Cited by 193Mitochondrial Function and PathologyNeuroprotection in Cerebral IschemiaSex and Gender in Healthcare

The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.

Sex differences in mitochondrial (dys)function: Implications for neuroprotection

Open access

Demarest, Tyler G., McCarthy, Margaret M.·2015·Journal of Bioenergetics and Biomembranes

DOI 10.1007/s10863-014-9583-7PMC PMC4988325

Open this paper in CoChat — free account

Abstract

Decades of research have revealed numerous differences in brain structure size, connectivity and metabolism between males and females. Sex differences in neurobehavioral and cognitive function after various forms of central nervous system (CNS) injury are observed in clinical practice and animal research studies. Sources of sex differences include early life exposure to gonadal hormones, chromosome compliment and adult hormonal modulation. It is becoming increasingly apparent that mitochondrial metabolism and cell death signaling are also sexually dimorphic. Mitochondrial metabolic dysfunction is a common feature of CNS injury. Evidence suggests males predominantly utilize proteins while females predominantly use lipids as a fuel source within mitochondria and that these differences may significantly affect cellular survival following injury. These fundamental biochemical differences have a profound impact on energy production and many cellular processes in health and disease. This review will focus on the accumulated evidence revealing sex differences in mitochondrial function and cellular signaling pathways in the context of CNS injury mechanisms and the potential implications for neuroprotective therapy development.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s10863-014-9583-7

