Oxytocin receptor polymorphism and childhood social experiences shape adult personality, brain structure and neural correlates of mentalizing
Abstract
Introduction The oxytocin system is involved in human social behavior and social cognition such as attachment, emotion recognition and mentalizing (i.e. the ability to represent mental states of oneself and others). It is shaped by social experiences in early life, especially by parent-infant interactions. The single nucleotid polymorphism rs53576 in the oxytocin receptor (OXTR) gene has been linked to social behavioral phenotypes.Method In 195 adult healthy subjects we investigated the interaction of OXTR rs53576 and childhood attachment security (CAS) on the personality traits "adult attachment style" and "alexithymia" (i.e. emotional self-awareness), on brain structure (voxel-based morphometry) and neural activation (fMRI) during an interactive mentalizing paradigm (prisoner's dilemma game; subgroup: n=163).Results We found that in GG-homozygotes, but not in A-allele carriers, insecure childhood attachment is - in adulthood - associated with a) higher attachment-related anxiety and alexithymia, b) higher brain gray matter volume of left amygdala and lower volumes in right superior parietal lobule (SPL), left temporal pole (TP), and bilateral frontal regions, and c) higher mentalizing-related neural activity in bilateral TP and precunei, and right middle and superior frontal gyri. Interaction effects of genotype and CAS on brain volume and/or function were associated with individual differences in alexithymia and attachment-related anxiety. Interactive effects were in part sexually dimorphic.Conclusion The interaction of OXTR genotype and CAS modulates adult personality as well as brain structure and function of areas implicated in salience processing and mentalizing. Rs53576 GG-homozygotes are partially more susceptible to childhood attachment experiences than A-allele carriers.
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Polymorphisms in the human OTR predict social behavioral phenotypes, including those associated with autism, and how early-life experiences shape later psychiatric outcomes.
“Several psychiatric genetic studies have suggested that polymorphisms in the human OTR predict not only social behavioral phenotypes, including those associated with autism (Skuse et al. 2014; Parker et al. 2014; LoParo and Waldman 2015), but also how early-life experiences shape later psychiatric outcomes”
From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as Schneider-Hassloff et al. 2016
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900 · see citing works
Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881 · see citing works
A Caution Regarding Rules of Thumb for Variance Inflation Factors
O’brien, R. M. (2007) · Quality & Quantity · doi:10.1007/s11135-006-9018-6 · Cited by 11,217 · see citing works
Does the chimpanzee have a theory of mind?
Premack, D., & Woodruff, G. (1978) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00076512 · Cited by 8,743 · see citing works
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Bagby, R. M., Parker, J. D. A., & Taylor, G. J. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90005-1 · Cited by 5,293 · see citing works
A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
Eickhoff, S. B., Stephan, K. E., Mohlberg, H., Grefkes, C., Fink, G. R., Amunts, K., & Zilles, K. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.034 · Cited by 4,033 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Adult attachment, working models, and relationship quality in dating couples.
Collins, N. L., & Read, S. J. (1990) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.58.4.644 · Cited by 3,678 · see citing works
Cattaneo, L., & Rizzolatti, G. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.41 · Cited by 3,137 · see citing works
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
Anterior Cingulate Conflict Monitoring and Adjustments in Control
Kerns, J. G., Cohen, J. D., MacDonald, A. W., Cho, R. Y., Stenger, V. A., & Carter, C. S. (2004) · Science · doi:10.1126/science.1089910 · Cited by 2,891 · see citing works
The brain basis of emotion: a meta-analytic review
Lindquist, K. A., Wager, T. D., Kober, H., Bliss-Moreau, E., & Barrett, L. F. (2012) · Behavioral and Brain Sciences · doi:10.1017/s0140525x11000446 · Cited by 2,320 · cited 3× · see citing works
“neuroimaging studies in humans have revealed that the amygdala, a brain structure implicated in responses to motivationally salient stimuli [Lindquist et al., 2012], is”
BackgroundInfluentialFunctional imaging of ‘theory of mind’
Gallagher, H. L., & Frith, C. D. (2003) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(02)00025-6 · Cited by 2,092 · see citing works
The Neural Basis of Mentalizing
Frith, C. D., & Frith, U. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.001 · Cited by 1,855 · see citing works
Models of the self and other: Fundamental dimensions underlying measures of adult attachment.
