Sperm retrieval and concomitant tumor resection in azoospermic men with congenital adrenal hyperplasia and bilateral testicular adrenal rest tumors: a case report
Open accessAbstract
PURPOSE: The objective of this study was to offer a new treatment approach for sperm retrieval simultaneously with tumor resection in azoospermic men with congenital adrenal hyperplasia (CAH), orchialgia, and bilateral testicular adrenal rest tumors (TARTs) who fail to respond to medical treatment. METHODS: This is a retrospective chart review from a couple's fertility center. RESULTS: Between May 2013 and May 2015, two azoospermic men with CAH and bilateral TARTs, with orchialgia, and desire to conceive underwent bilateral TART resection in the same surgical setting as sperm retrieval after remaining azoospermic with normalization of gonadotropins with treatment with human chorionic gonadotropin (hCG). Both men had adequate sperm retrieved for in vitro fertilization/intracytoplasmic sperm retrieval (IVF/ICSI) at the time of bilateral TART resections. They had complete TART resections with resolution of orchialgia. The wife of one patient had a successful pregnancy with use of retrieved sperm resulting in a live birth, and the sperm from the other man is cryopreserved for future use. CONCLUSIONS: It is feasible to perform successful sperm retrieval simultaneously with TART resection in azoospermic men with CAH after medical treatments with persistent azoospermia, rather than subjecting these men to multiple invasive procedures.
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Simultaneous successful intraoperative sperm retrieval was recently reported.
“simultaneous successful intraoperative sperm retrieval was recently reported.124”
From Congenital adrenal hyperplasia (2017) · cites this paper as [124]
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Cites
Congenital Adrenal Hyperplasia
Speiser, P., & White, P. C. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711263172211 · Cited by 1,409 · see citing works
Congenital adrenal hyperplasia
Speiser, P. W., & White, P. C. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021561 · Cited by 1,405
Therrell, B. L., Berenbaum, S. A., Manter-Kapanke, V., Simmank, J., Korman, K., Prentice, L., Gonzalez, J., & Gunn, S. (1998) · Pediatrics · doi:10.1542/peds.101.4.583 · Cited by 344 · see citing works
Nonclassical 21-Hydroxylase Deficiency
New, M. I. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1645 · Cited by 315 · see citing works
Forest, M. G. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh047 · Cited by 200 · see citing works
High prevalence of reduced fecundity in men with congenital adrenal hyperplasia
Reisch, N., Flade, L., Scherr, M., Rottenkolber, M., Pedrosa Gil, F., Bidlingmaier, M., Wolff, H., Schwarz, H.-P., Quinkler, M., Beuschlein, F., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1414 · Cited by 170 · cited 1× · see citing works
“It has even been suggested that glucocorticoid overtreatment may have an adverse effect on spermatogenesis by suppression of the hypothalamic-pituitarygonadal axis, and there may be individual variation in responses [19].”
Backgroundder Grinten, H. L. C., Otten, B. J., Hermus, A. R., Sweep, F. C. G. J., & de Kaa, C. A. H. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.03.051 · Cited by 139 · see citing works
Martinez-Aguayo, A., Rocha, A., Rojas, N., García, C., Parra, R., Lagos, M., Valdivia, L., Poggi, H., & Cattani, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0383 · Cited by 114 · see citing works
Testis Sparing Surgery for Steroid Unresponsive Testicular Tumors of the Adrenogenital Syndrome
Walker, B. R., Skoog, S. J., Winslow, B. H., Canning, D. A., & Tank, E. S. (1997) · The Journal of Urology · doi:10.1016/s0022-5347(01)65023-7 · Cited by 112 · see citing works
LEYDIG CELL TUMORS AND TUMORS ASSOCIATED WITH CONGENITAL ADRENAL HYPERPLASIA
Rich, M. A., & Keating, M. A. (2000) · Urologic Clinics of North America · doi:10.1016/s0094-0143(05)70099-9 · Cited by 97 · see citing works
Testicular Adrenal Rest Tumours in Congenital Adrenal Hyperplasia
der Grinten, H. L. C., Hermus, A. R. M. M., & Otten, B. J. (2009) · International Journal of Pediatric Endocrinology · doi:10.1155/2009/624823 · Cited by 80 · see citing works
Testicular masses in association with adrenogenital syndrome: US findings.