Cites

169 of 169 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED ARTICLE: Protective effects of melatonin against mitochondrial injury in a mouse model of multiple sclerosis
Kashani, I. R., Rajabi, Z., Akbari, M., Hassanzadeh, G., Mohseni, A., Eramsadati, M. K., Rafiee, K., Beyer, C., Kipp, M., & Zendedel, A. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-3946-5 · Cited by 56
Retracted
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., & Nagata, S. (1998) · Nature · doi:10.1038/34112 · Cited by 3,239
The prevalence of Parkinson's disease: a systematic review and meta-analysis
Pringsheim, T., Jette, N., Frolkis, A., & Steeves, T. D. L. (2014) · Movement Disorders · doi:10.1002/mds.25945 · Cited by 2,188
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101 · cited 2×
“Indeed, oxidative stress is sufficient to induce autophagy/mitophagy ((Scherz-Shouval et al. 2007) as cited by (Au et al. 2010)) and is necessary for the normal progression of autophagic recycling ((Zhu et al. 2007) as cited by (Au et al. 2010)).”
The Biologic Clock: The Mitochondria?
Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 2,019
Policy: NIH to balance sex in cell and animal studies
Clayton, J. A., & Collins, F. S. (2014) · Nature · doi:10.1038/509282a · Cited by 1,816
Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation
Hailey, D. W., Rambold, A. S., Satpute‐Krishnan, P., Mitra, K., Sougrat, R., Kim, P. K., & Lippincott‐Schwartz, J. (2010) · Cell · doi:10.1016/j.cell.2010.04.009 · Cited by 1,491
Mitochondria and calcium: from cell signalling to cell death
Duchen, M. R. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00057.x · Cited by 1,261
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
Rambold, A. S., Kostelecky, B., Elia, N., & Lippincott‐Schwartz, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107402108 · Cited by 1,188
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
Chu, C. T., Ji, J., Dagda, R. K., Jiang, J. F., Tyurina, Y. Y., Kapralov, A. A., Tyurin, V. A., Yanamala, N., Shrivastava, I. H., Mohammadyani, D., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2837 · Cited by 1,083
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
Brown, G. C., & Cooper, C. E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01290-3 · Cited by 1,055
Mechanisms of Mitochondrial Fission and FusionPreprint
van der Bliek, A. M., Shen, Q., & Kawajiri, S. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011072 · Cited by 903
Estradiol and the Developing Brain
McCARTHY, M. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00010.2007 · Cited by 885 · cited 2×
“For instance, in immature neurons, activation of ionotropic γ-aminobutyric acid receptors (GABAA) is excitatory and contributes to male vulnerability to excitotoxic injury in an androgen dependent manner (Nuñez et al. 2003; Nuñez and McCarthy 2008).”
Self-citation
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
Keller, J. N., Kindy, M. S., Holtsberg, F. W., St. Clair, D. K., Yen, H.-C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., & Mattson, M. P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00687.1998 · Cited by 863
Glutamate neurotoxicity in cortical cell culture is calcium dependent
Choi, D. W. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90069-2 · Cited by 810
Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain
Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., & Beal, M. F. (1993) · Annals of Neurology · doi:10.1002/ana.410340416 · Cited by 757 · cited 1×
“Mitochondrial DNA is oxidatively damaged with aging (Mecocci et al. 1993) and theorized as a main determining factor for lifespan (Harman 1956, 1972).”
Reframing sexual differentiation of the brain
McCarthy, M. M., & Arnold, A. P. (2011) · Nature Neuroscience · doi:10.1038/nn.2834 · Cited by 728
Self-citation
Sex Differences in the Brain: The Not So Inconvenient Truth
McCarthy, M. M., Arnold, A. P., Ball, G. F., Blaustein, J. D., & De Vries, G. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5372-11.2012 · Cited by 724
Self-citation
Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species
Starkov, A. A., Fiskum, G. M., Chinopoulos, C., Lorenzo, B. J., Browne, S. E., Patel, M. S., & Beal, M. F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1899-04.2004 · Cited by 711
Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males
Borrás, C., Sastre, J., García-Sala, D., Lloret, A., Pallardó, F. V., & Viña, J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01356-4 · Cited by 654
Nuclear activators and coactivators in mammalian mitochondrial biogenesis
Scarpulla, R. C. (2002) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(02)00343-3 · Cited by 638
Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase
Brown, G. C. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00238-3 · Cited by 602
Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities
Fatokun, A. A., Dawson, V. L., & Dawson, T. M. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12416 · Cited by 594
Oxidative stress caused by mitochondrial calcium overload
Peng, T., & Jou, M. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05634.x · Cited by 569
Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase
Brown, G. C. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00763-y · Cited by 540
Sex differences in Parkinson’s disease
Gillies, G. E., Pienaar, I. S., Vohra, S., & Qamhawi, Z. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.02.002 · Cited by 521
Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury
Koike, M., Shibata, M., Tadakoshi, M., Gotoh, K., Komatsu, M., Waguri, S., Kawahara, N., Kuida, K., Nagata, S., Kominami, E., et al. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070876 · Cited by 486
Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)
Wang, Y., Kim, N. S., Haince, J.-F., Kang, H. C., David, K. K., Andrabi, S. A., Poirier, G. G., Dawson, V. L., & Dawson, T. M. (2011) · Science Signaling · doi:10.1126/scisignal.2000902 · Cited by 476
Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency
Murakami, K., Kondo, T., 川瀬, 誠., Li, Y., Sato, S., Chen, S. F., & Chan, P. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00205.1998 · Cited by 467
Regulation of Autophagy by Extracellular Signal-Regulated Protein Kinases During 1-Methyl-4-Phenylpyridinium-Induced Cell Death
Zhu, J.-H., Horbinski, C., Guo, F., Watkins, S. C., Uchiyama, Y., & Chu, C. T. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060524 · Cited by 447
