Cited by 651Probiotics and Fermented FoodsStress Responses and CortisolGut microbiota and health

Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress

Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y., Jin, F.·2015·Neuroscience

Abstract

Increasing numbers of studies have suggested that the gut microbiota is involved in the pathophysiology of stress-related disorders. Chronic stress can cause behavioral, cognitive, biochemical, and gut microbiota aberrations. Gut bacteria can communicate with the host through the microbiota-gut-brain axis (which mainly includes the immune, neuroendocrine, and neural pathways) to influence brain and behavior. It is hypothesized that administration of probiotics can improve chronic-stress-induced depression. In order to examine this hypothesis, the chronic restraint stress depression model was established in this study. Adult specific pathogen free (SPF) Sprague-Dawley rats were subjected to 21 days of restraint stress followed by behavioral testing (including the sucrose preference test (SPT), elevated-plus maze test, open-field test (OFT), object recognition test (ORT), and object placement test (OPT)) and biochemical analysis. Supplemental Lactobacillus helveticus NS8 was provided every day during stress until the end of experiment, and selective serotonin reuptake inhibitor (SSRI) citalopram (CIT) served as a positive control. Results showed that L. helveticus NS8 improved chronic restraint stress-induced behavioral (anxiety and depression) and cognitive dysfunction, showing an effect similar to and better than that of CIT. L. helveticus NS8 also resulted in lower plasma corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels, higher plasma interleukin-10 (IL-10) levels, restored hippocampal serotonin (5-HT) and norepinephrine (NE) levels, and more hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression than in chronic stress rats. Taken together, these results indicate an anti-depressant effect of L. helveticus NS8 in rats subjected to chronic restraint stress depression and that this effect could be due to the microbiota-gut-brain axis. They also suggest the therapeutic potential of L. helveticus NS8 in stress-related and possibly other kinds of depression.

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Crossref · 10.1016/j.neuroscience.2015.09.033

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Authors
Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y., & Jin, F.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Sichuan Normal University (CN)
Corresponding author
Jin, F.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2015-12
Volume
310
Pages
561-577
ISSN
0306-4522 (ISSN-L)
OpenAlex
W2179857156
Cited by
651
References
143
Citations by year
2026: 22 · 2025: 53 · 2024: 62 · 2023: 58 · 2022: 114 · 2021: 98 · 2020: 80 · 2019: 66 · 2018: 46 · 2017: 30 · 2016: 21 · 2015: 1
FWCI
43.72
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
probiotics, chronic restraint stress, depression, anxiety, microbiota-gut-brain axis, gut microbiota, cognitive impairment, corticosterone, IL-10, hippocampal serotonin, norepinephrine, brain-derived neurotrophic factor, citalopram, stress-related disorders
MeSH terms
Adrenocorticotropic Hormone, Animals, Anxiety, Behavior, Animal, Body Weight, Corticosterone, Depression, Dopamine, Hippocampus, Interferon-gamma, Male, Norepinephrine, Restraint, Physical, Serotonin, Stress, Psychological, Tumor Necrosis Factor-alpha, Citalopram, Interleukin-10, Rats, Sprague-Dawley, Selective Serotonin Reuptake Inhibitors, Prefrontal Cortex, Brain-Derived Neurotrophic Factor, Probiotics, Rats, Lactobacillus helveticus

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