The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications
Open accessAbstract
The chitosan-coated magnetic nanoparticles (CS MNPs) were in situ synthesized by cross-linking method. In this method; during the adsorption of cationic chitosan molecules onto the surface of anionic magnetic nanoparticles (MNPs) with electrostatic interactions, tripolyphosphate (TPP) is added for ionic cross-linking of the chitosan molecules with each other. The characterization of synthesized nanoparticles was performed by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS/ESCA), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS), thermal gravimetric analysis (TGA), and vibrating sample magnetometry (VSM) analyses. The XRD and XPS analyses proved that the synthesized iron oxide was magnetite (Fe3O4). The layer of chitosan on the magnetite surface was confirmed by FTIR. TEM results demonstrated a spherical morphology. In the synthesis, at higher NH4OH concentrations, smaller sized nanoparticles were obtained. The average diameters were generally between 2 and 8 nm for CS MNPs in TEM and between 58 and 103 nm in DLS. The average diameters of bare MNPs were found as around 18 nm both in TEM and DLS. TGA results indicated that the chitosan content of CS MNPs were between 15 and 23 % by weight. Bare and CS MNPs were superparamagnetic. These nanoparticles were found non-cytotoxic on cancer cell lines (SiHa, HeLa). The synthesized MNPs have many potential applications in biomedicine including targeted drug delivery, magnetic resonance imaging (MRI), and magnetic hyperthermia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Encyclopedia of Analytical Chemistry: Applications, Theory and Instrumentation
(2006) · Wiley eBooks · doi:10.1002/9780470027318 · Cited by 7,403
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
Interpretation of Infrared Spectra, A Practical Approach
Coates, J. (2000) · Encyclopedia of Analytical Chemistry · doi:10.1002/9780470027318.a5606 · Cited by 4,411
Recent advances on chitosan-based micro- and nanoparticles in drug delivery
Agnihotri, S. A., Mallikarjuna, N. N., & Aminabhavi, T. M. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.010 · Cited by 2,586
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging
Veiseh, O., Gunn, J. W., & Zhang, M. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.002 · Cited by 1,832
Magnetic nanoparticle design for medical diagnosis and therapy
Mornet, S., Vasseur, S., Grasset, F., & Duguet, E. (2004) · Journal of Materials Chemistry · doi:10.1039/b402025a · Cited by 1,745
Neuberger, T., Schöpf, B., Hofmann, H., Hofmann, M., & von Rechenberg, B. (2005) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2005.01.064 · Cited by 1,728
Recent advances in iron oxide nanocrystal technology for medical imaging☆
COROT, C., ROBERT, P., IDEE, J., & PORT, M. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.013 · Cited by 1,465
Maaz, K., Mumtaz, A., Hasanain, S. K., & Ceylan, A. (2007) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2006.06.003 · Cited by 972
Cited by
Synthesis, characterization, applications, and challenges of iron oxide nanoparticles
Ali, A., Zafar, H., Zia, M., ul Haq, I., Phull, A. R., Ali, J. S., & Hussain, A. (2016) · Nanotechnology, Science and Applications · doi:10.2147/nsa.s99986 · Cited by 1,591
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interface
Arakha, M., Pal, S., Samantarrai, D., Panigrahi, T. K., Mallick, B. C., Pramanik, K., Mallick, B., & Jha, S. (2015) · Scientific Reports · doi:10.1038/srep14813 · Cited by 804
Rajput, S., Pittman, C. U., & Mohan, D. (2016) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2015.12.008 · Cited by 746
Ali, A., Shah, T., Ullah, R., Zhou, P., Guo, M., Ovais, M., Tan, Z., & Rui, Y. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.629054 · Cited by 650
Metadata
- Authors
- Unsoy, G., Yalcin, S., Khodadust, R., Gunduz, G., & Gunduz, U.
- Venue
- Journal of Nanoparticle Research
- Published
- 2012-10-06
- Volume
- 14
- Issue
- 11
- ISSN
- 1388-0764 (ISSN-L)
- 1572-896X
- OpenAlex
- W2017456485
- Cited by
- 354
- References
- 42
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications. https://app.cochat.ai/papers/10.1007/s11051-012-0964-8
- The paper
- Unsoy, G., Yalcin, S., Khodadust, R., Gunduz, G., & Gunduz, U. (2012). Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications. Journal of Nanoparticle Research. https://doi.org/10.1007/s11051-012-0964-8
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
