Cited by 459Characterization and Applications of Magnetic NanoparticlesUltrasound and Hyperthermia ApplicationsNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma

Jordan, Andreas, Scholz, Regina, Maier-Hauff, Klaus, van Landeghem, Frank K.H., Waldoefner, Norbert, Teichgraeber, Ulf, Pinkernelle, Jens, Bruhn, Harald, Neumann, Fabian, Thiesen, Burghard, von Deimling, Andreas, Felix, Roland·2006·Journal of Neuro-Oncology

DOI 10.1007/s11060-005-9059-z

Open this paper in CoChat — free account

Abstract

Thermotherapy using magnetic nanoparticles is a new technique for interstitial hyperthermia and thermoablation based on magnetic field-induced excitation of biocompatible superparamagnetic nanoparticles. To evaluate the potential of this technique for minimally invasive treatment, we carried out a systematic analysis of its effects on experimental glioblastoma multiforme in a rat tumor model. Tumors were induced by implantation of RG-2-cells into the brains of 120 male Fisher rats. Animals were randomly allocated to 10 groups of 12 rats each, including controls. Animals received two thermotherapy treatments following a single intratumoral injection of two different magnetic fluids (dextran- or aminosilane-coated iron-oxide nanoparticles). Treatment was carried out on days four and six after tumor induction using an alternating magnetic field applicator system operating at a frequency of 100 kHz and variable field strength of 0-18 kA/m. The effectiveness of treatment was determined by the survival time of the animals and histopathological examinations of the brain and the tumor.Thermotherapy with aminosilane-coated nanoparticles led up to 4.5-fold prolongation of survival over controls, while the dextran-coated particles did not indicate any advantage. Intratumoral deposition of the aminosilane-coated particles was found to be stable, allowing for serial thermotherapy treatments without repeated injection. Histological and immunohistochemical examinations after treatment revealed large necrotic areas close to particle deposits, a decreased proliferation rate and a reactive astrogliosis adjacent to the tumor.Thus, localized interstitial thermotherapy with magnetic nanoparticles has an antitumoral effect on malignant brain tumors. This method is suitable for clinical use and may be a novel strategy for treating malignant glioma, which cannot be treated successfully today. The optimal treatment schedules and potential combinations with other therapies need to be defined in further studies.

Integrity signals

Registry

Crossref · 10.1007/s11060-005-9059-z

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043330 · Cited by 21,807
Hyperthermia in combined treatment of cancer
Wust, P., Hildebrandt, B., Sreenivasa, G., Rau, B., Gellermann, J., Riess, H. B., FELIX, R., & Schlag, P. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00818-5 · Cited by 2,002
Self-citation
The cellular and molecular basis of hyperthermia
Hildebrandt, B. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00179-2 · Cited by 1,714
Clinical hyperthermia of prostate cancer using magnetic nanoparticles: Presentation of a new interstitial technique
Johannsen, M., Gneveckow, U., Eckelt, L., Feussner, A., Waldöfner, N., Scholz, R., Değer, S., Wust, P., Loening, S. A., & Jordan, A. (2005) · International Journal of Hyperthermia · doi:10.1080/02656730500158360 · Cited by 802
Self-citation
Inductive heating of ferrimagnetic particles and magnetic fluids: Physical evaluation of their potential for hyperthermia
Jordan, A., Wust, P., Fählin, H., John, W., Hinz, A., & FELIX, R. (1993) · International Journal of Hyperthermia · doi:10.3109/02656739309061478 · Cited by 694
