Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia

Martinez-Aguayo, A.; Rocha, A.; Rojas, N.; García, C.; Parra, R.; Lagos, M.; Valdivia, L.; Poggi, H.; Cattani, A.

doi:10.1210/jc.2007-0383

Cited by 114Sexual Differentiation and DisordersAdrenal Hormones and DisordersOvarian function and disorders

Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia

Open access

Martinez-Aguayo, A., Rocha, A., Rojas, N., García, C., Parra, R., Lagos, M., Valdivia, L., Poggi, H. +1 more·2007·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2007-0383

Open this paper in CoChat — free account

Abstract

Context: Infertility observed in adult males with congenital adrenal hyperplasia (CAH) has been associated with testicular adrenal rest tumors (TART) that may originate during childhood. Objective: Our objective was to describe the prevalence of TART and Sertoli and Leydig cell function in a group of boys aged 2–10 yr with CAH and to compare prevalence with that of a control group. Design: From August 2005 to January 2007, 19 patients with classical CAH (CAH group) were referred from seven endocrinology centers. Methods: We studied 19 subjects in the CAH group and, as a control group, 13 boys from the community that did not have testicular diseases. A complete physical exam was performed. High-resolution ultrasound was used to determine TART prevalence. Inhibin B and anti-Müllerian hormone were used as Sertoli cell markers. The ratio between basal testosterone levels and testosterone levels 72 h after β-human chorionic gonadotropin (5000 U/m2) treatment [(T72− T0)/T0] was used to evaluate Leydig cell response. Results: CAH and control groups were comparable in chronological age (5.9 vs. 5.6 yr; P = 0.67) and bone age/chronological age ratio (1.09 vs. 1.03; P = 0.09). TART prevalence was four of 19 (21%) in the CAH group. Lower values for inhibin B (49.2. vs. 65.2 pg/ml; P = 0.018), anti-Müllerian hormone (70.1 vs. 94.2 ng/ml; P = 0.002), and (T72− T0)/T0 (5.6 vs. 13.6; P < 0.01) were observed in the CAH group. Conclusion: TART in prepubertal males with classic CAH could be found during childhood. We also report differences in markers of gonadal function in a subgroup of patients, especially in those with inadequate control.

Integrity signals

Registry

Crossref · 10.1210/jc.2007-0383

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

TART has also been reported in 11βOH and HSD3B2 deficiency.
“and has also been reported in 11βOH and HSD3B2 deficiency, 117-119”
From Congenital adrenal hyperplasia (2017) · cites this paper as [117]
The prevalence of testicular adrenal rest tumors in boys aged 2 to 18 years with classic CAH varies from 21% to 28%.
“The prevalence of TARTs in boys aged 2 to 18 years who have classic CAH varies from 21% to 28% (227, 251); there have been few studies describing TARTs in males with NCCAH.”
From Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society* Clinical Practice Guideline (2018) · cites this paper as [251]
Testicular adrenal rest tumors are usually small and bilateral, not palpable, but easily detectable by ultrasound.
“TARTs are usually small and bilateral, not palpable, but easily detectable by ultrasound (227, 251).”
From Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society* Clinical Practice Guideline (2018) · cites this paper as [251]