NAD + Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death
Alano, C. C., Garnier, P., Ying, W., Higashi, Y., Kauppinen, T. M., & Swanson, R. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5552-09.2010 · Cited by 439
Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos
Wang, Y., Dawson, V. L., & Dawson, T. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.020 · Cited by 430
A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.
Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., & Kelly, D. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3949 · Cited by 410
Caspase‐3 Mediated Neuronal Death After Traumatic Brain Injury in Rats
Clark, R. S. B., Kochanek, P. M., Watkins, S. C., Chen, M., Dixon, C. E., Seidberg, N. A., Melick, J. A., Loeffert, J. E., Nathaniel, P. D., Jin, K. L., et al. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740740.x · Cited by 406
The Neurosteroids Progesterone and Allopregnanolone Reduce Cell Death, Gliosis, and Functional Deficits after Traumatic Brain Injury in Rats
Djebaı̈li, M., Guo, Q., Pettus, E. H., Hoffman, S. W., & Stein, D. G. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.106 · Cited by 387
Mitochondrial and Nuclear Cross Talk in Cell Death
Andrabi, S. A., Dawson, T. M., & Dawson, V. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.014 · Cited by 378
Poly(ADP-ribose) Polymerase-1-mediated Cell Death in Astrocytes Requires NAD+ Depletion and Mitochondrial Permeability Transition
Alano, C. C., Ying, W., & Swanson, R. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313329200 · Cited by 374
Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation
Dewing, P., Shi, T., Horvath, S., & Vilain, E. J. N. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00339-5 · Cited by 359
Innate Gender-based Proclivity in Response to Cytotoxicity and Programmed Cell Death Pathway
Du, L., Bayır, H., Lai, Y., Zhang, X., Kochanek, P. M., Watkins, S. C., Graham, S. H., & Clark, R. S. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405461200 · Cited by 355
Mitochondrial Participation in Ischemic and Traumatic Neural Cell Death
Fiskum, G. M. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.843 · Cited by 347
Calcium and Excitotoxic Neuronal Injury
Choi, D. W. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb44407.x · Cited by 346
Sex Differences in the Phosphorylation of Mitochondrial Proteins Result in Reduced Production of Reactive Oxygen Species and Cardioprotection in Females
Lagranha, C. J., Deschamps, A. M., Aponte, A. M., Steenbergen, C., & Murphy, E. (2010) · Circulation Research · doi:10.1161/circresaha.109.213645 · Cited by 328
Ischemic Nitric Oxide and Poly (ADP-Ribose) Polymerase-1 in Cerebral Ischemia: Male Toxicity, Female Protection
McCullough, L. D., Zeng, Z., Blizzard, K. K., Debchoudhury, I., & Hurn, P. D. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600059 · Cited by 325
Mitochondria and Ca2+in cell physiology and pathophysiology
Duchen, M. R. (2000) · Cell Calcium · doi:10.1054/ceca.2000.0170 · Cited by 310
Intra-mitochondrial Poly(ADP-ribosylation) Contributes to NAD+ Depletion and Cell Death Induced by Oxidative Stress
Du, L., Zhang, X., Han, Y. Y., Burke, N. A., Kochanek, P. M., Watkins, S. C., Graham, S. H., Carcillo, J. A., Szabó, C., & Clark, R. S. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301295200 · Cited by 310
Rapamycin is a neuroprotective treatment for traumatic brain injury
Erlich, S., Alexandrovich, A., Shohami, E., & Pinkas-Kramarski, R. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.003 · Cited by 295
Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters.Preprint
Virbasius, J. V., Virbasius, C.-M. A., & Scarpulla, R. C. (1993) · Genes & Development · doi:10.1101/gad.7.3.380 · Cited by 291
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP‐ribose) polymerase
Fonfría, E., Marshall, I. C. B., Benham, C. D., Boyfield, I., Brown, J. D., Hill, K., Hughes, J. P., Skaper, S. D., & McNulty, S. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705914 · Cited by 283
Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures.
Nicholls, D. (2004) · Current molecular medicine · doi:10.2174/1566524043479239 · Cited by 276
17β-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors
Weaver, C. E., Park-Chung, M., Gibbs, T. T., & Farb, D. H. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00449-6 · Cited by 276
Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology
Hyman, B. T., & Yuan, J. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3228 · Cited by 259
Assessment of Antioxidant Reserves and Oxidative Stress in Cerebrospinal Fluid after Severe Traumatic Brain Injury in Infants and Children
Bayır, H., Kagan, V. E., Tyurina, Y. Y., Tyurin, V. A., Ruppel, R. A., Adelson, P. D., Graham, S. H., Janesko, K. L., Clark, R. S. B., & Kochanek, P. M. (2002) · Pediatric Research · doi:10.1203/00006450-200205000-00005 · Cited by 258
The Glutathione System of Peroxide Detoxification Is Less Efficient in Neurons than in Astroglial Cells
Dringen, R., Kußmaul, L., Gutterer, J. M., Hirrlinger, J., & Hamprecht, B. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722523.x · Cited by 243
Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury
Yin, W., Signore, A. P., Iwai, M., Cao, G., Gao, Y., & Chen, J. (2008) · Stroke · doi:10.1161/strokeaha.108.520114 · Cited by 229
Mitochondrial mechanisms of estrogen neuroprotection
Simpkins, J. W., Yi, K. D., Yang, S., & Dykens, J. A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.11.013 · Cited by 207
Sex Differences in Mechanisms and Outcome of Neonatal Hypoxia-Ischemia in Rodent Models: Implications for Sex-Specific Neuroprotection in Clinical Neonatal Practice
Hill, C. A., & FITCH, R. H. (2012) · Neurology Research International · doi:10.1155/2012/867531 · Cited by 204
Immunocytochemical Evidence for a Mitochondrially Located Nitric Oxide Synthase in Brain and Liver
Bates, T. E., Loesch, A., Burnstock, G., & Clark, J. B. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2213 · Cited by 204
Starving Neurons Show Sex Difference in Autophagy
Du, L., Hickey, R. W., Bayir, H., Watkins, S. C., Tyurin, V. A., Guo, F., Kochanek, P. M., Jenkins, L. W., Ren, J., Gibson, G., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m804396200 · Cited by 204
Mitochondria: hub of injury responses in the developing brain
Hagberg, H., Mallard, C. E., Rousset, C. I., & Thornton, C. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70261-8 · Cited by 199
