The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.
Selenium and selenoproteins: it’s role in regulation of inflammation
Open accessAbstract
Selenium is an essential immunonutrient which holds the human's metabolic activity with its chemical bonds. The organic forms of selenium naturally present in human body are selenocysteine and selenoproteins. These forms have a unique way of synthesis and translational coding. Selenoproteins act as antioxidant warriors for thyroid regulation, male-fertility enhancement, and anti-inflammatory actions. They also participate indirectly in the mechanism of wound healing as oxidative stress reducers. Glutathione peroxidase (GPX) is the major selenoprotein present in the human body, which assists in the control of excessive production of free radical at the site of inflammation. Other than GPX, other selenoproteins include selenoprotein-S that regulates the inflammatory cytokines and selenoprotein-P that serves as an inducer of homeostasis. Previously, reports were mainly focused on the cellular and molecular mechanism of wound healing with reference to various animal models and cell lines. In this review, the role of selenium and its possible routes in translational decoding of selenocysteine, synthesis of selenoproteins, systemic action of selenoproteins and their indirect assimilation in the process of wound healing are explained in detail. Some of the selenium containing compounds which can acts as cancer preventive and therapeutics are also discussed. These compounds directly or indirectly exhibit antioxidant properties which can sustain the intracellular redox status and these activities protect the healthy cells from reactive oxygen species induced oxidative damage. Although the review covers the importance of selenium/selenoproteins in wound healing process, still some unresolved mystery persists which may be resolved in near future.
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“A second crucial family of proteins containing SeCys and involved in redox biology is thioredoxin reductases (TRs), which contribute to the regulation of gene expression of multiple transcription factors implicated in inflammatory and cell cycle pathways (e.g., NF-kB and p53) [442], as well as in the recycling of antioxidant molecules [441].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [441]
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“In the antioxidant enzymes GPXs, SeCys residues catalyse the reduction of hydrogen peroxide and peroxide radicals using glutathione as a substrate, thus lowering free radicals and consequent DNA damage [440,441].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [441]
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“SeP is responsible for the distribution of selenium to other organs and tissues [262].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [262]
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Cites
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680
Wound Healing--Aiming for Perfect Skin Regeneration
Martin, P. B. (1997) · Science · doi:10.1126/science.276.5309.75 · Cited by 4,842
The importance of selenium to human health
Rayman, M. P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02490-9 · Cited by 4,163
Wendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,032
The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms
Velnar, T., Bailey, T. A., & Smrkolj, V. (2009) · Journal of International Medical Research · doi:10.1177/147323000903700531 · Cited by 2,446
Characterization of Mammalian Selenoproteomes
Kryukov, G. V., Castellano, S., Novoselov, S. V., Lobanov, A. V., Zehtab, O., Guigó, R., & Gladyshev, V. N. (2003) · Science · doi:10.1126/science.1083516 · Cited by 2,385
Brigelius-Flohé, R., & Maiorino, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.11.020 · Cited by 1,904
Isotopic compositions of the elements 2013 (IUPAC Technical Report)
Meija, J., Coplen, T. B., Berglund, M., Brand, W. A., Bièvre, P. D., Gröning, M., Holden, N. E., Irrgeher, J., Loss, R. D., Walczyk, T., et al. (2016) · Pure and Applied Chemistry · doi:10.1515/pac-2015-0503 · Cited by 1,689
Selenoproteins: Molecular Pathways and Physiological Roles
Labunskyy, V. M., Hatfield, D. L., & Gladyshev, V. N. (2014) · Physiological Reviews · doi:10.1152/physrev.00039.2013 · Cited by 1,452
Research works printed but not linked: 2
- Abbas N, Shaaban S, Abdel-latif E (2015) Synthesis and antitumor activity of some new symmetrical diselenide derivatives. Res J Pharm Biol Chem Sci 6(2015):1655–1664
- Fairweather-Tait SJ, Collings R, Hurst R (2010) Selenium bioavailability: current knowledge and future research requirements. Am J Clin Nutr 91:1484–1491 · DOI
Cited by
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Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145
Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review
Alehagen, U., Opstad, T. B., Alexander, J., Larsson, A., & Aaseth, J. (2021) · Biomolecules · doi:10.3390/biom11101478 · Cited by 69
Ridha, R. K., Alasady, D. H., Azooz, E. A., & Mortada, W. I. (2024) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2024.106286 · Cited by 45
Ouyang, J., Cai, Y., Song, Y., Gao, Z., Bai, R., & Wang, A. (2022) · Nutrients · doi:10.3390/nu14224933 · Cited by 36
Metadata
- Authors
- Hariharan, S., & Dharmaraj, S.
- Affiliations
- Karpagam Academy of Higher Education (IN)
- Corresponding author
- Dharmaraj, Selvakumar
- Venue
- Inflammopharmacology
- Published
- 2020-03-06
- Volume
- 28
- Issue
- 3
- Pages
- 667-695
- ISSN
- 0925-4692 (ISSN-L)
- 1568-5608
- PMC
- PMC7222958
- OpenAlex
- W3010311908
- Cited by
- 659
- References
- 251
- Citations by year
- 2026: 82 · 2025: 142 · 2024: 124 · 2023: 148 · 2022: 98 · 2021: 53 · 2020: 12
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Inflammopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Karpagam Academy of Higher Education
- Russian Science Foundation
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- selenium, selenoproteins, selenocysteine, selenoprotein translation, glutathione peroxidase, selenoprotein S, selenoprotein P, inflammation, wound healing, oxidative stress, antioxidant activity, reactive oxygen species, redox homeostasis, immunonutrition, cancer prevention, thyroid regulation, male fertility
- MeSH terms
- Animals, Antioxidants, Humans, Inflammation, Oxidation-Reduction, Selenium, Reactive Oxygen Species, Selenoproteins
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