Griffin, D. W., & Bartholomew, K. (1994) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.67.3.430 · Cited by 1,762 · see citing works
Attachment and development: A prospective, longitudinal study from birth to adulthood
Sroufe, L. A. (2005) · Attachment & Human Development · doi:10.1080/14616730500365928 · Cited by 1,685 · see citing works
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,572 · cited 4× · see citing works
“…behavior and social cognition in humans such as attachment (attachment security and the tendency to share emotions with friends) [Buchheim et al., 2009; Tops et al., 2007], social memory [Bartz et al., 2011], emotion recognition [Shahrestani et al., 2013] and mentalizing [Domes et al., 2007].”
BackgroundInfluentialThe Enigmatic temporal pole: a review of findings on social and emotional processing
Olson, I. R., Plotzker, A., & Ezzyat, Y. (2007) · Brain · doi:10.1093/brain/awm052 · Cited by 1,370 · see citing works
A Stagewise Rejective Multiple Test Procedure Based on a Modified Bonferroni Test
Hommel, G. (1988) · Biometrika · doi:10.1093/biomet/75.2.383 · Cited by 1,367 · see citing works
Stoodley, C. J., & Schmahmann, J. D. (2010) · Cortex · doi:10.1016/j.cortex.2009.11.008 · Cited by 1,360 · see citing works
Simpson, J. A., Rholes, W. S., & Nelligan, J. S. (1992) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.62.3.434 · Cited by 1,315 · see citing works
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
Amunts, K., Kedo, O., Kindler, M., Pieperhoff, P., Mohlberg, H., Shah, N. J., Habel, U., Schneider, F., & Zilles, K. (2005) · Anatomy and Embryology · doi:10.1007/s00429-005-0025-5 · Cited by 1,264 · see citing works
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173 · see citing works
The problem of functional localization in the human brain
Brett, M., Johnsrude, I. S., & Owen, A. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn756 · Cited by 1,154 · see citing works
The Neuropeptide Oxytocin Regulates Parochial Altruism in Intergroup Conflict Among Humans
De Dreu, C. K. W., Greer, L. L., Handgraaf, M. J. J., Shalvi, S., Van Kleef, G. A., Baas, M., Ten Velden, F. S., Van Dijk, E., & Feith, S. W. W. (2010) · Science · doi:10.1126/science.1189047 · Cited by 1,148 · see citing works
Vulnerability genes or plasticity genes?
Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.44 · Cited by 1,017 · see citing works
Mind reading: Neural mechanisms of theory of mind and self-perspective
Vogeley, K., Bussfeld, P., Newen, A., Herrmann, S., Happé, F., Falkai, P., Maier, W., Shah, N. J., Fink, G. R., & Zilles, K. (2001) · NeuroImage · doi:10.1006/nimg.2001.0789 · Cited by 998 · see citing works
Neural Economics and the Biological Substrates of Valuation
Montague, P. R., & Berns, G. S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00974-1 · Cited by 994 · see citing works
The problem of functional localization in the human brain
Morgan, T. (2002) · Cited by 968 · see citing works
The Neural Bases of Social Cognition and Story Comprehension
Mar, R. A. (2011) · Annual Review of Psychology · doi:10.1146/annurev-psych-120709-145406 · Cited by 950 · see citing works
Production of subject-verb agreement, tense, mood, and negation in Italian agrammatic aphasia.
Valantis, F., Semenza, C., Rita, C., Marialuisa, G., Serena, D. P., Giorgio, A., Francesca, B., Anna, M., Nicola, S., & Gabriele, M. (2015) · Frontiers in Psychology · doi:10.3389/conf.fpsyg.2015.65.00011 · Cited by 872 · see citing works
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856 · cited 1× · see citing works
“…is shaped by social experiences in early life, especially by parent-infant AC C EP TE D M AN U SC R IP T interactions [Bales and Perkeybile, 2012; Ross and Young, 2009]: Studies in rats showed that variations in maternal care induced long-term changes in the OXT receptor expression (e.g. in the…”
BackgroundOxytocin receptor genetic variation relates to empathy and stress reactivity in humans
Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909579106 · Cited by 812 · see citing works
The neuropsychiatry of the cerebellum — insights from the clinic
Schmahmann, J. D., Weilburg, J. B., & Sherman, J. C. (2007) · The Cerebellum · doi:10.1080/14734220701490995 · Cited by 718 · see citing works
Champagne, F., Diorio, J., Sharma, S., & Meaney, M. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221224598 · Cited by 707 · see citing works
The neural correlates of theory of mind within interpersonal interactions
Rilling, J. K., Sanfey, A. G., Aronson, J. A., Nystrom, L. E., & Cohen, J. D. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.04.015 · Cited by 638 · see citing works
Neuroanatomical and neurochemical bases of theory of mind.
