Cited by 261Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesDevelopmental and Educational Neuropsychology

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Real-World Executive Functions in Adults with Autism Spectrum Disorder: Profiles of Impairment and Associations with Adaptive Functioning and Co-morbid Anxiety and Depression

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Wallace, Gregory L., Kenworthy, Lauren, Pugliese, Cara E., Popal, Haroon S., White, Emily I., Brodsky, Emily, Martin, Alex·2016·Journal of Autism and Developmental Disorders

DOI 10.1007/s10803-015-2655-7PMC PMC5111802

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Abstract

Although executive functioning (EF) difficulties are well documented among children and adolescents with autism spectrum disorder (ASD), little is known about real-world measures of EF among adults with ASD. Therefore, this study examined parent-reported real-world EF problems among 35 adults with ASD without intellectual disability and their correlations with adaptive functioning and co-morbid anxiety and depression symptomatology. A variable EF profile was found with prominent deficits occurring in flexibility and metacognition. Flexibility problems were associated with anxiety-related symptoms while metacognition difficulties were associated with depression symptoms and impaired adaptive functioning (though the metacognition-adaptive functioning relationship was moderated by ADHD symptoms). These persistent EF problems are predictors of broader functioning and therefore remain an important treatment target among adults with ASD.

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Authors: Wallace, G. L., Kenworthy, L., Pugliese, C. E., Popal, H. S., White, E. I., Brodsky, E., & Martin, A.
Affiliations: George Washington University (US)
Children's National (US)
National Institute of Mental Health (US)
Corresponding author: Wallace, Gregory L.
ORCID: Wallace, Gregory L.
Kenworthy, Lauren
Pugliese, Cara E.
Popal, Haroon S.
White, Emily I.
Martin, Alex
Venue: Journal of Autism and Developmental Disorders
Publisher: Springer Science and Business Media LLC
Published: 2015-11-16
Volume: 46
Issue: 3
Pages: 1071-1083
ISSN: 0162-3257 (ISSN-L)
1573-3432
DOI: 10.1007/s10803-015-2655-7
PMC: PMC5111802
OpenAlex: W2172314818
Cited by: 261
References: 49
Citations by year: 2026: 13 · 2025: 21 · 2024: 23 · 2023: 30 · 2022: 29 · 2021: 44 · 2020: 32 · 2019: 20 · 2018: 17 · 2017: 23 · 2016: 9
FWCI: 9.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Journal of Autism and Developmental Disorders (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (1-ZIA-MH002920)
National Institutes of Health (HD046388-01A2)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
Keywords: executive function, autism spectrum disorder, autistic adults, adaptive behavior, anxiety, depression, metacognition, cognitive flexibility, ADHD comorbidity, real-world functioning
MeSH terms: Autism Spectrum Disorder, Adaptation, Psychological, Adolescent, Adult, Anxiety, Depression, Female, Humans, Male, Neuropsychological Tests, Comorbidity, Young Adult, Executive Function

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Real-World Executive Functions in Adults with Autism Spectrum Disorder: Profiles of Impairment and Associations with Adaptive Functioning and Co-morbid Anxiety and Depression

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