Marked Gender Effect on Lipid Peroxidation after Severe Traumatic Brain Injury in Adult Patients
Bayir, H., Marion, D. W., Puccio, A. M., Wisniewski, S. R., Janesko, K. L., Clark, R. S. B., & Kochanek, P. M. (2004) · Journal of Neurotrauma · doi:10.1089/089771504772695896 · Cited by 194
Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia
Mehta, S. L., Kumari, S., Mendelev, N., & Li, P. A. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-79 · Cited by 184
Nitric oxide and mitochondria
Guy, C. B. (2006) · Frontiers in bioscience · doi:10.2741/2122 · Cited by 172
miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia
Siegel, C. S., Li, J., Liu, F., Benashski, S. E., & McCullough, L. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102635108 · Cited by 172
Loss of cardiolipin and mitochondria during programmed neuronal death: evidence of a role for lipid peroxidation and autophagy
Kirkland, R. A., Adibhatla, R. M., Hatcher, J. F., & Franklin, J. L. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00512-2 · Cited by 171
Closed Head Injury Induces Upregulation of Beclin 1 at the Cortical Site of Injury
Diskin, T., Tal‐Or, P., Erlich, S., Mizrachy, L., Alexandrovich, A. G., Shohami, E., & Pinkas‐Kramarski, R. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.750 · Cited by 169
Preconditioning limits mitochondrial Ca2+during ischemia in rat hearts: role of KATPchannels
Wang, L., Cherednichenko, G., Hernandez, L. A., Halow, J. M., Camacho, S. A., Figueredo, V. M., & Schaefer, S. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.5.h2321 · Cited by 169
Mitochondria as Therapeutic Targets of Estrogen Action in the Central Nervous System
Nilsen, J., & Brinton, R. D. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337193 · Cited by 166
Mitochondrial Localization of PARP-1 Requires Interaction with Mitofilin and Is Involved in the Maintenance of Mitochondrial DNA Integrity
Rossi, M. N., Carbone, M., Mostocotto, C., Mancone, C., Tripodi, M., Maione, R., & Amati, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.025882 · Cited by 163
Involvement of autophagy in hypoxic-excitotoxic neuronal death
Ginet, V., Spiehlmann, A., Rummel, C., Rudinskiy, N., Grishchuk, Y., Luthi‐Carter, R., Clarke, P. G., Truttmann, A. C., & Puyal, J. (2014) · Autophagy · doi:10.4161/auto.28264 · Cited by 163
LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons
Chu, C. T., Bayır, H., & Kagan, V. E. (2013) · Autophagy · doi:10.4161/auto.27191 · Cited by 159
Basal ganglia organization in amphibians: Afferent connections to the striatum and the nucleus accumbens
Mar�n, O., Gonz�lez, A., & Smeets, W. J. A. J. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970203)378:1 · Cited by 145
Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death
Lin, C.-J., Chen, T.-H., Yang, L.-Y., & Shih, C.-M. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.123 · Cited by 142
Novel Mitochondrial Targets for Neuroprotection
Pérez‐Pinzón, M. A., Stetler, R. A., & Fiskum, G. M. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.32 · Cited by 142
Neuronal NOS‐mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury
Bayır, H., Kagan, V. E., Clark, R. S. B., Janesko‐Feldman, K. L., Rafikov, R., Huang, Z., Zhang, X., Vagni, V., Billiar, T. R., & Kochanek, P. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04353.x · Cited by 140
Crosstalk between mitochondrial (dys)function and mitochondrial abundance
Michel, S., Wanet, A., Pauw, A. D., Rommelaere, G., Arnould, T., & Renard, P. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.23021 · Cited by 138
Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats
Rao, V. L. R., Dog⫧an, A., Todd, K. G., Bowen, K. K., & Dempsey, R. J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02617-8 · Cited by 135
Traumatic Brain Injury in Adult Rats Causes Progressive Nigrostriatal Dopaminergic Cell Loss and Enhanced Vulnerability to the Pesticide Paraquat
Hutson, C. B., Lazo, C. R., Mortazavi, F., Giza, C. C., Hovda, D. A., & Chesselet, M. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2010.1723 · Cited by 133
Sex Differences in Neuroprotection Provided by Inhibition of TRPM2 Channels following Experimental Stroke
Jia, J., Verma, S., Nakayama, S., Quillinan, N., Grafe, M. R., Hurn, P. D., & Herson, P. S. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.77 · Cited by 130
Sex differences in cell death
Li, H., Pin, S., Zeng, Z., Wang, M. M., Andreasson, K. I., & McCullough, L. D. (2005) · Annals of Neurology · doi:10.1002/ana.20538 · Cited by 128
Gender differences in free radical homeostasis during aging: shorter‐lived female C57BL6 mice have increased oxidative stress
Ali, S. S., Xiong, C., Lucero, J. D., Behrens, M. M., Dugan, L. L., & Quick, K. L. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00252.x · Cited by 124
Mitochondria Play a Central Role in Estrogen-Induced Neuroprotection
Simpkins, J. W., Wang, J., Wang, X., Perez, E., Prókai, L., & Dykens, J. A. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007053005073 · Cited by 124
Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke
Yuan, M., Siegel, C. S., Zeng, Z., Li, J., Liu, F., & McCullough, L. D. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.02.012 · Cited by 123
PARP-1 Inhibition Attenuates Neuronal Loss, Microglia Activation and Neurological Deficits after Traumatic Brain Injury
Stoica, B. A., Loane, D. J., Zhao, Z., Kabadi, S. V., Hanscom, M., Byrnes, K. R., & Faden, A. I. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.3194 · Cited by 122
The Mitochondrial Inner Membrane GTPase, Optic Atrophy 1 (Opa1), Restores Mitochondrial Morphology and Promotes Neuronal Survival following Excitotoxicity
Jahani‐Asl, A., Pilon‐Larose, K., Xu, W., MacLaurin, J. G., Park, D. S., McBride, H. M., & Slack, R. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.167155 · Cited by 118
The response of the sexes to nutritional stress
Widdowson, E. M. (1976) · Proceedings of the Nutrition Society · doi:10.1079/pns19760030 · Cited by 115 · cited 2×
“Sex differences in metabolism have long been observed in humans (reviewed in (Widdowson 1976).”
Effect of N -Acetylcysteine on Mitochondrial Function Following Traumatic Brain Injury in Rats
Xiong, Y., Peterson, P. L., & Lee, C. P. (1999) · Journal of Neurotrauma · doi:10.1089/neu.1999.16.1067 · Cited by 114
An Ounce of Prevention Is a Ton of Work: Mass Antibiotic Prophylaxis for Anthrax, New York City, 2001
