New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications

Nitric oxide: physiology, pathophysiology, and pharmacology.

Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works

NITRIC OXIDE AND MACROPHAGE FUNCTION

MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,184 · see citing works

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

Arnold, W. P., Mittal, C. K., Katsuki, S., & Murad, F. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3203 · Cited by 1,459 · see citing works

Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

Garthwaite, J., Southam, E., Boulton, C. L., Nielsen, E. B., Schmidt, K., & Mayer, B. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10233-2 · Cited by 1,101 · see citing works

Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors

Colquhoun, D. M. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702164 · Cited by 893 · see citing works

Cyclic GMP synthesis and function.

Waldman, S. A., & Murad, F. (1987) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06656-6 · Cited by 859 · see citing works

Concepts of neural nitric oxide-mediated transmission

Garthwaite, J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06285.x · Cited by 812 · see citing works

Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators

Mellion, B. T., Ignarro, L. J., Ohlstein, E. H., Pontecorvo, E., Hyman, A. L., & Kadowitz, P. (1981) · Blood · doi:10.1182/blood.v57.5.946.946 · Cited by 639 · see citing works

EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES

Ballard, S. A., Gingell, C., Tang, K., TURNER, L. A., Price, M. E., & NAYLOR, A. M. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)63299-3 · Cited by 590 · see citing works

NO-independent regulatory site on soluble guanylate cyclase

Stasch, J., Becker, E. M., Alonso‐Alija, C., Apeler, H., Dembowsky, K., Feurer, A., Gerzer, R., Minuth, T., Perzborn, E., Pleiß, U., et al. (2001) · Nature · doi:10.1038/35065611 · Cited by 546 · see citing works

Models of the diffusional spread of nitric oxide: Implications for neural nitric oxide signalling and its pharmacological properties

Wood, J., & Garthwaite, J. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90022-1 · Cited by 529 · see citing works

Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels

Stasch, J., Schmidt, P. M., Nedvetsky, P. I., Nedvetskaya, T. Y., Kumar, A. H. S., Meurer, S., Deile, M., Taye, A., Knorr, A., Lapp, H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28371 · Cited by 456 · see citing works

YC-1, a novel activator of platelet guanylate cyclase

Ko, F., Wu, C., Sc, K., Lee, F., & Teng, C. (1994) · Blood · doi:10.1182/blood.v84.12.4226.bloodjournal84124226 · Cited by 402 · see citing works

Compartmentation of Cyclic Nucleotide Signaling in the Heart

Fischmeister, R., Castro, L. R., Abi‐Gerges, A., Rochais, F., Jurevičius, J., Leroy, J., & Vandecasteele, G. (2006) · Circulation Research · doi:10.1161/01.res.0000246118.98832.04 · Cited by 368 · see citing works

Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.

Schrammel, A., Behrends, S., Schmidt, K., Koesling, D., & Mayer, B. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09113-8 · Cited by 360 · see citing works

Sensitizing soluble guanylyl cyclase to become a highly CO‐sensitive enzyme.

Friebe, A., Schultz, G., & Koesling, D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01078.x · Cited by 352 · see citing works

Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation.

Craven, P. A., & DeRubertis, F. R. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34310-7 · Cited by 328 · see citing works

A molecular basis for nitric oxide sensing by soluble guanylate cyclase

Zhao, Y., Brandish, P. E., Ballou, D. P., & Marletta, M. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14753 · Cited by 323 · see citing works

Nitric Oxide as a Neurotransmitter in Peripheral Nerves: Nature of Transmitter and Mechanism of Transmission

Rand, M. J., & Li, C. G. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003303 · Cited by 321 · see citing works

NO‐ and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle

Stasch, J., Schmidt, P. M., Alonso‐Alija, C., Apeler, H., Dembowsky, K., Haerter, M., Heil, M., Minuth, T., Perzborn, E., Pleiß, U., et al. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704778 · Cited by 313 · see citing works

Nitric Oxide: A Unique Endogenous Signaling Molecule in Vascular Biology

Ignarro, L. J. (1999) · Bioscience Reports · doi:10.1023/a:1020150124721 · Cited by 305 · see citing works

A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell

Rich, T. C., Fagan, K. A., Tse, T. E., Schaack, J. B., Cooper, D. M. F., & Karpen, J. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381398 · Cited by 276 · see citing works

Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase.

Wedel, B. J., Humbert, P., Harteneck, C., Foerster, J., Malkewitz, J., Böhme, E., Schultz, G., & Koesling, D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.7.2592 · Cited by 254 · see citing works

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

Rybalkin, S. D., Rybalkina, I. G., Shimizu‐Albergine, M., Tang, X., & Beavo, J. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg051 · Cited by 234 · see citing works

NO and CO differentially activate soluble guanylyl cyclase via a heme pivot‐bend mechanism

Ma, X., Sayed, N., Beuve, A. V., & van den Akker, F. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601521 · Cited by 232 · see citing works

NO activation of guanylyl cyclase

Russwurm, M., & Koesling, D. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600422 · Cited by 222 · see citing works

Exchange of Substrate and Inhibitor Specificities between Adenylyl and Guanylyl Cyclases

Sunahara, R. K., Beuve, A. V., Tesmer, J. J. G., Sprang, S. R., Garbers, D. L., & Gilman, A. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16332 · Cited by 220 · see citing works

Functional properties of a naturally occurring isoform of soluble guanylyl cyclase

Russwurm, M., Behrends, S., Harteneck, C., & Koesling, D. (1998) · Biochemical Journal · doi:10.1042/bj3350125 · Cited by 210 · see citing works

Activation of purified soluble guanylate cyclase by protoporphyrin IX.

Ignarro, L. J., Wood, K. S., & Wolin, M. S. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.9.2870 · Cited by 209 · see citing works

Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues.

