Cited by 799biodegradable polymer synthesis and propertiesBone Tissue Engineering MaterialsFacial Trauma and Fracture Management

Late degradation tissue response to poly(?-lactide) bone plates and screws

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Bergsma, J·1995·Biomaterials

Abstract

Patients with fractures of the zygomatic bone were treated with high molecular weight poly(L-lactic) acid (PLLA) bone plates and screws. Three years after implantation four patients returned to our department with a swelling at the site of implantation. At the recall of the remaining patients we found an identical type of swelling after the same implantation period. To investigate the nature of the tissue reaction, eight patients were reoperated for the removal of the swelling. The implantation period of the PLLA material varied from 3.3 to 5.7 years. Microscopic evaluation and molecular weight measurements were performed. The excised material showed remnants of degraded PLLA material surrounded by a dense fibrous capsule. Ultrastructural investigation showed crystal-like PLLA material internalized by various cells. The results of this investigation suggest that the PLLA material slowly degrades into particles with a high crystallinity. The intra- and extracellular degradation rate of these particles is very low. After 5.7 years of implantation, these particles were still not fully resorbed.

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Research works printed but not linked: 1

  1. Gogolewski S, Pennings AJ. Resorbable materials of poly(L-lactide). 3. Porous materials for medical applica- tion. Colloid Sci 1983; 261: 477-484.

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Authors
Bergsma, J.
Affiliations
University Medical Center Groningen (NL)
Corresponding author
Bergsma, J
Venue
Biomaterials
Publisher
Elsevier BV
Published
1995
Volume
16
Issue
1
Pages
25-31
ISSN
0142-9612 (ISSN-L)
OpenAlex
W2149064558
Cited by
799
References
22
Citations by year
2026: 13 · 2025: 10 · 2024: 10 · 2023: 23 · 2022: 22 · 2021: 23 · 2020: 28 · 2019: 32 · 2018: 22 · 2017: 24 · 2016: 35 · 2015: 30 · 2014: 33 · 2013: 35 · 2012: 35
FWCI
14.24
Type
journal article
Language
en
Open access
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Facial Trauma and Fracture Management
Keywords
poly(L-lactic acid), zygomatic fractures, tissue reaction, fibrous capsule, ultrastructure, molecular weight, biodegradation
MeSH terms
Acid Phosphatase, Adult, Alkaline Phosphatase, Biodegradation, Environmental, Bone Plates, Bone Screws, Collagen, Enzyme Activation, Humans, L-Lactate Dehydrogenase, Lactates, Longitudinal Studies, Lysosomes, Microscopy, Electron, Microscopy, Electron, Scanning, Middle Aged, Mitochondria, Mitochondrial Swelling, Molecular Weight, Phagosomes, Polyesters, Polymers, Reoperation, Substrate Specificity, Zygomatic Fractures, Lactic Acid

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