The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Pharmacology of proton pump inhibitors
Open accessAbstract
The gastric H,K-ATPase is the primary target for the treatment of acid-related diseases. Proton pump inhibitors (PPIs) are weak bases composed of two moieties, a substituted pyridine with a primary pKa of about 4.0, which allows selective accumulation in the secretory canaliculus of the parietal cell, and a benzimidazole with a second pKa of about 1.0. PPIs are acid-activated prodrugs that convert to sulfenic acids or sulfenamides that react covalently with one or more cysteines accessible from the luminal surface of the ATPase. Because of covalent binding, their inhibitory effects last much longer than their plasma half-life. However, the short half-life of the drug in the blood and the requirement for acid activation impair their efficacy in acid suppression, particularly at night. PPIs with longer half-life promise to improve acid suppression. All PPIs give excellent healing of peptic ulcers and produce good results in reflux esophagitis. PPIs combined with antibiotics eradicate Helicobacter pylori.
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Cites
Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase
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Metabolic Reprogramming: the Emerging Concept and Associated Therapeutic Strategies
Yoshida, G. J. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0221-y · Cited by 716
Llorente, C., Jepsen, P., Inamine, T., Wang, L., Bluemel, S., Wang, H. J., Loomba, R., Bajaj, J. S., Schubert, M. L., Sikaroodi, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00796-x · Cited by 257
Brusselaers, N., Wahlin, K., Engstrand, L., & Lagergren, J. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-017739 · Cited by 204
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Maintenance proton pump inhibition therapy and risk of oesophageal cancer
Brusselaers, N., Engstrand, L., & Lagergren, J. (2018) · Cancer Epidemiology · doi:10.1016/j.canep.2018.02.004 · Cited by 80
Metadata
- Authors
- Shin, J. M., & Sachs, G.
- Venue
- Current Gastroenterology Reports
- Published
- 2008-11-25
- Volume
- 10
- Issue
- 6
- Pages
- 528-534
- ISSN
- 1522-8037 (ISSN-L)
- 1534-312X
- OpenAlex
- W2064517127
- Cited by
- 538
- References
- 35
- FWCI
- 47.53
- Type
- book chapter
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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