Abu-Akel, A., & Shamay-Tsoory, S. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.07.012 · Cited by 616 · see citing works
Oxytocin is associated with human trustworthiness
ZAK, P., KURZBAN, R., & MATZNER, W. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.07.009 · Cited by 595 · see citing works
Fries, A. B. W., Ziegler, T. E., Kurian, J. R., Jacoris, S., & Pollak, S. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504767102 · Cited by 570 · see citing works
Epigenetics and the environmental regulation of the genome and its function
Zhang, T.-Y., & Meaney, M. J. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163625 · Cited by 565 · see citing works
Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer–Lindenberg, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003296107 · Cited by 564 · see citing works
The parent–infant dyad and the construction of the subjective self
Fonagy, P., Gergely, G., & Target, M. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01727.x · Cited by 555 · see citing works
Intranasal Administration of Oxytocin Increases Envy and Schadenfreude (Gloating)
Shamay-Tsoory, S. G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., & Levkovitz, Y. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.009 · Cited by 542 · cited 1× · see citing works
“…behavior in AC C EP TE D M AN U SC R IP T interactions with familiar or reliable others [Kosfeld et al., 2005; Zak et al., 2005], but decreased prosociality in situations of social uncertainty [Declerck et al., 2010] or social competition [De Dreu et al., 2010; Shamay-Tsoory et al., 2009].”
BackgroundInsel, T. R., & Hulihan, T. J. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.782 · Cited by 528 · see citing works
Lower CSF oxytocin concentrations in women with a history of childhood abuse
Heim, C., Young, L. J., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.112 · Cited by 518 · see citing works
Epigenetic mechanisms mediating the long-term effects of maternal care on development
Champagne, F. A., & Curley, J. P. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.009 · Cited by 504 · see citing works
Can Machines Think? Interaction and Perspective Taking with Robots Investigated via fMRI
Krach, S., Hegel, F., Wrede, B., Sagerer, G., Binkofski, F., & Kircher, T. T. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002597 · Cited by 490 · see citing works
Self-citationA sensorimotor paradigm for Bayesian model selection
Genewein, T., & Braun, D. A. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00291 · Cited by 487 · see citing works
Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Gamer, M., Zurowski, B., & Büchel, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000985107 · Cited by 487 · cited 2× · see citing works
“For the left amygdala enhanced responses to fearful faces in comparison to happy faces have been reported, and OXT administration reversed the response pattern [Gamer et al., 2010].”
BackgroundResultBakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2008) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsn004 · Cited by 474 · see citing works
No Gene Is an Island: The Flip-Flop Phenomenon
Lin, P., Vance, J. M., Pericak‐Vance, M. A., & Martin, E. R. (2007) · The American Journal of Human Genetics · doi:10.1086/512133 · Cited by 465 · see citing works
Social cognition and the anterior temporal lobes: a review and theoretical framework
Olson, I. R., McCoy, D., Klobusicky, E., & Ross, L. A. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss119 · Cited by 452 · see citing works
Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
CARTER, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.025 · Cited by 432 · see citing works
Francis, D. D., Young, L. J., Meaney, M. J., & Insel, T. R. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2002.00776.x · Cited by 415 · see citing works
Security of Attachment as a Predictor of Symbolic and Mentalising Abilities: A Longitudinal Study
Meins, E., Fernyhough, C., Russell, J. A., & Clark-Carter, D. D. (1998) · Social Development · doi:10.1111/1467-9507.00047 · Cited by 414 · see citing works
Impaired self-awareness and theory of mind: An fMRI study of mentalizing in alexithymia
Moriguchi, Y., Ohnishi, T., Lane, R. D., Maeda, M., Mori, T., Nemoto, K., Matsuda, H., & Komaki, G. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.04.186 · Cited by 397 · see citing works
Alexithymia, Not Autism, Predicts Poor Recognition of Emotional Facial Expressions
Cook, R., Brewer, R., Shah, P., & Bird, G. (2013) · Psychological Science · doi:10.1177/0956797612463582 · Cited by 378 · see citing works
Gender differences in alexithymia.
Levant, R. F., Hall, R. J., Williams, C. M., & Hasan, N. T. (2009) · Psychology of Men & Masculinity · doi:10.1037/a0015652 · Cited by 356 · see citing works
Oxytocin enhances the encoding of positive social memories in humans.
Guastella, A. J., Mitchell, P. B., & Mathews, F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.008 · Cited by 352 · see citing works
Dopaminergic-neuropeptide interactions in the social brain
Skuse, D. H., & Gallagher, L. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.09.007 · Cited by 340 · see citing works
Declerck, C. H., Boone, C., & Kiyonari, T. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.01.006 · Cited by 331 · see citing works
Rilling, J. K., DeMarco, A. C., Hackett, P. D., Thompson, R., Ditzen, B., Patel, R., & Pagnoni, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.013 · Cited by 303 · see citing works
Bethlehem, R. A. I., van Honk, J., Auyeung, B., & Baron-Cohen, S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.011 · Cited by 285 · see citing works
Shahrestani, S., Kemp, A. H., & Guastella, A. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.86 · Cited by 283 · see citing works
The contributions of oxytocin and vasopressin pathway genes to human behavior
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.014 · Cited by 283 · see citing works
Oxytocin receptor polymorphisms and adult attachment style in patients with depression
Costa, B., Pini, S., Gabelloni, P., Abelli, M., Lari, L., Cardini, A., Muti, M., Gesi, C., Landi, S., Galderisi, S., et al. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.006 · Cited by 282 · see citing works
Berthoz, S., Eric Artiges, A., de Moortele, P. V., Poline, J., Rouquette, S., Consoli, S. M., & Martinot, J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.6.961 · Cited by 278 · see citing works
Oxytocin enhances the experience of attachment security
Buchheim, A., Heinrichs, M., George, C., Pokorny, D., Koops, E., Henningsen, P., O’Connor, M.-F., & Gündel, H. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.002 · Cited by 277 · see citing works
Immunohistochemical localization of oxytocin receptors in human brain
Boccia, M. L., Petrusz, P., Suzuki, K., Marson, L., & Pedersen, C. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.048 · Cited by 276 · see citing works
Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W., Völzke, H., Freyberger, H. J., Herrmann, F. H., Kroemer, H., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.04.004 · Cited by 271 · see citing works
Chen, F. S., Kumsta, R., von Dawans, B., Monakhov, M., Ebstein, R. P., & Heinrichs, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113079108 · Cited by 268 · see citing works
Post-learning intranasal oxytocin modulates human memory for facial identity
Savaskan, E., Ehrhardt, R., Schulz, A., Walter, M., & Schächinger, H. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.12.004 · Cited by 262 · see citing works
Social cognition and the anterior temporal lobes
Ross, L. A., & Olson, I. R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.012 · Cited by 261 · see citing works
Individual Attachment Style Modulates Human Amygdala and Striatum Activation during Social Appraisal
Vrtička, P., Andersson, F., Grandjean, D., Sander, D., & Vuilleumier, P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002868 · Cited by 260 · see citing works
Metzger, C. D., van der Werf, Y. D., & Walter, M. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00024 · Cited by 242 · see citing works
Effects of oxytocin on recollections of maternal care and closeness
Bartz, J. A., Zaki, J., Ochsner, K. N., Bolger, N., Kolevzon, A., Ludwig, N., & Lydon, J. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012669107 · Cited by 235 · cited 3× · see citing works
“The social salience hypothesis postulates that OXT heightens attention to social cues, increases their salience via linking them to mesolimbic dopamine pathways and enhances the formation of social memories along with their reinforcing properties [Bartz et al., 2010; Insel and Young, 2001; Skuse and Gallagher, 2011].”
BackgroundSmeltzer, M. D., Curtis, J. T., Aragona, B. J., & Wang, Z. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.019 · Cited by 222 · see citing works
Interplay of oxytocin, vasopressin, and sex hormones in the regulation of social recognition
Gabor, C. S., Phan, A., Clipperton-Allen, A. E., Kavaliers, M., & Choleris, E. (2012) · Behavioral Neuroscience · doi:10.1037/a0026464 · Cited by 221 · see citing works
Everything You Never Wanted to Know about Circular Analysis, but Were Afraid to Ask
Kriegeskorte, N., Lindquist, M. A., Nichols, T. E., Poldrack, R. A., & Vul, E. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.86 · Cited by 214 · see citing works
Bradley, B., Westen, D., Mercer, K. B., Binder, E. B., Jovanovic, T., Crain, D., Wingo, A., & Heim, C. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000162 · Cited by 213 · see citing works
Sensitivity to Intranasal Oxytocin in Adult Men with Early Parental Separation
Meinlschmidt, G., & Heim, C. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.007 · Cited by 210 · see citing works
On Being Insecure about the Assessment of Attachment Styles
Kurdek, L. A. (2002) · Journal of Social and Personal Relationships · doi:10.1177/0265407502196005 · Cited by 209 · see citing works
Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience
Kumsta, R., Hummel, E., Chen, F. S., & Heinrichs, M. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00083 · Cited by 207 · see citing works
Oxytocin receptor genetic variation promotes human trust behavior
Krueger, F., Parasuraman, R., Iyengar, V., Thornburg, M., Weel, J., Lin, M., Clarke, E., McCabe, K., & Lipsky, R. H. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00004 · Cited by 207 · see citing works
Zarei, M., Patenaude, B., Damoiseaux, J., Morgese, C., Smith, S. M., Matthews, P., Barkhof, F., Rombouts, S., Sanz-Arigita, E. J., & Jenkinson, M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.09.001 · Cited by 199 · see citing works
Anxiety, cortisol, and attachment predict plasma oxytocin
Tops, M., Van Peer, J. M., Korf, J., Wijers, A. A., & Tucker, D. M. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00510.x · Cited by 197 · see citing works
Kusui, C., Kimura, T., Ogita, K., Nakamura, H., Matsumura, Y., Koyama, M., Azuma, C., & Murata, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6024 · Cited by 196 · see citing works
DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli
Jack, A., Connelly, J. J., & Morris, J. P. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00280 · Cited by 192 · cited 2× · see citing works
“Methylation status in the OXTR CpG island was shown to be functional in healthy humans: Higher levels of methylation were associated with higher neural activation in STG, SMG and dorsal ACC in a social perception task [Jack et al., 2012].”
BackgroundDempfle, A., Scherag, A., Hein, R., Beckmann, L., Chang-Claude, J. C., & Schäfer, H. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.106 · Cited by 190 · see citing works
Lukas, M., Bredewold, R., Neumann, I. D., & Veenema, A. H. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.020 · Cited by 183 · see citing works
Bach, M., Bach, D., de Zwaan, M., Serim, M., & Böhmer, F. (1996) · PubMed · Cited by 179 · see citing works
Consequences of Early Experiences and Exposure to Oxytocin and Vasopressin Are Sexually Dimorphic
Carter, C. S., Boone, E. M., Pournajafi-Nazarloo, H., & Bales, K. L. (2009) · Developmental Neuroscience · doi:10.1159/000216544 · Cited by 176 · see citing works
Genetic Correlates of Adult Attachment Style
Gillath, O., Shaver, P., Baek, J.-M., & Chun, D. S. (2008) · Personality and Social Psychology Bulletin · doi:10.1177/0146167208321484 · Cited by 166 · see citing works
McQuaid, R. J., McInnis, O. A., Stead, J. D. H., Matheson, K., & Anisman, H. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00128 · Cited by 158 · see citing works
Insecure attachment and personality disorder: a twin study of adults
Crawford, T. N., Livesley, W. J., Jang, K. L., Shaver, P. R., Cohen, P. R., & Ganiban, J. M. (2006) · European Journal of Personality · doi:10.1002/per.602 · Cited by 157 · see citing works
Bales, K. L., Plotsky, P. M., Young, L. J., Lim, M. M., Grotte, N., Ferrer, E., & Carter, C. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.009 · Cited by 150 · see citing works
Developmental experiences and the oxytocin receptor system
