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Cited by 23Genetic and phenotypic traits in livestockRuminant Nutrition and Digestive PhysiologyMilk Quality and Mastitis in Dairy Cows

Milk Fatty Acid Variability and Association with Polymorphisms in SCD1 and DGAT1 Genes in White Fulani and Borgou Cattle Breeds

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Houaga, Isidore, Muigai, Anne W. T., Ng’ang’a, Fredrick M., Ibeagha-Awemu, Eveline M., Kyallo, Martina, Youssao, Issaka A. K., Stomeo, Francesca·2018·Molecular Biology Reports
DOI 10.1007/s11033-018-4331-4PMC PMC6267235
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Abstract

The stearoyl-CoA desaturase 1 (SCD1) A293V and acyl CoA: diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphisms have been associated with significant variation in bovine milk fatty acid composition and unsaturation indices in western cattle breeds. This study aimed to estimate the milk fatty acid variability in indigenous Borgou and White Fulani cattle breeds of Benin, and the effects of the SCD1 A293V and DGAT1 K232A polymorphisms on milk and fatty acid composition and unsaturation indices. Thus, 85 Borgou and 96 White Fulani cows were genotyped for the SCD1 A293V and DGAT1 K232A polymorphisms and their milk and fatty acid composition and unsaturation indices were determined. Borgou presented milk with higher linoleic acid (P < 0.001), oleic acid (P < 0.05), C18 index (P < 0.001), total unsaturation index (P < 0.05), and lower total saturated fatty acid (SFA) compared to White Fulani. The SCD1 VV genotype was associated with higher protein and lactose contents in White Fulani (P < 0.05). In Borgou, the SCD1 AV genotype was associated with higher C14 and total unsaturation indices (P < 0.01), while the SCD1 V allele was associated with decrease in C14 index (P < 0.05). In White Fulani, the SCD1 VV genotype was associated with lower C18:1 cis-9 content (P < 0.05) while the DGAT1 K allele was associated with increased total SFA (P < 0.05), and decreased C18 index (P < 0.05), total unsaturation index (P < 0.01) and total monounsaturated fatty acid (P < 0.01). The SCD1 A293V and DGAT1 K232A may serve as genetic markers to improve milk fatty acid traits in Borgou and White Fulani breeds.

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  • Individuals carrying the lysine (K) allele of DGAT1 exhibit a higher milk fat percentage, whereas those with the alanine (A) allele show higher milk protein content and total milk yield.

    “Individuals carrying the lysine (K) allele exhibit a higher milk fat percentage in both Holstein and other indigenous dairy cattle breeds, whereas those with the alanine (A) allele show higher milk protein content and total milk yield [151,152,153,154].”

    From The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution (2026) · cites this paper as [152]

    The Results (Effects of the DGAT1 K232A polymorphism; page unavailable) report no significant effect of the polymorphism on milk composition in either Borgou or White Fulani cattle, contrary to the claimed allele-specific differences in those indigenous breeds. The Introduction mentions a prior association of the KK genotype with higher fat yield, but that is not higher fat percentage; it does not report higher protein content or milk yield for the A allele. (LLM, conf=0.83)

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  1. [35]Sambrook JF Russell DW Molecular cloning: a laboratory manual 2001 3 New York Cold Spring Harbor Lab Press

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Authors
Houaga, I., Muigai, A. W. T., Ng’ang’a, F. M., Ibeagha-Awemu, E. M., Kyallo, M., Youssao, I. A. K., & Stomeo, F.
Affiliations
  • Jomo Kenyatta University of Agriculture and Technology (KE)
  • Agriculture and Agri-Food Canada (CA)
  • International Livestock Research Institute (KE)
Corresponding author
Houaga, Isidore
ORCID
Venue
Molecular Biology Reports
Publisher
Springer Science and Business Media LLC
Published
2018-08-30
Volume
45
Issue
6
Pages
1849-1862
ISSN
  • 0301-4851 (ISSN-L)
  • 1573-4978
DOI
10.1007/s11033-018-4331-4
PMC
PMC6267235
OpenAlex
W2889375728
Cited by
23
References
48
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 3
FWCI
1.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Biology Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • CGSPace A Repository of Agricultural Research Outputs (Consultative Group for International Agricultural Research) (submittedVersion, cc-by)
Funders
  • Africa Biosciences Challenge Fund (BS01KEBMG014BMG014006ABC178)
  • Pan African University University Scholarship (MB400-004)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Milk Quality and Mastitis in Dairy Cows
Keywords
milk fatty acid composition, stearoyl-CoA desaturase, acyl-CoA:diacylglycerol acyltransferase, unsaturation index, Borgou cattle, White Fulani cattle, indigenous cattle breeds, genetic markers, linoleic acid, oleic acid, saturated fatty acids, monounsaturated fatty acids
MeSH terms
Alleles, Animals, Breeding, Cattle, Fatty Acids, Female, Gene Frequency, Genetic Markers, Genotype, Milk, Phenotype, Polymorphism, Genetic, Stearoyl-CoA Desaturase, Genetic Variation, Diacylglycerol O-Acyltransferase

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