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The Autism Diagnostic Observation Schedule, Module 4: Revised Algorithm and Standardized Severity Scores

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Hus, Vanessa, Lord, Catherine·2014·Journal of Autism and Developmental Disorders

DOI 10.1007/s10803-014-2080-3PMC PMC4104252

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Abstract

The recently published Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) includes revised diagnostic algorithms and standardized severity scores for modules used to assess younger children. A revised algorithm and severity scores are not yet available for Module 4, used with verbally fluent adults. The current study revises the Module 4 algorithm and calibrates raw overall and domain totals to provide metrics of autism spectrum disorder (ASD) symptom severity. Sensitivity and specificity of the revised Module 4 algorithm exceeded 80 % in the overall sample. Module 4 calibrated severity scores provide quantitative estimates of ASD symptom severity that are relatively independent of participant characteristics. These efforts increase comparability of ADOS scores across modules and should facilitate efforts to examine symptom trajectories from toddler to adulthood.

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Authors: Hus, V., & Lord, C.
Affiliations: University of Michigan (US)
ORCID: Lord, Catherine
Venue: Journal of Autism and Developmental Disorders
Publisher: Springer Science and Business Media LLC
Published: 2014-03-04
Volume: 44
Issue: 8
Pages: 1996-2012
ISSN: 0162-3257 (ISSN-L)
1573-3432
DOI: 10.1007/s10803-014-2080-3
PMC: PMC4104252
OpenAlex: W2049567796
Cited by: 547
References: 52
Citations by year: 2026: 33 · 2025: 43 · 2024: 53 · 2023: 43 · 2022: 68 · 2021: 69 · 2020: 52 · 2019: 49 · 2018: 42 · 2017: 46 · 2016: 21 · 2015: 25 · 2014: 3
FWCI: 17.66
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Autism and Developmental Disorders (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders: Foundation for the National Institutes of Health
Autism Speaks (AS7032)
Simons Foundation
Simons Foundation Autism Research Initiative
National Institute of Mental Health (R01MH081873)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
Keywords: Autism Diagnostic Observation Schedule, autism spectrum disorder, diagnostic algorithm, severity scoring, symptom severity, sensitivity and specificity, score calibration, symptom trajectories
MeSH terms: Adolescent, Adult, Calibration, Child, Child Development Disorders, Pervasive, Child, Preschool, Female, Humans, Longitudinal Studies, Male, Middle Aged, Psychiatric Status Rating Scales, Psychological Tests, Reference Standards, Sensitivity and Specificity, Young Adult

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The Autism Diagnostic Observation Schedule, Module 4: Revised Algorithm and Standardized Severity Scores

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