The DOI matches its Crossref record; 251 of the 251 references it cites were found in a registry or an index.
Selenium and selenoproteins: it’s role in regulation of inflammation
Open accessAbstract
Selenium is an essential immunonutrient which holds the human's metabolic activity with its chemical bonds. The organic forms of selenium naturally present in human body are selenocysteine and selenoproteins. These forms have a unique way of synthesis and translational coding. Selenoproteins act as antioxidant warriors for thyroid regulation, male-fertility enhancement, and anti-inflammatory actions. They also participate indirectly in the mechanism of wound healing as oxidative stress reducers. Glutathione peroxidase (GPX) is the major selenoprotein present in the human body, which assists in the control of excessive production of free radical at the site of inflammation. Other than GPX, other selenoproteins include selenoprotein-S that regulates the inflammatory cytokines and selenoprotein-P that serves as an inducer of homeostasis. Previously, reports were mainly focused on the cellular and molecular mechanism of wound healing with reference to various animal models and cell lines. In this review, the role of selenium and its possible routes in translational decoding of selenocysteine, synthesis of selenoproteins, systemic action of selenoproteins and their indirect assimilation in the process of wound healing are explained in detail. Some of the selenium containing compounds which can acts as cancer preventive and therapeutics are also discussed. These compounds directly or indirectly exhibit antioxidant properties which can sustain the intracellular redox status and these activities protect the healthy cells from reactive oxygen species induced oxidative damage. Although the review covers the importance of selenium/selenoproteins in wound healing process, still some unresolved mystery persists which may be resolved in near future.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A second crucial family of proteins containing SeCys and involved in redox biology is thioredoxin reductases (TRs), which contribute to the regulation of gene expression of multiple transcription factors implicated in inflammatory and cell cycle pathways (e.g., NF-kB and p53) [442], as well as in the recycling of antioxidant molecules [441].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [441]
In the citing paper
“In the antioxidant enzymes GPXs, SeCys residues catalyse the reduction of hydrogen peroxide and peroxide radicals using glutathione as a substrate, thus lowering free radicals and consequent DNA damage [440,441].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [441]
In the citing paper
“SeP is responsible for the distribution of selenium to other organs and tissues [262].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [262]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Items 201–251 of 251
Tan, Q., Li, J., Yin, H., Wang, L., Tang, W.-C., Zhao, F., Liu, X., & Zeng, H. (2009) · Investigational New Drugs · doi:10.1007/s10637-009-9235-7 · Cited by 42
Ghosh, P., Roy, S. S., Basu, A., Bhattacharjee, A., & Bhattacharya, S. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1012079 · Cited by 42
Talbi, W., Ghazouani, T., Braconi, D., et al. (2018) · Journal of Applied Microbiology · doi:10.1111/jam.14150 · Cited by 42
Selenium Is Depleted in Crohn’s Disease on Enteral Nutrition
Kuroki, F., Matsumoto, T., & Iida, M. (2003) · Digestive Diseases · doi:10.1159/000073346 · Cited by 41
Zhou, M., Ji, S., Wu, Z., Li, Y., Zheng, W., Zhou, H., & Chen, T. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.03.069 · Cited by 40
Posser, T., de Paula, M. T., Franco, J., Leal, R., & Rocha, J. D. D. (2011) · Archives of Toxicology · doi:10.1007/s00204-010-0602-0 · Cited by 39
Peng, F., Guo, X., Li, Z., Li, C., Wang, C., Lv, W., Wang, J., Xiao, F., Kamal, M. A., & Yuan, C. (2016) · Molecules · doi:10.3390/molecules21121731 · Cited by 39
Mehta, S. L., Mendelev, N., Kumari, S., & Li, P. A. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.11.022 · Cited by 37
Last, K., Maharaj, L., Perry, J., et al. (2006) · Annals of Oncology · doi:10.1093/annonc/mdl004 · Cited by 37
(2010) · Journal of Nutrition · doi:10.3945/jn.110.122473 · Cited by 36
Bischoff, M. S., Kinzl, L., & Schmelz, A. (1999) · Der Unfallchirurg · doi:10.1007/s001130050483 · Cited by 35
Synthesis, isomerization and biological activity of novel 2-selenohydantoin derivatives
Ivanenkov, Y. A., Veselov, M. S., Rezekin, I. G., et al. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.12.050 · Cited by 34
Zheng, X., Zhang, Y., Zhang, L. J., et al. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.06.040 · Cited by 34
Lobb, R. J., Jacobson, G. M., Cursons, R. T., & Jameson, M. B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103167 · Cited by 33
Facompre, N. D., Sinha, I., El‐Bayoumy, K., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27468 · Cited by 32
