The progress of silver nanoparticles in the antibacterial mechanism, clinical application and cytotoxicity
Open accessAbstract
Nanotechnology is a highly promising field, with nanoparticles produced and utilized in a wide range of commercial products. Silver nanoparticles (AgNPs) has been widely used in clothing, electronics, bio-sensing, the food industry, paints, sunscreens, cosmetics and medical devices, all of which increase human exposure and thus the potential risk related to their short- and long-term toxicity. Many studies indicate that AgNPs are toxic to human health. Interestingly, the majority of these studies focus on the interaction of the nano-silver particle with single cells, indicating that AgNPs have the potential to induce the genes associated with cell cycle progression, DNA damage and mitochondrial associated apoptosis. AgNPs administered through any method were subsequently detected in blood and were found to cause deposition in several organs. There are very few studies in rats and mice involving the in vivo bio-distribution and toxicity, organ accumulation and degradation, and the possible adverse effects and toxicity in vivo are only slowly being recognized. In the present review, we summarize the current data associated with the increased medical usage of nano-silver and its related nano-materials, compare the mechanism of antibiosis and discuss the proper application of nano-silver particles.
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Apart from antimicrobial effects, NAg-loaded scaffolds can also inhibit the abnormal inflammatory response effectively.
“Apart from their antimicrobial effects, NAg-loaded scaffolds can also inhibit the abnormal inflammatory response effectively”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as You et al., 2012
The Anti-inflammatory uses section reports that nano-crystalline silver dressings may aid wound healing through anti-inflammatory activity and that silver cream suppresses inflammatory markers. The Wound therapy section reports antibacterial effects for silver-loaded scaffolds, but does not show that those scaffolds effectively inhibit an abnormal inflammatory response. (LLM, conf=0.86)
Experimental — accuracy not yet measuredOur previous studies demonstrated that NAg-CCS was favorable and applicable for treating burn wounds.
“Our previous studies demonstrated that nanosilver (NAg)-loaded collagen-chitosan scaffold (NAg-CCS) was favorable and applicable for treating burn wounds.”
From Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization (2023) · cites this paper as You et al., 2012
The Wound therapy section (page unavailable) says silver-nanoparticle dressings may reduce infection and accelerate healing in second-degree burns. It discusses other silver-containing scaffolds, but does not identify or report findings for the specific nanosilver-loaded collagen-chitosan scaffold (NAg-CCS), so it cannot establish that prior studies found NAg-CCS favorable for treating burns. (LLM, conf=0.83)
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Gan, D., Xing, W., Jiang, L., Fang, J., Zhao, C., Ren, F., Fang, L., Wang, K., & Lu, X. (2019) · Nature Communications · doi:10.1038/s41467-019-09351-2 · Cited by 1,029 · see citing works
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Self-citation
- Authors
- You, C., Han, C., Wang, X., Zheng, Y., Li, Q., Hu, X., & Sun, H.
- Affiliations
- Second Affiliated Hospital of Zhejiang University (CN)
- 117th Hospital of People's Liberation Army (CN)
- Corresponding author
- Han, Chunmao
- Venue
- Molecular Biology Reports
- Published
- 2012-06-22
- Volume
- 39
- Issue
- 9
- Pages
- 9193-9201
- ISSN
- 0301-4851 (ISSN-L)
- 1573-4978
- PMC
- PMC7089021
- OpenAlex
- W2054671840
- Semantic Scholar
- 22ab2bdeed9b8bcb4d7a01ffdb5de0f7c846ca4d
- Cited by
- 447
- References
- 83
- Citations by year
- 2026: 24 · 2025: 25 · 2024: 28 · 2023: 49 · 2022: 48 · 2021: 74 · 2020: 35 · 2019: 28 · 2018: 27 · 2017: 24 · 2016: 22 · 2015: 18 · 2014: 22 · 2013: 22 · 2012: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Biology Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Keywords
- silver nanoparticles, antibacterial mechanism, clinical application, cytotoxicity, nanoparticle toxicity, tissue distribution, organ accumulation, DNA damage, apoptosis, human exposure, nanomaterials
- MeSH terms
- Animals, Anti-Inflammatory Agents, Anti-Bacterial Agents, Antineoplastic Agents, DNA Damage, Humans, Silver, Angiogenesis Inhibitors, Metal Nanoparticles
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