Neuroprotective potential of Malva neglecta is mediated via down-regulation of cholinesterase and modulation of oxidative stress markers
Abstract
Alzheimer's disease affects daily routine due to loss of memory and decline in cognition. In vitro data showed acetylcholine esterase inhibition activity of Malva neglecta but no in vivo evidence is available. The current study aims to investigate the anti-Alzheimer's activity of Malva neglecta methanolic extract in the AlCl 3-induced Alzheimer disease rats' model. Thirty Wistar rats were divided into six groups and respective doses were given orally for 21 days. Behavioural observations were recorded and biochemical analysis was performed on brain homogenate. Improvement in memory and cognition was noted in treated rats as compared to disease control. A dose-dependent decrease (0.530 ± 0.009 at 200 mg/kg, 0.212 ± 0.007 at 400 mg/kg, 0.173 ± 0.005 at 600 mg/kg) in AChE activity was noted in the treatment groups with reference to disease control value (1.572 ± 0.013). This decrease in AChE activity is linked with an increase in acetylcholine in the brain which plays a key role in retaining memory. Oxidative stress biomarkers; GSH (66.77 ± 0.01 at 600 mg/kg), SOD (26.60 ± 0.10 at 600 mg/kg), CAT (21.46 ± 0.01 at 600 mg/kg) levels were increased with a decrease in MDA (103.33 ±0.49 at 600 mg/kg) level in a dose-dependently manner in the treatment groups as compared to disease control respective values. It is concluded that Malva neglecta could ameliorate Alzheimer's symptoms possibly by decreasing AChE activity and oxidative stress.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Malva neglecta methanolic extract (200-600 mg/kg) and Tecoma stans extract (200-400 mg/kg) improved cognition, reduced AChE activity, and alleviated oxidative stress in AlCl3-treated mice.
“Malva neglecta methanolic extract (200–600 mg/kg) and Tecoma stans extract (200–400 mg/kg) both improved cognition, reduced AChE activity, and alleviated oxidative stress in AlCl3-treated mice [70,71].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [70]
Cites
1 retracted
Thenmozhi, A. J., Raja, T. R. W., Janakiraman, U., & Manivasagam, T. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1525-1 · Cited by 193 · see citing works
RetractedGlobal prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336 · see citing works
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744 · see citing works
Forecasting the global burden of Alzheimer's disease
Brookmeyer, R., Johnson, E., Ziegler‐Graham, K., & Arrighi, H. M. (2007) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2007.04.381 · Cited by 3,370 · see citing works
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works
Natural polyphenols: An overview
Abbas, M., Saeed, F., Anjum, F. M., Afzaal, M., Tufail, T., Bashir, M. S., Ishtiaq, A., Hussain, S., & Suleria, H. A. R. (2017) · International Journal of Food Properties · doi:10.1080/10942912.2016.1220393 · Cited by 769 · see citing works
Neuroprotective Effects of Quercetin in Alzheimer’s Disease
Khan, H. Z., Ullah, H., Aschner, M., Cheang, W. S., & Akkol, E. K. (2019) · Biomolecules · doi:10.3390/biom10010059 · Cited by 550 · see citing works
Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health
Marković, A. K., Torić, J., Barbarić, M., & Brala, C. J. (2019) · Molecules · doi:10.3390/molecules24102001 · Cited by 541 · see citing works
Synaptic degeneration in Alzheimer's disease
Arendt, T. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0536-x · Cited by 517 · see citing works
The toxicology of aluminum in the brain: a review.