Self-citation
Magnetically mediated hyperthermia: current status and future directions
Moroz, P., Jones, S. K., & Gray, B. N. (2002) · International Journal of Hyperthermia · doi:10.1080/02656730110108785 · Cited by 538
Endocytosis of dextran and silan-coated magnetite nanoparticles and the effect of intracellular hyperthermia on human mammary carcinoma cells in vitro
Jordan, A., Scholz, R., Wust, P., Schirra, H., Schiestel, T., Schmidt, H., & Felix, R. (1999) · Journal of Magnetism and Magnetic Materials · doi:10.1016/s0304-8853(98)00558-7 · Cited by 521
Self-citation
Rat brain tumor models in experimental neuro-oncology:The 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 Gliomas
Barth, R. F. (1998) · Journal of Neuro-Oncology · doi:10.1023/a:1005805203044 · Cited by 358
Effects of Magnetic Fluid Hyperthermia (MFH) on C3H mammary carcinomain vivo
Jordan, A., Scholz, R., Wust, P., Fähling, H., Krause, J., Wlodarczyk, W., Sander, B., Vogl, T., & FELIX, R. (1997) · International Journal of Hyperthermia · doi:10.3109/02656739709023559 · Cited by 325
Self-citation
Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: An in vivo Study
Yanase, M., Shinkai, M., Honda, H., Wakabayashi, T., Yoshida, J., & Kobayashi, T. (1998) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1998.tb00586.x · Cited by 322

Show all 23 references

Sorted by citations

Nanoparticles in Medicine: Therapeutic Applications and Developments
Zhang, L., Gu, F., Chan, J. M., Wang, A. Z., Langer, R., & Farokhzad, O. C. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100400 · Cited by 2,685
Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications
Reddy, L. H., Arias, J. L., Nicolas, J., & Couvreur, P. (2012) · Chemical Reviews · doi:10.1021/cr300068p · Cited by 2,010
Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme
Maier-Hauff, K., Ulrich, F., Nestler, D., Niehoff, H., Wust, P., Thiesen, B., Orawa, H., Budach, V., & Jordan, A. (2010) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0389-0 · Cited by 1,504
Self-citation
Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications
Rasmussen, J. W., Martinez, E., Louka, P., & Wingett, D. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2010.502560 · Cited by 1,366
Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles
Laurent, S., Dutz, S., Häfeli, U. O., & Mahmoudi, M. (2011) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2011.04.003 · Cited by 1,326
Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
Cheng, Z., Zaki, A. A., Hui, J. Z., Muzykantov, V. R., & Tsourkas, A. (2012) · Science · doi:10.1126/science.1226338 · Cited by 1,341
Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities
Kabanov, A. V., & Vinogradov, S. V. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900441 · Cited by 1,320
Biological applications of magnetic nanoparticles
Colombo, M., Carregal‐Romero, S., Casula, M. F., Gutiérrez, L., Morales, M. P., Böhm, I., Heverhagen, J. T., Prosperi, D., & Parak, W. J. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15337h · Cited by 1,340
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Assessment of the Evolution of Cancer Treatment Therapies
Arruebo, M., Vilaboa, N. E., Sáez, B., Lambea, J., Tres, A., Valladares, M., & González‐Fernández, Á. (2011) · Cancers · doi:10.3390/cancers3033279 · Cited by 932
Clinical applications of magnetic nanoparticles for hyperthermia
Thiesen, B., & Jordan, A. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730802104757 · Cited by 829
Self-citation
Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme
Maier-Hauff, K., Rothe, R., Scholz, R., Gneveckow, U., Wust, P., Thiesen, B., Feussner, A., von Deimling, A., Waldöfner, N., Felix, R., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9195-0 · Cited by 772
