The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Lipid composition of the cancer cell membrane
Open accessAbstract
Cancer cell possesses numerous adaptations to resist the immune system response and chemotherapy. One of the most significant properties of the neoplastic cells is the altered lipid metabolism, and consequently, the abnormal cell membrane composition. Like in the case of phosphatidylcholine, these changes result in the modulation of certain enzymes and accumulation of energetic material, which could be used for a higher proliferation rate. The changes are so prominent, that some lipids, such as phosphatidylserines, could even be considered as the cancer biomarkers. Additionally, some changes of biophysical properties of cell membranes lead to the higher resistance to chemotherapy, and finally to the disturbances in signalling pathways. Namely, the increased levels of certain lipids, like for instance phosphatidylserine, lead to the attenuation of the immune system response. Also, changes in lipid saturation prevent the cells from demanding conditions of the microenvironment. Particularly interesting is the significance of cell membrane cholesterol content in the modulation of metastasis. This review paper discusses the roles of each lipid type in cancer physiology. The review combined theoretical data with clinical studies to show novel therapeutic options concerning the modulation of cell membranes in oncology.
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Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol
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Cited by
Mitochondria‐associated endoplasmic reticulum membrane: Overview and inextricable link with cancer
Yang, X., Zhuang, J., Song, W., Shen, W., Wu, W., Shen, H., & Han, S. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17696 · Cited by 55
Wang, Y., Tu, M.-J., & Yu, A.-M. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1423416 · Cited by 21
Lupo, M. G., Marchianò, S., Adorni, M. P., Zimetti, F., Ruscica, M., Greco, M. F., Corsini, A., & Ferri, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084114 · Cited by 15
Metadata
- Authors
- Szlasa, W., Zendran, I., Zalesińska, A., Tarek, M., & Kulbacka, J.
- Venue
- Journal of Bioenergetics and Biomembranes
- Published
- 2020-07-26
- Volume
- 52
- Issue
- 5
- Pages
- 321-342
- ISSN
- 0145-479X (ISSN-L)
- 1573-6881
- OpenAlex
- W3044337970
- Cited by
- 435
- References
- 10
- FWCI
- 13.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