Breitwieser, G. E., & Szabo, G. T. (1988) · The Journal of General Physiology · doi:10.1085/jgp.91.4.469 · Cited by 204 · see citing works

Mechanism of YC-1-Induced Activation of Soluble Guanylyl Cyclase

Friebe, A., & Koesling, D. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.1.123 · Cited by 204 · see citing works

Guanylyl Cyclase/PSD-95 Interaction

Russwurm, M., Wittau, N., & Koesling, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105587200 · Cited by 198 · see citing works

Fluorescent sensors for rapid monitoring of intracellular cGMP

Nikolaev, V. O., Gambaryan, S. P., & Lohse, M. J. (2005) · Nature Methods · doi:10.1038/nmeth816 · Cited by 180 · see citing works

A Monte Carlo Model Reveals Independent Signaling at Central Glutamatergic Synapses

Franks, K. M., Bartol, T. M., & B, T. J. S. A. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75248-x · Cited by 175 · see citing works

Effects of the soluble guanylyl cyclase activator, YC‐1, on vascular tone, cyclic GMP levels and phosphodiesterase activity

Galle, J., Zabel, U., Hübner, U., Hatzelmann, A., Wagner, B., Wanner, C., & Schmidt, H. H. H. W. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702495 · Cited by 173 · see citing works

Unprecedented proximal binding of nitric oxide to heme: implications for guanylate cyclase

Lawson, D. M., Stevenson, C. E. M., Andrew, C. R., & Eady, R. R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5661 · Cited by 168 · see citing works

YC-1 Potentiates Nitric Oxide- and Carbon Monoxide-Induced Cyclic GMP Effects in Human Platelets

Friebe, A., Müllershausen, F., Smolenski, A., Walter, U., Schultz, G., & Koesling, D. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.6.962 · Cited by 167 · see citing works

Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors

Nausch, L., Ledoux, J., Bonev, A. D., Nelson, M. T., & Dostmann, W. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710387105 · Cited by 164 · see citing works

Identification of Residues Crucially Involved in the Binding of the Heme Moiety of Soluble Guanylate Cyclase

Schmidt, P. M., Schramm, M., Schröder, H., Wunder, F., & Stasch, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310141200 · Cited by 163 · see citing works

Identification of Histidine 105 in the β1 Subunit of Soluble Guanylate Cyclase as the Heme Proximal Ligand

Zhao, Y., Schelvis, J. P. M., Babcock, Ǵ., & Marletta, M. A. (1998) · Biochemistry · doi:10.1021/bi972686m · Cited by 161 · see citing works

Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses

Bellamy, T. C., Wood, J. G., Goodwin, D. A., & Garthwaite, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2928 · Cited by 158 · see citing works

Direct activation of PDE5 by cGMP

Müllershausen, F., Friebe, A., Feil, R., Thompson, W. J., Hofmann, F. B., & Koesling, D. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211041 · Cited by 156 · see citing works

Design of fluorescence resonance energy transfer (FRET)-based cGMP indicators: a systematic approach

Russwurm, M., Müllershausen, F., Friebe, A., Jäger, R., Russwurm, C., & Koesling, D. (2007) · Biochemical Journal · doi:10.1042/bj20070348 · Cited by 152 · see citing works

Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide

Zabel, U., Kleinschnitz, C., Oh, P., Nedvetsky, P. I., Smolenski, A., Müller, H., Kronich, P., Kügler, P., Walter, U., Schnitzer, J. E., et al. (2002) · Nature Cell Biology · doi:10.1038/ncb775 · Cited by 151 · see citing works

Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP

Cary, S. P., Winger, J. A., & Marletta, M. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506289102 · Cited by 145 · see citing works

The Catalytic Mechanism of Mammalian Adenylyl Cyclase

DESSAUER, C. W., & Gilman, A. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27787 · Cited by 138 · see citing works

Rapid nitric oxide–induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme

Müllershausen, F., Russwurm, M., Thompson, W. J., Liu, L., Koesling, D., & Friebe, A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200107001 · Cited by 125 · see citing works

Transphosphorylation and G protein activation

Otero, A. S. (1990) · Biochemical Pharmacology · doi:10.1016/0006-2952(90)90420-p · Cited by 125 · see citing works

Differential Sensitivity of Guanylyl Cyclase and Mitochondrial Respiration to Nitric Oxide Measured Using Clamped Concentrations

Bellamy, T. C., Griffiths, C., & Garthwaite, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205936200 · Cited by 124 · see citing works

Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase

Venema, R. C., Venema, V. J., Ju, H., Harris, M. B., Snead, C. M., Jilling, T., Dimitropoulou, C., Maragoudakis, M. E., & Catravas, J. D. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01025.2002 · Cited by 120 · see citing works

Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase

Olesen, S., Drejer, J., Axelsson, O., Moldt, P., Bang, L., Nielsen‐Kudsk, J. E., Busse, R., & Mülsch, A. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701603 · Cited by 116 · see citing works

Sub-second Kinetics of the Nitric Oxide Receptor, Soluble Guanylyl Cyclase, in Intact Cerebellar Cells

Bellamy, T. C., & Garthwaite, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006677200 · Cited by 111 · see citing works

The interactions of adenylate cyclases with P-site inhibitors

DESSAUER, C. W., Tesmer, J. J. G., Sprang, S. R., & Gilman, A. G. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01310-3 · Cited by 105 · see citing works

Dissociation of Nitric Oxide from Soluble Guanylate Cyclase

Kharitonov, V. G., Russwurm, M., Magde, D., Sharma, V. S., & Koesling, D. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7470 · Cited by 101 · see citing works

Biochemistry and Pharmacology of Novel Anthranilic Acid Derivatives Activating Heme-Oxidized Soluble Guanylyl Cyclase

Schindler, U., Strobel, H., Schönafinger, K., Linz, W., Löhn, M., Martorana, P. A., Rütten, H., Schindler, P. W., Busch, A. E., Sohn, M., et al. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.018747 · Cited by 100 · see citing works

ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells

Wyatt, T. A., Naftilan, A. J., Francis, S. H., & Corbin, J. D. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.2.h448 · Cited by 98 · see citing works

Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism

Ruiz‐Stewart, I., Tiyyagura, S. R., Lin, J. E., Kazerounian, S., Pitari, G. M., Schulz, S., Martin, E., Murad, F., & Waldman, S. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305080101 · Cited by 96 · see citing works

Phosphodiesterase 5 inhibitors and nitrergic transmission—from zaprinast to sildenafil

Gibson, A. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00824-4 · Cited by 95 · see citing works

Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase

Schmidt, P. M., Schramm, M., Schröder, H., & Stasch, J. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01674-1 · Cited by 90 · see citing works

Nitric oxide activation of guanylyl cyclase in cells revisited

Roy, B., & Garthwaite, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602544103 · Cited by 85 · see citing works

Effect of the selective phosphodiesterase type 5 inhibitor sildenafil on erectile dysfunction in the anesthetized dog.

Carter, A. J., Ballard, S. A., & NAYLOR, A. M. (1998) · PubMed · Cited by 84 · see citing works

EFFECT OF THE SELECTIVE PHOSPHODIESTERASE TYPE 5 INHIBITOR SILDENAFIL ON ERECTILE FUNCTION IN THE ANESTHETIZED DOG

Carter, A. J., Ballard, S. A., & NAYLOR, A. M. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)63097-0 · Cited by 80 · see citing works

[3H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP

Corbin, J. D., Blount, M. A., Weeks, J. L., Beasley, A., Kuhn, K. P., Ho, Y. S. J., Saidi, L. F., Hurley, J. H., Kotera, J., & Francis, S. H. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.6.1364 · Cited by 75 · see citing works

Inhibition of Deactivation of NO-sensitive Guanylyl Cyclase Accounts for the Sensitizing Effect of YC-1

Russwurm, M., Mergia, E., Müllershausen, F., & Koesling, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110570200 · Cited by 71 · see citing works

EPR Characterization of Axial Bond in Metal Center of Native and Cobalt-substituted Guanylate Cyclase

Makino, R., Matsuda, H., OBAYASHI, E., Shiro, Y., Iizuka, T., & Hori, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7714 · Cited by 70 · see citing works

Dynamics of cellular NO-cGMP signaling

. (2005) · Frontiers in bioscience · doi:10.2741/1666 · Cited by 69 · see citing works

Inhibition of Phosphodiesterase Type 5 by the Activator of Nitric Oxide–Sensitive Guanylyl Cyclase BAY 41-2272

Müllershausen, F., Russwurm, M., Friebe, A., & Koesling, D. (2004) · Circulation · doi:10.1161/01.cir.0000126286.47618.bd · Cited by 69 · see citing works

A New and Simple Method for Delivering Clamped Nitric Oxide Concentrations in the Physiological Range: Application to Activation of Guanylyl Cyclase-Coupled Nitric Oxide Receptors

Griffiths, C., Wykes, V., Bellamy, T. C., & Garthwaite, J. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.6.1349 · Cited by 68 · see citing works

Kinetics of a Cellular Nitric Oxide/cGMP/Phosphodiesterase-5 Pathway

Mo, E., Amin, H., Bianco, I. H., & Garthwaite, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400916200 · Cited by 66 · see citing works

Dual effects of intracellular magnesium on muscarinic potassium channel current in single guinea‐pig atrial cells.

Horie, M., & Irisawa, H. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017461 · Cited by 66 · see citing works

Probing the presence of the ligand‐binding haem in cellular nitric oxide receptors

Roy, B., Mo, E., Vernon, J., & Garthwaite, J. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707687 · Cited by 62 · see citing works

The effect of sildenafil on corpus cavernosal smooth muscle relaxation and cyclic GMP formation in the diabetic rabbit

Thompson, C. S., Mumtaz, F., Khan, M. A., Wallis, R. M., Mikhailidis, D. P., Morgan, Angelini, G. D., & Jeremy, J. Y. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01077-9 · Cited by 61 · see citing works

Relaxing effects induced by the soluble guanylyl cyclase stimulator BAY 41-2272 in human and rabbit corpus cavernosum

Baracat, J. S., Teixeira, C. E., Okuyama, C. E., Priviero, F. B. M., Faro, R., Antunes, E., & Nucci, G. D. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.012 · Cited by 59 · see citing works

The receptor-like properties of Nitric oxide-activated soluble guanylyl cyclase in intact cells

Bellamy, T. C., & Garthwaite, J. (2002) · Springer eBooks · doi:10.1007/978-1-4615-0927-1_15 · Cited by 57 · see citing works

Molecular Mechanisms Involved in the Synergistic Activation of Soluble Guanylyl Cyclase by YC-1 and Nitric Oxide in Endothelial Cells

Schmidt, K., Schrammel, A., Koesling, D., & Mayer, B. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.2.220 · Cited by 57 · see citing works

IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels. Indications of the regulation of GTP cyclohydrolase I activity by restriction of GTP availability in the cells.

Hatakeyama, K., Harada, T., & Kagamiyama, H. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36747-x · Cited by 56 · see citing works

Characterization of a Novel Type of Endogenous Activator of Soluble Guanylyl Cyclase

Balashova, N. V., Chang, F., Lamothe, M., Sun, Q., & Beuve, A. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411545200 · Cited by 56 · see citing works

BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro.