Self-citation
Targeted pharmaceutical nanocarriers for cancer therapy and imaging
Torchilin, V. P. (2007) · The AAPS Journal · doi:10.1208/aapsj0902015 · Cited by 771
Surface Engineering of Iron Oxide Nanoparticles for Targeted Cancer Therapy
Kievit, F. M., & Zhang, M. (2011) · Accounts of Chemical Research · doi:10.1021/ar2000277 · Cited by 606
Nanooncology: The future of cancer diagnosis and therapy
Thakor, A. S., & Gambhir, S. S. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21199 · Cited by 602
Nanotechnology in hyperthermia cancer therapy: From fundamental principles to advanced applications
Beik, J., Abed, Z., Ghoreishi, F. S., Hosseini-Nami, S., Mehrzadi, S., Shakeri‐Zadeh, A., & Kamrava, S. K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.062 · Cited by 581
Applications and potential toxicity of magnetic iron oxide nanoparticles
Liu, G., Gao, J., Ai, H., & Chen, X. (2013) · Small · doi:10.1002/smll.201201531 · Cited by 570
Thermotherapy of Prostate Cancer Using Magnetic Nanoparticles: Feasibility, Imaging, and Three-Dimensional Temperature Distribution
Johannsen, M., Gneveckow, U., Thiesen, B., Taymoorian, K., Cho, C. H., Waldöfner, N., Scholz, R., Jordan, A., Loening, S. A., & Wust, P. (2006) · European Urology · doi:10.1016/j.eururo.2006.11.023 · Cited by 531
Self-citation
Nanomaterials for Neural Interfaces
Kotov, N. A., Winter, J. O., Clements, I. P., Jan, E., Timko, B. P., Campidelli, S., Pathak, S., Mazzatenta, A., Lieber, C. M., Prato, M., et al. (2009) · Advanced Materials · doi:10.1002/adma.200801984 · Cited by 504
Cancer Nanotheranostics: Improving Imaging and Therapy by Targeted Delivery Across Biological Barriers
Kievit, F. M., & Zhang, M. (2011) · Advanced Materials · doi:10.1002/adma.201102313 · Cited by 504
From iron oxide nanoparticles towards advanced iron-based inorganic materials designed for biomedical applications
Figuerola, A., Di Corato, R., Manna, L., & Pellegrino, T. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2009.12.012 · Cited by 480
Magnetic nanoparticle hyperthermia for prostate cancer
Johannsen, M., Thiesen, B., Wust, P., & Jordan, A. (2010) · International Journal of Hyperthermia · doi:10.3109/02656731003745740 · Cited by 474
Self-citation
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Shin, D. (2008) · International Journal of Nanomedicine · doi:10.2147/ijn.s2824 · Cited by 467
Magnetic Nanoparticles in Cancer Theranostics
Gobbo, O. L., Sjaastad, K., Radomski, M. W., Volkov, Y., & Prina‐Mello, A. (2015) · Theranostics · doi:10.7150/thno.11544 · Cited by 462
Magnetic Particle Imaging-Guided Heating in Vivo Using Gradient Fields for Arbitrary Localization of Magnetic Hyperthermia Therapy
Tay, Z. W., Chandrasekharan, P., Chiu-Lam, A., Hensley, D. W., Dhavalikar, R., Zhou, X. Y., Yu, E. Y., Goodwill, P. W., Zheng, B., Rinaldi, C., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b00893 · Cited by 459
Recent advances in superparamagnetic iron oxide nanoparticles (SPIONs) for in vitro and in vivo cancer nanotheranostics
Kandasamy, G., & Maity, D. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.10.058 · Cited by 433
Nanoparticles and cancer therapy: Perspectives for application of nanoparticles in the treatment of cancers
Aghebati‐Maleki, A., Dolati, S., Ahmadi, M., Baghbanzhadeh, A., Asadi, M., Fotouhi, A., Yousefi, M., & Maleki, L. A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29126 · Cited by 437
EGFRvIII Antibody–Conjugated Iron Oxide Nanoparticles for Magnetic Resonance Imaging–Guided Convection-Enhanced Delivery and Targeted Therapy of Glioblastoma