Blank, S., Moskin, L. C., & Zucker, J. R. (2003) · Emerging infectious diseases · doi:10.3201/eid0906.030118 · Cited by 113
N-Acetyl-Serotonin Offers Neuroprotection through Inhibiting Mitochondrial Death Pathways and Autophagic Activation in Experimental Models of Ischemic Injury
Zhou, H., Wang, J., Jiang, J., Stavrovskaya, I. G., Li, M., Li, W., Wu, Q., Zhang, X., Luo, C., Zhou, S., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1948-13.2014 · Cited by 113
Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression
Giordano, G., Tait, L. J., Furlong, C. E., Cole, T. B., Kavanagh, T. J., & Costa, L. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.019 · Cited by 112
To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage
Huang, Q. B., & Shen, H. (2009) · Autophagy · doi:10.4161/auto.5.2.7640 · Cited by 108
The Dynamics of the Mitochondrial Organelle as a Potential Therapeutic Target
Stetler, R. A., Leak, R. K., Gao, Y., & Chen, J. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.158 · Cited by 106
Glutamate‐mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR‐induced release of Ca++ from intracellular stores and is prevented by estradiol
Hilton, G. D., Nuñez, J. L., Bambrick, L. L., Thompson, S. M., & McCarthy, M. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05189.x · Cited by 101
Self-citation
Sex differences in Parkinson’s disease
Lubomski, M., Rushworth, R. L., Lee, W., Bertram, K., & Williams, D. R. (2014) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2013.12.016 · Cited by 101
Neuroprotection by estrogen in the brain: the mitochondrial compartment as presumed therapeutic target
Arnold, S., & Beyer, C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06133.x · Cited by 97
Autophagy in acute brain injury: Feast, famine, or folly?
Smith, C. M., Chen, Y., Sullivan, M. L. G., Kochanek, P. M., & Clark, R. S. B. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.014 · Cited by 95
Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats
Gaviria, M., Privat, A., D’Arbigny, P., Kamenka, J. M., Haton, H., & Ohanna, F. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02581-6 · Cited by 95
Early-life sex-dependent vulnerability to oxidative stress: the natural twining model
Minghetti, L., Greco, A., Zanardo, V., & Suppiej, A. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.733751 · Cited by 95
Inhibition of Autophagy Contributes to Melatonin-Mediated Neuroprotection Against Transient Focal Cerebral Ischemia in Rats
Zheng, Y., Hou, J., Liu, J., Yao, M., Li, L., Zhang, B., Zhu, H., & Wang, Z. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13220fp · Cited by 94
Mitochondrial Nitric-Oxide Synthase: Enzyme Expression, Characterization, and Regulation
Haynes, V. L., Elfering, S. L., Traaseth, N. J., & Giulivi, C. (2004) · Journal of Bioenergetics and Biomembranes · doi:10.1023/b:jobb.0000041765.27145.08 · Cited by 92
Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection
Costa, L. G., de Laat, R., Dao, K., Pellacani, C., Cole, T. B., & Furlong, C. E. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.08.011 · Cited by 90
MK-801 Prevents Hippocampal Neurodegeneration in Neonatal Hypoxic-Ischemic Rats
Ford, L. M., Sanberg, P. R., Norman, A. B., & Fogelson, M. H. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520460072016 · Cited by 87
The nature of the sex-linked differences in glutathione peroxidase activity and aerobic oxidation of glutathione in male and female rat liver
Pinto, R. E., & Bartley, W. (1969) · Biochemical Journal · doi:10.1042/bj1150449 · Cited by 86
F 2 -Isoprostane and Neuron-Specific Enolase in Cerebrospinal Fluid after Severe Traumatic Brain Injury in Infants and Children
Varma, S., Janesko, K. L., Wisniewski, S. R., Bayır, H., Adelson, P. D., Thomas, N. J., & Kochanek, P. M. (2003) · Journal of Neurotrauma · doi:10.1089/089771503767870005 · Cited by 86
Estrogen and neuroprotection: higher constitutive expression of glutaredoxin in female mice offers protection against MPTP‐mediated neurodegeneration
Kenchappa, R. S., Diwakar, L., Jayasree Annepu, B., & Ravindranath, V. (2004) · The FASEB Journal · doi:10.1096/fj.03-1075fje · Cited by 82
Early nuclear translocation of endonuclease G and subsequent DNA fragmentation after transient focal cerebral ischemia in mice
Lee, B. I., Lee, D. J., Cho, K. J., & Kim, G. W. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.05.058 · Cited by 81
Glutaredoxin is essential for maintenance of brain mitochondrial complex I: studies with MPTP
Kenchappa, R. S., & Ravindranath, V. (2003) · The FASEB Journal · doi:10.1096/fj.02-0771fje · Cited by 80
A combination of four active compounds alleviates cerebral ischemia–reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK/mTOR and JNK pathways
Guo, Z., Cao, G., Yang, H., Zhou, H., Li, L., Cao, Z., Yu, B., & Kou, J. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23400 · Cited by 77
Autophagy in the brain of neonates following hypoxia–ischemia shows sex- and region-specific effects
Weis, S. N., Toniazzo, A. P., Ander, B. P., Zhan, X., Careaga, M., Ashwood, P., Wyse, Â. T. D. S., Netto, C. A., & Sharp, F. R. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.046 · Cited by 75
A Calcineurin Docking Motif (LXVP) in Dynamin-related Protein 1 Contributes to Mitochondrial Fragmentation and Ischemic Neuronal Injury
Slupe, A. M., Merrill, R. A., Flippo, K. H., Lobas, M. A., Houtman, J. C. D., & Strack, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.459677 · Cited by 73
Gender modulation of Ca2+ uptake in cardiac mitochondria
ARIELI, Y. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.04.023 · Cited by 72
Novel Therapeutic Strategies for Traumatic Brain Injury: Acute Antioxidant Reinforcement
Fernández-Gajardo, R., Matamala, J. M., Carrasco, R. A., Gutiérrez, R., Melo, R., & Rodrigo, R. (2014) · CNS Drugs · doi:10.1007/s40263-013-0138-y · Cited by 69
Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injury
Wagner, A. K., Fabio, A., Puccio, A. M., Hirschberg, R. E., Li, W., ZAFONTE, R. D., & Marion, D. W. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000153931.23488.dd · Cited by 68
Apoptosis and autophagy contribute to gender difference in cardiac ischemia–reperfusion induced injury in rats
Chen, C., Hu, L., Dong, T., Wang, G., Wang, L., Xi-ping, Z., Jiang, Y., Murao, K., Lu, S., Chen, J., et al. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.06.019 · Cited by 67
Sex differences in mitochondrial biogenesis determine neuronal death and survival in response to oxygen glucose deprivation and reoxygenation