KALSI, J. S., Rees, R. W., Hobbs, A. J., Royle, M., Kell, P. D., Ralph, D. J., Moncada, S., & Cellek, S. (2003) · PubMed · doi:10.1097/01.ju.0000043880.58140.69 · Cited by 55 · see citing works

The receptor-like properties of nitric oxide-activated soluble guanylyl cyclase in intact cells

Bellamy, T. C., & Garthwaite, J. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1014204426331 · Cited by 55 · see citing works

An Enzyme-linked Receptor Mechanism for Nitric Oxide-activated Guanylyl Cyclase

Roy, B., Halvey, E. J., & Garthwaite, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801712200 · Cited by 53 · see citing works

Interaction between the 90-kDa Heat Shock Protein and Soluble Guanylyl Cyclase: Physiological Significance and Mapping of the Domains Mediating Binding

Papapetropoulos, A., Zhou, Z., Gerassimou, C., Yetik-Anacak, G., Venema, R. C., Roussos, C., Sessa, W. C., & Catravas, J. D. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.012682 · Cited by 53 · see citing works

Superoxide-dependent consumption of nitric oxide in biological media may confound in vitro experiments

Keynes, R. G., Griffiths, C., & Garthwaite, J. (2003) · Biochemical Journal · doi:10.1042/bj20020933 · Cited by 52 · see citing works

BAY41-2272, a Novel Nitric Oxide Independent Soluble Guanylate Cyclase Activator, Relaxes Human and Rabbit Corpus Cavernosum In Vitro

KALSI, J. S., Rees, R. W., Hobbs, A. J., Royle, M., Kell, P. D., Ralph, D. J., Moncada, S., & Cellek, S. (2003) · The Journal of Urology · doi:10.1016/s0022-5347(05)64009-8 · Cited by 52 · see citing works

Properties of NO‐activated guanylyl cyclases expressed in cells

Gibb, B. J. M., Wykes, V., & Garthwaite, J. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705318 · Cited by 51 · see citing works

YC-1 Facilitates Release of the Proximal His Residue in the NO and CO Complexes of Soluble Guanylate Cyclase

Makino, R., OBAYASHI, E., Homma, N., Shiro, Y., & Hori, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209026200 · Cited by 50 · see citing works

Allosteric Activation of cGMP-Specific, cGMP-Binding Phosphodiesterase (PDE5) by cGMP

Okada, D., & Asakawa, S. (2002) · Biochemistry · doi:10.1021/bi025727+ · Cited by 47 · see citing works

“cAMP-Specific” Phosphodiesterase Contributes to cGMP Degradation in Cerebellar Cells Exposed to Nitric Oxide

Bellamy, T. C., & Garthwaite, J. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.1.54 · Cited by 44 · see citing works

AGAP1, a Novel Binding Partner of Nitric Oxide-sensitive Guanylyl Cyclase

Meurer, S., Pioch, S., Wagner, K., Müller‐Esterl, W., & Groß, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410565200 · Cited by 40 · see citing works

Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells

Bellamy, T. C., & Garthwaite, J. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704687 · Cited by 40 · see citing works

In Vivo Reconstitution of the Negative Feedback in Nitric Oxide/cGMP Signaling: Role of Phosphodiesterase Type 5 Phosphorylation

Müllershausen, F., Russwurm, M., Koesling, D., & Friebe, A. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-12-0890 · Cited by 40 · see citing works

NADPH and heme redox modulate pulmonary artery relaxation and guanylate cyclase activation by NO

Gupte, S. A., Rupawalla, T., Phillibert, D., & Wolin, M. S. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.6.l1124 · Cited by 39 · see citing works

Heat shock protein 90 regulates stabilization rather than activation of soluble guanylate cyclase

Nedvetsky, P. I., Meurer, S., Opitz, N., Nedvetskaya, T. Y., Müller, H., & Schmidt, H. H. H. W. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.12.025 · Cited by 38 · see citing works

Purification and Characterization of NO‐Sensitive Guanylyl Cyclase

Russwurm, M., & Koesling, D. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)96041-2 · Cited by 33 · see citing works

Effects of the sGC Stimulator BAY 41-2272 Are Not Mediated by Phosphodiesterase 5 Inhibition

Bischoff, E., & Stasch, J. (2004) · Circulation · doi:10.1161/01.cir.0000142209.28862.12 · Cited by 32 · see citing works

Effect of GTP analogues on purified soluble guanylate cyclase.

Brandwein, H. J., Lewicki, J. A., Waldman, S. A., & Murad, F. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68192-5 · Cited by 29 · see citing works

Membrane‐association and the sensitivity of guanylyl cyclase‐coupled receptors to nitric oxide

Wykes, V., & Garthwaite, J. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705745 · Cited by 29 · see citing works

Mechanisms of Activity-dependent Plasticity in Cellular Nitric Oxide-cGMP Signaling

Halvey, E. J., Vernon, J. D. R., Roy, B., & Garthwaite, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.030338 · Cited by 26 · see citing works

A Flavoprotein Mechanism Appears to Prevent an Oxygen-Dependent Inhibition of cGMP-Associated Nitric Oxide–Elicited Relaxation of Bovine Coronary Arteries

Iesaki, T., Gupte, S. A., & Wolin, M. S. (1999) · Circulation Research · doi:10.1161/01.res.85.11.1027 · Cited by 16 · see citing works

Intracellular Mg2+ diffusion within isolated rat skeletal muscle fibers

Bernengo, J. C., Collet, C., & Jacquemond, V. (2001) · Biophysical Chemistry · doi:10.1016/s0301-4622(00)00215-5 · Cited by 8 · see citing works

What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology

Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works

The role of nitric oxide in pre-synaptic plasticity and homeostasis

Hardingham, N. R., Dachtler, J., & Fox, K. D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00190 · Cited by 260 · see citing works

Gaseous O 2 , NO, and CO in Signal Transduction: Structure and Function Relationships of Heme-Based Gas Sensors and Heme-Redox Sensors

Shimizu, T., Huang, D., Fang, Y., Stráňava, M., Bartošová, M., Fojtíková, V., & Martínková, M. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00018 · Cited by 195 · see citing works

Nitric Oxide: A Guardian for Vascular Grafts?

de Mel, A., Murad, F., & Seifalian, A. M. (2011) · Chemical Reviews · doi:10.1021/cr200008n · Cited by 187 · see citing works

