CoChat
Sign Up
Cited by 7Maternal Mental Health During Pregnancy and PostpartumNeuroendocrine regulation and behaviorAttachment and Relationship Dynamics

The DOI matches its Crossref record, with a small difference in title or year; 3 of the 3 references it cites were found in a registry or an index.

Joint Roles of Oxytocin- and Dopamine-Related Genes and Childhood Parenting Experience in Maternal Supportive Social Network

Open access
Koyama, Yuna, Nawa, Nobutoshi, Ochi, Manami, Surkan, Pamela J., Fujiwara, Takeo·2024·Child Psychiatry & Human Development
DOI 10.1007/s10578-022-01434-4
Open this paper in CoChat — free account

Abstract

How genes and parenting determine maternal social support availability, an important preventive factor of postpartum depression, has been little studied. Our study aimed to examine the interaction effects of maternal sociality-related gene and parenting on maternal social support. We analyzed data of 115 triads of Japanese grandmothers, mothers, and their infants. An interaction between parenting and cumulative genetic risk, calculated on the sociality-related genes (OXTR rs53576, rs2254298, rs1042778; COMT rs4680), was found. Mothers with high genetic risk received less social support if received poorer parenting (B = - 0.02, 95%CI = - 0.04 to - 0.01), while no association among low-risk mothers. Poorer social support was associated with severer depression in high-risk mothers (B = - 0.88, 95%CI = - 1.45 to -0.30). Our results suggest that mothers carrying risk alleles of sociality-related genes are particularly sensitive to childhood parenting, underscoring the importance of childhood parenting and genetic risk to understand maternal help-seeking behavior.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s10578-022-01434-4

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 39

  1. Umberson D, Montez JK (2010) Social relationships and health: a flashpoint for health policy. J Health Soc Behav 51(Suppl):S54-66. https://doi.org/10.1177/0022146510383501 · DOI · Paper page
  2. Gryczkowski M, Jordan SS, Mercer SH (2018) Moderators of the relations between mothers’ and fathers’ parenting practices and children’s prosocial behavior. Child Psychiatry Hum Dev 49:409–419. https://doi.org/10.1007/s10578-017-0759-3 · DOI
  3. Eisenberg N, Spinrad TL, Taylor ZE, Liew J (2019) Relations of inhibition and emotion-related parenting to young children’s prosocial and vicariously induced distress behavior. Child Dev 90:846–858. https://doi.org/10.1111/cdev.12934 · DOI
  4. Zou S, Wu X (2020) Coparenting conflict behavior, parent-adolescent attachment, and social competence with peers: an investigation of developmental differences. J Youth Adolesc 49:267–282. https://doi.org/10.1007/s10964-019-01131-x · DOI
  5. Garcia OF, Serra E (2019) Raising children with poor school performance: parenting styles and short- and long-term consequences for adolescent and adult development. Int J Environ Res Public Health. https://doi.org/10.3390/ijerph16071089 · DOI
  6. Martinez-Escudero JA, Villarejo S, Garcia OF, Garcia F (2020) Parental Socialization and Its Impact across the lifespan. Behav Sci. https://doi.org/10.3390/bs10060101 · DOI
  7. Endedijk HM, Nelemans SA, Schür RR et al (2019) The role of stressful parenting and mineralocorticoid receptor haplotypes on social development during adolescence and young adulthood. J Youth Adolesc 48:1082–1099. https://doi.org/10.1007/s10964-019-00988-2 · DOI
  8. Skuse DH, Gallagher L (2011) Genetic influences on social cognition. Pediatr Res 69:85R-91R. https://doi.org/10.1203/PDR.0b013e318212f562 · DOI
  9. Johnson ZV, Young LJ (2017) Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience. Neurosci Biobehav Rev 76:87–98. https://doi.org/10.1016/j.neubiorev.2017.01.034 · DOI · Paper page
  10. Pearce E, Wlodarski R, Machin A, Dunbar RIM (2017) Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality. Proc Natl Acad Sci U S A 114:5300–5305. https://doi.org/10.1073/pnas.1700712114 · DOI · Paper page
  11. Schneider-Hassloff H, Straube B, Jansen A et al (2016) Oxytocin receptor polymorphism and childhood social experiences shape adult personality, brain structure and neural correlates of mentalizing. Neuroimage 134:671–684. https://doi.org/10.1016/j.neuroimage.2016.04.009 · DOI · Paper page
  12. Zheng S, Masuda T, Matsunaga M et al (2020) Oxytocin receptor gene (OXTR) and childhood adversity influence trust. Psychoneuroendocrinology 121:104840. https://doi.org/10.1016/j.psyneuen.2020.104840 · DOI
  13. Zhang Y, Yang X, Wang Z (2021) The COMT rs4680 polymorphism, family functioning and preschoolers’ attentional control indexed by intraindividual reaction time variability. Dev Psychobiol 63:713–724. https://doi.org/10.1002/dev.22040 · DOI
  14. Baumann C, Klauke B, Weber H et al (2013) The interaction of early life experiences with COMT val158met affects anxiety sensitivity. Genes Brain Behav 12:821–829. https://doi.org/10.1111/gbb.12090 · DOI
  15. Lovallo WR, Enoch M-A, Sorocco KH et al (2017) Joint Impact of Early Life Adversity and COMT Val158Met (rs4680) genotypes on the adult cortisol response to psychological stress. Psychosom Med 79:631–637. https://doi.org/10.1097/PSY.0000000000000481 · DOI
  16. Kwon A, Min D, Kim Y et al (2020) Interaction between catechol-O-methyltransferase polymorphism and childhood trauma in suicidal ideation of patients with post-traumatic stress disorder. Brain Behav 10:e01733. https://doi.org/10.1002/brb3.1733 · DOI
  17. Kim HS, Sherman DK, Sasaki JY et al (2010) Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proc Natl Acad Sci U S A 107:15717–15721. https://doi.org/10.1073/pnas.1010830107 · DOI · Paper page
  18. Cohen S, Doyle WJ, Turner R et al (2003) Sociability and susceptibility to the common cold. Psychol Sci 14:389–395. https://doi.org/10.1111/1467-9280.01452 · DOI
  19. Cole PM, Tan PZ (2015) Emotion socialization from a cultural perspective. In: Grusec JE, Hastings PD (eds) Handbook of socialization: theory and research. The Guilford Press, pp. 499–519
  20. Moore SR, Thoemmes F (2016) What is the biological reality of gene-environment interaction estimates? An assessment of bias in developmental models. J Child Psychol Psychiatry 57:1258–1267. https://doi.org/10.1111/jcpp.12579 · DOI
  21. Fujiwara T, Weisman O, Ochi M et al (2019) Genetic and peripheral markers of the oxytocin system and parental care jointly support the cross-generational transmission of bonding across three generations. Psychoneuroendocrinology 102:172–181. https://doi.org/10.1016/j.psyneuen.2018.12.004 · DOI
  22. Silk JB (2007) The adaptive value of sociality in mammalian groups. Philos Trans R Soc London Ser B, Biol Sci 362:539–559. https://doi.org/10.1098/rstb.2006.1994 · DOI
  23. Dennis C-L, Dowswell T (2013) Psychosocial and psychological interventions for preventing postpartum depression. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD001134.pub3 · DOI · Paper page
  24. Inekwe JN, Lee E (2022) Perceived social support on postpartum mental health: an instrumental variable analysis. PLoS ONE 17:e0265941. https://doi.org/10.1371/journal.pone.0265941 · DOI
  25. Eitenmüller P, Köhler S, Hirsch O, Christiansen H (2022) The impact of Prepartum depression and birth experience on postpartum mother-infant bonding: a longitudinal path analysis. Front Psychiatry 13:815822. https://doi.org/10.3389/fpsyt.2022.815822 · DOI
  26. Campbell J, Matoff-Stepp S, Velez ML et al (2021) Pregnancy-associated deaths from homicide, suicide, and drug overdose: review of research and the intersection with intimate partner violence. J Womens Health 30:236–244. https://doi.org/10.1089/jwh.2020.8875 · DOI
  27. Taylor ZE, Conger RD, Robins RW, Widaman KF (2015) Parenting practices and perceived social support: longitudinal relations with the social competence of mexican-origin children. J Lat Psychol 3:193–208. https://doi.org/10.1037/lat0000038 · DOI
  28. Casale M, Cluver L, Crankshaw T et al (2015) Direct and indirect effects of caregiver social support on adolescent psychological outcomes in two south African AIDS-affected communities. Am J Commun Psychol 55:336–346. https://doi.org/10.1007/s10464-015-9705-3 · DOI
  29. Mitchell PH, Powell L, Blumenthal J et al (2003) A short social support measure for patients recovering from myocardial infarction: the ENRICHD social support inventory. J Cardiopulm Rehabil 23:398–403. https://doi.org/10.1097/00008483-200311000-00001 · DOI
  30. Frick PJ (1991) The Alabama parenting questionnaire. Unpubl Rat scale. Univ Alabama, Alabama
  31. Savelieva K, Hintsanen M, Dobewall H et al (2019) The role of oxytocinergic genes in the intergenerational transmission of parent-child relationship qualities. Horm Behav 114:104540. https://doi.org/10.1016/j.yhbeh.2019.06.004 · DOI
  32. Goldman D, Oroszi G, Ducci F (2005) The genetics of addictions: uncovering the genes. Nat Rev Genet 6:521–532. https://doi.org/10.1038/nrg1635 · DOI · Paper page
  33. Zhang L, Hu L, Li X et al (2014) The DRD2 rs1800497 polymorphism increase the risk of mood disorder: evidence from an update meta-analysis. J Affect Disord 158:71–77. https://doi.org/10.1016/j.jad.2014.01.015 · DOI
  34. Cox JL, Holden JM, Sagovsky R (1987) Detection of postnatal depression. Development of the 10-item edinburgh postnatal depression scale. Br J Psychiatry 150:782–786. https://doi.org/10.1192/bjp.150.6.782 · DOI · Paper page
  35. Okano T (1996) Validation and reliability of a Japanese version of the EPDS. Arch Psychiatr Diagnosis Clin Eval 7:525–533
  36. van Buuren S, Groothuis-Oudshoorn K (2010) Mice: multivariate imputation by chained equations in R. J Stat Softw 45(3):1–68
  37. Rubin DB (1987) Multiple imputation for nonresponse in surveys. John Wiley, New York · DOI · Paper page
  38. Belsky J, van IJzendoorn MH, (2017) Genetic differential susceptibility to the effects of parenting. Curr Opin Psychol 15:125–130. https://doi.org/10.1016/j.copsyc.2017.02.021 · DOI
  39. Schneiderman I, Kanat-Maymon Y, Ebstein RP, Feldman R (2014) Cumulative risk on the oxytocin receptor gene (OXTR) underpins empathic communication difficulties at the first stages of romantic love. Soc Cogn Affect Neurosci 9:1524–1529. https://doi.org/10.1093/scan/nst142 · DOI