Sharma, J., Johnston, M. V., & Hossain, M. A. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-9 · Cited by 67
The Potential Role of Mitochondria in Pediatric Traumatic Brain Injury
Robertson, C., Soane, L., Siegel, Z. T. G., & Fiskum, G. M. (2006) · Developmental Neuroscience · doi:10.1159/000094169 · Cited by 67
Inhibition of autophagy as a therapeutic strategy of iron-induced brain injury after hemorrhage
Chen, C.-W., Chen, T.-Y., Tsai, K.-L., Lin, C., Yokoyama, K. K., Lee, W., Chiueh, C. C., & Hsu, C. (2012) · Autophagy · doi:10.4161/auto.21289 · Cited by 65
Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones
Arnold, S., de Araújo, G. W., & Beyer, C. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0085 · Cited by 65 · cited 1×
“Expression of apoptotic proteins BCL-2 and BAX are upregulated after progesterone treatment in female astrocytes but decreased in male astrocytes indicating opposing effects of progesterone on critical apoptosis mediating proteins (Arnold et al. 2008).”
The mitochondrial calcium regulator cyclophilin d is an essential component of oestrogen-mediated neuroprotection in amyotrophic lateral sclerosis
Kim, H. J., Magranè, J., Starkov, A. A., & Manfredi, G. (2012) · Brain · doi:10.1093/brain/aws208 · Cited by 64
Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury
Yan, H. Q., Ma, X., Chen, X., Li, Y., Shao, L., & Dixon, C. E. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.087 · Cited by 63
Neurotoxicity of Dopamine and Protective Effects of the NMDA Receptor Antagonist AP-5 Differ between Male and Female Dopaminergic Neurons
Lieb, K., Andrae, J., Reisert, I., & Pilgrim, C. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1052 · Cited by 62
Amantadine Improves Cognitive Outcome and Increases Neuronal Survival after Fluid Percussion Traumatic Brain Injury in Rats
Wang, T., Huang, X.-J., Van, K. C., Went, G. T., Nguyen, J. T., & Lyeth, B. G. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.2917 · Cited by 61
ADP-ribosyl transferase and NAD glycohydrolase activities in rat liver mitochondria
Masmoudi, A. S., & Mandel, P. (1987) · Biochemistry · doi:10.1021/bi00381a027 · Cited by 61
Sex-specific responses to stroke
Turtzo, L. C., & McCullough, L. D. (2009) · Future Neurology · doi:10.2217/fnl.09.66 · Cited by 61
TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death
Verma, S., Quillinan, N., Yang, Y., Nakayama, S., Cheng, J. G., Kelley, M. H., & Herson, P. S. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.09.044 · Cited by 61
An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress
Starkov, A. A. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.07.005 · Cited by 60
Androgens predispose males to GABAA-mediated excitotoxicity in the developing hippocampus
Nuñez, J. L., & McCarthy, M. M. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.01.001 · Cited by 59
Self-citation
Mitochondrial fusion and fission after spinal sacord injury in rats
Cao, Y., Lv, G., Wang, Y., Fan, Z., Bi, Y., Zhao, L., & Guo, Z. (2013) · Brain Research · doi:10.1016/j.brainres.2013.05.033 · Cited by 59
Neonatal hypoxia–ischemia induces sex-related changes in rat brain mitochondria
Weis, S. N., Pettenuzzo, L. F., Krolow, R., Valentim, L. M., Mota, C. S., Dalmaz, C., Wyse, Â. T. D. S., & Netto, C. A. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.10.002 · Cited by 58
Local Administration of the Poly(ADP-Ribose) Polymerase Inhibitor INO-1001 Prevents NAD + Depletion and Improves Water Maze Performance after Traumatic Brain Injury in Mice
Clark, R. S. B., Vagni, V., Nathaniel, P. D., Jenkins, L. W., Dixon, C. E., & Szabó, C. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2007.0305 · Cited by 56
NMDA receptor antagonist MK-801 reduces neuronal damage and preserves learning and memory in a rat model of traumatic brain injury
Rui-zhan, H., Hu, J. J., Weng, Y., Li, D., & Huang, Y. (2009) · Neuroscience Bulletin · doi:10.1007/s12264-009-0608-x · Cited by 55
Gender-specific role of mitochondria in the vulnerability of 6-hydroxydopamine-treated mesencephalic neurons
Misiak, M., Beyer, C., & Arnold, S. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.04.009 · Cited by 55
A new model for prenatal brain damage
Nuñez, J. L., Alt, J., & McCarthy, M. M. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00053-0 · Cited by 55
Self-citation
Sex differences in survival and mitochondrial bioenergetics during aging inDrosophila
Ballard, J. W. O., Melvin, R. G., Miller, J. T., & Katewa, S. D. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00331.x · Cited by 53
Depolarizing stimulation upregulates GA‐binding protein in neurons: a transcription factor involved in the bigenomic expression of cytochrome oxidase subunits
Zhang, C., & Wong‐Riley, M. T. T. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00997.x · Cited by 52
Glutamate-Mediated Excitotoxic Death of Cultured Striatal Neurons Is Mediated by Non-NMDA Receptors
Chen, Q., Harris, C. L., Brown, C. S., Howe, A. R., Surmeier, D. J., & Reiner, A. J. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1098 · Cited by 52
Mitochondrial Dysfunction and NAD+ Metabolism Alterations in the Pathophysiology of Acute Brain Injury
Owens, K., Park, J. H., Schuh, R. A., & Kristián, T. (2013) · Translational Stroke Research · doi:10.1007/s12975-013-0278-x · Cited by 51
Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat
van Bregt, D. R., Thomas, T. C., Hinzman, J. M., Cao, T., Liu, M., Bing, G., Gerhardt, G. A., Pauly, J. R., & Lifshitz, J. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.12.003 · Cited by 49
Androgens and stroke: Good, bad or indifferent?
Quillinan, N., Deng, G., Grewal, H., & Herson, P. S. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.02.004 · Cited by 47
Inhibition of X-Linked Inhibitor of Apoptosis with Embelin Differentially Affects Male versus Female Behavioral Outcome following Neonatal Hypoxia-Ischemia in Rats
Hill, C. A., Alexander, M. L., McCullough, L. D., & FITCH, R. H. (2011) · Developmental Neuroscience · doi:10.1159/000331651 · Cited by 46
Sex‐ and brain region‐specific role of cytochrome c oxidase in 1‐methyl‐4‐phenylpyridinium‐mediated astrocyte vulnerability
Boyalla, S. S., Victor, M. B., Roemgens, A., Beyer, C., & Arnold, S. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22669 · Cited by 45
NAD+ and Nicotinamide: Sex Differences in Cerebral Ischemia
Siegel, C. S., & McCullough, L. D. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.068 · Cited by 42
