Interaction between Aβ Peptide and α Synuclein: Molecular Mechanisms in Overlapping Pathology of Alzheimer’s and Parkinson’s in Dementia with Lewy Body Disease

NMRPipe: A multidimensional spectral processing system based on UNIX pipes

Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., & Bax, A. (1995) · Journal of Biomolecular NMR · doi:10.1007/bf00197809 · Cited by 15,961

α-Synuclein in Lewy bodies

Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop

McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

Piotto, M., Saudek, V., & Sklenář, V. (1992) · Journal of Biomolecular NMR · doi:10.1007/bf02192855 · Cited by 3,720

Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins

Marion, D., & Wüthrich, K. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)91093-8 · Cited by 3,160

University of California, San Francisco

(1974) · Medical History · doi:10.1017/s0025727300019682 · Cited by 2,218

Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease

Zhang, L., Yu, S., Zhang, R., Xing, Y., Li, Y., & Li, L. (2013) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-120260 · Cited by 37

Neuropsychiatric symptoms and α-Synuclein profile of patients with Parkinson’s disease dementia, dementia with Lewy bodies and Alzheimer’s disease

Bougea, A. M., Stefanis, L., Paraskevas, G. P., Emmanouilidou, E., Efthymiopoulou, Ε., Vekrelis, K., & Kapaki, E. N. (2018) · Journal of Neurology · doi:10.1007/s00415-018-8992-7 · Cited by 35

Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease

Kallhoff, V., Peethumnongsin, E., & Zheng, H. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-6 · Cited by 33

Heterotypic interactions in amyloid function and disease

Konstantoulea, K., Louros, N. N., Rousseau, F., & Schymkowitz, J. W. H. (2021) · FEBS Journal · doi:10.1111/febs.15719 · Cited by 34

Cross Dimerization of Amyloid-β and αSynuclein Proteins in Aqueous Environment: A Molecular Dynamics Simulations Study

Jose, J. C., Chatterjee, P., & Sengupta, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106883 · Cited by 32

Effect of α-Synuclein on Amyloid β-Induced Toxicity: Relevance to Lewy Body Variant of Alzheimer Disease

Resende, R., Marques, S., Ferreiro, E. B., Simões, I., Oliveira, C. R., & Pereira, C. (2013) · Neurochemical Research · doi:10.1007/s11064-013-0982-7 · Cited by 31

Seed-Induced Heterogeneous Cross-Seeding Self-Assembly of Human and Rat Islet Polypeptides

Hu, R., Ren, B., Zhang, M., Chen, H., Liu, Y., Liu, L., Gong, X., Jiang, B., Ma, J., & Zheng, J. (2017) · ACS Omega · doi:10.1021/acsomega.6b00559 · Cited by 31

α-Synuclein Aggregation and Modulating Factors

Paleologou, K. E., & El‐Agnaf, O. M. A. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-5416-4_6 · Cited by 33

Neuropathology of Parkinson’s Disease

Jellinger, K. A. (2014) · Springer eBooks · doi:10.1007/978-3-319-08046-8_2 · Cited by 31

Effects of single and combined immunotherapy approach targeting amyloid β protein and α‐synuclein in a dementia with Lewy bodies–like model

Mandler, M., Rockenstein, E. M., Overk, C., Mante, M., Florio, J. B., Adame, A., Kim, C., Santic, R., Schneeberger, A., Mattner, F., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.02.002 · Cited by 29

Pyridine-derived γ-secretase modulators

Wan, Z., Hall, A., Sang, Y., Xiang, J., Yang, E., Smith, B. B., Harrison, D. C., Yang, G. Z., Yu, H., Price, H. S., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.06.042 · Cited by 29

α-Synuclein Aggregated with Tau and β-Amyloid in Human Platelets from Healthy Subjects: Correlation with Physical Exercise