Yokel, R. A. (2000) · PubMed · Cited by 461 · see citing works
Weisz, G. M., Kammerer, D. R., & Carle, R. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.12.074 · Cited by 249 · see citing works
Weinreb, O., Amit, T., Mandel, S. A., & Youdim, M. B. H. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0143-4 · Cited by 244 · see citing works
Daglia, M., Lorenzo, A. D., Nabavi, S. F., Talas, Z., & Nabavi, S. F. (2014) · Current Pharmaceutical Biotechnology · doi:10.2174/138920101504140825120737 · Cited by 244 · see citing works
Müller, W. E., Eckert, A., Kurz, C., Eckert, G. P., & Leuner, K. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8141-5 · Cited by 243 · see citing works
Emanuele, E., D’Angelo, A., Tomaino, C., Binetti, G. G., Ghidoni, R., Politi, P., Bernardi, L., Maletta, R., Bruni, A. C., & Geroldi, D. (2005) · Archives of Neurology · doi:10.1001/archneur.62.11.1734 · Cited by 220 · see citing works
Kumar, A., Dogra, S., & Prakash, A. K. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.012 · Cited by 212 · see citing works
Ren, Z., Zhang, R., Li, Y., Yu, L., Yang, Z., & Yang, H. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3127 · Cited by 188 · see citing works
Natural Products as Anti-glycation Agents: Possible Therapeutic Potential for Diabetic Complications
Elosta, A., Ghous, T., & Ahmed, N. (2012) · Current Diabetes Reviews · doi:10.2174/157339912799424528 · Cited by 172 · see citing works
Winter, A. N., Brenner, M. C., Punessen, N., Snodgrass, M., Byars, C., Arora, Y., & Linseman, D. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6297080 · Cited by 160 · see citing works
Han, J., Miyamae, Y., Shigemori, H., & Isoda, H. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.049 · Cited by 146 · see citing works
Phenolic profile evolution of different ready-to-eat baby-leaf vegetables during storage
Santos, J., Oliveira, M. B. P. P., Ibáñez, E., & Herrero, M. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.12.085 · Cited by 139 · see citing works
Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease
Haque, E., Javed, H., Azimullah, S., Khair, S. B. A., & Ojha, S. K. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s90616 · Cited by 138 · see citing works
Özüdoğru, B., Akaydın, G., Erik, S., & Yeşilada, E. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.04.050 · Cited by 109 · see citing works
Thenmozhi, A. J., Raja, T. R. W., Janakiraman, U., & Manivasagam, T. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1689-8 · Cited by 104 · see citing works
Pinto, N. B., Alexandre, B. D. S., Neves, K. R. T., Silva, A. H., Leal, L. K. A. M., & Viana, G. S. D. B. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/161092 · Cited by 99 · see citing works
Dalar, A., Türker, M., & Konczak, I. (2012) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2012.03.001 · Cited by 92 · see citing works
Sawmiller, D. R., Habib, A., Li, S., Darlington, D., Hou, H., Tian, J., Shytle, R. D., de Smith, A. J., Giunta, B. N., Mori, T., et al. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.08.018 · Cited by 90 · see citing works
Medina, S., Collado‐González, J., Ferreres, F., Londoño‐Londoño, J., Jiménez‐Cartagena, C., Guy, A., Durand, T., Galano, J., & Gil‐Izquierdo, Á. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.02.049 · Cited by 78 · see citing works
Mannose receptor is present in a functional state in rat microglial cells
Marzolo, M., Rommy von Bernhardi, M., & Inestrosa, N. C. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19991101)58:3 · Cited by 65 · see citing works
Saleem, U., Khalid, S., Zaib, S., Anwar, F., Ahmad, B., Ullah, I., Zeb, A., & Ayaz, M. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112401 · Cited by 59 · see citing works
Self-citationBioactive Compounds and Their Neuroprotective Effects in Diabetic Complications
Oh, Y. S. (2016) · Nutrients · doi:10.3390/nu8080472 · Cited by 58 · see citing works
Deloncle, R., Huguet, F., Fernandez, B., Quellard, N., Babin, P., & Guillard, O. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00214-x · Cited by 54 · see citing works
A literature review of spirituality in coping with early‐stage Alzheimer's disease
Beuscher, L. M., & Beck, C. C. (2008) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2007.02126.x · Cited by 52 · see citing works
Petrásek, T., Vojtěchová, I., Lobellová, V., Popelíková, A., Janikova, M., Brožka, H., Houdek, P., Sládek, M., Sumová, A., Krištofiková, Z., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00250 · Cited by 51 · see citing works
Antioxidants Attenuate Isolation- and L-DOPA-Induced Aggression in Mice
Hira, S., Saleem, U., Anwar, F., & Ahmad, B. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00945 · Cited by 43 · see citing works
Self-citationPolyphenolic profile of green/red spotted Italian Cichorium intybus salads by RP-HPLC-PDA-ESI-MS n
Papetti, A., Maietta, M., Corana, F., Marrubini, G., & Gazzani, G. (2017) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2017.08.010 · Cited by 40 · see citing works
Chauhdary, Z., Saleem, U., Ahmad, B., Shah, S., & Shah, M. A. (2019) · PubMed · Cited by 32 · see citing works
Self-citationSaleem, U., Raza, Z., Anwar, F., Ahmad, B., Hira, S., & Ali, T. (2019) · Medicina · doi:10.3390/medicina55050184 · Cited by 31 · see citing works
Self-citationFeng, Q., Ma, Y., Mu, S., Wu, J., Chen, S. X., OuYang, L., & Lei, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091512 · Cited by 28 · see citing works
Saleem, U., Raza, Z., Anwar, F., Chaudary, Z., & Ahmad, B. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2772-5 · Cited by 26 · see citing works
Self-citationPropolis attenuates oxidative injury in brain and lung of nitric oxide synthase inhibited rats
Talas, Z. S., Özdemir, İ., Çiftçi, O., & Çakır, O. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 16 · see citing works
Aslam, M., & Sial, A. A. (2014) · International Scholarly Research Notices · doi:10.1155/2014/156976 · Cited by 15 · see citing works
Malva neglecta: A natural inhibitor of bacterial growth and biofilm formation
Elias, K., Patrick, A. R. E. F., Mohammad, J., & Nawas, T. (2017) · Journal of Medicinal Plants Research · doi:10.5897/jmpr2017.6422 · Cited by 8 · see citing works
Ladenheim, H. S., García, A., Avagnina, A., Porta, J., & Elsner, B. (1995) · PubMed · Cited by 6 · see citing works
Neuroprotective effects of 3,5-di-o-caffeoylquinic acid in vitro and in vivo
Han, J., & Isoda, H. (2011) · BMC Proceedings · doi:10.1186/1753-6561-5-s8-p20 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Abduljawad, A. A., Elawad, M. A., Elkhalifa, M. E. M., Ahmed, A., Hamdoon, A. A. E., Salim, L. H. M., Ashraf, M., Ayaz, M., Hassan, S. S. U., & Bungau, S. (2022) · Molecules · doi:10.3390/molecules27206804 · Cited by 63 · see citing works
“As this is a permanent reaction, when the reactive species are attached to certain biological molecules, this alters them both structurally and functionally [35,36] and causes genetic mutations.”
BackgroundSelf-citationAyaz, M., Nawaz, A., Ahmad, S., Mosa, O. F., Hamdoon, A. A. E., Elkhalifa, M. E. M., Sadiq, A., Ullah, F., Wadood, A., Kabra, A., et al. (2022) · Journal of Food Quality · doi:10.1155/2022/1189034 · Cited by 58 · see citing works
Self-citationMahnashi, M. H., Alqahtani, Y. S., Alyami, B. A., Alqarni, A. O., Ayaz, M., Ghufran, M., Ullah, F., Sadiq, A., Ullah, I., Haq, I. U., et al. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/7924171 · Cited by 51 · see citing works
Self-citationKhalil, A. T., Khan, M. D., Razzaque, S., Afridi, S., Ullah, I., Iqbal, J., Tasneem, S., Shah, A., Shinwari, Z. K., Revaprasadu, N., et al. (2021) · Applied Nanoscience · doi:10.1007/s13204-021-02030-z · Cited by 50 · see citing works
Self-citationAyaz, M., Mosa, O. F., Nawaz, A., Hamdoon, A. A. E., Elkhalifa, M. E. M., Sadiq, A., Ullah, F., Ahmed, A., Kabra, A., Khan, H. Z., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155272 · Cited by 49 · see citing works
Self-citationTherapeutic insights elaborating the potential of retinoids in Alzheimer’s disease
Behl, T., Kaur, D., Sehgal, A., Singla, R. K., Makeen, H. A., Albratty, M., Alhazmi, H. A., Meraya, A. M., & BUNGAU, S. G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.976799 · Cited by 42 · see citing works
Imran, M., Iqbal, A., Badshah, S. L., Sher, A. A., Ullah, H., Ayaz, M., Mosa, O. F., Mostafa, N. M., & Daglia, M. (2023) · Marine Drugs · doi:10.3390/md21050273 · Cited by 41 · see citing works
Self-citationAntiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism
Saleem, U., Shehzad, A., Shah, S., Raza, Z., Shah, M. A., Bibi, S., Chauhdary, Z., & Ahmad, B. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00707-6 · Cited by 43 · see citing works
Self-citationAlkinani, K. B., Ali, E. M. M., Al-Shaikh, T. M., Khan, J. A., Al-naomasi, T. M., Ali, S. S., Abduljawad, A. A., Mosa, O. F., & Zafar, T. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/4655150 · Cited by 33 · see citing works
Nasar, M. Q., Shah, M. T., Khalil, A. T., Kakar, M. Q., Ayaz, M., Dablool, A. S., & Shinwari, Z. K. (2022) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2022.109252 · Cited by 31 · see citing works
Self-citationALNasser, M. N., Alboraiy, G. M., Alsowig, E. M., & Alqattan, F. M. (2025) · Brain Sciences · doi:10.3390/brainsci15020215 · Cited by 35 · see citing works
Saleem, U., Bibi, S., Shah, M. A., Ahmad, B., Saleem, A., Chauhdary, Z., Anwar, F., Javaid, N., Hira, S., Akhtar, M. F., et al. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/5007 · Cited by 27 · see citing works
Self-citationAnti‐inflammatory potential of berberine‐rich extract via modulation of inflammation biomarkers
Naz, I., Masoud, M. S., Chauhdary, Z., Shah, M. A., & Panichayupakaranant, P. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14389 · Cited by 27 · see citing works
Self-citationAyaz, M., Wadood, A., Sadiq, A., Ullah, F., Anichkina, O. A., & Ghufran, M. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1940286 · Cited by 26 · see citing works
Self-citationThe role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer’s disease: A review
Ahmad, N., Lesa, K. N., Sudarmanto, A., Fakhrudin, N., & Ikawati, Z. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1070677 · Cited by 26 · see citing works
Green Nano‐Biotechnology: A New Sustainable Paradigm to Control Dengue Infection
Zohra, T., Khalil, A. T., Saeed, F., Latif, B., Salman, M., Ikram, A., Ayaz, M., & Murthy, H. C. A. (2022) · Bioinorganic Chemistry and Applications · doi:10.1155/2022/3994340 · Cited by 24 · see citing works
Self-citation(2024) · Asian Journal of Agriculture and Biology · doi:10.35495/ajab.2023.364 · Cited by 22 · see citing works
Elawad, M. A., Ayaz, M., Mosa, O. F., Usman, A., Hamdoon, A. A. E., Almawash, S., Salim, L. H. M., Ahmed, A., & Elkhalifa, M. E. M. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400525 · Cited by 20 · see citing works
Self-citationSabir, S., Saleem, U., Akash, M. S. H., Qasim, M., & Chauhdary, Z. (2022) · ACS Omega · doi:10.1021/acsomega.2c00028 · Cited by 19 · see citing works
Self-citationSaleem, A., Hameed, I., Akhtar, M. F., Ashraf, G. M., Alghamdi, B. S. A., Rahman, M. H., & Almashjary, M. N. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1002999 · Cited by 18 · see citing works
Khan, F. A., Ali, G., Rahman, K., Khan, Y. A., Ayaz, M., Mosa, O. F., Nawaz, A., Hassan, S. S. U., & BUNGAU, S. G. (2022) · Molecules · doi:10.3390/molecules27175431 · Cited by 18 · see citing works
Self-citationUllah, I., & Ayaz, M. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00514-z · Cited by 17 · see citing works
Self-citationramadan, M. M., El‐Said, M. M., El-Messery, T. M., & Mohamed, R. S. (2021) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.15759 · Cited by 17 · see citing works
Mahnashi, M. H., Ayaz, M., Alqahtani, Y. S., Alyami, B. A., Shahid, M. M., Alqahtani, O. S., Kabrah, S. M., Zeb, A., Ullah, F., & Sadiq, A. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116786 · Cited by 17 · see citing works
Self-citationMahnashi, M. H., Alyami, B. A., Alqahtani, Y. S., Alqarni, A. O., Jan, M. S., Ayaz, M., Ullah, F., Shahid, M. M., Rashid, U., & Sadiq, A. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03420-0 · Cited by 16 · see citing works
Self-citationRahman, K., Ali, G., Khan, R., Khan, I. R., Ali, I., Mosa, O. F., Ahmed, A., Ayaz, M., Nawaz, A., & Murthy, H. C. A. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s354779 · Cited by 15 · see citing works
Self-citationZou, M., Wang, R., Yin, Q.-M., & Liu, L. (2021) · Medicinal Chemistry Research · doi:10.1007/s00044-021-02777-8 · Cited by 14 · see citing works
Wani, Z. A., Farooq, A., Sarwar, S., Negi, V. S., Shah, A. A., Singh, B., Siddiqui, S., Pant, S., Alghamdi, H., & Mustafa, M. (2022) · Biology · doi:10.3390/biology11101415 · Cited by 13 · see citing works
Rehman, Y. U., Iqbal, A., Ali, G., Alotaibi, G., Ahmed, A., & Ayaz, M. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04309-w · Cited by 11 · see citing works
Self-citationMohamed, R. S., Fouda, K. A., Salama, A., & Akl, E. M. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100588 · Cited by 11 · see citing works
Saleem, U., Chauhdary, Z., Islam, S., Zafar, A., Khayat, R. O. S., Althobaiti, N. A., Shah, G. M., Alqarni, M. A., & Shah, M. A. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01046-w · Cited by 12 · see citing works
Self-citationEditorial: Current Trends in Medicinal Plant Research and Neurodegenerative Disorders
Ayaz, M., Ali, T., Sadiq, A., Ullah, F., & Naseer, M. I. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.922373 · Cited by 10 · see citing works
Self-citationLi, H., Chen, Z., Shen, Y., Xiong, T., Chen, A., Chen, L., Ye, Y., Jiang, Q., Zhang, Y., Sun, J., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05571-3 · Cited by 9 · see citing works
Nasar, M. Q., Zohra, T., Khalil, A. T., Ovais, M., Ullah, I., Ayaz, M., Zahoor, M., & Shinwari, Z. K. (2022) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902022e20989 · Cited by 9 · see citing works
Self-citationOjetunde, A. O. (2024) · Biology Medicine & Natural Product Chemistry · doi:10.14421/biomedich.2024.131.7-33 · Cited by 8 · see citing works
Alotaibi, B. S., Saleem, U., Ahmad, A., Chaudhary, Z., Farrukh, M., Khayat, R. O. S., Alsharif, I., Baokbah, T. A. S., Albalawi, A. E., Althobaiti, N. A., et al. (2024) · Italian Journal of Food Science · doi:10.15586/ijfs.v36i2.2551 · Cited by 8 · see citing works
Self-citationMahnashi, M. H., Ayaz, M., Ghufran, M., Almazni, I. A., Alqahtani, O. S., Alyami, B. A., Alqahtani, Y. S., Khan, H. A., Sadiq, A., & Waqas, M. S. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2265494 · Cited by 7 · see citing works
Self-citationYoussef, B., Ibrahim, E. A., Moselhy, S. S., ElShebiney, S. A., & ELabd, W. K. (2025) · Discover Nano · doi:10.1186/s11671-025-04356-x · Cited by 7 · see citing works
Aslam, B., Hussain, A., Faisal, M. N., Kousar, S., Roobi, A., Sajid, M. R., & Gul, A. (2024) · PubMed Central · doi:10.22038/ijbms.2023.72553.15780 · Cited by 6 · see citing works