Sexual dimorphism in cerebral ischemia injury.
Zuo, W., Zhang, W., & Chen, N. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.024 · Cited by 42
Autophagy-mediated turnover of Dynamin-related Protein 1
Purnell, P. R., & Fox, H. S. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-86 · Cited by 41
Gemfibrozil Pretreatment Affecting Antioxidant Defense System and Inflammatory, but not Nrf-2 Signaling Pathways Resulted in Female Neuroprotection and Male Neurotoxicity in the Rat Models of Global Cerebral Ischemia–Reperfusion
Mohagheghi, F., Khalaj, L., Ahmadiani, A., & Rahmani, B. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9338-3 · Cited by 41
Thioltransferase (Glutaredoxin) Mediates Recovery of Motor Neurons from Excitotoxic Mitochondrial Injury
Kenchappa, R. S., Diwakar, L., Boyd, M. R., & Ravindranath, V. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08402.2002 · Cited by 40
Intra-mitochondrial poly(ADP-ribosyl)ation: Potential role for alpha-ketoglutarate dehydrogenase
Pankotai, E., Lacza, Z., Murányi, M., & Szabó, C. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.01.013 · Cited by 39
Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: Implications in excitotoxicity
Diwakar, L., Kenchappa, R. S., Jayasree Annepu, B., & Ravindranath, V. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.03.008 · Cited by 37
Gender Differences in Amino Acid Use during Endurance Exercise
Lamont, L. S. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00116.x · Cited by 36
The neuroactive steroid 3-α-ol-5-β-pregnan-20-one hemisuccinate, a selective NMDA receptor antagonist improves behavioral performance following spinal cord ischemia
Lapchak, P. A. (2003) · Brain Research · doi:10.1016/j.brainres.2003.10.047 · Cited by 35
ADP‐Ribosylation of Highly Purified Rat Brain Mitochondria
Masmoudi, A., Islam, F., & Mandel, P. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb04854.x · Cited by 34
Sex-Specific Role of Thioredoxin in Neuroprotection Against Iron-Induced Brain Injury Conferred by Estradiol
Chen, T.-Y., Tsai, K.-L., Lee, T.-Y., Chiueh, C. C., Lee, W., & Hsu, C. (2009) · Stroke · doi:10.1161/strokeaha.109.562850 · Cited by 32
Induction of Mitochondrial Dysfunction by Poly(ADP-Ribose) Polymer: Implication for Neuronal Cell Death
Baek, S., Bae, O., Kim, E. K., & Yu, S.-W. (2013) · Molecules and Cells · doi:10.1007/s10059-013-0172-0 · Cited by 32
Sex differences in brain proteomes of neuron‐specific STAT3‐null mice after cerebral ischemia/reperfusion
Domenico, F. D., Casalena, G., Jia, J., Rukhsana Sultana, A., Barone, E., Cai, J., Pierce, W. M. J., Cini, C., Mancuso, C., Marzia Perluigi, A., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07721.x · Cited by 31
Protection of cortical cells by equine estrogens against glutamate-induced excitotoxicity is mediated through a calcium independent mechanism
Perrella, J., & Bhavnani, B. R. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-34 · Cited by 30
Reperfusion Promotes Mitochondrial Biogenesis following Focal Cerebral Ischemia in Rats
Xie, Y., Li, J., Fan, G., Qi, S., & Li, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092443 · Cited by 28
Quantification of Poly(ADP-Ribose)-Modified Proteins in Cerebrospinal Fluid from Infants and Children after Traumatic Brain Injury
Fink, E. L., Lai, Y., Zhang, X., Janesko‐Feldman, K. L., Adelson, P. D., Szabó, C., Berger, R. P., Sarnaik, A., Kochanek, P. M., & Clark, R. S. B. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.52 · Cited by 24
Mitochondria as Generators and Targets of Nitric Oxide
Giulivi, C. (2007) · Novartis Foundation symposium · doi:10.1002/9780470725207.ch7 · Cited by 23
Effects of Nicotine Administration on Striatal Dopamine Signaling after Traumatic Brain Injury in Rats
Shin, S. S., Bray, E. R., & Dixon, C. E. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.1966 · Cited by 23
Evaluation of Autophagy Using Mouse Models of Brain Injury
Au, A. K., Bayır, H., Kochanek, P., & Clark, R. (2009) · Biochimica et Biophysica Acta · doi:10.1016/j.bbadis.2009.10.010 · Cited by 23
Sex differences in cerebral injury after severe haemorrhage and ventricular fibrillation in pigs
Semenas, E., Nozari, A., Sharma, H. S., BASU, S., Rubertsson, S., & Wiklund, L. (2009) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2009.02125.x · Cited by 22
Comparative analyses of the neurodegeneration induced by the non-competitive NMDA-receptor-antagonist drug MK801 in mice and rats
Bender, C. L., de Olmos, S., Bueno, A. M., de Olmos, J. S., & Lorenzo, A. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.05.002 · Cited by 21
Redox Activated MAP Kinase Death Signaling Cascade Initiated by ASK1 is not Activated in Female Mice Following MPTP: Novel Mechanism of Neuroprotection
Saeed, U., Karunakaran, S., Meka, D. P., Koumar, R. C., Ramakrishnan, S., Joshi, S. D., Nidadavolu, P., & Ravindranath, V. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9058-5 · Cited by 21
Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells
Zhang, C., Yuan, X., Li, H., Zhao, Z.-J., Liao, Y., Wang, X., Su, J., Sang, S., & Liu, Q. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.072 · Cited by 21
Gemfibrozil Pretreatment Resulted in a Sexually Dimorphic Outcome in the Rat Models of Global Cerebral Ischemia–Reperfusion via Modulation of Mitochondrial Pro-survival and Apoptotic Cell Death Factors as well as MAPKs
Mohagheghi, F., Ahmadiani, A., Rahmani, B., Moradi, F., Romond, N. B., & Khalaj, L. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9932-0 · Cited by 20
An Approach to Experimental Synaptic Pathology Using Green Fluorescent Protein-Transgenic Mice and Gene Knockout Mice to Show Mitochondrial Permeability Transition Pore-Driven Excitotoxicity in Interneurons and Motoneurons
Martin, L. J. (2010) · Toxicologic Pathology · doi:10.1177/0192623310389475 · Cited by 20
Effect of starvation on the survival of male and female mice.
Jikumaru, M., Hiramoto, K., Honma, T., Sato, E. F., Sekiyama, A., & Inoue, M. (2007) · PubMed · Cited by 14
17β‐estradiol does not protect cerebellar granule cells from excitotoxicity or apoptosis
Miñano-Molina, A. J., Cerbón, M. A., Xifró, X., Malagelada, C., Aguilera, J., & Rodrı́guez-Álvarez, J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04475.x · Cited by 10
Mitochondrial mechanisms of estrogen neuroprotection.
Simpkins, J., & Dykens, J. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.04.007 · Cited by 7