Daniele, S., Pietrobono, D., Fusi, J., Gerfo, A. L., Cerri, E., Chico, L., Iofrida, C., Petrozzi, L., Baldacci, F., Giacomelli, C., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00017 · Cited by 28

Differences in cognitive profiles between Lewy body and Parkinson’s disease dementia

Martini, A., Weis, L., Schifano, R., Pistonesi, F., Fiorenzato, E., Antonini, A., & Biundo, R. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-019-02129-2 · Cited by 28

Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer’s disease neurons

Whiten, D. R., Brownjohn, P. W., Moore, S., De, S., Strano, A., Zuo, Y., Haneklaus, M., Klenerman, D., & Livesey, F. J. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa146 · Cited by 28

α-synuclein-assisted oligomerization of β-amyloid (1–42)

Chau, E., & Kim, J. R. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109120 · Cited by 30

Interactions of amyloid coaggregates with biomolecules and its relevance to neurodegeneration

Murakami, K., & Ono, K. (2022) · The FASEB Journal · doi:10.1096/fj.202200235r · Cited by 28

Is the p3 Peptide (Aβ17-40, Aβ17-42) Relevant to the Pathology of Alzheimer’s Disease?1

Kuhn, A. J., & Raskatov, J. A. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191201 · Cited by 31

High discriminatory ability of peripheral and CFSF biomarkers in Lewy body diseases

Bougea, A. M., Stefanis, L., Emmanouilidou, E., Vekrelis, K., & Kapaki, E. N. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-019-02137-2 · Cited by 27

Catalytic Prion-Like Cross-Talk between a Key Alzheimer’s Disease Tau-Fragment R3 and the Type 2 Diabetes Peptide IAPP

Arya, S., Claud, S. L., Cantrell, K. L., & Bowers, M. T. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00516 · Cited by 27

CSF Amyloid-β Peptides in Neuropathologically Diagnosed Dementia with Lewy Bodies and Alzheimer's Disease

Mollenhauer, B., Esselmann, H., Trenkwalder, C., Schulz‐Schaeffer, W., Kretzschmar, H. A., Otto, M., Wiltfang, J., & Bibl, M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101551 · Cited by 26

The discriminative capacity of CSF β-amyloid 42 and Tau in neurodegenerative diseases in the Chinese population

Ye, L., Li, X., Zhang, Y.-B., Cheng, H.-R., Ma, Y., Chen, D.-F., Tao, Q., Li, H., & Wu, Z. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116756 · Cited by 25

A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5)

Wilkaniec, A., Czapski, G. A., Adamczyk, A., Gajkowska, B., & Strosznajder, J. B. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.11.018 · Cited by 26

High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse

Piccarducci, R., Pietrobono, D., Pellegrini, C., Daniele, S., Fornai, M., Antonioli, L., Trincavelli, M. L., Blandizzi, C., & Martini, C. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5030475 · Cited by 26

Amyloid cross-seeding between Aβ and hIAPP in relation to the pathogenesis of Alzheimer and type 2 diabetes

Zhang, Y., Tang, Y., Zhang, D., Liu, Y., He, J., Chang, Y., & Zheng, J. (2020) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2020.09.033 · Cited by 24

Dual amyloid cross-seeding reveals steric zipper-facilitated fibrillization and pathological links between protein misfolding diseases

Zhang, Y., Zhang, M., Liu, Y., Zhang, D., Tang, Y., Ren, B., & Zheng, J. (2021) · Journal of Materials Chemistry B · doi:10.1039/d0tb02958k · Cited by 26

The Mechanisms of the Roles of α-Synuclein, Amyloid-β, and Tau Protein in the Lewy Body Diseases: Pathogenesis, Early Detection, and Therapeutics

Noguchi‐Shinohara, M., & Ono, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210215 · Cited by 24

Molecular Mechanisms of the Bindings between Non-Amyloid β Component Oligomers and Amylin Oligomers

Atsmon‐Raz, Y., & Miller, Y. (2016) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6b07731 · Cited by 24