Signaling and stress: The redox landscape in NOS2 biology

Thomas, D. D., Heinecke, J. L., Ridnour, L. A., Cheng, R. Y., Kesarwala, A. H., Switzer, C. H., McVicar, D. W., Roberts, D. D., Glynn, S., Fukuto, J. M., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.002 · Cited by 150 · see citing works

Nitric Oxide Releasing Materials Triggered by Near-Infrared Excitation Through Tissue Filters

Burks, P. T., Garcia, J. V., Gonzalezirias, R., Tillman, J. T., Niu, M., Mikhailovsky, A. A., Zhang, J., Zhang, F., & Ford, P. C. (2013) · Journal of the American Chemical Society · doi:10.1021/ja408516w · Cited by 138 · see citing works

Copper and homocysteine in cardiovascular diseases

Kang, Y. J. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.11.004 · Cited by 134 · see citing works

The gentle art of saying NO: how nitric oxide gets things done in the hypothalamus

Chachlaki, K., Garthwaite, J., & Prévot, V. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.69 · Cited by 118 · see citing works

From synaptically localized to volume transmission by nitric oxide

Garthwaite, J. (2015) · The Journal of Physiology · doi:10.1113/jp270297 · Cited by 119 · see citing works

Metal complex strategies for photo-uncaging the small molecule bioregulators nitric oxide and carbon monoxide

Ford, P. C. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.07.018 · Cited by 119 · see citing works

A comparison of the chemistry associated with the biological signaling and actions of nitroxyl (HNO) and nitric oxide (NO)

Fukuto, J. M., Cisneros, C. J., & Kinkade, R. L. (2012) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2012.08.027 · Cited by 118 · see citing works

Platelet Inhibition by Nitrite Is Dependent on Erythrocytes and Deoxygenation

Srihirun, S., Sriwantana, T., Unchern, S., Kittikool, D., Noulsri, E., Pattanapanyasat, K., Fucharoen, S., Piknova, B., Schechter, A. N., & Sibmooh, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030380 · Cited by 109 · see citing works

Nitric oxide signalling in the brain and its control of bodily functions

Chachlaki, K., & Prévot, V. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14800 · Cited by 108 · see citing works

The solution chemistry of nitric oxide and other reactive nitrogen species

Ford, P. C., & Miranda, K. M. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.07.004 · Cited by 100 · see citing works

Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide

Zhou, Z., Martin, E., Sharina, I. G., Esposito, I., Szabó, C., Bucci, M., Cirino, G., & Papapetropoulos, A. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.06.029 · Cited by 88 · see citing works

Role of Modified Atmosphere in Pest Control and Mechanism of Its Effect on Insects

Cao, Y., Xu, K., Zhu, X.-Y., Bai, Y., Yang, W., & Li, C. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00206 · Cited by 76 · see citing works

Nitric Oxide as Key Mediator of Neuron-to-Neuron and Endothelia-to-Glia Communication Involved in the Neuroendocrine Control of Reproduction

Bellefontaine, N., Hanchate, N. K., Parkash, J., Campagne, C., Seranno, S. D., Clasadonte, J., de Tassigny, X. D., & Prévot, V. (2011) · Neuroendocrinology · doi:10.1159/000324147 · Cited by 75 · see citing works

Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme

Ghosh, A., & Stuehr, D. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205854109 · Cited by 74 · see citing works

Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91phox to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock

Tunçtan, B., Korkmaz, B., Sari, A. N., Kacan, M., Unsal, D., Serin, M. S., Buharalioglu, C. K., Şahan-Fırat, S., Cuez, T., Schunck, W.-H., et al. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.05.001 · Cited by 63 · see citing works

From curiosity to applications. A personal perspective on inorganic photochemistry

Ford, P. C. (2016) · Chemical Science · doi:10.1039/c6sc00188b · Cited by 63 · see citing works

Thiol-Based Redox Modulation of Soluble Guanylyl Cyclase, the Nitric Oxide Receptor

Beuve, A. V. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6591 · Cited by 61 · see citing works

CO metabolism, sensing, and signaling

Gullotta, F., di Masi, A., Coletta, M., & Ascenzi, P. (2011) · BioFactors · doi:10.1002/biof.192 · Cited by 60 · see citing works

Long non-coding RNAs: new players in ocular neovascularization

Xu, X., Li, K., Li, X., Yao, J., Qin, J., & Yan, B. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3320-5 · Cited by 59 · see citing works

Protein modifications involved in neurotransmitter and gasotransmitter signaling

Sen, N., & Snyder, S. H. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.07.004 · Cited by 53 · see citing works

Nitric Oxide Signaling

Underbakke, E. S., Sürmeli, N. B., Smith, B. C., Wynia‐Smith, S. L., & Marletta, M. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-08-097774-4.00320-x · Cited by 51 · see citing works

Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase

Stuehr, D. J., Misra, S., Dai, Y., & Ghosh, A. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100336 · Cited by 50 · see citing works

Differentiation of cGMP-dependent and -independent nitric oxide effects on platelet apoptosis and reactive oxygen species production using platelets lacking soluble guanylyl cyclase

Rukoyatkina, N., Walter, U., Friebe, A., & Gambaryan, S. P. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-05-0319 · Cited by 48 · see citing works

Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer

Baruteau, J., Perocheau, D. P. B., Hanley, J., Lorvellec, M., Rocha‐Ferreira, E., Karda, R., Ng, J., Suff, N., Diaz, J. F. A., Rahim, A. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05972-1 · Cited by 45 · see citing works

Neuronal nitric oxide synthase (nNOS) splice variant function: Insights into nitric oxide signaling from skeletal muscle

Balke, J. E., Zhang, L., & Percival, J. M. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.11.004 · Cited by 44 · see citing works

Nitric Oxide Synthesis and cGMP Production Is Important for Neurite Growth and Synapse Remodeling after Axotomy