Vanzulli, A., DelMaschio, A., Paesano, P. L., Braggion, F., Livieri, C., Angeli, E., Tomasi, G., Gatti, C., Severi, F., & Chiumello, G. (1992) · Radiology · doi:10.1148/radiology.183.2.1561344 · Cited by 77 · see citing works
Stikkelbroeck, N. M. M. L., Hermus, A. R. M. M., Suliman, H. M., Jager, G. J., & Otten, B. J. (2004) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2004.17.4.645 · Cited by 71 · see citing works
Murphy, H. (2001) · Human Reproduction · doi:10.1093/humrep/16.2.263 · Cited by 64 · see citing works
Willi, U., Atares, M., Prader, A., & ZACHMANN, M. (1991) · Pediatric Radiology · doi:10.1007/bf02018626 · Cited by 58 · see citing works
Testicular Adrenal Rest Tumours in Congenital Adrenal Hyperplasia
der Grinten, H. L. C.-V., Hermus, A., & Otten, B. (2009) · International Journal of Pediatric Endocrinology · doi:10.1186/1687-9856-2009-624823 · Cited by 51 · see citing works
Tiryaki, T., Aycan, Z., Hücümenoğlu, S., & Atayurt, H. (2005) · Pediatric Surgery International · doi:10.1007/s00383-005-1547-x · Cited by 47 · see citing works
The testicular ‘tumour’ of adrenogenital syndrome—a persistent diagnostic pitfall
KNUDSEN, J. L., Savage, A. L., & Mobb, G. E. (1991) · Histopathology · doi:10.1111/j.1365-2559.1991.tb00239.x · Cited by 46 · see citing works
Mitotane for 21-hydroxylase deficiency in an infertile man
Bry-Gauillard, H., Cartes, A., & Young, J. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1410041 · Cited by 38 · see citing works
Gooren, L. J. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90488-3 · Cited by 32 · see citing works
Rohayem, J., Tüttelmann, F., Mallidis, C., Nieschlag, E., Kliesch, S., & Zitzmann, M. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0449 · Cited by 26 · see citing works
Collet, T., & Pralong, F. P. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2691 · Cited by 19 · see citing works
Marchini, G. S., Cocuzza, M., de Souza, R. P., Torricelli, F. C. M., Hallak, J., & Srougi, M. (2011) · Sao Paulo Medical Journal · doi:10.1590/s1516-31802011000500010 · Cited by 11 · see citing works
Nicopoullos, J. D. M., Ramsay, J. W. A., & CASSAR, J. (2003) · Archives of Andrology · doi:10.1080/01485010390204940 · Cited by 10 · see citing works
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Speiser, P. W., Arlt, W., Auchus, R. J., Baskin, L. S., Conway, G. S., Merke, D. P., Meyer-Bahlburg, H. F. L., Miller, W. L., Murad, M. H., Oberfield, S. E., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01865 · Cited by 1,234 · see citing works
Congenital adrenal hyperplasia
El-Maouche, D., Arlt, W., & Merke, D. P. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31431-9 · Cited by 669 · see citing works
MANAGEMENT OF ENDOCRINE DISEASE: Gonadal dysfunction in congenital adrenal hyperplasia
Claahsen-van der Grinten, H. L., Stikkelbroeck, N., Falhammar, H., & Reisch, N. (2021) · European Journal of Endocrinology · doi:10.1530/eje-20-1093 · Cited by 72 · see citing works
Tanaka, M., Enatsu, N., Chiba, K., & Fujisawa, M. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12068 · Cited by 20 · see citing works
- Authors
- Kavoussi, P. K., Summers-Colquitt, R. B., Odenwald, K. C., Kressin, M., Kavoussi, K. M., Pool, T. B., & Kavoussi, S. K.
- Affiliations
- Texas Fertility Center (US)
- St David's Medical Center (US)
- Corresponding author
- Kavoussi, Parviz K.
- Venue
- Journal of Assisted Reproduction and Genetics
- Published
- 2016-02-09
- Volume
- 33
- Issue
- 4
- Pages
- 545-548
- ISSN
- 0740-7769 (ISSN-L)
- 1058-0468
- 1573-7330
- PMC
- PMC4818631
- OpenAlex
- W2256646421
- Cited by
- 17
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2021: 4 · 2020: 1 · 2018: 1 · 2017: 4
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Assisted Reproduction and Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- None
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- sperm retrieval, testicular adrenal rest tumor, congenital adrenal hyperplasia, azoospermia, orchialgia, tumor resection, in vitro fertilization, human chorionic gonadotropin, male infertility, live birth
- MeSH terms
- Adrenal Hyperplasia, Congenital, Adult, Female, Fertility, Fertilization in Vitro, Gonadotropins, Humans, Male, Pregnancy, Spermatozoa, Testicular Neoplasms, Testis, Sperm Injections, Intracytoplasmic, Live Birth, Sperm Retrieval, Azoospermia
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