Saadullah, M., Sehar, A., Chauhdary, Z., Siddique, R., Tariq, H., Asif, M., Bukhari, S. A., & Sethi, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0311140 · Cited by 6 · see citing works
RetractedBadoni, H., Painuli, S., Panwar, S., Sharma, P., & Semwal, P. (2023) · Brain Disorders · doi:10.1016/j.dscb.2023.100109 · Cited by 5 · see citing works
Hu, X., Han, M., Liu, J., Li, F., & Cui, Y. (2024) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-024-04965-9 · Cited by 5 · see citing works
Neuroprotective effect of Thymus vulgaris on paraquat induced Parkinson's disease
Akhter, N., Rafiq, I., Jamil, A., Chauhdary, Z., Mustafa, A., & Nisar, A. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151740 · Cited by 5 · see citing works
Maidadi, B., Ntchapda, F., Miaffo, D., & Kamgue, O. G. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9519743 · Cited by 5 · see citing works
Dragomir, A.-F., Zugravu, A., Stoleru, S., Poenaru, E., Dumitrescu, M. C., Albu, G., Tomescu, T.-N., Ivan, G. R., Lacatus, M. G., Barbu, A. C., et al. (2026) · Biology · doi:10.3390/biology15090690 · Cited by 3 · see citing works
Sarwar, S., Sarwar, N., Ali, H., Rafiullah, R., Khan, R., Ahmad, A., Ullah, A., Soonmin, H., & Ullah, N. (2025) · Biomedicines · doi:10.3390/biomedicines13010093 · Cited by 2 · see citing works
Ayaz, M., Ullah, F., Sadiq, A., Nawaz, A., Yessimbekov, Z., & Ashraf, M. Z. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85591-4.00020-9 · Cited by 2 · see citing works
Self-citationAlhasaniah, A. H., Ahmad, Z., Zeb, A., Mahnashi, M. H., Sadiq, A., & Ayaz, M. (2023) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2023.123911 · Cited by 1 · see citing works
Self-citationMahnashi, M. H., Ali, S., Alshehri, O. M., Almazni, I. A., Asiri, S. A., Sadiq, A., Zafar, R., & Jan, M. S. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2251052 · Cited by 1 · see citing works
Modeling particulate charging in ESPs (electrostatic precipitators)
Lawless, P. A., & Sparks, L. E. (1988) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
Saleem, A., Hameed, I., Akhtar, M. F., Rahman, M. H., & Ash, G. M. (2022) · Research Square · doi:10.21203/rs.3.rs-1214323/v1
Significance of phytochemicals in cancer therapy
Srivastava, A. K., Singh, D. R., & Singh, R. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15960-2.00001-5
Safdar, R., & Saleem, U. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02411-2
Self-citationAljaezi, I., Saleem, U., Farrukh, M., Muzzamil, A., Erum, A., Alotaibi, B. S., Abu-Seer, E. A., Obidan, A., Alahmari, M., & Shah, M. A. (2026) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/apjtb.apjtb_386_26
Self-citation
- Authors
- Saleem, U., Akhtar, R., Anwar, F., Shah, M. A., Chaudary, Z., Ayaz, M., & Ahmad, B.
- Affiliations
- Government College University, Faisalabad (PK)
- Riphah International University (PK)
- University of Malakand (PK)
- Corresponding author
- Saleem, Uzma
- Venue
- Metabolic Brain Disease
- Published
- 2021-02-11
- Volume
- 36
- Issue
- 5
- Pages
- 889-900
- ISSN
- 0885-7490 (ISSN-L)
- 1573-7365
- OpenAlex
- W3128772904
- Cited by
- 53
- References
- 45
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 11 · 2023: 9 · 2022: 18 · 2021: 8
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolic Brain Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Malva neglecta, Alzheimer's disease, acetylcholinesterase inhibition, oxidative stress, neuroprotection, memory and cognition, acetylcholine, antioxidant enzymes, lipid peroxidation, methanol extract
- MeSH terms
- Alzheimer Disease, Animals, Cholinesterases, Cognition, Female, Glutathione, Male, Plant Extracts, Superoxide Dismutase, Down-Regulation, Rats, Wistar, Oxidative Stress, Neuroprotective Agents, Maze Learning, Malva, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review