The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling
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In the citing paper
“Thus, the modulation of gut microbiota and neurotransmitter levels are two key mechanisms of curcumin effects on IBS.”
From Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies (2025) · cites this paper as [78]
In the citing paper
“It has also been demonstrated that curcumin could modulate the levels of 5-hydroxytryptamine (5-HT), increasing those in the hippocampus and decreasing those in the colon of IBS rats [78].”
From Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies (2025) · cites this paper as [78]
In the citing paper
“The main reason may be that curcumin modulates 5-hydroxytryptamine (5-HT) levels, decreasing 5-HT in the colon of IBS rat models and increasing its levels in the hippocampus [47].”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [47]
In the citing paper
“curcumin shows mechanistic and preliminary clinical potential by modulating several IBS-related pathways”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [47]
In the citing paper
“A recent study using a rat model of IBS also found that curcumin was able to exert beneficial effects via the “brain-gut” axis [33]. Curcumin administration increased serotonin (5-HT), brain-derived neurotrophic factor (BDNF) and phosphorylation of cAMP response element-binding protein (pCREB) expression in the hippocampus and colon [33].”
From A Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome (IBS) (2018) · cites this paper as [33]
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Citations
Cites
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AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384
Xu, Y., Ku, B., Tie, L., Yao, H., Jiang, W., Ma, X., & Li, X. (2006) · Brain Research · doi:10.1016/j.brainres.2006.09.009 · Cited by 298
Self-citationWheatcroft, J., Wakelin, D., Smith, A., Mahoney, C. R., Mawe, G., & Spiller, R. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00719.x · Cited by 205 · cited 1×
“Recently, the distinct changes in intestinal 5HT content, 5-HT release and reuptake are found in IBS patients (Dunlop et al. 2005; Wheatcroft et al. 2005).”
BackgroundAntidepressants for irritable bowel syndrome: Figure 1
Clouse, R. E. (2003) · Gut · doi:10.1136/gut.52.4.598 · Cited by 74
Management of Irritable Bowel Syndrome
TORII, A., & TODA, G. (2004) · Internal Medicine · doi:10.2169/internalmedicine.43.353 · Cited by 49
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Cited by
A Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome (IBS)
Ng, Q., Soh, A., Loke, W., Venkatanarayanan, N., Lim, D., & Yeo, W.-S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100298 · Cited by 95
Giacosa, A., Riva, A., Petrangolini, G., Allegrini, P., Fazia, T., Bernardinelli, L., Peroni, G., & Rondanelli, M. (2022) · Nutrients · doi:10.3390/nu14030416 · Cited by 24
Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies
Abalo, R., Gallego-Barceló, P., & Gabbia, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199345 · Cited by 5
Pastras, P., Aggeletopoulou, I., Bali, M., & Triantos, C. (2026) · Nutrients · doi:10.3390/nu18020183 · Cited by 1
Metadata
- Authors
- Yu, Y., Wu, S., Li, J., Wang, R., Xie, X., Yu, X., Pan, J., Xu, Y., & Zheng, L.
- Venue
- Metabolic Brain Disease
- Published
- 2014-05-08
- Volume
- 30
- Issue
- 1
- Pages
- 47-55
- ISSN
- 0885-7490
- 1573-7365
- Cited by
- 69
- References
- 6
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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