In vitro radical scavenging and cytotoxic activities of novel hybrid selenocarbamates
Romano, B., Plano, D., Encı́o, I., et al. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.02.048 · Cited by 32
Synergistic effect of Ebselen and gamma radiation on breast cancer cells
Thabet, N. M., & Moustafa, E. M. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2017.1325024 · Cited by 32
Zhao, Y., Sun, Q., Zhang, X., et al. (2017) · Soft Matter · doi:10.1039/c7sm01687e · Cited by 32
Liu, M., Fu, J., Li, J., Wang, L., Tan, Q., Ren, X., Peng, Z., & Zeng, H. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.03.001 · Cited by 31
Phenylalkyl isoselenocyanates vs phenylalkyl isothiocyanates: Thiol reactivity and its implications
Crampsie, M. A., Pandey, M. K., Desai, D. H., Spallholz, J. E., Amin, S., & Sharma, A. K. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.08.022 · Cited by 30
Chakraborty, P., Roy, S., & Bhattacharya, S. (2015) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520615666150113123401 · Cited by 29
Ferrocene incorporated selenoureas as anticancer agents
Hussain, R. A., Badshah, A., Pezzuto, J. M., et al. (2015) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2015.04.024 · Cited by 29
Blaß, S., Goost, H., Burger, C., Tolba, R. H., Stoffel‐Wagner, B., Stehle, P., & Ellinger, S. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-157 · Cited by 29
Synthesis of 28a-homoselenolupanes and 28a-homoselenolupane saponins
Sidoryk, K., Rárová, L., Oklešťková, J., et al. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob01938b · Cited by 28
Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2
Bubenik, J. L., Miniard, A. C., & Driscoll, D. M. (2014) · RNA Biology · doi:10.1080/15476286.2014.996472 · Cited by 27
Das, J. K., Sarkar, S., Hossain, S. U., et al. (2013) · PubMed · Cited by 26
Choi, A., Jo, M. J., Jung, M.-J., et al. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.06.046 · Cited by 25
Ducros, V., & Favier, A. E. (2004) · EMC - Endocrinologie · doi:10.1016/j.emcend.2003.10.001 · Cited by 25
Anticancer properties of sodium selenite in human glioblastoma cell cluster spheroids
Berthier, S., Arnaud, J., Champelovier, P., Col, E., Garrel, C., Cottet‐Rousselle, C., Boutonnât, J., Laporte, F., Faure, P., & Hazane‐Puch, F. (2017) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2017.04.012 · Cited by 25
Sodium selenite attenuates lung adenocarcinoma progression by repressing SOX2-mediated stemness
Chen, W., An, J., Guo, J., Wu, Y., Yang, L., Dai, J., Gong, K., Miao, S., Xi, S., & Du, J. (2018) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-018-3561-4 · Cited by 25
Modulation of selenoprotein P expression by TGF‐β1 is mediated by Smad proteins
Mostert, V., Dreher, I., Köhrle, J., Wolff, S., & Abel, J. (2001) · BioFactors · doi:10.1002/biof.5520140118 · Cited by 24
Tobe, T., Ueda, K., Ando, M., et al. (2015) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-015-1254-6 · Cited by 24
Moore, M. A., Wandera, R. C., Xia, Y., et al. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00089-9 · Cited by 22
Guo, P., Zhao, P., Liu, J., Ma, H., Bai, J. Y., Cao, Y., Liu, Y., He, H., & Qi, C. (2012) · Biological Trace Element Research · doi:10.1007/s12011-012-9563-x · Cited by 21
Martin, J., & Hurlbut, J. A. (1976) · Phosphorous and Sulfur and the Related Elements · doi:10.1080/03086647608073336 · Cited by 21
Zubair, M., Ali, M., Ahmad, M., et al. (2015) · Journal of Entomology and Zoology Studies · Cited by 21
Shen, Q., Fan, L., & Newburger, P. E. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20619 · Cited by 20
Enzymatic preparation of α- and β-deuterated or tritiated amino acids with l-methionine γ-lyase
Esaki, N., Sawada, S., Tanaka, H., et al. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90586-3 · Cited by 19
Methylseleninic Acid Suppresses Pancreatic Cancer Growth Involving Multiple Pathways
Wang, L., Hu, H., Wang, Z., Xiong, H., Cheng, Y., Liao, J. D., Deng, Y., & Lü, J. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2014.868911 · Cited by 19
Epigenetic Effects of Dietary Trace Elements
Lau, A. T. Y., Tan, H. W., & Xu, Y. (2017) · Current Pharmacology Reports · doi:10.1007/s40495-017-0098-x · Cited by 19
Singh, U. S., Null, K., & Sinha, R. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700356 · Cited by 18
Selenium and sulindac are synergistic to inhibit intestinal tumorigenesis in Apc/p21 mice
Bi, X., Pohl, N. M., Dong, H., & Yang, W. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-8 · Cited by 18
Wu, X. F., Cao, Y., Zhang, J., et al. (2016) · Biotechnology Letters · doi:10.1007/s10529-016-2056-9 · Cited by 18
Preparation of Two Organoselenium Compounds and Their Induction of Apoptosis to SMMC-7221 Cells
Guo, P., Wang, Q., Liu, J., et al. (2013) · Biological Trace Element Research · doi:10.1007/s12011-013-9715-7 · Cited by 16
Recent insights into human bronchial proteomics – how are we progressing and what is next?
Tan, H. W., Xu, Y., Wu, D., & Lau, A. T. Y. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1417847 · Cited by 16
Hu, B., Cheng, R., Gao, X., Pan, X., Kong, F., Liu, X., Xu, K., & Tang, B. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b02206 · Cited by 16
Selenium: recent clinical advances
Burk, R. F. (2001) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200103000-00011 · Cited by 14
Endo, M., Hasegawa, H., Kaneko, T., et al. (2016) · Journal of Oral and Maxillofacial Surgery Medicine and Pathology · doi:10.1016/j.ajoms.2016.08.006 · Cited by 10
Takeda, T. (2015) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2015.08.018 · Cited by 7
Phyto-transport and Assimilation of Selenium
Yu, X.-Z., & Gu, J. (2013) · Soil biology · doi:10.1007/978-3-642-35564-6_9 · Cited by 5
Tan, Q., Ren, X., Li, J., et al. (2009) · PubMed · Cited by 4
Research works printed but not linked: 2
- Abbas N, Shaaban S, Abdel-latif E (2015) Synthesis and antitumor activity of some new symmetrical diselenide derivatives. Res J Pharm Biol Chem Sci 6(2015):1655–1664
- Fairweather-Tait SJ, Collings R, Hurst R (2010) Selenium bioavailability: current knowledge and future research requirements. Am J Clin Nutr 91:1484–1491 · DOI
Cited by
Sorted by citations
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145
Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review
Alehagen, U., Opstad, T. B., Alexander, J., Larsson, A., & Aaseth, J. (2021) · Biomolecules · doi:10.3390/biom11101478 · Cited by 69
Ridha, R. K., Alasady, D. H., Azooz, E. A., & Mortada, W. I. (2024) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2024.106286 · Cited by 45
Ouyang, J., Cai, Y., Song, Y., Gao, Z., Bai, R., & Wang, A. (2022) · Nutrients · doi:10.3390/nu14224933 · Cited by 36
Metadata
- Authors
- Hariharan, S., & Dharmaraj, S.
- Affiliations
- Karpagam Academy of Higher Education (IN)
- Corresponding author
- Dharmaraj, Selvakumar
- Venue
- Inflammopharmacology
- Published
- 2020-03-06
- Volume
- 28
- Issue
- 3
- Pages
- 667-695
- ISSN
- 0925-4692 (ISSN-L)
- 1568-5608
- PMC
- PMC7222958
- OpenAlex
- W3010311908
- Cited by
- 659
- References
- 251
- Citations by year
- 2026: 82 · 2025: 142 · 2024: 124 · 2023: 148 · 2022: 98 · 2021: 53 · 2020: 12
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Inflammopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Karpagam Academy of Higher Education
- Russian Science Foundation
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- selenium, selenoproteins, selenocysteine, selenoprotein translation, glutathione peroxidase, selenoprotein S, selenoprotein P, inflammation, wound healing, oxidative stress, antioxidant activity, reactive oxygen species, redox homeostasis, immunonutrition, cancer prevention, thyroid regulation, male fertility
- MeSH terms
- Animals, Antioxidants, Humans, Inflammation, Oxidation-Reduction, Selenium, Reactive Oxygen Species, Selenoproteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
