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Cited by 459Characterization and Applications of Magnetic NanoparticlesUltrasound and Hyperthermia ApplicationsNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma

Jordan, Andreas, Scholz, Regina, Maier-Hauff, Klaus, van Landeghem, Frank K.H., Waldoefner, Norbert, Teichgraeber, Ulf, Pinkernelle, Jens, Bruhn, Harald, Neumann, Fabian, Thiesen, Burghard, von Deimling, Andreas, Felix, Roland·2006·Journal of Neuro-Oncology
DOI 10.1007/s11060-005-9059-z
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Abstract

Thermotherapy using magnetic nanoparticles is a new technique for interstitial hyperthermia and thermoablation based on magnetic field-induced excitation of biocompatible superparamagnetic nanoparticles. To evaluate the potential of this technique for minimally invasive treatment, we carried out a systematic analysis of its effects on experimental glioblastoma multiforme in a rat tumor model. Tumors were induced by implantation of RG-2-cells into the brains of 120 male Fisher rats. Animals were randomly allocated to 10 groups of 12 rats each, including controls. Animals received two thermotherapy treatments following a single intratumoral injection of two different magnetic fluids (dextran- or aminosilane-coated iron-oxide nanoparticles). Treatment was carried out on days four and six after tumor induction using an alternating magnetic field applicator system operating at a frequency of 100 kHz and variable field strength of 0-18 kA/m. The effectiveness of treatment was determined by the survival time of the animals and histopathological examinations of the brain and the tumor.Thermotherapy with aminosilane-coated nanoparticles led up to 4.5-fold prolongation of survival over controls, while the dextran-coated particles did not indicate any advantage. Intratumoral deposition of the aminosilane-coated particles was found to be stable, allowing for serial thermotherapy treatments without repeated injection. Histological and immunohistochemical examinations after treatment revealed large necrotic areas close to particle deposits, a decreased proliferation rate and a reactive astrogliosis adjacent to the tumor.Thus, localized interstitial thermotherapy with magnetic nanoparticles has an antitumoral effect on malignant brain tumors. This method is suitable for clinical use and may be a novel strategy for treating malignant glioma, which cannot be treated successfully today. The optimal treatment schedules and potential combinations with other therapies need to be defined in further studies.

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Metadata

Authors
Jordan, A., Scholz, R., Maier-Hauff, K., van Landeghem, F. K. H., Waldoefner, N., Teichgraeber, U., Pinkernelle, J., Bruhn, H., Neumann, F., Thiesen, B., von Deimling, A., & Felix, R.
Affiliations
Charité – Universitätsmedizin Berlin (DE)
Corresponding author
Jordan, Andreas
ORCID
Bruhn, Harald
Venue
Journal of Neuro-Oncology
Publisher
Springer Science and Business Media LLC
Published
2005-11-29
Volume
78
Issue
1
Pages
7-14
ISSN
  • 0167-594X (ISSN-L)
  • 1573-7373
DOI
10.1007/s11060-005-9059-z
OpenAlex
W2093807603
Cited by
459
References
23
Citations by year
2026: 5 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 19 · 2021: 30 · 2020: 23 · 2019: 20 · 2018: 31 · 2017: 30 · 2016: 20 · 2015: 28 · 2014: 32 · 2013: 29 · 2012: 28
FWCI
10.36
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Neuro-Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
European Regional Development Fund
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
magnetic nanoparticles, heat therapy, glioblastoma, high-grade glioma, interstitial hyperthermia, thermal ablation, superparamagnetic iron oxide nanoparticles, dextran-coated nanoparticles, alternating magnetic field, intratumoral injection, tumor necrosis, astrocyte activation, rat tumor model, survival
MeSH terms
Animals, Brain Neoplasms, Glioma, Hyperthermia, Induced, Immunohistochemistry, Magnetic Resonance Imaging, Magnetics, Male, Rats, Inbred F344, Survival Analysis, Nanostructures, Rats

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