Bales, K. L., & Perkeybile, A. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.013 · Cited by 142 · see citing works
A Longitudinal Study of Mother‐Child Relationships and Theory of Mind in the Preschool Period
Symons, D. K., & Clark, S. E. (2000) · Social Development · doi:10.1111/1467-9507.00108 · Cited by 139 · see citing works
Alexithymia and levels of processing: Evidence for an overall deficit in remembering emotion words
Luminet, O., Vermeulen, N., Demaret, C., Taylor, G. J., & Bagby, R. M. (2005) · Journal of Research in Personality · doi:10.1016/j.jrp.2005.09.001 · Cited by 138 · see citing works
Bradley, B., Davis, T. A., Wingo, A. P., Mercer, K. B., & Ressler, K. J. (2013) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v4i0.21659 · Cited by 137 · see citing works
M.I.N.I. Mini International Neuropsychiatric Interview
Sheehan, D. V., Janavs, J., Baker, R. A., Harnett-Sheehan, K., Knapp, E., & Sheehan, M. F. (2000) · Medical Entomology and Zoology · Cited by 118 · see citing works
Vrtička, P., Bondolfi, G., Sander, D., & Vuilleumier, P. (2012) · Social Neuroscience · doi:10.1080/17470919.2011.647410 · Cited by 116 · see citing works
Personality-dependent effects of oxytocin: greater social benefits for high alexithymia scorers
Luminet, O., Grynberg, D., Ruzette, N., & Mikolajczak, M. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.05.005 · Cited by 107 · see citing works
Cortical activation in alexithymia as a response to emotional stimuli
Karlsson, H., Näätänen, P., & Stenman, H. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.034728 · Cited by 105 · see citing works
Bindungen - das Gefüge psychischer Sicherheit
Grossmann, K., & Grossmann, K. E. (2014) · doi:10.5555/9783608201529 · Cited by 102 · see citing works
Sex and species differences in plasma oxytocin using an enzyme immunoassay
Kramer, K. M., Cushing, B. S., Carter, C. S., Wu, J., & Ottinger, M. A. (2004) · Canadian Journal of Zoology · doi:10.1139/z04-098 · Cited by 99 · see citing works
Insausti, R., & Amaral, D. G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374236-0.10024-0 · Cited by 97 · see citing works
Genetic Influences on Social Cognition
Skuse, D., & Gallagher, L. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212f562 · Cited by 95 · see citing works
Hostinar, C. E., Cicchetti, D., & Rogosch, F. A. (2014) · Development and Psychopathology · doi:10.1017/s0954579414000066 · Cited by 92 · see citing works
Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal
Riem, M. M. E., van IJzendoorn, M. H., Tops, M., Boksem, M. A. S., Rombouts, S. A. R. B., & Bakermans-Kranenburg, M. J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.01.011 · Cited by 91 · see citing works
Online mentalising investigated with functional MRI
Kircher, T. T. J., Blümel, I., Marjoram, D. K. S., Lataster, T., A, L. K. M., Weber, J., van Os, J., & Krach, S. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.026 · Cited by 86 · see citing works
Self-citationMoriguchi, Y., Ohnishi, T., Decety, J., Hirakata, M., Maeda, M., Matsuda, H., & Komaki, G. (2008) · Human Brain Mapping · doi:10.1002/hbm.20653 · Cited by 86 · see citing works
Xu, G., McLaren, D. G., Ries, M. L., Fitzgerald, M. E., Bendlin, B. B., Rowley, H. A., Sager, M. A., Atwood, C., Asthana, S., & Johnson, S. C. (2008) · Brain · doi:10.1093/brain/awn254 · Cited by 82 · see citing works
Mentalizing language development in a longitudinal attachment sample: implications for alexithymia
Lemche, E., Klann-Delius, G., Koch, R., & Joraschky, P. (2004) · Psychotherapy and Psychosomatics · doi:10.1159/000080390 · Cited by 80 · see citing works
Mizumoto, Y., Kimura, T., & Ivell, R. (1997) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)00195-0 · Cited by 79 · see citing works
Raby, K. L., Cicchetti, D., Carlson, E. A., Egeland, B. R., & Collins, W. A. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12093 · Cited by 77 · see citing works
Adult attachment insecurity and hippocampal cell density
Quirin, M., Gillath, O., Pruessner, J. C., & Eggert, L. D. (2010) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsp042 · Cited by 71 · see citing works
Partial support for ZNF804A genotype‐dependent alterations in prefrontal connectivity
Paulus, F. M., Krach, S., Bedenbender, J., Pyka, M., Sommer, J. B., Krug, A., Knake, S., Nöthen, M. M., Witt, S. H., Rietschel, M., et al. (2011) · Human Brain Mapping · doi:10.1002/hbm.21434 · Cited by 68 · see citing works
