Cited by 193Mitochondrial Function and PathologyNeuroprotection in Cerebral IschemiaSex and Gender in Healthcare

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Sex differences in mitochondrial (dys)function: Implications for neuroprotection

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Demarest, Tyler G., McCarthy, Margaret M.·2015·Journal of Bioenergetics and Biomembranes

DOI 10.1007/s10863-014-9583-7PMC PMC4988325

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Abstract

Decades of research have revealed numerous differences in brain structure size, connectivity and metabolism between males and females. Sex differences in neurobehavioral and cognitive function after various forms of central nervous system (CNS) injury are observed in clinical practice and animal research studies. Sources of sex differences include early life exposure to gonadal hormones, chromosome compliment and adult hormonal modulation. It is becoming increasingly apparent that mitochondrial metabolism and cell death signaling are also sexually dimorphic. Mitochondrial metabolic dysfunction is a common feature of CNS injury. Evidence suggests males predominantly utilize proteins while females predominantly use lipids as a fuel source within mitochondria and that these differences may significantly affect cellular survival following injury. These fundamental biochemical differences have a profound impact on energy production and many cellular processes in health and disease. This review will focus on the accumulated evidence revealing sex differences in mitochondrial function and cellular signaling pathways in the context of CNS injury mechanisms and the potential implications for neuroprotective therapy development.

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Research works printed but not linked: 1

Demarest TG, Waddell J, Schuh RA, McKenna MC, Fiskum G (2013) Sexually dimorphic impairment of brain mitochondrial respiration following neonatal hypoxic-ischemia [abstract]. J Neurotrauma 30:A4

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Authors: Demarest, T. G., & McCarthy, M. M.
Affiliations: University of Maryland, Baltimore (US)
Corresponding author: Demarest, Tyler G.
ORCID: McCarthy, Margaret M.
Venue: Journal of Bioenergetics and Biomembranes
Publisher: Springer Science and Business Media LLC
Published: 2014-10-08
Volume: 47
Issue: 1-2
Pages: 173-188
ISSN: 0145-479X (ISSN-L)
1573-6881
DOI: 10.1007/s10863-014-9583-7
PMC: PMC4988325
OpenAlex: W1980632245
Cited by: 192
References: 169
Citations by year: 2026: 14 · 2025: 23 · 2024: 24 · 2023: 23 · 2022: 17 · 2021: 28 · 2020: 18 · 2019: 16 · 2018: 13 · 2017: 11 · 2016: 4 · 2015: 1
FWCI: 0.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Bioenergetics and Biomembranes (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD016596)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Keywords: sex differences, mitochondrial dysfunction, neuroprotection, central nervous system injury, brain energy metabolism, cell death signaling, gonadal hormones, sex hormones, neuroprotective therapy
MeSH terms: Adult, Central Nervous System, Central Nervous System Diseases, Energy Metabolism, Female, Humans, Male, Mitochondria, Sex Characteristics, Mitochondrial Diseases

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Sex differences in mitochondrial (dys)function: Implications for neuroprotection

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