The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Potential Anti-inflammatory Effects of Proton Pump Inhibitors: A Review and Discussion of the Clinical Implications
Open accessAbstract
Proton pump inhibitors (PPIs) are potent blockers of gastric acid secretion, and are widely regarded as the agents of choice for the treatment of acid-peptic disorders. For patients with upper gastrointestinal symptoms of uncertain etiology, improvement with PPI therapy is considered prima facie evidence of a pathogenetic role for acid-peptic disease. In addition to anti-secretory effects, however, PPIs have been found to have anti-oxidant properties and direct effects on neutrophils, monocytes, endothelial, and epithelial cells that might prevent inflammation. Those anti-inflammatory effects of the PPIs might influence a variety of inflammatory disorders, both peptic and non-peptic, within and outside of the gastrointestinal tract. The purpose of this report is to review the mechanisms whereby PPIs might exert anti-inflammatory effects exclusive of gastric acid inhibition, to discuss the clinical implications of those effects, and to emphasize that a clinical response to PPIs should not be construed as proof for an underlying acid-peptic disorder.
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Risk of Community-Acquired Pneumonia and Use of Gastric Acid–Suppressive Drugs
Laheij, R. J. F. (2004) · JAMA · doi:10.1001/jama.292.16.1955 · Cited by 877
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Overprescribing proton pump inhibitors
Forgacs, I., & Loganayagam, A. (2008) · BMJ · doi:10.1136/bmj.39406.449456.be · Cited by 553
Pharmacology of proton pump inhibitors
Shin, J. M., & Sachs, G. (2008) · Current Gastroenterology Reports · doi:10.1007/s11894-008-0098-4 · Cited by 538
Acid-suppressive medication use and the risk for hospital-acquired pneumonia
Herzig, S. J. (2009) · JAMA · doi:10.1001/jama.2009.722 · Cited by 486
Effect of Proton Pump Inhibitor Pretreatment on Resistance of Solid Tumors to Cytotoxic Drugs
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Spechler, S. J., Genta, R. M., & Souza, R. F. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01179.x · Cited by 358
Self-citationOxygen, ischemia and inflammation.
Weiss, S. J. (1986) · PubMed · Cited by 308
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Cited by
Eosinophilic esophagitis: Updated consensus recommendations for children and adults
Liacouras, C. A., Furuta, G. T., Hirano, I., Atkins, D., Attwood, S. E., Bonis, P. A., Burks, A. W., Chehade, M., Collins, M. H., Dellon, E. S., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.02.040 · Cited by 2,073
Self-citationDellon, E. S., Liacouras, C. A., Molina-Infante, J., Furuta, G. T., Spergel, J. M., Zevit, N., Spechler, S. J., Attwood, S. E., Straumann, A., Aceves, S. S., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.009 · Cited by 1,162
Self-citationfor the SIF-AIGO-FIMMG Group, Scarpignato, C., on behalf of the Italian Society of Pharmacology, T. I. A. O. H. G., Gatta, L., Zullo, A., & Blandizzi, C. (2016) · BMC Medicine · doi:10.1186/s12916-016-0718-z · Cited by 469
Singh, S., Garg, S. K., Singh, P. P., Iyer, P. G., & El-Serag, H. B. (2014) · Gut · doi:10.1136/gutjnl-2013-305997 · Cited by 298
Barrett Esophagus and Risk of Esophageal Cancer: A Clinical Review
Spechler, S. J. (2013) · JAMA · doi:10.1001/jama.2013.226450 · Cited by 284
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Metadata
- Authors
- Kedika, R. R., Souza, R. F., & Spechler, S. J.
- Venue
- Digestive Diseases and Sciences
- Published
- 2009-08-28
- Volume
- 54
- Issue
- 11
- Pages
- 2312-2317
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2025605750
- Cited by
- 324
- References
- 38
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Kedika, R. R., Souza, R. F., & Spechler, S. J. (2009). Potential Anti-inflammatory Effects of Proton Pump Inhibitors: A Review and Discussion of the Clinical Implications. Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-009-0951-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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