Flagged first, then by citations

Research works printed but not linked: 1

Demarest TG, Waddell J, Schuh RA, McKenna MC, Fiskum G (2013) Sexually dimorphic impairment of brain mitochondrial respiration following neonatal hypoxic-ischemia [abstract]. J Neurotrauma 30:A4

Sorted by citations

Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know
Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533
Sex differences in biological aging with a focus on human studies
Hägg, S., & Jylhävä, J. (2021) · eLife · doi:10.7554/elife.63425 · Cited by 442
“These differences may contribute to altered mitochondrial function during stress conditions such as injury or starvation, where sex-specific effects are also noted on mitochondrial respiration (Demarest and McCarthy, 2015).”
Background
Age and Sex Are Critical Factors in Ischemic Stroke Pathology
Roy-O’Reilly, M. A., & McCullough, L. D. (2018) · Endocrinology · doi:10.1210/en.2018-00465 · Cited by 498
Mechanisms of sex differences in Alzheimer’s disease
Lopez-Lee, C., Torres, E. R. S., Carling, G., & Gan, L. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.024 · Cited by 376
Mitochondria: A central target for sex differences in pathologies
Ventura-Clapier, R., Moulin, M., Piquereau, J., Lemaire, C., Mericskay, M., Veksler, V., & Garnier, A. (2017) · Clinical Science · doi:10.1042/cs20160485 · Cited by 371

See all 193

Authors: Demarest, T. G., & McCarthy, M. M.
Affiliations: University of Maryland, Baltimore (US)
Corresponding author: Demarest, Tyler G.
ORCID: McCarthy, Margaret M.
Venue: Journal of Bioenergetics and Biomembranes
Publisher: Springer Science and Business Media LLC
Published: 2014-10-08
Volume: 47
Issue: 1-2
Pages: 173-188
ISSN: 0145-479X (ISSN-L)
1573-6881
DOI: 10.1007/s10863-014-9583-7
PMC: PMC4988325
OpenAlex: W1980632245
Cited by: 192
References: 169
Citations by year: 2026: 14 · 2025: 23 · 2024: 24 · 2023: 23 · 2022: 17 · 2021: 28 · 2020: 18 · 2019: 16 · 2018: 13 · 2017: 11 · 2016: 4 · 2015: 1
FWCI: 0.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Bioenergetics and Biomembranes (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD016596)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Keywords: sex differences, mitochondrial dysfunction, neuroprotection, central nervous system injury, brain energy metabolism, cell death signaling, gonadal hormones, sex hormones, neuroprotective therapy
MeSH terms: Adult, Central Nervous System, Central Nervous System Diseases, Energy Metabolism, Female, Humans, Male, Mitochondria, Sex Characteristics, Mitochondrial Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sex differences in mitochondrial (dys)function: Implications for neuroprotection

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks