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Metabolic Syndrome: Does it Differ Between Women and Men?
Abstract
Cardiovascular disease represents a massive healthcare burden worldwide. Gender differences in the pathophysiology, presentation and prognosis of cardiovascular disease have been described in the literature. Metabolic syndrome, characterized by a cluster of metabolic abnormalities is associated with increased risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease. With the global obesity epidemic, the prevalence of metabolic syndrome is rising rapidly in the developed as well as developing world. However, there is considerable variation in the prevalence based on geography, age, sex and, definition used for diagnosis. Data on gender related differences in metabolic syndrome is relatively scarce. Here, we aim to review the gender differences in epidemiology and pathophysiology of metabolic syndrome as well as its individual components. Knowledge of gender differences in metabolic syndrome can help design gender specific preventative and therapeutic strategies that will have a positive impact on overall population health.
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“The clinical implications of this issue are unclear [15,136].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [136]
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Metadata
- Authors
- Rochlani, Y., Pothineni, N. V., & Mehta, J. L.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- Corresponding author
- Rochlani, Yogita
- Venue
- Cardiovascular Drugs and Therapy
- Published
- 2015-05-21
- Volume
- 29
- Issue
- 4
- Pages
- 329-338
- ISSN
- 0920-3206 (ISSN-L)
- 1573-7241
- OpenAlex
- W329676011
- Cited by
- 152
- References
- 94
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 13 · 2023: 14 · 2022: 19 · 2021: 19 · 2020: 18 · 2019: 10 · 2018: 12 · 2017: 16 · 2016: 13 · 2015: 2
- FWCI
- 12.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cardiovascular Drugs and Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- metabolic syndrome, sex differences, gender differences, cardiovascular disease, type 2 diabetes, atherosclerotic cardiovascular disease, obesity, pathophysiology
- MeSH terms
- Animals, Female, Hormones, Humans, Male, Polycystic Ovary Syndrome, Sex Characteristics, Metabolic Syndrome
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