Cited by 54Medicinal Plants and NeuroprotectionCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatments

Neuroprotective potential of Malva neglecta is mediated via down-regulation of cholinesterase and modulation of oxidative stress markers

Saleem, Uzma, Akhtar, Rubina, Anwar, Fareeha, Shah, Muhammad Ajmal, Chaudary, Zunera, Ayaz, Muhammad, Ahmad, Bashir·2021·Metabolic Brain Disease

Abstract

Alzheimer's disease affects daily routine due to loss of memory and decline in cognition. In vitro data showed acetylcholine esterase inhibition activity of Malva neglecta but no in vivo evidence is available. The current study aims to investigate the anti-Alzheimer's activity of Malva neglecta methanolic extract in the AlCl 3-induced Alzheimer disease rats' model. Thirty Wistar rats were divided into six groups and respective doses were given orally for 21 days. Behavioural observations were recorded and biochemical analysis was performed on brain homogenate. Improvement in memory and cognition was noted in treated rats as compared to disease control. A dose-dependent decrease (0.530 ± 0.009 at 200 mg/kg, 0.212 ± 0.007 at 400 mg/kg, 0.173 ± 0.005 at 600 mg/kg) in AChE activity was noted in the treatment groups with reference to disease control value (1.572 ± 0.013). This decrease in AChE activity is linked with an increase in acetylcholine in the brain which plays a key role in retaining memory. Oxidative stress biomarkers; GSH (66.77 ± 0.01 at 600 mg/kg), SOD (26.60 ± 0.10 at 600 mg/kg), CAT (21.46 ± 0.01 at 600 mg/kg) levels were increased with a decrease in MDA (103.33 ±0.49 at 600 mg/kg) level in a dose-dependently manner in the treatment groups as compared to disease control respective values. It is concluded that Malva neglecta could ameliorate Alzheimer's symptoms possibly by decreasing AChE activity and oxidative stress.

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Crossref · 10.1007/s11011-021-00683-x

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45 of 45 references verified0 citation errors · 0 not checkable

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  • Malva neglecta methanolic extract (200-600 mg/kg) and Tecoma stans extract (200-400 mg/kg) improved cognition, reduced AChE activity, and alleviated oxidative stress in AlCl3-treated mice.

    “Malva neglecta methanolic extract (200–600 mg/kg) and Tecoma stans extract (200–400 mg/kg) both improved cognition, reduced AChE activity, and alleviated oxidative stress in AlCl3-treated mice [70,71].”

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Authors
Saleem, U., Akhtar, R., Anwar, F., Shah, M. A., Chaudary, Z., Ayaz, M., & Ahmad, B.
Affiliations
  • Government College University, Faisalabad (PK)
  • Riphah International University (PK)
  • University of Malakand (PK)
Corresponding author
Saleem, Uzma
Venue
Metabolic Brain Disease
Published
2021-02-11
Volume
36
Issue
5
Pages
889-900
ISSN
  • 0885-7490 (ISSN-L)
  • 1573-7365
OpenAlex
W3128772904
Cited by
53
References
45
Citations by year
2026: 3 · 2025: 3 · 2024: 11 · 2023: 9 · 2022: 18 · 2021: 8
FWCI
12.97
Type
journal article
Language
en
Open access
closed
Locations
  • Metabolic Brain Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Malva neglecta, Alzheimer's disease, acetylcholinesterase inhibition, oxidative stress, neuroprotection, memory and cognition, acetylcholine, antioxidant enzymes, lipid peroxidation, methanol extract
MeSH terms
Alzheimer Disease, Animals, Cholinesterases, Cognition, Female, Glutathione, Male, Plant Extracts, Superoxide Dismutase, Down-Regulation, Rats, Wistar, Oxidative Stress, Neuroprotective Agents, Maze Learning, Malva, Rats

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