Cooke, R. M., Mistry, R., Challiss, R. A. J., & Straub, V. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3659-12.2013 · Cited by 42 · see citing works

NO rapidly mobilizes cellular heme to trigger assembly of its own receptor

Dai, Y., Faul, E., Ghosh, A., & Stuehr, D. J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2115774119 · Cited by 43 · see citing works

Nitric Oxide Signaling in the Microcirculation

Buerk, D. G., Barbee, K. A., & Jaron, D. (2011) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.v39.i5.40 · Cited by 39 · see citing works

Photochemistry of trans-Cr(cyclam)(ONO)2+, a Nitric Oxide Precursor

Ostrowski, A. D., Absalonson, R. O., Leo, M. A. D., Wu, G. X., Pavlovich, J. G., Adamson, J., Azhar, B., Iretskii, A. V., Megson, I. L., & Ford, P. C. (2011) · Inorganic Chemistry · doi:10.1021/ic200094x · Cited by 37 · see citing works

Hippocampus and Nitric Oxide

Hu, Y. F., & Zhu, D. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800254-4.00006-4 · Cited by 36 · see citing works

Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats

Tjong, Y.-W., Ip, S., Lao, L., Wu, J. C. Y., Fong, H. H. S., Sung, J. J. �., Berman, B., & Che, C. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01697.x · Cited by 34 · see citing works

The KiNG of reproduction: Kisspeptin/ nNOS interactions shaping hypothalamic GnRH release

Delli, V., Silva, M. S. B., Prévot, V., & Chachlaki, K. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111302 · Cited by 34 · see citing works

Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Garcia, J. V., Zhang, F., & Ford, P. C. (2013) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2012.0129 · Cited by 31 · see citing works

Interactions betweenN-Ethylmaleimide-Sensitive Factor and GluR2 in the Nucleus Accumbens Contribute to the Expression of Locomotor Sensitization to Cocaine

Lu, H., Wu, P., Yang, Y., Xiao, W., Fan, J., Liu, J., Li, Y., Luo, Y., Hu, Z., Jin, Y., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2594-13.2014 · Cited by 31 · see citing works

Hypoxic Vasospasm Mediated by cIMP

Gao, Y., Chen, Z., Leung, S. W. S., & Vanhoutte, P. M. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000167 · Cited by 31 · see citing works

Signaling via IRAG is essential for NO/cGMP-dependent inhibition of platelet activation

Schinner, E., Salb, K., & Schlossmann, J. (2011) · Platelets · doi:10.3109/09537104.2010.544151 · Cited by 30 · see citing works

Inhibition of neuronal nitric oxide synthase prevents alterations in medial prefrontal cortex excitability induced by repeated cocaine administration

Nasif, F. J., Hu, X., Ramírez, O. A., & Pérez, M. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2105-3 · Cited by 30 · see citing works

Motion of proximal histidine and structural allosteric transition in soluble guanylate cyclase

Yoo, B., Lamarre, I., Martin, J. L., Rappaport, F., & Négrerie, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423098112 · Cited by 25 · see citing works

Nitric oxide release from a photoactive water-soluble ruthenium nitrosyl. Biological effects

Crisalli, M., Franco, L. P., Silva, B. R., Holanda, A. K. M., Bendhack, L. M., da Silva, R. S., & Ford, P. C. (2018) · Journal of Coordination Chemistry · doi:10.1080/00958972.2018.1469129 · Cited by 25 · see citing works

Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways

Cheng, R. Y. S., Basudhar, D., Ridnour, L. A., Heinecke, J. L., Kesarwala, A. H., Glynn, S. A., Switzer, C., Ambs, S., Miranda, K. M., & Wink, D. A. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.08.003 · Cited by 24 · see citing works

Activation of MEK1/ERK1/2/iNOS/sGC/PKG pathway associated with peroxynitrite formation contributes to hypotension and vascular hyporeactivity in endotoxemic rats

Korkmaz, B., Buharalioglu, C. K., Şahan-Fırat, S., Cuez, T., Demiryürek, A. T., & Tunçtan, B. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.02.004 · Cited by 24 · see citing works

Nitric Oxide-Induced Calcium Release: Activation of Type 1 Ryanodine Receptor, a Calcium Release Channel, through Non-Enzymatic Post-Translational Modification by Nitric Oxide

Kakizawa, S. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00142 · Cited by 24 · see citing works

Transmembrane guanylate cyclase in intestinal pathophysiology

Steinbrecher, K. A., & Cohen, M. B. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328341ead5 · Cited by 23 · see citing works

The anti‐aggregating effect of BAY 41‐2272, a stimulator of soluble guanylyl cyclase, requires the presence of nitric oxide

Roger, S., Badier‐Commander, C., Paysant, J., Cordi, A. A., Verbeuren, T. J., & Félétou, M. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00943.x · Cited by 22 · see citing works

Behavioral responses to hypoxia and hyperoxia in Drosophila larvae

Morton, D. B. (2011) · Fly · doi:10.4161/fly.5.2.14284 · Cited by 21 · see citing works

Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever

Remy, M. M., Sahin, M., Flatz, L., Regen, T., Xu, L., Kreutzfeldt, M., Fallet, B., Doras, C., Rieger, T., Bestmann, L., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.008 · Cited by 20 · see citing works

The Role of Reactive Oxygen and Nitrogen Species in the Expression and Splicing of Nitric Oxide Receptor

Sharina, I. G., & Martin, E. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6687 · Cited by 19 · see citing works

Regulation of sGC <i>via</i> hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives

Ghosh, A., & Stuehr, D. J. (2017) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2016.6690 · Cited by 19 · see citing works

Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability?