Self-citationDistress of ostracism: oxytocin receptor gene polymorphism confers sensitivity to social exclusion
McQuaid, R. J., McInnis, O. A., Matheson, K., & Anisman, H. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu166 · Cited by 67 · see citing works
Oxytocin's Fingerprint in Personality Traits and Regional Brain Volume
Andari, E., Schneider, F. C., Mottolese, R., Vindras, P., & Sirigu, A. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs328 · Cited by 63 · see citing works
Lucht, M. J., Barnow, S., Sonnenfeld, C., Ulrich, I., Grabe, H. J., Schroeder, W., Völzke, H., Freyberger, H. J., John, U., Herrmann, F. H., et al. (2012) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2012.700731 · Cited by 58 · see citing works
Hammen, C. L., Bower, J. E., & Cole, S. W. (2014) · Journal of Personality Disorders · doi:10.1521/pedi_2014_28_152 · Cited by 58 · see citing works
Attachment and psychopathology in a community sample
Ward, M. J., Lee, S. S., & Polan, H. J. (2006) · Attachment & Human Development · doi:10.1080/14616730601048241 · Cited by 57 · see citing works
Chang, W. H., Lee, I. H., Chen, K. C., Chi, M. H., Chiu, N.-T., Yao, W. J., Lu, R., Yang, Y. K., & Chen, P. S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.05.020 · Cited by 54 · see citing works
Donges, U., Kugel, H., Stuhrmann, A., Grotegerd, D., Redlich, R., Lichev, V., Rosenberg, N., Ihme, K. A., Suslow, T., & Dannlowski, U. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.036 · Cited by 51 · see citing works
Attachment style, affective loss and gray matter volume: A voxel‐based morphometry study
Benetti, S., McCrory, E. J. P., Arulanantham, S., Sanctis, T. D., McGuire, P. K., & Mechelli, A. (2010) · Human Brain Mapping · doi:10.1002/hbm.20954 · Cited by 43 · see citing works
McInnis, O. A., McQuaid, R. J., Matheson, K., & Anisman, H. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01133 · Cited by 42 · see citing works
The effect of Neuregulin 1 on neural correlates of episodic memory encoding and retrieval
Krug, A., Markov, V., Krach, S., Jansen, A., Zerres, K., Eggermann, T., Stöcker, T., Shah, N. J., Nöthen, M. M., Treutlein, J., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.062 · Cited by 34 · see citing works
Self-citationNeumann, E. (2002) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 8 · see citing works
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Acosta, H., Tuulari, J. J., Scheinin, N. M., Hashempour, N., Rajasilta, O., Lavonius, T. I., Pelto, J., Saunavaara, V., Parkkola, R., Lähdesmäki, T., et al. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00175 · Cited by 80 · see citing works
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Ahern, T. H., Olsen, S., Tudino, R., & Beery, A. K. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105209 · Cited by 27 · see citing works
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- Authors
- Schneider-Hassloff, H., Straube, B., Jansen, A., Nuscheler, B., Wemken, G., Witt, S. H., Rietschel, M., & Kircher, T.
- Affiliations
- Philipps University of Marburg (DE)
- Heidelberg University (DE)
- Corresponding author
- Schneider-Hassloff, H.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 134
- Pages
- 671-684
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2339111812
- Semantic Scholar
- 4928ae73e2e2f296f8ba67420a4d8939be612dc4
- Cited by
- 71
- References
- 132
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 13 · 2019: 7 · 2018: 8 · 2017: 10 · 2016: 4
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Funders
- State of Hesse
- DFG (KI 588/14-1, JA 1890/7-1, RI 908/11-1, WI 3439/3-1; KI 588/16-1)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin receptor, OXTR rs53576, insecure attachment, adult attachment styles, attachment anxiety, alexithymia, mentalization, brain gray matter volume, amygdala, superior parietal lobule, temporal pole, precuneus, parent-infant interaction, gene-environment interaction, sex differences, personality traits, social cognition
- MeSH terms
- Adult, Affective Symptoms, Anxiety, Brain, Brain Mapping, Female, Gene Frequency, Homozygote, Humans, Magnetic Resonance Imaging, Male, Object Attachment, Parent-Child Relations, Personality, Sex Characteristics, Social Behavior, Receptors, Oxytocin, Polymorphism, Single Nucleotide, Young Adult, Theory of Mind
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