Probiotics ameliorates LPS induced neuroinflammation injury on Aβ 1-42, APP, γ-β secretase and BDNF levels in maternal gut microbiota and fetal neurodevelopment processes
Open accessAbstract
The gut microbiota influences brain development and functioning through the gut-brain axis. This is first study regulate maternal gut microbiota and fetal neurodevelopment processes by using probiotics such as Bifidobacterium bifidum (BIF) and Lactobacillus salivarius (LAC) in the prenatal period. In this study, Wistar Albino female rats were divided into five groups; Control, lipopolysaccharide (LPS, 100 µg/kg), LPS + LAC, LPS + BIF and LPS + LAC + BIF (4 × 10 9 ml CFU). Maternal rats were given probiotics for 21 days. Inflammation was induced by lipopolysaccharide (LPS), on the 17th day of pregnancy. After birth, the brain tissues of the maternal and neonatal rats were removed and their blood was collected. Fecal calprotectin levels of pregnant rats were measured as an important biomarker in determining intestinal flora disruption. Calprotectin levels were high in LPS group (p < 0.05). Aβ 1-42, APP, γ secretase and β- secretase levels were higher in both maternal and neonatal LPS groups (p < 0.05). These levels were statistically decreased in the probiotic groups compared to the LPS group, as demonstrated in both biochemical and histological analyzes (p < 0.05). While BDNF mRNA expression decreased in LPS groups, APP level increased in the same group. The difference between groups in mRNA expressions in the neonatal brain tissues was similar to maternal brain tissues. What's more, BDNF/actin and APP/actin rates were proven by western blot and the damage caused by neuroinflammation in the brain tissue and the preservation of the intestinal microbiota were visualized histopathologically on the morphological structures in all groups. It will shed light on new therapeutic strategies for the impact of the use of probiotics on the neurodevelopmental processes of the neonatal against LPS-induced inflammatory responses and impaired gut microbiota in the prenatal period.
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LPS may alter gut homeostasis, inflammation, and permeability while activating various immune cells, including macrophages, neutrophils, and dendritic cells.
“LPS may alter gut homeostasis, inflammation, and permeability (91, 92) while activating various immune cells, including macrophages, neutrophils, and dendritic cells.”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [92]
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- Authors
- Kar, F., Hacioglu, C., Kar, E., Donmez, D. B., & Kanbak, G.
- Affiliations
- Kutahya Saglik Bilimleri Universitesi (TR)
- Eskişehir Osmangazi University (TR)
- Corresponding author
- Kar, Fatih
- Venue
- Metabolic Brain Disease
- Published
- 2022-03-21
- Volume
- 37
- Issue
- 5
- Pages
- 1387-1399
- ISSN
- 0885-7490 (ISSN-L)
- 1573-7365
- OpenAlex
- W4220867618
- Cited by
- 42
- References
- 42
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 9 · 2023: 7 · 2022: 7
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Metabolic Brain Disease (publishedVersion)
- PubMed (publishedVersion)
- DSpace - Düzce (Duzce University) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- probiotics, maternal gut microbiota, fetal brain development, lipopolysaccharide-induced neuroinflammation, Bifidobacterium bifidum, Lactobacillus salivarius, gut-brain axis, amyloid-beta 42, APP, gamma-secretase, beta-secretase, brain-derived neurotrophic factor, calprotectin, neonatal brain
- MeSH terms
- Gastrointestinal Microbiome, Neuroinflammatory Diseases, Actins, Animals, Female, Lipopolysaccharides, Pregnancy, RNA, Messenger, Rats, Wistar, Brain-Derived Neurotrophic Factor, Probiotics, Leukocyte L1 Antigen Complex, Rats, Amyloid Precursor Protein Secretases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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