The neuropathologic substrate of Parkinson disease dementia

Jellinger, K. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0613-1 · Cited by 27

Amyloid Protein Cross-Seeding Provides a New Perspective on Multiple Diseases In Vivo

Ge, W., Deng, X., Shi, W., Lin, W.-J., Chen, L., Liang, H., Wang, X., Zhang, T., Zhao, F., Guo, W., et al. (2022) · Biomacromolecules · doi:10.1021/acs.biomac.2c01233 · Cited by 24

Interaction between α-synuclein and tau in Parkinson's disease

Jellinger, K. A. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.10.006 · Cited by 22

Significance of cerebral amyloid angiopathy and other co-morbidities in Lewy body diseases

Jellinger, K. A. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02345-9 · Cited by 21

Lewy Body Disorders

Jellinger, K. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-30377-2_15 · Cited by 22

Addenbrooke’s Cognitive Examination III (ACE-III) and mini-ACE for the detection of dementia and mild cognitive impairment

Beishon, L., Batterham, A. P., Quinn, T. J., Nelson, C. P., Panerai, R. B., Robinson, T. G., & Haunton, V. J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013282 · Cited by 21

Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators

Oehlrich, D., Rombouts, F. J. R., Berthelot, D., Bischoff, F., Cleyn, M. A. J. D., Jarošková, L., Macdonald, G. J., Mercken, M. H., Surkyn, M., Trabanco, A. A., et al. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.06.100 · Cited by 19

Repurposing of intestinal defensins as multi-target, dual-function amyloid inhibitors via cross-seeding

Tang, Y., Zhang, D., Gong, X., & Zheng, J. (2022) · Chemical Science · doi:10.1039/d2sc01447e · Cited by 19

The role of α-synuclein in neurodegeneration — An update

Jellinger, K. A. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0013-1 · Cited by 19

Pyridazine-derived γ-secretase modulators

Wan, Z., Hall, A., Jin, Y., Xiang, J., Yang, E., Eatherton, A. J., Smith, B. B., Yang, G. Z., Yu, H., Wang, J., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.04.143 · Cited by 18

Concomitant protein pathogenesis in Parkinson’s disease and perspective mechanisms

Han, Y., & He, Z. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1189809 · Cited by 18

Interaction of Proteins Involved in Neuronal Proteinopathies

Kulichikhin, K. Y., Malikova, O. A., Zobnina, A. E., Zalutskaya, N. M., & Rubel, A. A. (2023) · Life · doi:10.3390/life13101954 · Cited by 17

Structure-based study of antiamyloidogenic cyclic d,l-α-peptides

Chemerovski‐Glikman, M., Richman, M., & Rahimipour, S. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.07.097 · Cited by 17

CSF Biomarkers and Its Associations with 18F-AV133 Cerebral VMAT2 Binding in Parkinson’s Disease—A Preliminary Report

Gao, R., Zhang, G., Chen, X., Yang, A., Smith, G. S., Wong, D. F., & Zhou, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164762 · Cited by 17

Alpha-synuclein deposition patterns in Alzheimer’s disease: association with cortical amyloid beta and variable tau load

Neubauer, A., Weissenbrunner, D., Pekrun, S., Roeber, S., Ruf, V. C., Feyen, P. L. C., Strübing, F., & Herms, J. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02952-w · Cited by 17

Discrimination between Alpha-Synuclein Protein Variants with a Single Nanometer-Scale Pore

Bakshloo, M. A., Yahiaoui, S., Bourderioux, M., Daniel, R., Pastoriza‐Gallego, M., Kasianowicz, J. J., & Oukhaled, A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00164 · Cited by 15

Integrative analysis of common neurodegenerative diseases using gene association, interaction networks and mRNA expression data.

