Synthesis, characterization and cytocompatibility of a degradable polymer using ferric catalyst for esophageal tissue engineering
Abstract
This study focused on the synthesis, characterization and cytocompatibility of a biodegradable polymer by the cross-linking from poly(ethylene glycol-co-lactide) dimethacrylate (PLEGDMA), polyethylene glycol diacrylate (PEGDA) and N-isopropylacrylamide, where PLEGDMA was synthesized by ring-opening oligomerization of poly(ethylene glycol) with different molecular weights (Mn = 400, 600, 1000, 2000 Da) and L-lactide using low toxic iron(III) acetylacetonate (Fe(acac)3) as the catalyst and subsequently being terminated with dimethacrylate. The product, PLEGDMA, was analyzed to confirm its chemistry using FTIR spectroscopy, (1)H NMR spectra and gel permeation chromatography etc. The thermodynamic properties, mechanical behaviors, surface hydrophilicity, degradability and cytotoxicity of the cross-linked product were evaluated by differential scanning calorimetry, tensile tests, contact angle measurements and cell cultures. The effects of reaction variables such as PEGDA content and reactants ratio were optimized to achieve a material with low glass transition temperature (Tg), high wettability and preferable mechanical characteristics. Using a tubular mould which has been patented in our group, a tubular scaffold with predetermined dimension and pattern was fabricated, which aims at guiding the growth and phenotype regulation of esophageal primary cells like fibroblast and smooth muscle cell towards fabricating tissue engineered esophagus in future.
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Use of simple iron(iii) catalysts were reported for CL and LA, but in most cases, relatively high dispersities were obtained.
“The use of simple iron(iii) catalysts were reported for CL58 and LA,59,60 but in most cases, relatively high dispersities were obtained.61,62”
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- Authors
- Lei, Y.-N., Zhu, Y.-B., Gong, C.-F., Lv, J.-J., Kang, C., & Hou, L.-X.
- Affiliations
- Ningbo University (CN)
- Venue
- Journal of Materials Science: Materials in Medicine
- Published
- 2013-10-23
- Volume
- 25
- Issue
- 2
- Pages
- 273-282
- ISSN
- 0957-4530 (ISSN-L)
- 1573-4838
- OpenAlex
- W1998786035
- Cited by
- 12
- References
- 27
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Materials Science Materials in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- biodegradable polymers, poly(ethylene glycol) diacrylate, N-isopropylacrylamide, polymer networks, esophageal tissue engineering, tubular scaffolds, cytocompatibility, degradability, wettability, mechanical properties, glass transition temperature, fibroblasts, smooth muscle cells
- MeSH terms
- Biocompatible Materials, Cells, Cultured, Esophagus, Ferric Compounds, Humans, Microscopy, Electron, Scanning, Polymers, Spectroscopy, Fourier Transform Infrared, Tissue Engineering
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