The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Real-World Executive Functions in Adults with Autism Spectrum Disorder: Profiles of Impairment and Associations with Adaptive Functioning and Co-morbid Anxiety and Depression
Open accessAbstract
Although executive functioning (EF) difficulties are well documented among children and adolescents with autism spectrum disorder (ASD), little is known about real-world measures of EF among adults with ASD. Therefore, this study examined parent-reported real-world EF problems among 35 adults with ASD without intellectual disability and their correlations with adaptive functioning and co-morbid anxiety and depression symptomatology. A variable EF profile was found with prominent deficits occurring in flexibility and metacognition. Flexibility problems were associated with anxiety-related symptoms while metacognition difficulties were associated with depression symptoms and impaired adaptive functioning (though the metacognition-adaptive functioning relationship was moderated by ADHD symptoms). These persistent EF problems are predictors of broader functioning and therefore remain an important treatment target among adults with ASD.
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“Difficulties with habituation and flexibility, associated with disrupted integration between mPFC and limbic regions, can also be treated directly with benefits for anxiety and depression (Kenworthy et al., 2014; Lawson et al., 2015; Wallace et al., 2016).”
From Sensory, emotional and cognitive contributions to anxiety in autism spectrum disorders (2017) · cites this paper as Wallace et al., 2016
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Cited by
Sorted by citations
Sensory, emotional and cognitive contributions to anxiety in autism spectrum disorders
South, M., & Rodgers, J. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00020 · Cited by 270
“Difficulties with habituation and flexibility, associated with disrupted integration between mPFC and limbic regions, can also be treated directly with benefits for anxiety and depression (Kenworthy et al., 2014; Lawson et al., 2015; Wallace et al., 2016).”
BackgroundBeck, J. S., Lundwall, R. A., Gabrielsen, T., Cox, J. C., & South, M. (2020) · Autism · doi:10.1177/1362361320912147 · Cited by 224
Jones, C. R. G., Simonoff, E., Baird, G., Pickles, A., Marsden, A. J. S., Tregay, J., Happé, F., & Charman, T. (2018) · Autism Research · doi:10.1002/aur.1873 · Cited by 259
Anxiety Disorders and Obsessive-Compulsive Disorder in Individuals with Autism Spectrum Disorder
Postorino, V., Kerns, C. M., Vivanti, G., Bradshaw, J., Siracusano, M., & Mazzone, L. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0846-y · Cited by 186
COVID-19 Pandemic and Impact on Patients with Autism Spectrum Disorder
Baweja, R. K., Brown, S. L., Edwards, E. M., & Murray, M. J. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-04950-9 · Cited by 186
Metadata
- Authors
- Wallace, G. L., Kenworthy, L., Pugliese, C. E., Popal, H. S., White, E. I., Brodsky, E., & Martin, A.
- Affiliations
- George Washington University (US)
- Children's National (US)
- National Institute of Mental Health (US)
- Corresponding author
- Wallace, Gregory L.
- ORCID
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2015-11-16
- Volume
- 46
- Issue
- 3
- Pages
- 1071-1083
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC5111802
- OpenAlex
- W2172314818
- Cited by
- 261
- References
- 49
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 23 · 2023: 30 · 2022: 29 · 2021: 44 · 2020: 32 · 2019: 20 · 2018: 17 · 2017: 23 · 2016: 9
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (1-ZIA-MH002920)
- National Institutes of Health (HD046388-01A2)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- executive function, autism spectrum disorder, autistic adults, adaptive behavior, anxiety, depression, metacognition, cognitive flexibility, ADHD comorbidity, real-world functioning
- MeSH terms
- Autism Spectrum Disorder, Adaptation, Psychological, Adolescent, Adult, Anxiety, Depression, Female, Humans, Male, Neuropsychological Tests, Comorbidity, Young Adult, Executive Function
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