Psychiatric Disorders in Adult and Paediatric Patients with Inflammatory Bowel Diseases—A Systematic Review and Meta-Analysis
Abstract
Background: Inflammatory bowel diseases [IBD], which are associated with a high disease burden, are also reported to be accompanied by a high prevalence of psychiatric disorders. However, the literature on IBD and psychiatric disorders has not been reviewed. Methods: This systematic review followed the PRISMA guidelines, and its protocol was registered at PROSPERO [ID: CRD42020214359]. PubMed, Embase and PsycINFO were consulted for the literature search. Studies reporting on diagnosed psychiatric disorders in IBD were included. Pooled prevalence rates were calculated using random effects meta-analyses. Study quality was assessed using the Newcastle–Ottawa Scale [NOS]. Results: Sixty-nine studies were identified with an average cohort size of 60 114 patients. Pooled prevalence rates were: mood disorders, 10% (95% confidence interval [CI] = 7%; 15%); anxiety disorders, 12% [95% CI = 8%; 18%]; substance misuse, 3% [95% CI = 1%; 7%]; psychotic disorders, 2% [95% CI = 1%; 4%]; behavioural disorders, 1% [95% CI = 0%; 3%]; personality disorders, 3% [95% CI = 1%; 10%]; developmental disorders, 1% [95% CI = 0%; 3%]; and behavioural and emotional disorders with onset usually during childhood, 1% [95% CI = 1%; 3%]. All analyses had high statistical heterogeneity [I2 > 99%]. Seven studies reported an increased risk of suicide in IBD patients compared to controls. Conclusion: The prevalence of psychiatric comorbidities was high [11–82%] in patients with IBD and was higher than in the background population. Addressing mental health problems in patients with IBD can improve their adherence to treatment and the somatic disease course and, consequently, reduce morbidity and mortality.
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Children with IBD have higher rates of mental disorders, most commonly anxiety and depression.
“A systematic review of psychiatric disorders in IBD, which included pediatric (nine studies), adult (36 studies) and both adult and pediatric participants (24 studies), found higher rates of mental disorders for children with IBD as well as for adults—most commonly anxiety and depression (11).”
From The 2023 Impact of Inflammatory Bowel Disease in Canada: Mental Health and Inflammatory Bowel Disease (2023) · cites this paper as [11]
In a review and meta-analysis of 60,114 adult and pediatric IBD patients, prevalence of mood disorders was 10%, anxiety disorders 12%, substance misuse 3%, psychotic disorders 2%, behavioral disorders 1%, personality disorders 3%, developmental disorders 1%, and behavioral and emotional disorders with onset usually during childhood 1%.
“A review and meta-analysis of 60.114 adult and pediatric IBD patients identified high prevalence of: mood disorders, 10%; anxiety disorders, 12%; substance misuse, 3%; psychotic disorders, 2%; behavioral disorders, 1%; personality disorders, 3%; developmental disorders, 1%; and behavioral and emotional disorders with onset usually during childhood, 1% [102].”
From Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood (2023) · cites this paper as [102]
Depression and anxiety disorders were the most studied mental health disorders, both in pediatric and adult IBD patients.
“depression and anxiety disorders were the most studied mental health disorders, both in pediatric and adult IBD patients [41,101,102].”
From Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood (2023) · cites this paper as [102]
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Dotson, J. L., Bricker, J. B., Kappelman, M. D., Chisolm, D. J., & Crandall, W. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000521 · Cited by 19 · see citing works
Ulcerative colitis in Finland:
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Anxiety, depression, and inflammation after restorative proctocolectomy
Gorrepati, V. S., Yadav, S. K., Stuart, A., Koltun, W. A., Messaris, E., Williams, E., & Coates, M. D. (2018) · International Journal of Colorectal Disease · doi:10.1007/s00384-018-3110-y · Cited by 13 · see citing works
Cross-sectional analysis of patient phone calls to an inflammatory bowel disease clinic.
Corral, J. E., Yarur, A. J., Diaz, L., et al. (2015) · PubMed · Cited by 12 · see citing works
Beery, R. M. M., Barnes, E. L., Nadkarni, A., & Korzenik, J. R. (2017) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izx005 · Cited by 12 · see citing works
Depression Predicts Prolonged Length of Hospital Stay in Pediatric Inflammatory Bowel Disease
Patel, P. V., Pantell, M. S., Heyman, M. B., & Verstraete, S. G. (2019) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002426 · Cited by 11 · see citing works
Blaney, C., Sommer, J. L., El-Gabalawy, R. M., Bernstein, C. N., Walld, R., Hitchon, C. A., Bolton, J. M., Sareen, J., Patten, S. B., Singer, A. G., et al. (2020) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796019000854 · Cited by 11 · see citing works
One-year risk of opioid use disorder after index hospitalization for inflammatory bowel disease
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Mental disorders in ulcerative colitis
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Predictors of Excessive CT Scan Use in a Surgical Cohort of Patients With Crohn's Disease
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Flagged first, then by citations
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Sorted by citations
Graff, L. A., Geist, R., Kuenzig, M. E., Benchimol, E. I., Kaplan, G. G., Windsor, J. W., Bitton, A., Coward, S., Jones, J. L., Lee, K., et al. (2023) · Journal of the Canadian Association of Gastroenterology · doi:10.1093/jcag/gwad012 · Cited by 30 · see citing works
“A systematic review of psychiatric disorders in IBD, which included pediatric (nine studies), adult (36 studies) and both adult and pediatric participants (24 studies), found higher rates of mental disorders for children with IBD as well as for adults—most commonly anxiety and depression (11).”
BackgroundSălcudean, A., Nan, A. G., Bodo, C. R., Cosma, M. C., Strete, E. G., & Lica, M. M. (2023) · Diagnostics · doi:10.3390/diagnostics13111868 · Cited by 24 · see citing works
He, Y., Chen, C.-L., He, J., & Liu, S.-D. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i44.5872 · Cited by 10 · see citing works
- Authors
- Arp, L., Jansson, S., Wewer, V., & Burisch, J.
- Affiliations
- Amager Hospital (DK)
- Corresponding author
- Arp, Laura
- Venue
- Journal of Crohn's and Colitis
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-07-01
- Volume
- 16
- Issue
- 12
- Pages
- 1933-1945
- ISSN
- 1873-9946 (ISSN-L)
- 1876-4479
- OpenAlex
- W4283773290
- Cited by
- 38
- References
- 94
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 11 · 2023: 9
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Crohn s and Colitis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- inflammatory bowel disease, psychiatric comorbidity
- MeSH terms
- Adult, Mental Disorders, Child, Humans, Inflammatory Bowel Diseases, Cohort Studies, Comorbidity, Prevalence
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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