The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Gut Microbiota and Autism: Key Concepts and Findings
Abstract
There is an emerging body of evidence linking the intestinal microbiota with autism spectrum disorders (ASD). Studies have demonstrated differences in the composition of gut bacteria between children with ASD and controls. Certain intestinal bacteria have been observed in abundance and may be involved in the pathogenesis of ASD; including members of the Clostridium and Sutterella genus. Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities. In this article, we review studies examining the relationship between intestinal bacteria and ASD, and discuss bacterial species that may be implicated and proposed mechanisms.
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In the citing paper
“Additionally, many studies have reported dysbiosis of the gut microbiota in individuals with ASD (26–28).”
From Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis (2019) · cites this paper as [26]
In the citing paper
“So far, a variety of mechanism has been proposed in ASD associated with the function of gut microbiota, including immune activation/dysfunction, bacterial-derived toxin (e.g., LPS, phenols, p-cresol, 4-EPS), metabolites aberrations in fermentation process or products, such as propionic acid (PPA) and other SCFAs, and the dysregulated metabolism of free amino acids61.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [61]
Citations
Cites
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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
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Cited by
Sorted by citations
Sgritta, M., Dooling, S. W., Buffington, S. A., Momin, E. N., Francis, M. B., Britton, R. A., & Costa-Mattioli, M. (2019) · Neuron · doi:10.1016/j.neuron.2018.11.018 · Cited by 865
The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857
The effects of vegetarian and vegan diets on gut microbiota
Tomova, A., Bukovsky, I., Rembert, E., Yonas, W., Alwarith, J., Barnard, N. D., & Kahleova, H. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00047 · Cited by 713
Costa, L. G., Cole, T. B., Dao, K., Chang, Y. C., Coburn, J. L., & Garrick, J. M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107523 · Cited by 511
Autism Spectrum Disorders and the Gut Microbiota
Fattorusso, A., Di Genova, L., Dell’Isola, G., Mencaroni, E., & Esposito, S. (2019) · Nutrients · doi:10.3390/nu11030521 · Cited by 484
Metadata
- Authors
- Ding, H. T., Taur, Y., & Walkup, J. T.
- Affiliations
- NewYork–Presbyterian Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Ding, Helen T.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2016-11-24
- Volume
- 47
- Issue
- 2
- Pages
- 480-489
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W2552521103
- Cited by
- 232
- References
- 68
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 23 · 2023: 19 · 2022: 29 · 2021: 35 · 2020: 33 · 2019: 36 · 2018: 22 · 2017: 13
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, autism spectrum disorder, intestinal bacteria, Clostridium, Sutterella, microbial toxins, gut fermentation, immune abnormalities, metabolic abnormalities, animal models of autism, pathogenesis
- MeSH terms
- Autism Spectrum Disorder, Gastrointestinal Microbiome, Animals, Autistic Disorder, Child, Humans, Clostridium histolyticum, Hathewaya histolytica, Gastrointestinal Absorption
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