Hadjipanayis, C. G., Machaidze, R., Kaluzová, M., Wang, L., Schuette, A. J., Chen, H., Wu, X., & Mao, H. Z. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1022 · Cited by 428
Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans
Mahmoudi, K., Bouras, A., Bozec, D., Ivkov, R., & Hadjipanayis, C. G. (2018) · International Journal of Hyperthermia · doi:10.1080/02656736.2018.1430867 · Cited by 417
Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies
Soetaert, F., Korangath, P. C., Serantes, D., Fiering, S., & Ivkov, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.025 · Cited by 418
Physics of heat generation using magnetic nanoparticles for hyperthermia
Dennis, C. L., & Ivkov, R. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.836758 · Cited by 390
Nanoparticles for Radiation Therapy Enhancement: the Key Parameters
Retif, P., Pinel, S., Toussaint, M., Frochot, C., Chouikrat, R., Bastogne, T., & Barberi‐Heyob, M. (2015) · Theranostics · doi:10.7150/thno.11642 · Cited by 383
Post-mortem studies in glioblastoma patients treated with thermotherapy using magnetic nanoparticles
van Landeghem, F. K. H., Maier-Hauff, K., Jordan, A., Hoffmann, K., Gneveckow, U., Scholz, R., Thiesen, B., Brück, W., & von Deimling, A. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.044 · Cited by 354
Self-citation
Multifunctional nanoparticles for brain tumor imaging and therapy
Cheng, Y., Morshed, R. A., Auffinger, B., Tobias, A. L., & Lesniak, M. S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.006 · Cited by 359
Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity
Ajdary, M., Moosavi, M. A., Rahmati, M., Falahati, M., Mahboubi, M., Mandegary, A., Jangjoo, S., Mohammadinejad, R., & Varma, R. S. (2018) · Nanomaterials · doi:10.3390/nano8090634 · Cited by 358
Preparation and properties of magnetic nano‐ and microsized particles for biological and environmental separations
Horák, D., Babič, M., Macková, H., & Beneš, M. J. (2007) · Journal of Separation Science · doi:10.1002/jssc.200700088 · Cited by 342
EGFR-Targeted Magnetic Nanoparticle Heaters Kill Cancer Cells without a Perceptible Temperature Rise
Creixell, M., Bohórquez, A. C., Torres‐Lugo, M., & Rinaldi, C. (2011) · ACS Nano · doi:10.1021/nn201822b · Cited by 329
Nanoparticles: Functionalization and Multifunctional Applications in Biomedical Sciences
Subbiah, R., Veerapandian, M., & Yun, K. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710794183024 · Cited by 331
Nanosystems: the use of nanoalloys, metallic, bimetallic, and magnetic nanoparticles in biomedical applications
McNamara, K., & Tofail, S. A. M. (2015) · Physical Chemistry Chemical Physics · doi:10.1039/c5cp00831j · Cited by 315
Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting
Cole, A. J., David, A. E., Wang, J., Galbán, C. J., Hill, H. L., & Yang, V. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.11.040 · Cited by 308
Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy
Alphandéry, E., Faure, S., Seksek, O., Guyot, F., & Chebbi, I. (2011) · ACS Nano · doi:10.1021/nn201290k · Cited by 306
Application of hyperthermia induced by superparamagnetic iron oxide nanoparticles in glioma treatment
Gamarra, L. F., Silva, A. C., de Oliveira, T. R., Mamani, J. B., Malheiros, S. M. F., Malavolta, L., Pavon, L. F., Sibov, T. T., Amaro, E., & Gamarra, L. F. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s14737 · Cited by 298
Magnetic nanoparticles for interstitial thermotherapy – feasibility, tolerance and achieved temperatures
Wust, P., Gneveckow, U., Wust, P., Gneveckow, U., Johannsen, M., Böhmer, D., Henkel, T. O., Kahmann, F., Sehouli, J., FELIX, R., et al. (2006) · International Journal of Hyperthermia · doi:10.1080/02656730601106037 · Cited by 295