Gabach, L. A., Carlini, V. P., Monti, M. C., Maglio, L. E., de Barioglio, S. R., & Pérez, M. F. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3084-y · Cited by 19 · see citing works

Nitric oxide as a multimodal brain transmitter

Garthwaite, J. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818810683 · Cited by 18 · see citing works

Identification of Residues in the Heme Domain of Soluble Guanylyl Cyclase that are Important for Basal and Stimulated Catalytic Activity

Baskaran, P., Heckler, E. J., van den Akker, F., & Beuve, A. V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026976 · Cited by 16 · see citing works

Modern Strategies of Drug Therapy: Multi-Target Drug Delivery, Bioimaging, Diagnostics

Fedorova, O. V., Ovchinnikova, I. G., Rusinov, G. L., Avdeeva, V. V., Zhdanov, А. P., Zhizhin, K. Y., Kuznetsov, N. T., Zakharova, L. Y., Kuznetsova, D. A., Razuvayeva, Y. S., et al. (2025) · Russian Journal of General Chemistry · doi:10.1134/s1070363225606726 · Cited by 15 · see citing works

Sulfhydryl-dependent dimerization of soluble guanylyl cyclase modulates the relaxation of porcine pulmonary arteries to nitric oxide

Ye, L., Liu, J., Liu, H., Lei, Y., Dou, D., Chen, Z., Xu, X., Raj, J. U., & Gao, Y. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1176-x · Cited by 15 · see citing works

The effects of extremely low-frequency pulsed electromagnetic fields on analgesia in the nitric oxide pathway

Demirkazık, A., Özdemir, E., Arslan, G., Taşkıran, A. Ş., & Pelit, A. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.08.003 · Cited by 14 · see citing works

Effect of nitrergic system on colonic motility in a rat model of irritable bowel syndrome

Temiz, T. K., Demir, O., Şimşek, F., Kaplan, Y. C., Bahçeci, S., Karadas, B., Çelik, A., & Köylüoğlu, G. (2016) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.186189 · Cited by 13 · see citing works

Systems Biology of HBOC-Induced Vasoconstriction

Hai, C.-M. (2012) · Current Drug Discovery Technologies · doi:10.2174/157016312802650751 · Cited by 12 · see citing works

Information processing deficits and nitric oxide signalling in the phencyclidine model of schizophrenia

Pålsson, E., Lowry, J., & Klamer, D. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1992-7 · Cited by 11 · see citing works

Angiotensin (5–8) modulates nociception at the rat periaqueductal gray via the NO–sGC pathway and an endogenous opioid

Guethe, L. M., Pelegrini-da-Silva, A., Borelli, K. G., Juliano, M. A., Pelosi, G. G., Pesquero, J. B., Silva, C. L. M., Corrêa, F. M. D. A., Murad, F., Prado, W. A., et al. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.048 · Cited by 10 · see citing works

Pharmacological NOS-1 Inhibition Within the Hippocampus Prevented Expression of Cocaine Sensitization: Correlation with Reduced Synaptic Transmission

de la Villarmois, E. A., Gabach, L. A., Bianconi, S., Poretti, M. B., Occhieppo, V. B., Schiöth, H. B., Carlini, V. P., & Pérez, M. F. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01725-3 · Cited by 10 · see citing works

Role of xanthine oxidoreductase in the anti-thrombotic effects of nitrite in ratsin vivo

Kramkowski, K., Leszczynska, A., Przyborowski, K., Kaminski, T. W., Rykaczewska, U., Sitek, B., Zakrzewska, A., Proniewski, B., Smolenski, R. T., Chabielska, E., et al. (2015) · Platelets · doi:10.3109/09537104.2015.1083545 · Cited by 10 · see citing works

A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclase

Newton, M. J., Niewczas, I. S., Clark, J., & Bellamy, T. C. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.03.041 · Cited by 9 · see citing works

Rapid and Slow Nitric Oxide Responses During Conducted Vasodilation in the In Vivo Intestine and Brain Cortex Microvasculatures

Bohlen, H. G. (2011) · Microcirculation · doi:10.1111/j.1549-8719.2011.00127.x · Cited by 9 · see citing works

BK Channels – Focus on Polyamines, Ethanol/Acetaldehyde and Hydrogen Sulfide (H2S)

Hermann, A., Guzel, F., & Thomas, M. (2012) · InTech eBooks · doi:10.5772/35179 · Cited by 7 · see citing works

Role of Angiotensin Modulation in Primary Headaches

Tronvik, E., & Stovner, L. J. (2014) · Current Pain and Headache Reports · doi:10.1007/s11916-014-0417-4 · Cited by 7 · see citing works

Modulated by Gasotransmitters: BK Channels

Hermann, A., Ситдикова, Г. Ф., & Weiger, T. M. (2012) · Springer eBooks · doi:10.1007/978-3-642-30338-8_6 · Cited by 7 · see citing works

Inhibition of endocytosis suppresses the nitric oxide-dependent release of Cl- in retinal amacrine cells

Dunn, V. K., & Gleason, E. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201184 · Cited by 6 · see citing works

Coupling nitric oxide photo-uncaging with radiotherapy

Ford, P. C., Frigino, I., Tinsley, J. R., & DiBenedetto, J. A. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216630 · Cited by 6 · see citing works

Interplay of KNDy and nNOS neurons: A new possible mechanism of GnRH secretion in the adult brain

Prashar, V., Arora, T., Singh, R., Sharma, A., & Parkash, J. (2021) · Reproductive Biology · doi:10.1016/j.repbio.2021.100558 · Cited by 6 · see citing works

Nitric Oxide Signaling in Health and Disease

Bryan, N. S., & Lancaster, J. R. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_11 · Cited by 7 · see citing works

Nitric Oxide Signaling in Health and Disease

Bryan, N. S., & Lancaster, J. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_13 · Cited by 5 · see citing works

Effects of Danggwisayeok-tang (Dangguisinitang) on MIA-Induced Osteoarthritis Rats

Yang, D.-H., Woo, C., Kim, J., & An, H.-D. (2015) · Journal of Korean Medicine Rehabilitation · doi:10.18325/jkmr.2015.25.2.037 · Cited by 4 · see citing works

The Need for Further Studies Examining the Role of Endothelial Nitric Oxide Synthase Polymorphisms in Drug Response

Pereira, S. C., Filho, C. K. C., & Lacchini, R. (2021) · Pharmacogenomics · doi:10.2217/pgs-2021-0038 · Cited by 2 · see citing works

Photoactivated metal complexes for drug delivery

Ford, P. C., Garcia, J. V., Guzmán, C., Kulkarni, S., & Wein, E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823144-9.00101-1 · Cited by 2 · see citing works

Nitric Oxide Donors in Nerve Regeneration

Damodaran, V. B., Bhatnagar, D., Rubin, H. N., & Reynolds, M. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809275-0.00006-5 · Cited by 2 · see citing works

Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?

