L., Troisi, R. J., & Savage, S. A. (2009) · Cancer · doi:10.1002/cncr.24121 · Cited by 2,199
Self-citationInsulin-like growth factors and neoplasia
Pollak, M., Schernhammer, E. S., & Hankinson, S. E. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1387 · Cited by 1,477
Research works printed but not linked: 4
- Unni KK (1996) Dahlin’s bone tumors: general aspects and data on 11,087 cases. In. 5 edn. Philadelphia: Lippincott-Raven, pp 143–183
- Dorfman HA, Czerniak B (1997) Bone tumors. St. Louis, Mosby, pp 128–252
- Hernández M, Castellet J, Narvaiza JL et al (1988) Curvas y tablas de crecimiento. Instituto de investigación sobre crecimiento y desarrollo. Orbegozo Editorial Garsi, Fundación F. Madrid
- Ruddon RW (1987) Cancer biology. Oxford University Press, New York
Cited by
Sorted by citations
Items 101–116 of 116
Li, X., Zhao, G., & Li, L. (2019) · Cancer Biomarkers · doi:10.3233/cbm-182046 · Cited by 3
Identification of key genes in osteosarcoma – before and after CDK7 treatment
An, Y., Wang, Y., Xu, G., Liao, Y., Huang, G., Jin, X., Xie, C., Li, Q., & Yin, D. (2021) · Medicine · doi:10.1097/md.0000000000027304 · Cited by 3
Lucas, S. E., Yang, T., Wimberly, C. E., Parmar, K. V., Hansen, H. M., de Smith, A. J., Morimoto, L. M., Metayer, C., Ostrom, Q. T., Eward, W. C., et al. (2024) · Cancer Epidemiology · doi:10.1016/j.canep.2024.102599 · Cited by 3
Primary bone cancer in Leonbergers may be associated with a higher bodyweight during adolescence
Anfinsen, K. P., Grotmol, T., Bruland, Ø. S., & Jónasdóttir, T. J. (2015) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2015.02.003 · Cited by 2
(v) Epidemiology of bone & soft tissue sarcomas
Beckingsale, T. B., & Shaw, C. (2015) · Orthopaedics and Trauma · doi:10.1016/j.mporth.2015.03.001 · Cited by 2
Rostami, M., Einafshar, E., Shojaee, M., Soukhtanloo, M., & Jalili‐Nik, M. (2025) · BioNanoScience · doi:10.1007/s12668-025-01885-8 · Cited by 1
Poradowski, D., CIAPUTA, R., Obmińska‐Mrukowicz, B., Nowak, M., Gorzynska, E., & Janus, I. (2016) · Pakistan Veterinary Journal · Cited by 1
Osteosarcoma: Genetics of Inherited Susceptibility
Mirabello, L. J. (2013) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0023880
Self-citationWang, J., Liu, H., Liu, X., & Qi, X. (2015)
Etiology of malign bone tumors
Aksu, N. (2019) · Demiroglu Science University Florence Nightingale Journal of Medicine · doi:10.5606/fng.btd.2019.021
Chu, S. (2019) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/79560
Orpinel‐González, C., Iglesias‐González, M., Herrera‐Loya, J., Martínez‐Méndez, C., Ramírez‐Torres, A., & Ramírez‐Medina, R. (2024) · Medicine International · doi:10.3892/mi.2024.197
Pandi, K., Ramasamy, J., Kasimayan, K., Sakthivel, P., Thirupathi, R., Aravindhan, K., Kumaravel, H., Cheriyan, B. V., & Cheriyan, B. V. (2025) · Journal of Natural Remedies · doi:10.18311/jnr/2025/48036
McAloney, C. A., Fan, T. M., & Roberts, R. D. (2026) · Springer eBooks · doi:10.1007/978-3-032-04454-9_9
Epidemiology of bone cancer in Saudi Arabia: a nationwide population-based study (2004–2020)
Alghamdi, I., Alaidarous, H. A. A., Alghamdi, M., Alghamdi, K. A., Alghamdi, M. A., Alghamdi, M. S., Alzahrani, A. A., Alghamdi, T. A. S., Alomari, O. M., Alghamdi, K., et al. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1780642
Onyije, F. M., Dolatkhah, R., Olsson, A., Bouaoun, L., & Schüz, J. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1797553
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Metadata
- Authors
- Mirabello, L., Pfeiffer, R., Murphy, G., Daw, N. C., Patiño-Garcia, A., Troisi, R. J., Hoover, R. N., Douglass, C., Schüz, J., Craft, A. W., & Savage, S. A.
- Affiliations
- National Institutes of Health (US)
- St. Jude Children's Research Hospital (US)
- Harvard University (US)
- Johannes Gutenberg University Mainz (DE)
- Newcastle University (GB)
- Corresponding author
- Mirabello, Lisa
- ORCID
- Venue
- Cancer Causes & Control
- Published
- 2011-04-05
- Volume
- 22
- Issue
- 6
- Pages
- 899-908
- ISSN
- 0957-5243 (ISSN-L)
- 1573-7225
- PMC
- PMC3494416
- OpenAlex
- W2107929386
- Cited by
- 116
- References
- 74
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 9 · 2021: 10 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 11 · 2014: 5 · 2013: 7 · 2012: 6
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cancer Causes & Control (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (Z99 CA999999)
- National Cancer Institute (Y99 CA999999)
- Topics
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- osteosarcoma, birth weight, tall stature, puberty, cancer risk factors, pooled analysis
- MeSH terms
- Adolescent, Adult, Birth Weight, Body Height, Bone Neoplasms, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Risk Factors, Osteosarcoma, Case-Control Studies, Young Adult
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