Cited by 11biodegradable polymer synthesis and propertiesBlock Copolymer Self-Assembly3D Printing in Biomedical Research

Structure–Property Relationships of 3D-Printable Chain-Extended Block Copolymers with Tunable Elasticity and Biodegradability

Kim, Ryung Il, Lee, Geonchang, Lee, Jung-Hyun, Park, Ji Jong, Lee, Albert S., Hwang, Seung Sang·2021·ACS Applied Polymer Materials

Abstract

Elastomeric bioscaffolds with tunable elasticity and biodegradability were synthesized via ring opening polymerization of polycaprolactone (PCL) and polylactide (PLA) with a bifunctional polyethylene glycol macroinitiator, followed by chain extension with diisocyanate to form urethane linkages. Through fine tuning of the macroinitiator and PCL/PLA weight fraction and molecular weight, a data set of elastomeric bioscaffolds gives structure–property insights into their thermal, mechanical, and biodegradability properties as they relate to triblock copolymer composition and mechanical weight. These materials were targeted to be 3D-printed by commercial devices, and their unique rheological properties enable impeccable multiscale microstructure formation. Simplicity in synthesis and fabrication as well as tunable biodegradability (1 day to 2 months) and elasticity (modulus 32–94 MPa) suggest the vast wide-ranging utility and prospective application in bioscaffolds for future therapeutic treatments.

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Crossref · 10.1021/acsapm.1c00860

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55 of 55 references verified0 citation errors · 0 not checkable

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Authors
Kim, R. I., Lee, G., Lee, J.-H., Park, J. J., Lee, A. S., & Hwang, S. S.
Affiliations
  • Korea University (KR)
  • Korea Institute of Science and Technology (KR)
  • Vision Technology Korea Corp., 402 Science Park, 1646 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea
Corresponding author
  • Lee, Albert S.
  • Hwang, Seung Sang
Venue
ACS Applied Polymer Materials
Published
2021-08-18
Volume
3
Issue
9
Pages
4708-4716
ISSN
2637-6105 (ISSN-L)
OpenAlex
W3193792608
Cited by
11
References
55
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 1
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Locations
ACS Applied Polymer Materials (publishedVersion)
Funders
  • Ministry of Science and ICT, South Korea (2018M3A9E2023257)
  • Ministry of Trade, Industry and Energy (20008734)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
polycaprolactone, polylactic acid, ring-opening polymerization, urethane linkage, 3D printing, structure-property relationships, rheology, microstructure formation, mechanical properties, thermal properties

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