Cottrell, E. C. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16276 · Cited by 1 · see citing works

Inhibitory Effect of Galangin from Alpinia officinarum on Lipopolysaccharide-induced Nitric Oxide Synthesis in RAW 264.7 macrophages

Lee, H. J. (2014) · Korean Journal of Food Science and Technology · doi:10.9721/kjfst.2014.46.4.511 · Cited by 1 · see citing works

Haem-based Sensors of Nitric Oxide

Williams, D. E., Fischer, J. T., Heckler, I., & Boon, E. M. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781788012836-00015 · Cited by 1 · see citing works

The role of the L-arginine-NO-cGMP-dependent pathway in the development of sensitization to mephedrone effects on the locomotor activity in mice

Bielecka‐Papierz, G., Serefko, A., Szopa, A., Talarek, S., Wróbel, A., Szewczyk, B., Radziwoń-Zaleska, M., Kołtun-Jasion, M., & Poleszak, E. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114103 · Cited by 1 · see citing works

Intracellular Messenger Substances: “Second Messengers”

Krauss, G. (2014) · doi:10.1002/9783527667475.ch08 · Cited by 1 · see citing works

Pharmacology of Nitrovasodilators

Page, N. A., & Fung, H. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_13

Study on Pharmacological Activation as Cosmetic Material of Gentianae scabrae bunge Extract

Choi, H. W., In, M.-H., Mun, Y. J., lim, K. S., & Woo, W.-H. (2015) · 동의생리병리학회지 · doi:10.15188/kjopp.2015.06.29.3.223

New Insights in Glutamate-Mediated Mechanisms Underlying Benzodiazepines Dependence and Cocaine Vulnerability

de la Villarmois, E. A., Gabach, L. A., & Pérez, M. F. (2015) · Springer eBooks · doi:10.1007/978-3-319-17103-6_13

Mitochondrial Antioxidants in Neuroprotection

Fiskum, G., & Laird, M. D. (2012) · Oxidative stress and disease · doi:10.1201/b12308-26

An Experimental Study on the Anti-inflammatory Effects of Cheonggisan Extract in Allergic Late Inflammation

Jo, S.-Y., Kang, M.-S., Kim, Y. M., & Kim, H.-T. (2016) · The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology · doi:10.6114/jkood.2016.29.3.095

Variability of nitric oxide signalling in atrial fibrillation: potential modulation.

Procter, N. E. K. (2015) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)

Biofunctionalization of biomaterials for nitric oxide delivery: potential applications in regenerative medicine

Tsai, K. J., Rammou, A., Gao, C., & de Mel, A. (2018) · Advanced Health Care Technologies · doi:10.2147/ahct.s144816

The influence of nitric oxide and nitrite on coronary vascular resistance, platelet function and inflammation in patients undergoing revascularisation after NSTEMI and stable angina

Freeman, P. M. (2018) · ORCA Online Research @Cardiff (Cardiff University)

Guanylate Cyclase

Koch, K. (2012) · Springer eBooks · doi:10.1007/978-1-4419-0461-4_243

Guanylate Cyclase

Koch, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_243

Guanylate Cyclase

Koch, K. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_243-1

Nitric Oxide

Kakizawa, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-24551-5_32

Endocytosis and the Nitric Oxide-Dependent Release of Chloride

Dunn Jr, V. K. (2018) · doi:10.31390/gradschool_dissertations.4657

Nitric Oxide

Kakizawa, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-15070-8_33

Multilevel-Untersuchung des nitrinergen Systems bei affektiven Störungen und schizophrenen Psychosen

Kehrwald, C. (2024) · doi:10.21248/gups.85806

Nitric oxide-mediated neuroinflammatory pathways as treatment targets in neurodegeneration

Cale, J. A., Farr, T. D., Serres, S., & Steinert, J. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22354-9.00005-x

Aspects cliniques, biologiques et pronostiques de la fièvre de Lassa en contexte endémo-épidémique en Afrique de l’Ouest : exemple du Nigeria

Duvignaud, A. (2020) · doi:10.70675/ea8fc87dz94a1z4c62z80f5z4e0d7cd1cbd3

An Enzyme-linked Receptor Mechanism for Nitric Oxide-activated Guanylyl Cyclase

Roy, B., Halvey, E. J., & Garthwaite, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801712200 · Cited by 53 · see citing works

The receptor-like properties of nitric oxide-activated soluble guanylyl cyclase in intact cells

Bellamy, T. C., & Garthwaite, J. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1014204426331 · Cited by 55 · see citing works

Dynamics of cellular NO-cGMP signaling

. (2005) · Frontiers in bioscience · doi:10.2741/1666 · Cited by 69 · see citing works

Kinetics of a Cellular Nitric Oxide/cGMP/Phosphodiesterase-5 Pathway

Mo, E., Amin, H., Bianco, I. H., & Garthwaite, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400916200 · Cited by 66 · see citing works

On the activation of soluble guanylyl cyclase by nitric oxide

Bellamy, T. C., Wood, J., & Garthwaite, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012368499 · Cited by 141 · see citing works