Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1
Open accessAbstract
As aged population dramatically increases in these decades, efforts should be made on the intervention for curing age-associated neurologic degenerative diseases such as Alzheimer's disease (AD). Caffeoylquinic acid (CQA), an antioxidant component and its derivatives are natural functional compounds isolated from a variety of plants. In this study, we determined the neuroprotective effect of 3,5-di-O-CQA on Abeta(1-42) treated SH-SY5Y cells using MTT assay. To investigate the possible neuroprotective mechanism of 3,5-di-O-CQA, we performed proteomics analysis, real-time PCR analysis and measurement of the intracellular ATP level. In addition, we carried out the measurement of escape latency time to find the hidden platform in Morris water maze (MWM), real-time PCR using senescence-accelerated-prone mice (SAMP) 8 and senescence-accelerated-resistant mice (SAMR) 1 mice. Results showed that 3,5-di-O-CQA had neuroprotective effect on Abeta (1-42) treated cells. The mRNA expression of glycolytic enzyme (phosphoglycerate kinase-1; PGK1) and intracellular ATP level were increased in 3,5-di-O-CQA treated SH-SY5Y cells. We also found that 3,5-di-O-CQA administration induced the improvement of spatial learning and memory on SAMP8 mice, and the overexpression of PGK1 mRNA. These findings suggest that 3,5-di-O-CQA has a neuroprotective effect on neuron through the upregulation of PGK1 expression and ATP production activation.
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The human neuroblastoma SH-SY5Y is among the most used cell lines, a subclone of the parental neuronal line SK-N-SH, which originated in 1970 from a biopsy metastatic tumor.
“The human neuroblastoma SH-SY5Y is among the most used cell lines [131,136,137,138,139,140,141,142], a subclone of a parental neuronal line SK-N-SH, which originated in 1970 from a biopsy metastatic tumor.”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [139]
Certain CAW active compounds increase learning and memory and provide neuroprotection in rodents in vivo.
“The neurological effects of certain CAW active compounds are also observed in vivo, increasing learning and memory while providing neuroprotection in rodents [2,13,112].”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [112]
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Self-citation
- Authors
- Han, J., Miyamae, Y., Shigemori, H., & Isoda, H.
- Affiliations
- University of Tsukuba (JP)
- Corresponding author
- Isoda, H.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 169
- Issue
- 3
- Pages
- 1039-1045
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1987076477
- Cited by
- 146
- References
- 42
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 16 · 2023: 8 · 2022: 12 · 2021: 13 · 2020: 12 · 2019: 14 · 2018: 5 · 2017: 12 · 2016: 11 · 2015: 3 · 2014: 7 · 2013: 8 · 2012: 6
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Terrestrial Environment Research Center (University of Tsukuba) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- caffeoylquinic acid derivatives, neuroprotection, PGK1, glycolysis, ATP production, amyloid-beta 42, SH-SY5Y cells, Alzheimer's disease, spatial learning and memory, neurodegeneration
- MeSH terms
- Adenosine Triphosphate, Aging, Animals, Brain, Cell Survival, Humans, Memory, Neurons, Peptide Fragments, Phosphoglycerate Kinase, Quinic Acid, RNA, Messenger, Electrophoresis, Gel, Two-Dimensional, Up-Regulation, Polymerase Chain Reaction, Amyloid beta-Peptides, Cell Death, Neuroprotective Agents, Maze Learning, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Gene Expression Profiling, Models, Animal, Cell Line, Tumor, Mice
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