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Cited by 206Characterization and Applications of Magnetic NanoparticlesMagnetic Properties and Synthesis of FerritesNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

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Bloemen, Maarten, Brullot, Ward, Luong, Tai Thien, Geukens, Nick, Gils, Ann, Verbiest, Thierry·2012·Journal of Nanoparticle Research
DOI 10.1007/s11051-012-1100-5PMC PMC3460177
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Abstract

Superparamagnetic iron oxide nanoparticles can provide multiple benefits for biomedical applications in aqueous environments such as magnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles' surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality water-dispersible nanoparticles around 10 nm in size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11051-012-1100-5) contains supplementary material, which is available to authorized users.

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Figures

Fig. 1 Overview of the chemical reactions during the functionalization of iron oxide nanoparticles with silanes. The formation of the silanol molecule occurs by reaction with water. Subsequent polycondensation renders a silane network on the surface of the nanoparticle
Fig. 1 Overview of the chemical reactions during the functionalization of iron oxide nanoparticles with silanes. The formation of the silanol molecule occurs by reaction with water. Subsequent polycondensation renders a silane network on the surface of the nanoparticleCC BY · PubMed Central
Fig. 2 Transmission electron microscopy image of oleic acid-stabilized iron oxide nanoparticles. The scale bar represents 20 nm. The inset shows the size distribution: 9.3 ± 1.6 nm
Fig. 2 Transmission electron microscopy image of oleic acid-stabilized iron oxide nanoparticles. The scale bar represents 20 nm. The inset shows the size distribution: 9.3 ± 1.6 nmCC BY · PubMed Central
Fig. 3 Vibrating sample magnetometry signal of the nanoparticles showing a hysteresis curve. The data points are fitted by a Langevin function to determine the magnetic core size
Fig. 3 Vibrating sample magnetometry signal of the nanoparticles showing a hysteresis curve. The data points are fitted by a Langevin function to determine the magnetic core sizeCC BY · PubMed Central
Fig. 4 X-ray powder diffraction spectrum of the oleic acid-coated iron oxide nanoparticles. The solid and dashed vertical drop-down lines represent the peak positions of a reference magnetite and maghemite spectrum, respectively (AMCSD 0007824 and 0007899)
Fig. 4 X-ray powder diffraction spectrum of the oleic acid-coated iron oxide nanoparticles. The solid and dashed vertical drop-down lines represent the peak positions of a reference magnetite and maghemite spectrum, respectively (AMCSD 0007824 and 0007899)CC BY · PubMed Central
Fig. 5 Zeta potential values for PEG-, carboxylic acid-, and amine-coated nanoparticles in various pH solutions. Every data point was derived from 10 measurements by the software
Fig. 5 Zeta potential values for PEG-, carboxylic acid-, and amine-coated nanoparticles in various pH solutions. Every data point was derived from 10 measurements by the softwareCC BY · PubMed Central

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Research works printed but not linked: 1

  1. Sun J, Zhou S, Hou P, Yang Y (2006) Synthesis and characterization of biocompatible Fe3O4 nanoparticles. J Biomed Mater Res, pp 333–341. doi: 10.1002/jbm.a · DOI

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Metadata

Authors
Bloemen, M., Brullot, W., Luong, T. T., Geukens, N., Gils, A., & Verbiest, T.
Affiliations
KU Leuven (BE)
Corresponding author
Bloemen, Maarten
ORCID
Venue
Journal of Nanoparticle Research
Publisher
Springer Science and Business Media LLC
Published
2012-08-07
Volume
14
Issue
9
Pages
1100-1100
ISSN
  • 1388-0764 (ISSN-L)
  • 1572-896X
DOI
10.1007/s11051-012-1100-5
PMC
PMC3460177
OpenAlex
W2008890153
Cited by
206
References
40
Citations by year
2026: 8 · 2025: 12 · 2024: 10 · 2023: 15 · 2022: 13 · 2021: 18 · 2020: 19 · 2019: 14 · 2018: 14 · 2017: 24 · 2016: 25 · 2015: 16 · 2014: 14 · 2013: 4
FWCI
6.20
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Nanoparticle Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion, other-oa)
Funders
  • Fonds Wetenschappelijk Onderzoek
  • KU Leuven
  • Vlaamse regering
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
superparamagnetic iron oxide nanoparticles, oleic acid coating, surface functionalization, sonication, colloidal stability, polyethylene glycol, carboxylic acids, amines, sulfhydryl groups, magnetic separation, magnetic resonance imaging, water-dispersible nanoparticles

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