Self-citation
Drug loaded magnetic nanoparticles for cancer therapy
Jurgons, R., Seliger, C., Hilpert, A., Trahms, L., Odenbach, S., & Alexiou, C. (2006) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/18/38/s24 · Cited by 282
Magnetic (Hyper)Thermia or Photothermia? Progressive Comparison of Iron Oxide and Gold Nanoparticles Heating in Water, in Cells, and In Vivo
Espinosa, A., Kolosnjaj‐Tabi, J., Abou‐Hassan, A., Sangnier, A. P., Curcio, A., Silva, A., Corato, R. D., Neveu, S., Pellegrino, T., Liz‐Marzán, L. M., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201803660 · Cited by 285
Magnetic fluid hyperthermia: Advances, challenges, and opportunity
Kozissnik, B., Bohórquez, A. C., Dobson, J., & Rinaldi, C. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.837200 · Cited by 275
Inorganic nanomaterials for bioimaging, targeted drug delivery and therapeutics
Liang, R., Wei, M., Evans, D. G., & Duan, X. (2014) · Chemical Communications · doi:10.1039/c4cc03118k · Cited by 268
Nanoparticles for Thermal Cancer Therapy
Day, E. S., Morton, J. G., & West, J. L. (2009) · Journal of Biomechanical Engineering · doi:10.1115/1.3156800 · Cited by 263
Water-Dispersible Sugar-Coated Iron Oxide Nanoparticles. An Evaluation of their Relaxometric and Magnetic Hyperthermia Properties
Lartigue, L., Innocenti, C., Thangavel, K., Awwad, A., Duque, M. D. M. S., Guari≠, Y., Larionova≠, J., Guérin, C., Montero, J., Barragan‐Montero, V., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja111448t · Cited by 270
Optimizing Magnetic Nanoparticle Design for Nanothermotherapy
Gazeau, F., Lévy, M., & Wilhelm, C. (2008) · Nanomedicine · doi:10.2217/17435889.3.6.831 · Cited by 256
Magnetic iron oxide nanoparticles for brain imaging and drug delivery
Qiao, R., Fu, C., Forgham, H., Javed, I., Huang, X., Zhu, J., Whittaker, A. K., & Davis, T. P. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114822 · Cited by 257
Nanoparticles aggravate heat stress induced cognitive deficits, blood–brain barrier disruption, edema formation and brain pathology
SHARMA, H. S., & Sharma, A. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)62013-x · Cited by 248
A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study
Balivada, S., Rachakatla, R. S., Wang, H., Samarakoon, T., Dani, R. K., Pyle, M. M., Kroh, F. O., Walker, B., Leaym, X., Koper, O., et al. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-119 · Cited by 238
Structural Investigation of MFe2O4 (M = Fe, Co) Magnetic Fluids
Jacintho, G. V. M., Brolo, A. G., Cório, P., Suarez, P. A. Z., & Rubim, J. C. (2009) · The Journal of Physical Chemistry C · doi:10.1021/jp9013477 · Cited by 232
Superparamagnetic iron oxide nanoparticulate system: synthesis, targeting, drug delivery and therapy in cancer
Palanisamy, S., & Wang, Y.-M. (2019) · Dalton Transactions · doi:10.1039/c9dt00459a · Cited by 230
Controlling nanoparticle delivery in magnetic nanoparticle hyperthermia for cancer treatment: Experimental study in agarose gel
Salloum, M., Ma, R., Weeks, D., & Zhu, L. K. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730801907937 · Cited by 226
Magnetic nanofluids (Ferrofluids): Recent advances, applications, challenges, and future directions
Philip, J. (2022) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2022.102810 · Cited by 233
Multifunctional superparamagnetic iron oxide nanoparticles: design, synthesis and biomedical photonic applications
Zhang, L., Dong, W., & Sun, H. (2013) · Nanoscale · doi:10.1039/c3nr01616a · Cited by 215
Review on magnetic nanoparticle-mediated hyperthermia for cancer therapy
Arunima Rajan, S., & Sahu, N. K. (2020) · Journal of Nanoparticle Research · doi:10.1007/s11051-020-05045-9 · Cited by 214