Liu, Y., Koyutürk, M., Maxwell, S., Zhao, Z., & Chance, M. R. (2012) · Europe PMC (PubMed Central) · Cited by 16

Parkinson's disease – pathology, aetiology and diagnosis

Macphee, G. J. A., & Stewart, D. A. (2012) · Reviews in Clinical Gerontology · doi:10.1017/s095925981200007x · Cited by 15

Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease

Leitao, A. D. G., Ahammad, R. U., Spencer, B. J., Wu, C., Masliah, E., & Rissman, R. A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106285 · Cited by 16

C-terminal part of α-synuclein mediates its activity in promoting proliferation of dopaminergic cells

Yin, J., Han, J., Zhang, C., Ma, Q., Li, X., Cheng, F., Liu, G., Li, Y., Uéda, K., Chan, P., et al. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0592-y · Cited by 15

Glymphatic dysfunction in Parkinson's disease: Aging-associated impairments, imaging biomarkers, and therapeutic strategies

Lv, Y., Ding, X.-S., Gao, L., Han, Z., Feng, C., Li, Y.-N., Wang, Y., Yang, Q., Simon, D. K., Wang, X., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102995 · Cited by 17

Experimental and Computational Protocols for Studies of Cross-Seeding Amyloid Assemblies

Ren, B., Hu, R., Zhang, M., Liu, Y., Xu, L., Jiang, B., Ma, J., Ma, B., Nussinov, R., & Zheng, J. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7811-3_27 · Cited by 14

Functionalization of α-synuclein fibrils

Povilonienė, S., Časaitė, V., Bukauskas, V., Šetkus, A., Staniulis, J., & Meškys, R. (2015) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.6.12 · Cited by 15

Conformational-Specific Self-Assembled Peptides as Dual-Mode, Multi-Target Inhibitors and Detectors for Different Amyloid Proteins

Ren, B., Tang, Y., Zhang, D., Liu, Y., Zhang, Y., Chen, H., Hu, R., Zhang, M., & Zheng, J. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb02775a · Cited by 13

The Therapeutic Potential of LRRK2 and α-Synuclein in Parkinson's Disease

Sen, S., & West, A. B. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2430 · Cited by 12

MultiTEP platform–based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency

Davtyan, H., Zagorski, K., Petrushina, I., Kazarian, K., Goldberg, N. R. S., Petrosyan, J., Blurton-Jones, M. M., Masliah, E., Cribbs, D. H., Agadjanyan, M. G., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.006 · Cited by 15

A new strategy to reconcile amyloid cross‐seeding and amyloid prevention in a binary system of α‐synuclein fragmental peptide and hIAPP

Tang, Y., Zhang, D., Liu, Y., Zhang, Y., Zhou, Y., Chang, Y., Zheng, B., Xu, A., & Zheng, J. (2021) · Protein Science · doi:10.1002/pro.4247 · Cited by 13

Oligomerization by co-assembly of β-amyloid and α-synuclein

Kim, J. R. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1153839 · Cited by 13

Multiple system atrophy with amyloid-β-predominant Alzheimer’s disease neuropathologic change

Kon, T., Ichimata, S., Luca, D. G. D., Martínez-Valbuena, I., Kim, A., Yoshida, K., Alruwaita, A. A., Kleiner, G., Strafella, A. P., Forrest, S. L., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae141 · Cited by 13

Cerebrospinal fluid α-synuclein predicts neurodegeneration and clinical progression in non-demented elders

Initiative, A. D. N., Li, J., Bi, Y., Shen, X., Wang, H.-F., Xu, W., Tan, C., Dong, Q., Wang, Y., Tan, L., et al. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00222-1 · Cited by 12

CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans

Spies, P. E., Slats, D., Rikkert, M. G. M. O., Tseng, J., Claassen, J. A. H. R., & Verbeek, M. M. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.09.063 · Cited by 12

“Janus-Faced” α-Synuclein: Role in Parkinson’s Disease

Ray, B., Mahalakshmi, A. M., Tuladhar, S., Bhat, A., Srinivasan, A., Pellegrino, C., Kannan, A., Bolla, S. R., Chidambaram, S. B., & Sakharkar, M. K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.673395 · Cited by 14

Recruitment of Aβ into α-Synuclein Condensates Catalyzes Primary Nucleation of α-Synuclein Aggregation

Morris, O. M., Röntgen, A., Toprakcioglu, Z., Cali, M. P., Dada, S., & Vendruscolo, M. (2025) · ACS Central Science · doi:10.1021/acscentsci.5c00614 · Cited by 12

α-synuclein as an emerging pathophysiological biomarker of Alzheimer’s disease

Beatino, M. F., Luca, C. D., Campese, N., Belli, E., Piccarducci, R., Giampietri, L., Martini, C., Perugi, G., Siciliano, G., Ceravolo, R., et al. (2022) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2022.2068952 · Cited by 11

Graph theoretical network analysis, in silico exploration, and validation of bioactive compounds from Cynodon dactylon as potential neuroprotective agents against α-synuclein

Rajeshkumar, R. R., Kumar, B. K., Pavadai, P., Theivendren, P., Sundar, K., Ammunje, D. N., Pandian, S. R. K., Murugesan, S., Kabilan, S. J., & Kunjiappan, S. (2022) · Bioimpacts · doi:10.34172/bi.2022.24113 · Cited by 11

Oligomer Formation and Cross‐Seeding: The New Frontier

Farmer, K. M., Gerson, J. E., & Kayed, R. (2016) · Israel Journal of Chemistry · doi:10.1002/ijch.201600103 · Cited by 10

The Association Between Plasma α-Synuclein (α-syn) Protein, Urinary Alzheimer-Associated Neuronal Thread Protein (AD7c-NTP), and Apolipoprotein Epsilon 4 (ApoE ε4) Alleles and Cognitive Decline in 60 Patients with Alzheimer’s Disease Compared with 28 Age-Matched Normal Individuals

Lv, S., Zhou, X., Li, Y., Zhang, S., Wang, Y., Jia, S., Niu, X., Wang, L., & Peng, D. (2021) · Medical Science Monitor · doi:10.12659/msm.932998 · Cited by 9

Effect of Bacterial Amyloid Protein Phenol−Soluble Modulin Alpha 3 on the Aggregation of Amyloid Beta Protein Associated with Alzheimer’s Disease

Peng, B., Xu, S., Liang, Y., Dong, X., & Sun, Y. P. (2023) · Biomimetics · doi:10.3390/biomimetics8060459 · Cited by 11

Immunohistochemical Demonstration of the pGlu79 α-Synuclein Fragment in Alzheimer’s Disease and Its Tg2576 Mouse Model

Bluhm, A., Schrempel, S., Schilling, S., von Hörsten, S., Schulze, A., Roßner, S., & Hartlage‐Rübsamen, M. (2022) · Biomolecules · doi:10.3390/biom12071006 · Cited by 8

Evidence for modest familial co-aggregation between dementia and parkinsonism

Feldman, A. L., Wirdefeldt, K., Johansson, A. L. V., Gatz, M., & Pedersen, N. L. (2013) · European Journal of Epidemiology · doi:10.1007/s10654-013-9864-1 · Cited by 8

Future Direction of Designing Antioxidant Polymers in Modulating Protein Aggregation Process

Mondal, A., Khan, M. E. H., Ghosh, P., & De, P. (2021) · Journal of Molecular and Engineering Materials · doi:10.1142/s2251237321400013 · Cited by 8

Alpha-synuclein and Parkinson disease

LIU, H. (2007) · Neural Regeneration Research · doi:10.1016/s1673-5374(07)60053-x · Cited by 8

Presenilin-2 gene mutation presenting as Lewy Body dementia?

Raciti, L., Nicoletti, A. S. Q., Pira, F. L., Andreoli, V., Contrafatto, D., Lanzafame, S., Maci, T., Gambardella, A., Quattrone, A., & Zappia, M. (2011) · Neurological Sciences · doi:10.1007/s10072-011-0497-4 · Cited by 8

Interference of α-Synuclein Uptake by Monomeric β-Amyloid1–40 and Potential Core Acting Site of the Interference

Chan, D. K. Y., Braidy, N., Xu, Y. H., Chataway, T., Guo, F., Guillemin, G. J., Teo, C., & Gai, W. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9644-2 · Cited by 8

SARS-CoV-2 Spike amyloid fibrils specifically and selectively accelerates amyloid fibril formation of human prion protein and the amyloid β peptidePreprint

Larsson, J. N. K., Hellstrand, E., Hammarström, P., & Nyström, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.01.555834 · Cited by 9

Exploratory Assessment of K-means Clustering to Classify 18F-Flutemetamol Brain PET as Positive or Negative

Zukotynski, K., Black, S. E., Kuo, P. H., Bhan, A., Adamo, S. M., Scott, C. J. M., Lam, B., Masellis, M., Kumar, S., Fischer, C. E., et al. (2021) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000003668 · Cited by 7

Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer’s disease

Hartlage‐Rübsamen, M., Ratz, V., Zeitschel, U., Finzel, L., Machner, L., Köppen, J., Schulze, A., Demuth, H., von Hörsten, S., Höfling, C., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0726-2 · Cited by 7

Nanoaggregates Derived from Amyloid-beta and Alpha-synuclein Characterized by Sequential Quadruple Force Mapping

Shin, E. J., & Park, J. W. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c00058 · Cited by 7

The overlap of corticobasal degeneration and Alzheimer changes: An autopsy case

Zhang, W., Zheng, R., Wang, Z., & Yuan, Y. (2009) · Neuropathology · doi:10.1111/j.1440-1789.2009.01012.x · Cited by 7

Postencephalitic Parkinsonism

Jellinger, K. A. (2011) · Wiley eBooks · doi:10.1002/9781444341256.ch19 · Cited by 7

Off-pathway oligomers of α -synuclein and A β inhibit secondary nucleation of α -synuclein amyloid fibrils

Schützmann, M. P., & Hoyer, W. (2025) · Journal of Molecular Biology · doi:10.1016/j.jmb.2025.169048 · Cited by 7

Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease

Paganelli, R., Paganelli, A., Pawelec, G., & Iorio, A. D. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00336-w · Cited by 6

Factors Affecting Pathological Amyloid Protein Transformation: From Post-Translational Modifications to Chaperones

Muronets, V. I., Kudryavtseva, S. S., Kurochkina, L. P., Leisi, E. V., Stroylova, Y. Y., & Schmalhausen, E. V. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297924604003 · Cited by 5

Experimental methods for studying amyloid cross‐interactions

Kalitnik, A. A., Lassota, A., Polańska, O., Gąsior‐Głogowska, M., Szefczyk, M., Barbach, A., Chilimoniuk, J., Jęśkowiak, I., Wojciechowska, A. W., Wojciechowski, J. W., et al. (2025) · Protein Science · doi:10.1002/pro.70151 · Cited by 5

A splice‐switching antisense oligonucleotide targeting APP reduces accumulation of α‐synuclein in a mouse model of Parkinson's disease

Ahammad, R. U., Spencer, B. J., Quach, B., Salehi, S. N., & Rissman, R. A. (2025) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70117 · Cited by 4

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Varenyk, Y., Theodorakis, P. E., Pham, D. Q. H., Li, M. S., & Krupa, P. (2024) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.4c00503 · Cited by 4

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Manzine, P. R., Vatanabe, I. P., Grigoli, M. M., Pedroso, R. V., Monteiro, M. P. A. O., de Oliveira, D. D. S. M. S., Nascimento, C. M. C., Peron, R., Orlandi, F. D. S., & Cominetti, M. R. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220408124809 · Cited by 4

Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α‐syn co‐pathology

Friesen, M., Ziegler‐Waldkirch, S., Egenolf, M., d’Errico, P., Helm, C., Mezö, C., Dokalis, N., Erny, D., Katzmarski, N., Coelho, R., et al. (2021) · Brain Pathology · doi:10.1111/bpa.13032 · Cited by 4

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Leitao, A. D. G., Spencer, B. J., Sarsoza, F. M., Ngolab, J., Amalraj, J., Masliah, E., Wu, C., & Rissman, R. A. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230232 · Cited by 3

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Liu, Q., Song, S., Liu, L., & Hong, W. (2025) · Biomolecules · doi:10.3390/biom15040571 · Cited by 5

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Heid, L. F., Kupreichyk, T., Schützmann, M. P., Schneider, W., Stoldt, M., & Hoyer, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216132 · Cited by 3

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Lin, X., Guo, Y., Dong, R., Wang, B., & Bi, Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.935869 · Cited by 3

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Khatua, P., Mondal, S., Gupta, M., & Bandyopadhyay, S. (2022) · ACS Omega · doi:10.1021/acsomega.2c06235 · Cited by 3

Alcoholic Hericium erinaceus mycelia extract induces SIRT-1/ERK-1/2 mediated autophagy to prevent accumulation and spreading of alpha-synuclein and amyloid-beta peptide on the A53T transgenic mice

Lin, Y., Huang, C., Tsai, B. C., Kumar, K. A., Hsieh, D. J., Chiu, P., Chang, Y., Ho, T., Kuo, W., & Ju, D. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105874 · Cited by 4

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Li, R., Huang, X., Shen, L., Zhang, T., Liu, N., Hou, X., & Wong, G. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05383-0 · Cited by 3

Dementia with Lewy bodies

Racine, C. A. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511581410.002 · Cited by 3

Designing novel peptides with amyloid-β binding and clearance potential using BiLSTM and molecular dynamics

Yata, V. K., Das, O. P., Dansana, J., Gadtya, A., Meher, B. R., Bukke, S. P. N., & Kolliputi, N. (2025) · Frontiers in Artificial Intelligence · doi:10.3389/frai.2025.1709505 · Cited by 2

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Araya, K., Nakamura, K., Ishibashi, E., Noguchi, T. Q. P., Kuragano, M., & Tokuraku, K. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153506 · Cited by 2

New Perspectives in Reducing Amyloid Aggregation and Toxicity

Chemerovski‐Glikman, M., Richman, M., & Rahimipour, S. (2015) · Israel Journal of Chemistry · doi:10.1002/ijch.201500010 · Cited by 2

Neuropathology of Movement Disorders

Jellinger, K. A. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-5316-3.00076-9 · Cited by 2

Reply: Dynamic functional connectivity changes in Lewy body disease

Biundo, R., Fiorenzato, E., & Antonini, A. (2019) · Brain · doi:10.1093/brain/awz316 · Cited by 2

Commentary to “Interaction between Aβ Peptide and α Synuclein: Molecular Mechanisms in Overlapping Pathology of Alzheimer’s and Parkinson’s in Dementia with Lewy Body Disease”

Mandal, P. K., & Pettegrew, J. W. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9553-0

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Köppen, J., Schulze, A., Machner, L., Wermann, M., Eichentopf, R., Guthardt, M., Hähnel, A., Klehm, J., Kriegeskorte, M.-C., Hartlage‐Rübsamen, M., et al. (2020) · Molecules · doi:10.3390/molecules25030580 · Cited by 79

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Marsh, S., & Blurton-Jones, M. (2012) · UCL Discovery (University College London)

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Huang, F., Liu, Y., Wang, Y., Xu, J., Lian, J., Zou, Y. F., Wang, C., Ding, F., & Sun, Y. (2023) · Physical Chemistry Chemical Physics · doi:10.1039/d3cp04138g · Cited by 24

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Obi, K., Mochizuki, H., Akiyama, H., Iwatubo, T., Hasegawa, M., & Mizuno, Y. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.1896