Cited by

Sorted by citations

Metadata

Authors
Koyama, Y., Nawa, N., Ochi, M., Surkan, P. J., & Fujiwara, T.
Affiliations
  • Tokyo Medical and Dental University (JP)
  • Johns Hopkins University (US)
Corresponding author
Fujiwara, Takeo
ORCID
Venue
Child Psychiatry & Human Development
Publisher
Springer Science and Business Media LLC
Published
2022-09-13
Volume
55
Issue
3
Pages
614-621
ISSN
  • 0009-398X (ISSN-L)
  • 1573-3327
DOI
10.1007/s10578-022-01434-4
OpenAlex
W4295509775
Cited by
7
References
3
Citations by year
2025: 2 · 2024: 3 · 2023: 2
FWCI
1.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Child Psychiatry & Human Development (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
Funders
National Center for Child Health and Development (the Research Development Grant (24-12))
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
Keywords
oxytocin receptor gene, dopamine receptor genes, COMT gene, maternal social support, parenting quality, gene-environment interaction, cumulative genetic risk, postpartum depression, grandmother, mothers, infants
MeSH terms
Grandparents, Adult, Catechol O-Methyltransferase, Female, Humans, Infant, Japan, Male, Mother-Child Relations, Mothers, Social Support, Parenting, Receptors, Oxytocin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review