Combined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients
Grauer, O. M., Jaber, M., Heß, K., Weckesser, M., Schwindt, W., Maring, S., Wölfer, J., & Stummer, W. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-03005-x · Cited by 186
Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †
Spirou, S. V., Basini, M., Lascialfari, A., Sangregorio, C., & Innocenti, C. (2018) · Nanomaterials · doi:10.3390/nano8060401 · Cited by 179
Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy
Contreras‐Cáceres, R., Cabeza, L., Perazzoli, G., Díaz, A., López‐Romero, J. M., Melguizo, C., & Prados, J. C. (2019) · Nanomaterials · doi:10.3390/nano9040656 · Cited by 173
Nanotechnology based approaches in cancer therapeutics
Biswas, A. K., Islam, M. R., Choudhury, Z. S., Mostafa, A., & Kadir, M. F. (2014) · Advances in Natural Sciences Nanoscience and Nanotechnology · doi:10.1088/2043-6262/5/4/043001 · Cited by 165
Iron and manganese based magnetocaloric materials for near room temperature thermal management
Chaudhary, V., Chen, X., & Ramanujan, R. V. (2018) · Progress in Materials Science · doi:10.1016/j.pmatsci.2018.09.005 · Cited by 161
Combining magnetic particle imaging and magnetic fluid hyperthermia in a theranostic platform
Hensley, D. W., Tay, Z. W., Dhavalikar, R., Zheng, B., Goodwill, P. W., Rinaldi, C., & Conolly, S. (2016) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aa5601 · Cited by 152
Nanoshell-mediated photothermal therapy improves survival in a murine glioma model
Day, E. S., Thompson, P. A., Zhang, L., Lewinski, N. A., Ahmed, N. M., Drezek, R. A., Blaney, S. M., & West, J. L. (2010) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0470-8 · Cited by 148
Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy
Ittrich, H., Peldschus, K., Raabe, N., Kaul, M. G., & Adam, G. (2013) · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · doi:10.1055/s-0033-1335438 · Cited by 149
3D-printed bioceramic scaffolds with a Fe 3 O 4 /graphene oxide nanocomposite interface for hyperthermia therapy of bone tumor cells
Zhang, Y., Zhai, D., Xu, M., Yao, Q., Chang, J., & Wu, C. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb00390g · Cited by 141
Magnetic nanoparticles: an emerging technology for malignant brain tumor imaging and therapy
Wankhede, M., Bouras, A., Kaluzová, M., & Hadjipanayis, C. G. (2012) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.12.1 · Cited by 139
Applications of Nanoparticles for MRI Cancer Diagnosis and Therapy
Błasiak, B., van Veggel, F. C. J. M., & Tomanek, B. (2013) · Journal of Nanomaterials · doi:10.1155/2013/148578 · Cited by 138
Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model
Basel, M. T., Balivada, S., Wang, Shrestha, Seo, Pyle, Ayabaweera, Dani, R. K., Koper, Tamura, M., et al. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s28344 · Cited by 137
Magnetic Nanoparticle Targeted Hyperthermia of Cutaneous Staphylococcus aureus Infection
Kim, M.-H., Yamayoshi, I., Mathew, S., Lin, H., Nayfach, J., & Simon, S. I. (2013) · Annals of Biomedical Engineering · doi:10.1007/s10439-012-0698-x · Cited by 135
Iron oxide nanoparticles: synthesis, functionalization, and applications in diagnosis and treatment of cancer
Hernández-Hernandez, A. A., Aguirre‐Álvarez, G., Cariño‐Cortés, R., Mendoza-Huízar, L. H., & Jiménez-Alvarado, R. (2020) · Chemical Papers · doi:10.1007/s11696-020-01229-8 · Cited by 138
Nanoparticles for Imaging and Treating Brain Cancer
Meyers, J. D., Doane, T. L., Burda, C., & Basilion, J. P. (2012) · Nanomedicine · doi:10.2217/nnm.12.185 · Cited by 135
Superparamagnetic iron oxide nanoparticles: promises for diagnosis and treatment of cancer.
Laurent, S., & Mahmoudi, M. (2011) · PubMed Central · Cited by 130
Magnetic Fluid Hyperthermia Based on Magnetic Nanoparticles: Physical Characteristics, Historical Perspective, Clinical Trials, Technological Challenges, and Recent Advances
Etemadi, H., & Plieger, P. G. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000061 · Cited by 132
One-pot preparation of hyaluronic acid‐coated iron oxide nanoparticles for magnetic hyperthermia therapy and targeting CD44-overexpressing cancer cells
Soleymani, M., Velashjerdi, M., Shaterabadi, Z., & Barati, A. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116130 · Cited by 128
Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma
Lal, S., Verma, J., & Noorden, C. J. F. V. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s57501 · Cited by 129
Magnetic Nanoparticles: From Synthesis to Theranostic Applications
Khizar, S., Ahmad, N. M., Zine, N., Jaffrezic-Renault, N. J., Errachid, A., & Elaı̈ssari, A. (2021) · ACS Applied Nano Materials · doi:10.1021/acsanm.1c00852 · Cited by 129
Magnetic mesoporous silica spheres for hyperthermia therapy
Martín-Saavedra, F. M., Ruíz-Hernández, E., Boré, A., Arcos, D., Vallet‐Regí, M., & Vilaboa, N. E. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.06.030 · Cited by 126
Magnetic nanoparticles and nanocomposites for remote controlled therapies
Hauser, A. K., Wydra, R. J., Stocke, N. A., Anderson, K. W., & Hilt, J. Z. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.039 · Cited by 125
Treatment of Canine Oral Melanoma with Nanotechnology-Based Immunotherapy and Radiation
Hoopes, P. J., Wagner, R. J., Duval, K. E. A., Kang, K., Gladstone, D. J., Moodie, K. L., Crary-Burney, M., Arias‐Pulido, H., Veliz, F. A., Steinmetz, N. F., et al. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00126 · Cited by 127
Therapeutic Nanomedicine for Brain Cancer
Tzeng, S. Y., & Green, J. J. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.38 · Cited by 124
Processing of Iron Oxide Nanoparticles by Supercritical Fluids
Lam, U. T., Mammucari, R., Suzuki, K., & Foster, N. R. (2008) · Industrial & Engineering Chemistry Research · doi:10.1021/ie070494+ · Cited by 122
Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles
Boros, E., Bowen, A. M., Josephson, L., Vasdev, N., & Holland, J. P. (2014) · Chemical Science · doi:10.1039/c4sc02778g · Cited by 121
Enhanced reduction in cell viability by hyperthermia induced by magnetic nanoparticles
Torres‐Lugo, M., Rodriguez, H. L., Latorre‐Esteves, M., Méndez, J., Soto, O., Rodriguez, A. R., & Rinaldi, C. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s14613 · Cited by 120
Nanoparticles: Novel vehicles in treatment of Glioblastoma
Pourgholi, F., Hajivalili, M., Jadidi‐Niaragh, F., Kafil, H. S., & Yousefi, M. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.12.014 · Cited by 120
Application of iron oxide nanoparticles in glioma imaging and therapy: from bench to bedside
Liu, H., Zhang, J., Chen, X., Du, X., Zhang, J., Liu, G., & Zhang, W. (2016) · Nanoscale · doi:10.1039/c6nr00147e · Cited by 122
A review on hyperthermia via nanoparticle-mediated therapy
Sohail, A., Ahmad, Z., Bég, O. A., Arshad, S., & Sherin, L. (2017) · Bulletin du Cancer · doi:10.1016/j.bulcan.2017.02.003 · Cited by 119
Enhanced antitumor efficacy of biocompatible magnetosomes for the magnetic hyperthermia treatment of glioblastoma
Fèvre, R. L., Durand‐Dubief, M., Chebbi, I., Mandawala, C., Lagroix, F., Valet, J., Idbaïh, A., Adam, C., Delattre, J., Schmitt, C., et al. (2017) · Theranostics · doi:10.7150/thno.18927 · Cited by 123
Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Charge
Dante, S., Petrelli, A., Petrini, E. M., Marotta, R., Maccione, A., Alabastri, A., Quarta, A., Donato, F. D., Ravasenga, T., Sathya, A., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b00397 · Cited by 117
Anin-vivoexperimental study of temperature elevations in animal tissue during magnetic nanoparticle hyperthermia
Salloum, M., Ma, R., & Zhu, L. K. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730802203377 · Cited by 117
Proposal of New Safety Limits for In Vivo Experiments of Magnetic Hyperthermia Antitumor Therapy
de la Parte, B. H., Rodrigo, I., Gutiérrez-Basoa, J., Correcher, S. I., Medina, C. M., Echevarría-Uraga, J. J., García, J. Á., Plazaola, F., & Garcı́a-Alonso, I. (2022) · Cancers · doi:10.3390/cancers14133084 · Cited by 116
Magnetoliposomes: Versatile Innovative Nanocolloids for Use in Biotechnology and Biomedicine
Soenen, S. J., Hodenius, M., & Cuyper, M. D. (2009) · Nanomedicine · doi:10.2217/17435889.4.2.177 · Cited by 113
Effective Elimination of Cancer Stem Cells by Magnetic Hyperthermia
Sadhukha, T., Niu, L., Wiedmann, T. S., & Panyam, J. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400015b · Cited by 114
Nanoparticle-Based Therapies for Wound Biofilm Infection: Opportunities and Challenges
Kim, M. (2016) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2016.2527600 · Cited by 113
Use of bacterial magnetosomes in the magnetic hyperthermia treatment of tumours: A review
Alphandéry, E., Chebbi, I., Guyot, F., & Durand‐Dubief, M. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.821527 · Cited by 110
NanoFerrite Particle Based Radioimmunonanoparticles: Binding Affinity and In Vivo Pharmacokinetics
Natarajan, A., Gruettner, C., Ivkov, R., DeNardo, G. L., Mirick, G. R., Yuan, A., Foreman, A. R., & DeNardo, S. J. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800015n · Cited by 110
Cancer therapy using nanoformulated substances: scientific, regulatory and financial aspects
Alphandéry, E., Grand-Dewyse, P., Lefèvre, R., Mandawala, C., & Durand‐Dubief, M. (2015) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2015.1086647 · Cited by 108
Synthesis of composite magnetic nanoparticles Fe3O4 with alendronate for osteoporosis treatment
Lee, M. S., Su, C.-M., Yeh, J., Wu, P., Tsai, T., & Lou, S.-L. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s112415 · Cited by 110

Authors: Jordan, A., Scholz, R., Maier-Hauff, K., van Landeghem, F. K. H., Waldoefner, N., Teichgraeber, U., Pinkernelle, J., Bruhn, H., Neumann, F., Thiesen, B., von Deimling, A., & Felix, R.
Affiliations: Charité – Universitätsmedizin Berlin (DE)
Corresponding author: Jordan, Andreas
ORCID: Bruhn, Harald
Venue: Journal of Neuro-Oncology
Publisher: Springer Science and Business Media LLC
Published: 2005-11-29
Volume: 78
Issue: 1
Pages: 7-14
ISSN: 0167-594X (ISSN-L)
1573-7373
DOI: 10.1007/s11060-005-9059-z
OpenAlex: W2093807603
Cited by: 459
References: 23
Citations by year: 2026: 5 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 19 · 2021: 30 · 2020: 23 · 2019: 20 · 2018: 31 · 2017: 30 · 2016: 20 · 2015: 28 · 2014: 32 · 2013: 29 · 2012: 28
FWCI: 10.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Neuro-Oncology (publishedVersion)
PubMed (publishedVersion)
Funders: European Regional Development Fund
Topics: Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: magnetic nanoparticles, heat therapy, glioblastoma, high-grade glioma, interstitial hyperthermia, thermal ablation, superparamagnetic iron oxide nanoparticles, dextran-coated nanoparticles, alternating magnetic field, intratumoral injection, tumor necrosis, astrocyte activation, rat tumor model, survival
MeSH terms: Animals, Brain Neoplasms, Glioma, Hyperthermia, Induced, Immunohistochemistry, Magnetic Resonance Imaging, Magnetics, Male, Rats, Inbred F344, Survival Analysis, Nanostructures, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks