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Cited by 182Natural Antidiabetic Agents StudiesMedicinal Plant ResearchDiabetes Treatment and Management

Phytotherapy in the management of diabetes: A review

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Governa, Paolo, Baini, Giulia, Borgonetti, Vittoria, Cettolin, Giulia, Giachetti, Daniela, Magnano, Anna, Miraldi, Elisabetta, Biagi, Marco·2018·Molecules
DOI 10.3390/molecules23010105PMC PMC6017385

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Abstract

Phytotherapy has long been a source of medicinal products and over the years there have been many attempts to use herbal medicines for the treatment of diabetes. Several medicinal plants and their preparations have been demonstrated to act at key points of glucidic metabolism. The most common mechanisms of action found include the inhibition of α-glucosidase and of AGE formation, the increase of GLUT-4 and PPARs expression and antioxidant activity. Despite the large amount of literature available, the actual clinical effectiveness of medicinal plants in controlling diabetes-related symptoms remains controversial and there is a crucial need for stronger evidence-based data. In this review, an overview of the medicinal plants, which use in the management of diabetes is supported by authoritative monographs, is provided. References to some species which are currently under increasing clinical investigation are also reported.

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  • Herbals/botanicals have demonstrated potent anti-diabetic effects via a variety of mechanisms, such as enhancing insulin sensitivity, stimulating insulin secretion, blocking carbohydrate absorption, and reducing oxidative stress.

    “Herbals/botanicals have demonstrated potent anti-diabetic effects via a variety of mechanisms, such as enhancing insulin sensitivity, stimulating insulin secretion, blocking the absorption of carbohydrates, and reducing OS; the inhibition of α-glucosidase enzyme and the generation of advanced glycation products, the transcription of GLUT-4 and PPAR, and the presence of antioxidants.”

    From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [137]

    The Conclusions identify α-glucosidase inhibition, increased GLUT-4 and PPAR expression, and antioxidant activity as common mechanisms. The Cinnamon section also describes improved insulin sensitivity and stimulated insulin release. But the Introduction says clinical effectiveness remains controversial, so describing botanical anti-diabetic effects broadly as demonstrated and potent overstates the review's conclusion. (LLM, conf=0.87)

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Authors
Governa, P., Baini, G., Borgonetti, V., Cettolin, G., Giachetti, D., Magnano, A., Miraldi, E., & Biagi, M.
Affiliations
University of Siena (IT)
Corresponding author
Governa, Paolo
ORCID
Venue
Molecules
Publisher
MDPI AG
Published
2018-01-04
Volume
23
Issue
1
Pages
105
ISSN
1420-3049 (ISSN-L)
DOI
10.3390/molecules23010105
PMC
PMC6017385
OpenAlex
W2774849955
Cited by
182
References
8
Citations by year
2026: 13 · 2025: 16 · 2024: 18 · 2023: 20 · 2022: 31 · 2021: 32 · 2020: 28 · 2019: 11 · 2018: 12 · 2016: 1
FWCI
3.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecules (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion, other-oa)
  • Use Siena air (University of Siena) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
herbal medicine, diabetes mellitus, medicinal plants, α-glucosidase inhibition, advanced glycation end products, GLUT4, peroxisome proliferator-activated receptors, antioxidant activity, clinical effectiveness
MeSH terms
Diabetes Mellitus, Humans, Hypoglycemic Agents, Phytotherapy, Plants, Medicinal, Ethnobotany

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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