RADIOGRAPHIC ATLAS OF SKELETAL DEVELOPMENT OF THE HAND AND WRIST
GREULICH, W. W., & Pyle, S. I. (1959) · The American Journal of the Medical Sciences · doi:10.1097/00000441-195909000-00030 · Cited by 5,598 · see citing works
CDC growth charts: United States.
Kuczmarski, R. J., Ogden, C. L., Grummer‐Strawn, L. M., Flegal, K. M., Guo, S. S., Wei, R. X., Mei, Z., Curtin, L. R., Roche, A. F., & Johnson, C. L. (2000) · PubMed · Cited by 5,298 · see citing works
Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood
Sharpe, R., McKinnell, C., Kivlin, C., & Fisher, J. (2003) · Reproduction · doi:10.1530/rep.0.1250769 · Cited by 1,272 · see citing works
Growth and Maturation during Adolescence
Tanner, J. M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1981.tb06734.x · Cited by 539 · see citing works
Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction
Anawalt, B., Bebb, R. A., Matsumoto, A. M., Groome, N. P., Illingworth, P. J., McNeilly, A. S., & Bremner, W. J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784094 · Cited by 414 · see citing works
High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia
Stikkelbroeck, N. M. M. L., Otten, B. J., Pasic, A., Jager, G. J., Sweep, C. G. J. F., Noordam, K., & Hermus, A. R. M. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8090 · Cited by 305 · see citing works
Inhibin B as a Serum Marker of Spermatogenesis: Correlation to Differences in Sperm Concentration and Follicle-Stimulating Hormone Levels. A Study of 349 Danish Men1
Jensen, T. K., Andersson, A., Hjøllund, N. H., Scheike, T., Kolstad, H. A., Giwercman, A., Henriksen, T. B., Ernst, E., Bonde, J. P., Olsen, J., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4456 · Cited by 303 · see citing works
Inhibin B as a Serum Marker of Spermatogenesis: Correlation to Differences in Sperm Concentration and Follicle-Stimulating Hormone Levels. A Study of 349 Danish Men
Jensen, T. K. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.12.4059 · Cited by 225 · see citing works
Measurements of Serum Müllerian Inhibiting Substance in the Evaluation of Children with Nonpalpable Gonads
Lee, M., Donahoe, P. K., Silverman, B. L., Hasegawa, T., Hasegawa, Y., Gustafson, M. L., Chang, Y., & MacLaughlin, D. T. (1997) · New England Journal of Medicine · doi:10.1056/nejm199705223362102 · Cited by 195 · see citing works
Anti-müllerian hormone and testosterone serum levels are inversely during normal and precocious pubertal development.
Rey, R. A., Lordereau-Richard, I., Carel, J., Barbet, P., Cate, R. L., Roger, M., Chaussain, J., & Josso, N. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.5.8077315 · Cited by 189 · see citing works
The Testicular “Tumor” of the Adrenogenital Syndrome
Rutgers, J. L., Young, R. H., & Scully, R. E. (1988) · The American Journal of Surgical Pathology · doi:10.1097/00000478-198807000-00001 · Cited by 188 · see citing works
MACROGENITOSOMIA PRECOX ASSOCIATED WITH HYPERPLASIA OF THE ANDROGENIC TISSUE OF THE ADRENAL AND DEATH FROM CORTICOADRENAL INSUFFICIENCY CASE REPORT1
Wilkins, L., Fleischmann, W., & Howard, J. E. (1940) · Endocrinology · doi:10.1210/endo-26-3-385 · Cited by 176 · see citing works
Serum Inhibin B and Follicle-Stimulating Hormone Levels as Tools in the Evaluation of Infertile Men: Significance of Adequate Reference Values from Proven Fertile Men
Andersson, A., Petersen, J. H., Jørgensen, N., Jensen, T. K., & Skakkebæk, N. E. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032148 · Cited by 170 · see citing works
Testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia: evaluation of pituitary-gonadal function before and after successful testis-sparing surgery in eight patients
Claahsen-van der Grinten, H. L., Otten, B. J., Takahashi, S., Meuleman, E. J. H., Hulsbergen-van de Kaa, C., Sweep, F. C. G. J., & Hermus, A. R. M. M. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1311 · Cited by 139 · see citing works
Embryology of the adrenal glands and its relevance to diagnostic imaging
Barwick, T. D., Malhotra, A., Webb, J. A. W., Savage, M. O., & Reznek, R. H. (2005) · Clinical Radiology · doi:10.1016/j.crad.2005.04.006 · Cited by 134 · see citing works
Adrenocorticotropic Hormone Directly Stimulates Testosterone Production by the Fetal and Neonatal Mouse Testis
O’Shaughnessy, P. J., Fleming, L. M., Jackson, G., Hochgeschwender, U., Reed, P., & Baker, P. J. (2003) · Endocrinology · doi:10.1210/en.2003-0277 · Cited by 129 · see citing works
Testicular adrenal rest tumours in postpubertal males with congenital adrenal hyperplasia: sonographic and MR features
Stikkelbroeck, N. M. M. L., Suliman, H. M., Otten, B. J., Hermus, A. R., Blickman, J. G., & Jager, G. J. (2003) · European Radiology · doi:10.1007/s00330-002-1786-3 · Cited by 126 · see citing works
Identification of a novel population of adrenal-like cells in the mammalian testis
Val, P., Jeays-Ward, K., & Swain, A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.07.030 · Cited by 114 · see citing works
Testicular adrenal rest tissue in congenital adrenal hyperplasia: comparison of MR imaging and sonographic findings.
Avila, N. A., Premkumar, A., & Merke, D. P. (1999) · American Journal of Roentgenology · doi:10.2214/ajr.172.4.10587136 · Cited by 109 · see citing works
Basal Inhibin B and the Testosterone Response to Human Chorionic Gonadotropin Correlate in Prepubertal Boys1
Kubini, K., ZACHMANN, M., Albers, N., Hiort, O., Bettendorf, M., Woelfle, J., BIDLINGMAIER, F., & Klingmüller, D. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6285 · Cited by 107 · see citing works
Steroidogenic Enzyme Activities, Morphology, and Receptor Studies of a Testicular Adrenal Rest in a Patient with Congenital Adrenal Hyperplasia
Clark, R. V., Albertson, B. D., Munabi, A. K., CASSORLA, F. G., Aguilera, G., Warren, D. W., Sherins, R. J., & Loriaux, D. L. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-5-1408 · Cited by 99 · see citing works
Male infertility due to congenital adrenal hyperplasia: testicular biopsy findings, hormonal evaluation, and therapeutic results in three patients
Bonaccorsi, A. C., Adler, I., & Figueiredo, J. G. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59119-5 · Cited by 93 · see citing works
Basal Inhibin B and the Testosterone Response to Human Chorionic Gonadotropin Correlate in Prepubertal Boys
Kubini, K. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.1.134 · Cited by 76 · see citing works
Pattern of the Response of Testosterone and Its Precursors to Human Chorionic Gonadotropin Stimulation in Relation to Age in Infants and Children*
Forest, M. G. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-1-132 · Cited by 75 · see citing works
Massive Hyperplasia of Testicular Adrenal Rests in a Patient with Nelson’s Syndrome
Johnson, R. E., & Scheithauer, B. W. (1982) · American Journal of Clinical Pathology · doi:10.1093/ajcp/77.4.501 · Cited by 68 · see citing works
Intratesticular adrenal rests diagnosed by ultrasound.
Seidenwurm, D. J., Smathers, R. L., Kan, P., & Hoffman, A. R. (1985) · Radiology · doi:10.1148/radiology.155.2.3885314 · Cited by 67 · see citing works
Successful treatment with ICSI of infertility caused by azoospermia associated with adrenal rests in the testes: Case report
Murphy, H. (2001) · Human Reproduction · doi:10.1093/humrep/16.2.263 · Cited by 64 · see citing works
Fertility in Patients with Congenital Adrenal Hyperplasia
der Grinten, H. L. C., Stikkelbroeck, N. M. M. L., Sweep, F. C. G. J., Hermus, A. R. M. M., & Otten, B. J. (2006) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2006.19.5.677 · Cited by 58 · see citing works
Is inhibin B a potential marker of gonadotoxicity in prepubertal children treated for cancer?
Crofton, P. M., Thomson, A. B., Evans, A., Groome, N. P., Bath, L., Kelnar, C. J. H., & Wallace, W. H. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01712.x · Cited by 57 · see citing works
The use of the hCG stimulation test in the endocrine evaluation of cryptorchidism
Davenport, M., Brain, C. E., VANDENBERG, C., ZAPPALA, S., Duffy, P. G., Ransley, P. G., & Grant, D. (1995) · British Journal of Urology · doi:10.1111/j.1464-410x.1995.tb00776.x · Cited by 55 · see citing works
Gonadal and adrenal catheterization during adrenal suppression and gonadal stimulation in a patient with bilateral testicular tumors and congenital adrenal hyperplasia
Combes-Moukhovsky, M.-E., Kottler, M., Valensi, P. E., Boudou, P., Sibony, M., & Attali, J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.5.7962333 · Cited by 51 · see citing works
Paediatric Applications of Anti-Müllerian Hormone Research
Josso, N. (2008) · Hormone Research · doi:10.1159/000184300 · Cited by 51 · see citing works
Altered serum profile of inhibin B, Pro‐αC and anti‐Müllerian hormone in prepubertal and pubertal boys with varicocele
Trigo, R., Bergadá, I., Rey, R. A., Ballerini, M. G., Bedecarrás, P., Bergadá, C., Gottlieb, S., & Campo, S. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02051.x · Cited by 44 · see citing works
Role of Inhibins in Childhood and Puberty
Bergadá, I., Bergadá, C., & Campo, S. (2001) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2001.14.4.343 · Cited by 44 · see citing works
Puberty and Fertility in Congenital Adrenal Hyperplasia
Otten, B. J., Stikkelbroeck, M., der Grinten, H. L. C., & Hermus, A. R. M. M. (2005) · KARGER eBooks · doi:10.1159/000084093 · Cited by 43 · see citing works
Decreased Serum Inhibin B/FSH Ratio as a Marker of Sertoli Cell Function in Male Survivors After Chemotherapy in Childhood and Adolescence
Bordallo, M. A. N., Guimarãcs, M. M., Pessoa, C. H. C. N., Carriço, M. K., Dimetz, T., Gazolla, H. M., Dobbin, J., & Castilho, I. A. M. A. (2004) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2004.17.6.879 · Cited by 43 · see citing works
[Growth patterns in height and weight in children aged 0 to 17 years and cranial circumference in children aged 0 to 2 years from medium-high and high socioeconomic status in Santiago. Comparison with growth in children from medium-low and low status in the Northern area of Santiago].
Youlton, R., & Valenzuela, C. (1990) · PubMed · Cited by 36 · see citing works
Plasma testosterone in male puberty. II. hCG stimulation test in boys with hypospadia.
Knorr, D., Beckmann, D., BIDLINGMAIER, F., Fj, H., & Wg, S. (1979) · PubMed · Cited by 35 · see citing works
Salt-wasting congenital adrenal hyperplasia: Detection of mutations in CYP21B gene in a Chilean population1
Fardella, C. E., Poggi, H., Pineda, P., Soto, J., Torrealba, I., Cattani, A., Oestreicher, E., & Foradori, A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5071 · Cited by 35 · see citing works
Self-citation
Kinetics of the Steroidogenic Response to Single versus Repeated Doses of Human Chorionic Gonadotropin in Boys in Prepuberty and Early Puberty
Dunkel, L., Perheentupa, J., & Apter, D. (1985) · Pediatric Research · doi:10.1203/00006450-198501000-00001 · Cited by 35 · see citing works
PLASMA TESTOSTERONE IN MALE PUBERTY
Knorr, D., Beckmann, D., BIDLINGMAIER, F., Fj, H., & pell, W. G. S. (1979) · European Journal of Endocrinology · doi:10.1530/acta.0.0900365 · Cited by 21 · see citing works

Flagged first, then by citations

3 of the 44 references couldn’t be matched to a known paper.

Sorted by citations

Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society Clinical Practice Guideline.
Speiser, P. W., Azziz, R., Baskin, L. S., Ghizzoni, L., Hensle, T. W., Merke, D. P., Meyer-Bahlburg, H. F. L., Miller, W. L., Montori, V. M., Oberfield, S. E., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2631 · Cited by 1,484 · see citing works
Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society* Clinical Practice Guideline
Speiser, P. W., Arlt, W., Auchus, R. J., Baskin, L. S., Conway, G. S., Merke, D. P., Meyer-Bahlburg, H. F. L., Miller, W. L., Murad, M. H., Oberfield, S. E., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01865 · Cited by 1,234 · see citing works
Congenital adrenal hyperplasia
El-Maouche, D., Arlt, W., & Merke, D. P. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31431-9 · Cited by 669 · see citing works
Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients
Arlt, W., Willis, D. S., Wild, S. H., Krone, N., Doherty, E. J., Hahner, S., Han, T. S., Carroll, P. V., Conway, G. S., Rees, D. A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0917 · Cited by 506 · see citing works
Testicular adrenal rest tumours in congenital adrenal hyperplasia
Claahsen-van der Grinten, H. L., Otten, B. J., Stikkelbroeck, M. M. L., Sweep, F. C. G. J., & Hermus, A. R. M. M. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.09.007 · Cited by 187 · see citing works
Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia
Turcu, A. F., & Auchus, R. J. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.02.002 · Cited by 177 · see citing works
High prevalence of reduced fecundity in men with congenital adrenal hyperplasia
Reisch, N., Flade, L., Scherr, M., Rottenkolber, M., Pedrosa Gil, F., Bidlingmaier, M., Wolff, H., Schwarz, H.-P., Quinkler, M., Beuschlein, F., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1414 · Cited by 170 · see citing works
Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia
Falhammar, H., Nyström, H. F., Ekström, U., Granberg, S., Wedell, A., & Thorén, M. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-0828 · Cited by 170 · see citing works
Testicular Adrenal Rest Tumors: Current Insights on Prevalence, Characteristics, Origin, and Treatment
Engels, M., Span, P. N., van Herwaarden, A. E., Sweep, F. C. G. J., Stikkelbroeck, N. M. M. L., & Claahsen-van der Grinten, H. L. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00258 · Cited by 163 · see citing works
Clinical perspectives in congenital adrenal hyperplasia due to 11β-hydroxylase deficiency
Bulsari, K., & Falhammar, H. (2016) · Endocrine · doi:10.1007/s12020-016-1189-x · Cited by 139 · see citing works
Nonclassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency: clinical presentation, diagnosis, treatment, and outcome
Falhammar, H., & Nordenström, A. (2015) · Endocrine · doi:10.1007/s12020-015-0656-0 · Cited by 127 · see citing works
Clinical Outcome, Hormonal Status, Gonadotrope Axis, and Testicular Function in 219 Adult Men Born With Classic 21-Hydroxylase Deficiency. A French National Survey
Bouvattier, C., Esterle, L., Renoult-Pierre, P., de la Perrière, A. B., Illouz, F., Kerlan, V., Pascal-Vigneron, V., Drui, D., Christin-Maitre, S., Galland, F., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4124 · Cited by 116 · see citing works
Health Problems in Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
Reisch, N., Arlt, W., & Krone, N. P. (2011) · Hormone Research in Paediatrics · doi:10.1159/000327794 · Cited by 107 · see citing works
Clinical outcomes in the management of congenital adrenal hyperplasia
Falhammar, H., & Thorén, M. (2012) · Endocrine · doi:10.1007/s12020-011-9591-x · Cited by 106 · see citing works
Fertility in patients with congenital adrenal hyperplasia
Reichman, D. E., White, P. C., New, M. I., & Rosenwaks, Z. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.11.002 · Cited by 104 · see citing works
High frequency of adrenal myelolipomas and testicular adrenal rest tumours in adult Norwegian patients with classical congenital adrenal hyperplasia because of 21-hydroxylase deficiency: <i>Adrenal tumours and TART in 21-OHD</i>
Nermoen, I., Rørvik, J., Holmedal, S. H., Hykkerud, D. L., Fougner, K. J., Svartberg, J., Husebye, E. S., & Løvås, K. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04151.x · Cited by 103 · see citing works
Treatment and health outcomes in adults with congenital adrenal hyperplasia
Han, T. S., Walker, B. R., Arlt, W., & Ross, R. J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.239 · Cited by 102 · see citing works
Steroid 21-hydroxylase deficiency in congenital adrenal hyperplasia
Parsa, A. A., & New, M. I. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.06.015 · Cited by 100 · see citing works
Testicular Adrenal Rest Tumours in Congenital Adrenal Hyperplasia
der Grinten, H. L. C., Hermus, A. R. M. M., & Otten, B. J. (2009) · International Journal of Pediatric Endocrinology · doi:10.1155/2009/624823 · Cited by 80 · see citing works
Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following adrenalectomy
Tiosano, D., Vlodavsky, E., Filmar, S., Weiner, Z., Goldsher, D., & Bar-Shalom, R. (2010) · Hormone Research in Paediatrics · doi:10.1159/000295722 · Cited by 65 · see citing works
Testicular Adrenal Rest Tumors in Boys and Young Adults with Congenital Adrenal Hyperplasia
Kim, M. S., Goodarzian, F., Keenan, M. F., Geffner, M. E., Koppin, C. M., Filippo, R. E. D., & Kokorowski, P. K. (2016) · The Journal of Urology · doi:10.1016/j.juro.2016.09.072 · Cited by 64 · see citing works
Increased prevalence of testicular adrenal rest tumours during adolescence in congenital adrenal hyperplasia
Claahsen-van der Grinten, H. L., Dehzad, F., Kamphuis-van Ulzen, K., & de Korte, C. L. (2014) · Hormone Research in Paediatrics · doi:10.1159/000365570 · Cited by 61 · see citing works
Testicular adrenal rest tumors in congenital adrenal hyperplasia—cross-sectional study of 51 Croatian male patients
Dumić, M., Duspara, V., Grubić, Z., Oguić, S. K., Škrabić, V., & Kuŝec, V. (2017) · European Journal of Pediatrics · doi:10.1007/s00431-017-3008-7 · Cited by 61 · see citing works
Testicular Adrenal Rest Tumors in Patients With Congenital Adrenal Hyperplasia
Delfino, M., Elia, J., Imbrogno, N., Argese, N., Mazzilli, R., Toscano, V., & Mazzilli, F. (2012) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2012.31.3.383 · Cited by 52 · see citing works
The Adrenal Cortex and its Disorders
Miller, W. L. (2009) · Wiley eBooks · doi:10.1002/9781444316728.ch13 · Cited by 51 · see citing works
The Testes: Disorders of Sexual Differentiation and Puberty in the Male
Hughes, I. A. (2008) · Elsevier eBooks · doi:10.1016/b978-141604090-3.50021-1 · Cited by 50 · see citing works
Testicular adrenal rest tumours in boys, adolescents and adult men with congenital adrenal hyperplasia may be associated with the CYP21A2 mutation
Mouritsen, A., Jørgensen, N., Main, K. M., Schwartz, M., & Juul, A. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2009.00967.x · Cited by 48 · see citing works
Common markers of testicular Sertoli cells
You, X., Chen, Q., Yuan, D., Zhang, C., & Zhao, H. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.1924060 · Cited by 44 · see citing works
Infertility and Reproductive Function in Patients with Congenital Adrenal Hyperplasia
Lekarev, O., Lin-Su, K., & Vogiatzi, M. G. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.07.009 · Cited by 38 · see citing works
Review of Health Problems in Adult Patients with Classic Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
Reisch, N. (2019) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0820-2085 · Cited by 38 · see citing works
Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia
Yu, M. K., Jung, M. K., Kim, K. E., Kwon, A. R., Chae, H. W., Kim, D. H., & Kim, H.-S. (2015) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2015.20.3.155 · Cited by 34 · see citing works
An Evidence-Based Model of Multidisciplinary Care for Patients and Families Affected by Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
Schaeffer, T. L., Tryggestad, J. B., Mallappa, A., Hanna, A., Krishnan, S., Chernausek, S. D., Chalmers, L. J., Reiner, W. G., Kropp, B. P., & Wisniewski, A. B. (2010) · International Journal of Pediatric Endocrinology · doi:10.1155/2010/692439 · Cited by 42 · see citing works
Testicular adrenal rest tumors in children with congenital adrenal hyperplasia
Al-Ghamdi, W. M., Shazly, M. A., & Al-Agha, A. E. (2021) · Saudi Medical Journal · doi:10.15537/smj.2021.42.9.20210257 · Cited by 32 · see citing works
Adrenal rest tissue in gonads of patients with classical congenital adrenal hyperplasia: Multicenter study of 45 French male patients
Pierre, P. R., Despert, F., Tranquart, F., Coutant, R., Tardy, V., Kerlan, V., Sonnet, E., Baron, S., LORCY, Y., Émy, P., et al. (2012) · Annales d Endocrinologie · doi:10.1016/j.ando.2012.09.005 · Cited by 31 · see citing works
Cardiovascular health, growth and gonadal function in children and adolescents with congenital adrenal hyperplasia
Mooij, C. F., Webb, E. A., der Grinten, H. L. C., & Krone, N. P. (2016) · Archives of Disease in Childhood · doi:10.1136/archdischild-2016-311910 · Cited by 31 · see citing works
Growth and Reproductive Outcomes in Congenital Adrenal Hyperplasia
Nebesio, T. D., & Eugster, E. A. (2010) · International Journal of Pediatric Endocrinology · doi:10.1155/2010/298937 · Cited by 33 · see citing works
Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia
Mendes-dos-Santos, C. T., Martins, D. L., Guerra-Júnior, G., Baptista, M. T. M., de-Mello, M. P., de Oliveira, L. C., Morcillo, A. M., & Lemos-Marini, S. H. V. (2018) · Hormone Research in Paediatrics · doi:10.1159/000492082 · Cited by 26 · see citing works
An Evidence-Based Model of Multidisciplinary Care for Patients and Families Affected by Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
Schaeffer, T. L., Tryggestad, J. B., Mallappa, A., Hanna, A., Krishnan, S., Chernausek, S. D., Chalmers, L. J., Reiner, W. G., Kropp, B., & Wisniewski, A. B. (2010) · International Journal of Pediatric Endocrinology · doi:10.1186/1687-9856-2010-692439 · Cited by 26 · see citing works
The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency
Kang, M. J., Kim, J. H., Lee, S. H., Lee, Y. A., Shin, C. H., & Yang, S. W. (2011) · Endocrine Journal · doi:10.1507/endocrj.k11e-034 · Cited by 25 · see citing works
Testicular adrenal rest tumours in young adult males with congenital adrenal hyperplasia: prevalence and impact on testicular function
Chihaoui, M., Kanoun, F., Chaker, F., Yazidi, M., Bouchrit, K., Mizouni, H., Feki, M., Kharrat, M., & Slimane, H. (2016) · Andrologia · doi:10.1111/and.12416 · Cited by 23 · see citing works
Growth and Reproductive Outcomes in Congenital Adrenal Hyperplasia
Nebesio, T. D., & Eugster, E. (2010) · International Journal of Pediatric Endocrinology · doi:10.1186/1687-9856-2010-298937 · Cited by 22 · see citing works
Endocrinology and Metabolism
Al-Tubaikh, J. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-28575-2_3 · Cited by 22 · see citing works
Russian clinical practice guidelines «congenital adrenal hyperplasia»
Mokrysheva, N. G., Mel'nichenko, G. A., Adamyan, L. V., Troshina, E. A., Молашенко, Н. В., Игоревна, С. А., Uvarova, E. V., Esayan, E. R. M., Andreeva, E. N., Ужегова, Ж. А., et al. (2021) · Obesity and metabolism · doi:10.14341/omet12787 · Cited by 27 · see citing works
Typical characteristics of children with congenital adrenal hyperplasia due to 11β-hydroxylase deficiency: a single-centre experience and review of the literature
Breil, T., Yakovenko, V., Inta, I. M., Choukair, D., Klose, D., Mittnacht, J., Schulze, E., Alrajab, A., Grulich‐Henn, J., & Bettendorf, M. (2019) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2018-0298 · Cited by 20 · see citing works
Testicular adrenal rest tumors in boys with congenital adrenal hyperplasia: 3D US and elastography – Do we get more information for diagnosis and monitoring?
Jędrzejewski, G., Beń‐Skowronek, I., Woźniak, M. M., Brodzisz, A., Budzyńska, E., & Wieczorek, A. P. (2013) · Journal of Pediatric Urology · doi:10.1016/j.jpurol.2013.02.008 · Cited by 20 · see citing works
Federal clinical practice guidelines on the management of the patients presenting with congenital adrenal hyperplasia
Kareva, M., & Чугунов, І. (2014) · Problems of Endocrinology · doi:10.14341/probl201460242-50 · Cited by 21 · see citing works
Sperm retrieval and concomitant tumor resection in azoospermic men with congenital adrenal hyperplasia and bilateral testicular adrenal rest tumors: a case report
Kavoussi, P. K., Summers-Colquitt, R. B., Odenwald, K. C., Kressin, M., Kavoussi, K. M., Pool, T. B., & Kavoussi, S. K. (2016) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-016-0665-9 · Cited by 17 · see citing works
The role of imaging in congenital adrenal hyperplasia
Teixeira, S. R., Elias, P. C. L., Andrade, M. T. S., Melo, A., & Elías, J. (2014) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/0004-2730000003371 · Cited by 16 · see citing works
Testicular adrenal rest tumors – Epidemiology, diagnosis and treatment
de Jesus, L. E., de Oliveira, A. P. P., Porto, L. C., & Dekermacher, S. (2023) · Journal of Pediatric Urology · doi:10.1016/j.jpurol.2023.10.005 · Cited by 15 · see citing works
The Adrenal Cortex and Its Disorders
Miller, W. L., Flück, C. E., Breault, D. T., & Feldman, B. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-62520-3.00014-2 · Cited by 14 · see citing works
Unusual scrotal pathology: an overview
Rosevear, H. M., Mishail, A., Sheynkin, Y., & Wald, M. (2009) · Nature Reviews Urology · doi:10.1038/nrurol.2009.149 · Cited by 14 · see citing works
Testicular adrenal rest tumors in a patient with untreated congenital adrenal hyperplasia
Jin, H. Y., Choi, J. H., Kim, G.-H., Lee, C. S., & Yoo, H. W. (2011) · Korean Journal of Pediatrics · doi:10.3345/kjp.2011.54.3.137 · Cited by 12 · see citing works
Testicular adrenal rest tumor in infertile man with congenital adrenal hyperplasia: case report and literature review
Marchini, G. S., Cocuzza, M., de Souza, R. P., Torricelli, F. C. M., Hallak, J., & Srougi, M. (2011) · Sao Paulo Medical Journal · doi:10.1590/s1516-31802011000500010 · Cited by 11 · see citing works
Long-Term Health Outcomes of Korean Adults With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
Lim, S. G., Lee, Y. A., Jang, H. N., Kong, S. H., Ahn, C. H., Kim, S. W., Shin, C. H., & Kim, J. H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.761258 · Cited by 10 · see citing works
Longitudinal Characterization and Sonographic Staging of Testicular Adrenal Rest Tumors
Vaid, S., Kulkarni, S., Marko, J., Sinaii, N., Sukin, C., Burkardt, D. D., Eustace, Q., Mallappa, A., & Merke, D. P. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf498 · Cited by 10 · see citing works
May AMH levels distinguish LOCAH from PCOS among hirsute women?
Öncül, M., Şahmay, S., Tüten, A., Açıkgöz, A. S., & Gürleyen, H. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2014.03.032 · Cited by 9 · see citing works
Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia: 6 years of follow-up
Werneck, G. C., Rodrigues, E. M. R., Mantovani, R. M., Lane, J. S. S., & Silva, I. N. (2019) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2018-0512 · Cited by 9 · see citing works
Bilateral Adrenal and Testicular Mass in a Patient with Congenital Adrenal Hyperplasia
Pişkinpaşa, H. (2019) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2019.113 · Cited by 8 · see citing works
Leydig Cell Tumor and Malignant Lymphoma in a Patient with Nonclassical 21-Hydroxylase Deficiency
Inaba, H., Suzuki, S., Shigematsu, S., Shinomiya, K., Ohfusa, H., Shimojo, Y., Uehara, T., & Hashizume, K. (2009) · Internal Medicine · doi:10.2169/internalmedicine.48.1733 · Cited by 8 · see citing works
Prenatal and Pregnancy Management of Congenital Adrenal Hyperplasia
Nowotny, H. F., Tschaidse, L., Auer, M. K., & Reisch, N. (2024) · Clinical Endocrinology · doi:10.1111/cen.15131 · Cited by 9 · see citing works
Screening for testicular adrenal rest tumors among children with congenital adrenal hyperplasia at King Fahad Medical City, Saudi Arabia
Huneif, M. A., Mutairi, M. A., Alhazmy, Z. H., AlOsaimi, F. K., AlShoomi, A. M., Alghofely, M. A., & Alsaheel, A. Y. (2021) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2021-0291 · Cited by 7 · see citing works
Testicular adrenal rest tumours in boys with congenital adrenal hyperplasia: case report and literature review.
Budzyńska, E., & Beń‐Skowronek, I. (2011) · PubMed · Cited by 7 · see citing works
Disorders of Sex Development
Davies, J. H., Malone, P., & Fairhurst, J. (2010) · Medical radiology · doi:10.1007/174_2010_81 · Cited by 5 · see citing works
Testicular Adrenal Rests Tumors and Testicular Microlithiasis in a Brazilian Case Series with Classic Congenital Adrenal Hyperplasia
de Carvalho, L. O. M. C., Lora, R. M. G., Penna, C. R. R., & Beserra, I. C. R. (2016) · Intern J Endocrinol Metab · doi:10.5812/ijem.40611 · Cited by 5 · see citing works
Challenges in managing disorders of sex development associated with adrenal dysfunction
Finkielstain, G. P., & Rey, R. A. (2023) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2023.2256393 · Cited by 5 · see citing works
Alteración de la fertilidad masculina por hiperplasia suprarrenal congénita: Azoospermia reversible con terapia de glucocorticoide
Enzo Devoto, C., Marcia Madariaga, A., & Fernández, W. (2011) · Revista médica de Chile · doi:10.4067/s0034-98872011000800012 · Cited by 5 · see citing works
Androgen Deficiency Disorders
Allan, C. A., & McLachlan, R. I. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00139-8 · Cited by 5 · see citing works
Development and Function of the Ovaries and Testes in the Fetus and Neonate
Freire, A. V., Ropelato, M. G., & Rey, R. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814823-5.00037-4 · Cited by 4 · see citing works
Hyperplasie congénitale des surrénales: les formes précoces
Samara‐Boustani, D., Bachelot, A., Pinto, G., Thibaud, E., Touraine, P. A., & Polak, M. (2009) · EMC - Pédiatrie - Maladies infectieuses · doi:10.1016/s1637-5017(09)72438-x · Cited by 4 · see citing works
Ovarian carcinoma in a 14-year-old with classical salt-wasting congenital adrenal hyperplasia and bilateral adrenalectomy
Pina, C., Khattab, A., Katzman, P. A., Bruckner, L. B., Andolina, J., New, M. I., & Yau, M. (2014) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2014-0299 · Cited by 4 · see citing works
Possible andrologic markers in elevated neonatal 17-hydroxyprogesterone
Cavarzere, P., Vincenzi, M., Gaudino, R., Franceschi, R., Perlini, S., Camilot, M., Teofoli, F., Antoniazzi, F., & Tatò, L. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.04.040 · Cited by 3 · see citing works
Prevalence of adrenal rest tumors and course of gonadal dysfunction in a clinical sample of men with congenital adrenal hyperplasia: a longitudinal analysis over 10 years
Auer, M. K., Büyükerzurmulu, D., Lottspeich, C., Bidlingmaier, M., Rieger, E., Nowotny, H. F., Tschaidse, L., Auchus, R. J., & Reisch, N. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae112 · Cited by 3 · see citing works
Bilateral testicular tumors in a young male with congenital 11β-hydroxilase deficiency
Vajda, Z., Borbély, G., Jakab, Z., Riesz, P., & Rácz, K. (2010) · Orvosi Hetilap · doi:10.1556/oh.2010.28993 · Cited by 3 · see citing works
The role of anti-Mullerian hormone in the differentiation, development, and functioning of the reproductive system
Устинкина, Т. И., & Борисович, Ш. С. (2011) · Problems of Endocrinology · doi:10.14341/probl201157639-44 · Cited by 3 · see citing works
Hypergonadotrophic hypogonadism due to testicular adrenal rest tumours presenting with hypogonadotrophic hypergonadism
Ashby, H. L., Gama, R. M., Sur, H., Inglis, J. A., Ford, C., & Gama, R. M. (2012) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2011.011236 · Cited by 3 · see citing works
Androgen Deficiency Disorders
Allan, C. A., & McLachlan, R. I. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00139-6 · Cited by 3 · see citing works
Congenital Adrenal Hyperplasia and Testicular Adrenal Rest Tumors Causing Infertility and Detected by 18F-FDG PET/CT
Yakut, E. (2023) · Bulletin of Urooncology · doi:10.4274/uob.galenos.2023.2022.12.1 · Cited by 2 · see citing works
A unique case of large cell calcifying type sertoli tumor
DeSanto, M. R., & Deem, S. (2024) · Urology Case Reports · doi:10.1016/j.eucr.2024.102725 · Cited by 2 · see citing works
Hypogonadism in Males with Congenital Adrenal Hyperplasia
Stikkelbroeck, N. M. M. L., & der Grinten, H. L. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-53298-1_7 · Cited by 2 · see citing works
A recent overview of non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency: pathophysiology, recognition, and management
Podgórski, R., Podgórska, D., & Sumińska, M. (2023) · Pediatria Polska · doi:10.5114/polp.2023.133534 · Cited by 1 · see citing works
Infertility risk assessment with ultrasound in congenital adrenal hyperplasia male patients
Wang, Z., Wang, R., Wang, X., Zheng, S., Li, M., Yu, Y., Liu, Z., Sun, S., & Zhan, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-62954-8 · Cited by 3 · see citing works
Testicular adrenal rest tumors in a patient with untreated congenital adrenal hyperplasia
Jin, H. Y., Choi, J. H., Kim, G.-H., Lee, C. S., & Yoo, H. W. (2011) · Korean Journal of Pediatrics · doi:10.3345/kjp.2011.54.3.136 · Cited by 2 · see citing works
A Case of Bilateral Testicular Tumors Subsequently Diagnosed as Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
Sha, Y.-K., Sha, Y.-W., Ding, L., Liu, W.-W., Song, Y.-Q., Jin, L., He, X., Qiu, P., Zhang, L., & Li, P. (2016) · Europe PMC (PubMed Central) · doi:10.22074/ijfs.2015.4618 · Cited by 2 · see citing works
Computed tomography findings of testicular adrenal rest tumors resulted from 21-hydroxylase deficiency
Li, X., Xu, Z., & Wang, X. (2018) · Journal of X-Ray Science and Technology · doi:10.3233/xst-17388 · Cited by 2 · see citing works
Anti-mullerian hormone serum level in patients with congenital adrenal hyperplasia
Ziora, K. T., Borawska-Dziadek, E., Oświęcimska, J. M., Świętochowska, E., Ostrowska, Z., Kajdaniuk, D., Wikiera, B., Bieniasz, J., Noczyńska, A., Bursa, J., et al. (2016) · Pediatric Endocrinology · doi:10.18544/ep-01.15.03.1647 · Cited by 1 · see citing works
Patient and Parent Perspectives on Testicular Adrenal Rest Tumors in Congenital Adrenal Hyperplasia
Nebesio, T. D., Kim, M. S., Szymanski, K. M., Kokorowski, P. K., Geffner, M. E., Eugster, E. A., & on behalf of the Life with Congenital Adrenal Hyperplasia Study Group (2023) · Hormone Research in Paediatrics · doi:10.1159/000529211 · Cited by 1 · see citing works
Current and future perspectives on clinical management of classic 21-hydroxylase deficiency
Yogi, A., & Kashimada, K. (2023) · Endocrine Journal · doi:10.1507/endocrj.ej23-0075 · Cited by 1 · see citing works
Testicular adrenal rest tumors in Indonesian boys with congenital adrenal hyperplasia
Chandra, E., Utari, A., Adriaansen, B. P. H., Westra, D., Ningrum, F. H., Santoso, A. G., van Herwaarden, A. E., & der Grinten, H. L. C. (2025) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2025-0026 · Cited by 1 · see citing works
The role of the newborn screening programme (NSP) for the diagnosis of a 17-year-old boy with congenital Adrenal Hyperplasia (cah) due to 21 OH deficiency
Stoeva, I., Kostova, A., Moskova, M., Тодорова, А., Todorov, T., Kirov, A., & Aroyo, A. (2014) · Scripta Scientifica Medica · doi:10.14748/ssm.v46i4.1014 · Cited by 1 · see citing works
Adrenal imaging
Guest, P. G. (2011) · doi:10.1093/med/9780199235292.003.0504 · Cited by 1 · see citing works
The development of ectopic testicular adrenal rest tissue (TART) in the children and adolescents presenting with congenital adrenal cortical dysfunction
Чугунов, І., Soldatova, T. V., Vorontsov, A. V., Vladimirova, V. P., Bogolyubov, S. V., Orlova, E., & Kareva, M. (2015) · Problems of Endocrinology · doi:10.14341/probl20156139-15 · Cited by 1 · see citing works
Classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-OHD) in adult males: Clinical presentation, hormone function and the detection of adrenal and testicular adrenal rest tumors (TARTs)
Martin, P., Russmann, M. L. E., Mendeluk, G. R., Fierro, M. F., Marino, R. M., & Pardes, E. (2020) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2020.07.003 · Cited by 1 · see citing works
Treatment and Outcome of Congenital Adrenal Hyperplasia: 21-Hydroxylase Deficiency
Lee, P. A., Fuqua, J. S., & Nebesio, T. D. (2010) · International Journal of Pediatric Endocrinology · doi:10.1155/2010/276843 · Cited by 1 · see citing works
Current World Literature
(2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32831c7e5c · Cited by 1 · see citing works
Endocrine Neoplasia in Childhood
Blair, J. (2009) · Wiley eBooks · doi:10.1002/9781444316728.ch17
Adrenal Glands Abnormalities
Al-Tubaikh, J. A. (2010) · Springer eBooks · doi:10.1007/978-3-642-03709-2_41
Hiperplasia suprarrenal congénita: formas precoces
Samara‐Boustani, D., Bachelot, A., Pinto, G., Thibaud, E., Touraine, P. A., & Polak, M. (2010) · EMC - Pediatría · doi:10.1016/s1245-1789(10)70185-2
Relationship between validity of center of gravity transferring velocities measured by rotary encoder and three-dimensional motion analysis during sit-to-stand movement in the elderly
Yamada, T., & Demura, S. (2013) · International Journal of Health · doi:10.14419/ijh.v1i2.1014
A Patient With Bilaterally Enlarged Testes
Mitchell, D. (2011) · Laboratory Medicine · doi:10.1309/lm9rkasm3rzre8rd
Secondary testicular structures in the patients presenting with congenital adrenal cortical dysfunction
Кузнецова, Э. С., & Калинченко, Н. Ю. (2012) · Problems of Endocrinology · doi:10.14341/probl201258442-47

Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia
Yu, M. K., Jung, M. K., Kim, K. E., Kwon, A. R., Chae, H. W., Kim, D. H., & Kim, H.-S. (2015) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2015.20.3.155 · Cited by 34 · see citing works
Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with its Development in 6 Months to 18 Years-old Patients with Congenital Adrenal Hyperplasia
Norooziasl, S., Afshar, Z., Ghaemi, N., Vakili, R., Alamdaran, S. A., Shaye, Z. A., Eshraqhi, P., & Moazzen, N. (2021) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.22038/ijp.2021.57453.4511
Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
der Grinten, H. L. C., Sweep, F. C. G. J., Blickman, J. G., Hermus, A. R., & Otten, B. J. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0201 · Cited by 142 · see citing works
Testicular adrenal rest tumors in children with congenital adrenal hyperplasia
Al-Ghamdi, W. M., Shazly, M. A., & Al-Agha, A. E. (2021) · Saudi Medical Journal · doi:10.15537/smj.2021.42.9.20210257 · Cited by 32 · see citing works
Clinical
Yu, M. K., Jung, M. K., Kim, K. E., Chae, H. W., & Kim, D. H. (2016)

Authors: Martinez-Aguayo, A., Rocha, A., Rojas, N., García, C., Parra, R., Lagos, M., Valdivia, L., Poggi, H., & Cattani, A.
Affiliations: Endocrinology Unit, Department of Pediatrics (A.M.-A., A.R., A.C.)
Pontificia Universidad Católica de Chile (CL)
Department of Radiology and Pediatrics (C.G., R.P.)
Molecular Biology Laboratory (M.L., L.V., H.P.), Pontificia Universidad Católica de Chile, 833-0074, Santiago, Chile
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2007-12-01
Volume: 92
Issue: 12
Pages: 4583-4589
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2007-0383
OpenAlex: W1972363573
Cited by: 114
References: 44
Citations by year: 2026: 3 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 1 · 2021: 6 · 2020: 1 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 9 · 2015: 10 · 2014: 6 · 2013: 5 · 2012: 5
FWCI: 3.58
Type: journal article
Language: en
Open access: green
repositorio.uchile.cl
Licence: cc-by-nc-nd
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Universidad de Chile (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords: testicular adrenal rest tumor, congenital adrenal hyperplasia, Leydig cell function, Sertoli cell function, inhibin B, anti-Müllerian hormone, prepubertal boys, male infertility
MeSH terms: Adrenal Hyperplasia, Congenital, Adrenal Rest Tumor, Anthropometry, Child, Child, Preschool, DNA, Hormones, Humans, Inhibins, Leydig Cells, Male, Sertoli Cells, Testicular Neoplasms, Anti-Mullerian Hormone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks