The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Sex differences in mitochondrial (dys)function: Implications for neuroprotection
Open accessAbstract
Decades of research have revealed numerous differences in brain structure size, connectivity and metabolism between males and females. Sex differences in neurobehavioral and cognitive function after various forms of central nervous system (CNS) injury are observed in clinical practice and animal research studies. Sources of sex differences include early life exposure to gonadal hormones, chromosome compliment and adult hormonal modulation. It is becoming increasingly apparent that mitochondrial metabolism and cell death signaling are also sexually dimorphic. Mitochondrial metabolic dysfunction is a common feature of CNS injury. Evidence suggests males predominantly utilize proteins while females predominantly use lipids as a fuel source within mitochondria and that these differences may significantly affect cellular survival following injury. These fundamental biochemical differences have a profound impact on energy production and many cellular processes in health and disease. This review will focus on the accumulated evidence revealing sex differences in mitochondrial function and cellular signaling pathways in the context of CNS injury mechanisms and the potential implications for neuroprotective therapy development.
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“important sex differences exist in mitochondrial function [14–16], substrate utilization, and insulin sensitivity [17–24], immune responses [25–28], muscle morphology and body composition [29–32], iron metabolism [33–40], thermoregulation [41–44], hydration [45,46]{Sims, 2008 #55, [47–53], appetite control [54–59], and energy availability and endocrine function [60–65].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [15]
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1 retracted
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Research works printed but not linked: 1
- Demarest TG, Waddell J, Schuh RA, McKenna MC, Fiskum G (2013) Sexually dimorphic impairment of brain mitochondrial respiration following neonatal hypoxic-ischemia [abstract]. J Neurotrauma 30:A4
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Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know
Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533
Sex differences in biological aging with a focus on human studies
Hägg, S., & Jylhävä, J. (2021) · eLife · doi:10.7554/elife.63425 · Cited by 442
“These differences may contribute to altered mitochondrial function during stress conditions such as injury or starvation, where sex-specific effects are also noted on mitochondrial respiration (Demarest and McCarthy, 2015).”
BackgroundAge and Sex Are Critical Factors in Ischemic Stroke Pathology
Roy-O’Reilly, M. A., & McCullough, L. D. (2018) · Endocrinology · doi:10.1210/en.2018-00465 · Cited by 498
Mechanisms of sex differences in Alzheimer’s disease
Lopez-Lee, C., Torres, E. R. S., Carling, G., & Gan, L. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.024 · Cited by 376
Mitochondria: A central target for sex differences in pathologies
Ventura-Clapier, R., Moulin, M., Piquereau, J., Lemaire, C., Mericskay, M., Veksler, V., & Garnier, A. (2017) · Clinical Science · doi:10.1042/cs20160485 · Cited by 371
Metadata
- Authors
- Demarest, T. G., & McCarthy, M. M.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Demarest, Tyler G.
- Venue
- Journal of Bioenergetics and Biomembranes
- Published
- 2014-10-08
- Volume
- 47
- Issue
- 1-2
- Pages
- 173-188
- ISSN
- 0145-479X (ISSN-L)
- 1573-6881
- PMC
- PMC4988325
- OpenAlex
- W1980632245
- Cited by
- 192
- References
- 169
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 24 · 2023: 23 · 2022: 17 · 2021: 28 · 2020: 18 · 2019: 16 · 2018: 13 · 2017: 11 · 2016: 4 · 2015: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Bioenergetics and Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD016596)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Keywords
- sex differences, mitochondrial dysfunction, neuroprotection, central nervous system injury, brain energy metabolism, cell death signaling, gonadal hormones, sex hormones, neuroprotective therapy
- MeSH terms
- Adult, Central Nervous System, Central Nervous System Diseases, Energy Metabolism, Female, Humans, Male, Mitochondria, Sex Characteristics, Mitochondrial Diseases
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