Structure–Property Relationships of 3D-Printable Chain-Extended Block Copolymers with Tunable Elasticity and Biodegradability
Abstract
Elastomeric bioscaffolds with tunable elasticity and biodegradability were synthesized via ring opening polymerization of polycaprolactone (PCL) and polylactide (PLA) with a bifunctional polyethylene glycol macroinitiator, followed by chain extension with diisocyanate to form urethane linkages. Through fine tuning of the macroinitiator and PCL/PLA weight fraction and molecular weight, a data set of elastomeric bioscaffolds gives structure–property insights into their thermal, mechanical, and biodegradability properties as they relate to triblock copolymer composition and mechanical weight. These materials were targeted to be 3D-printed by commercial devices, and their unique rheological properties enable impeccable multiscale microstructure formation. Simplicity in synthesis and fabrication as well as tunable biodegradability (1 day to 2 months) and elasticity (modulus 32–94 MPa) suggest the vast wide-ranging utility and prospective application in bioscaffolds for future therapeutic treatments.
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Catalysts which can only start block copolymerisations with one of the monomers have been reported.
“Catalysts, which can only start block copolymerisations with one of the monomers, have been reported.85,86”
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“65 ppm (peak h), corresponding to the methylene protons of the PEG block [43] (Figures 2b and 2c).”
Background
- Authors
- Kim, R. I., Lee, G., Lee, J.-H., Park, J. J., Lee, A. S., & Hwang, S. S.
- Affiliations
- Korea University (KR)
- Korea Institute of Science and Technology (KR)
- Vision Technology Korea Corp., 402 Science Park, 1646 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea
- Corresponding author
- Lee, Albert S.
- Hwang, Seung Sang
- Venue
- ACS Applied Polymer Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-08-18
- Volume
- 3
- Issue
- 9
- Pages
- 4708-4716
- ISSN
- 2637-6105 (ISSN-L)
- OpenAlex
- W3193792608
- Cited by
- 11
- References
- 55
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Polymer Materials (publishedVersion)
- Funders
- Ministry of Science and ICT, South Korea (2018M3A9E2023257)
- Ministry of Trade, Industry and Energy (20008734)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- polycaprolactone, polylactic acid, ring-opening polymerization, urethane linkage, 3D printing, structure-property relationships, rheology, microstructure formation, mechanical properties, thermal properties
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