Health-related quality of life in adolescents with inflammatory bowel disease depends on disease activity and psychiatric comorbidity
Abstract
Adolescent patients with inflammatory bowel disease (IBD) show an increased risk for behavioral and emotional dysfunction. Health-related quality of life (HRQoL) is influenced by medical illnesses, as well as by psychiatric disorders, but for adolescents with IBD, the extent to which HRQoL is influenced by these two factors is unclear. For 47 adolescent IBD patients, we analyzed disease activity, HRQoL and whether or not a psychiatric disorder was present. Disease activity was estimated using pediatric Ulcerative Colitis Activity Index and pediatric Crohn's Disease Activity Index. The IMPACT-III and the EQ-5D were used to measure HRQoL and QoL, respectively. In addition, patient and parent diagnostic interviews were performed. 55.3 % patients fulfilled DSM-IV criteria for one or more psychiatric disorders. In all patients, psychiatric comorbidity together with disease activity contributed to a reduction in quality of life. Adolescents with IBD are at a high risk for clinically relevant emotional or behavioral problems resulting in significantly lower HRQoL. We conclude that accessible, optimally structured psychotherapeutic and/or psychiatric help is needed in adolescent patients with IBD.
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Psychological symptoms, perceived stress, and disease severity can have a deleterious effect on HRQOL.
“It has been confirmed that psychological symptoms, perceived stress, and disease severity can have a deleterious effect on HRQOL (103, 104).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [104]
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- Authors
- Engelmann, G., Erhard, D., Petersen, M., Parzer, P., Schlarb, A. A., Resch, F., Brunner, R., Hoffmann, G. F., Lenhartz, H., & Richterich, A.
- Affiliations
- Lukaskrankenhaus (DE)
- Heidelberg University (DE)
- Bielefeld University (DE)
- Katholisches Kinderkrankenhaus Wilhelmstift (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Engelmann, G.
- Venue
- Child Psychiatry & Human Development
- Published
- 2014-05-18
- Volume
- 46
- Issue
- 2
- Pages
- 300-307
- ISSN
- 0009-398X (ISSN-L)
- 1573-3327
- OpenAlex
- W2004339494
- Cited by
- 72
- References
- 38
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 2 · 2014: 2 · 2012: 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Child Psychiatry & Human Development (publishedVersion)
- PubMed (publishedVersion)
- PUB – Publications at Bielefeld University (Bielefeld University) (submittedVersion)
- Publikationen an der Universität Bielefeld (Universität Bielefeld) (submittedVersion)
- Funders
- Dietmar Hopp Stiftung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Health Professions › Speech and Hearing › Adolescent and Pediatric Healthcare
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- inflammatory bowel disease, adolescents, health-related quality of life, disease activity, psychiatric comorbidity, ulcerative colitis, Crohn's disease, emotional and behavioral problems, psychotherapy, EQ-5D
- MeSH terms
- Adolescent, Mental Disorders, Child, Cross-Sectional Studies, Female, Humans, Male, Quality of Life, Inflammatory Bowel Diseases, Comorbidity
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