Cited by 121Alcoholism and Thiamine DeficiencyBiochemical Acid Research StudiesFolate and B Vitamins Research

Metabolic and structural role of thiamine in nervous tissues

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Bâ, Abdoulaye·2008·Cellular and Molecular Neurobiology

Abstract

In the literature, previous descriptions of the role of thiamine (B1 vitamin) focused mostly on its biochemical functions as a coenzyme precursor of some key enzymes of the carbohydrate metabolism. This report reviews recent developments on the metabolic and structural role of thiamine, e.g., the coenzyme and noncoenzyme functions of the vitamin. Taking into account analysis of our experimental data relating to the effects of thiamine deficiency on developing central nervous system (CNS) and data available in literature, we seek to establish a clear difference between the metabolic and structural role of thiamine. Our experimental data indicate that the specific and nonspecific effects express two diametrically diverse functions of thiamine in development: the nonspecific effects show up the metabolic consequences of thiamine deficiency resulting in apoptosis and severe cellular deficit; inversely, the specific effects announced the structural consequences of thiamine deficiency, described as cellular membrane damage, irregular and ectopic cells. The review highlights the existence of noncoenzyme functions of this vitamin through its interactions with biological membranes.

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Crossref · 10.1007/s10571-008-9297-7

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Authors
Bâ, A.
Affiliations
Université Félix Houphouët-Boigny (CI)
Corresponding author
Bâ, Abdoulaye
Venue
Cellular and Molecular Neurobiology
Published
2008-07-19
Volume
28
Issue
7
Pages
923-931
ISSN
  • 0272-4340 (ISSN-L)
  • 1573-6830
OpenAlex
W2105339966
Cited by
121
References
66
Citations by year
2026: 7 · 2025: 13 · 2024: 7 · 2023: 13 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 6
FWCI
0.63
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Neurobiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
Keywords
thiamine, thiamine deficiency, central nervous system development, apoptosis, membrane damage
MeSH terms
Animals, Brain, Cell Membrane, Hippocampus, Humans, Nerve Degeneration, Neurons, Thiamine, Thiamine Deficiency, Apoptosis, Rats, Neurogenesis

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