Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking
Open accessAbstract
Research has demonstrated that certain genotypes are expressed in different forms, depending on input from the social environment. To examine sensitivity to cultural norms regarding emotional support seeking as a type of social environment, we explored the behavioral expression of oxytocin receptor polymorphism (OXTR) rs53576, a gene previously related to socio-emotional sensitivity. Seeking emotional support in times of distress is normative in American culture but not in Korean culture. Consequently, we predicted a three-way interaction of culture, distress, and OXTR genotype on emotional support seeking. Korean and American participants (n = 274) completed assessments of psychological distress and emotional support seeking and were genotyped for OXTR. We found the predicted three-way interaction: among distressed American participants, those with the GG/AG genotypes reported seeking more emotional social support, compared with those with the AA genotype, whereas Korean participants did not differ significantly by genotype; under conditions of low distress, OXTR groups did not differ significantly in either cultural group. These findings suggest that OXTR rs53576 is sensitive to input from the social environment, specifically cultural norms regarding emotional social support seeking. These findings also indicate that psychological distress and culture are important moderators that shape behavioral outcomes associated with OXTR genotypes.
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Men and women homozygous for the A allele of rs53576 reported seeking less emotional social support.
“men and women homozygous for the A allele reported seeking less emotional social support (Kim et al., 2010).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Kim et al., 2010
The OXT receptor (rs53576) polymorphism is associated with emotional social support seeking in Americans but not in Koreans.
“A recent genetic study has also reported that while the OXT receptor (rs53576) polymorphism is associated with emotional social support seeking in Americans, it is not in Koreans [Kim et al., 2010].”
From Oxytocin blurs the self-other distinction during trait judgments and reduces medial prefrontal cortex responses: Oxytocin Blurs Self-Other Distinction (2016) · cites this paper as Kim et al., 2010
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- Authors
- Kim, H. S., Sherman, D. K., Sasaki, J. Y., Xu, J., Chu, T. Q., Ryu, C., Suh, E. M., Graham, K., & Taylor, S. E.
- Affiliations
- University of California, Santa Barbara (US)
- Tufts University (US)
- Yonsei University (KR)
- University of California, Los Angeles (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-08-19
- Volume
- 107
- Issue
- 36
- Pages
- 15717-15721
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2936623
- OpenAlex
- W2140989038
- Cited by
- 341
- References
- 36
- Citations by year
- 2025: 4 · 2024: 10 · 2023: 6 · 2022: 19 · 2021: 16 · 2020: 20 · 2019: 18 · 2018: 31 · 2017: 39 · 2016: 34 · 2015: 30 · 2014: 31 · 2013: 28 · 2012: 32
- FWCI
- 36.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0734230, 0729532)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
- Keywords
- oxytocin receptor, OXTR rs53576, emotional support seeking, psychological distress, cultural norms, gene-environment interaction, Korean culture, American culture, social support
- MeSH terms
- Cultural Characteristics, Emotions, Humans, Polymorphism, Genetic, Social Support, Stress, Psychological, United States, Receptors, Oxytocin, Republic of Korea
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