The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Interaction between Aβ Peptide and α Synuclein: Molecular Mechanisms in Overlapping Pathology of Alzheimer’s and Parkinson’s in Dementia with Lewy Body Disease
Abstract
Amyloidogenic proteins (Abeta peptide) in Alzheimer's disease (AD) and alpha-synuclein (alpha-Syn) in Parkinson's disease (PD) are typically soluble monomeric precursors, which undergo remarkable conformational changes and culminate in the form of aggregates in diseased condition. Overlap of clinical and neuropathological features of both AD and PD are observed in dementia with Lewy body (DLB) disease, the second most common form of dementia after AD. The identification of a 35-amino acid fragment of alpha-Syn in the amyloid plaques in DLB brain have raised the possibility that Abeta and alpha-Syn interact with each other. In this report, the molecular interaction of alpha-Syn with Abeta40 and/or Abeta42 are investigated using multidimensional NMR spectroscopy. NMR data in the membrane mimic environment indicate specific sites of interaction between membrane-bound alpha-Syn with Abeta peptide and vice versa. These Abeta-alpha-Syn interactions are demonstrated by reduced amide peak intensity or change in chemical shift of amide proton of the interacting proteins. Based on NMR results, the plausible molecular mechanism of overlapping pathocascade of AD and PD in DLB due to interactions between alpha-Syn and Abeta is described. To the best of our knowledge, it is the first report using multidimensional NMR spectroscopy that elucidates molecular interactions between Abeta and alpha-Syn which may lead to onset of DLB.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Evidence suggests that Aβ can directly affect α-synuclein toxicity, and it is also known that tau protein and α-synuclein can directly interact promoting their co-assembly [124–126].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [124]
Citations
Cites
NMRPipe: A multidimensional spectral processing system based on UNIX pipes
Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., & Bax, A. (1995) · Journal of Biomolecular NMR · doi:10.1007/bf00197809 · Cited by 15,961
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836
Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions
Piotto, M., Saudek, V., & Sklenář, V. (1992) · Journal of Biomolecular NMR · doi:10.1007/bf02192855 · Cited by 3,720
Marion, D., & Wüthrich, K. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)91093-8 · Cited by 3,160
University of California, San Francisco
(1974) · Medical History · doi:10.1017/s0025727300019682 · Cited by 2,218
Jarrett, J. T., Berger, E. P., & Lansbury, P. T. (1993) · Biochemistry · doi:10.1021/bi00069a001 · Cited by 2,022
Masliah, E., Rockenstein, E. M., Veinbergs, I., Mallory, M. E., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., & Mucke, L. (2000) · Science · doi:10.1126/science.287.5456.1265 · Cited by 1,779
Self-citationAlpha-synuclein and neurodegenerative diseases
Goedert, M. (2001) · Nature reviews. Neuroscience · doi:10.1038/35081564 · Cited by 1,428
Translating cell biology into therapeutic advances in Alzheimer's disease
Selkoe, D. J. (1999) · Nature · doi:10.1038/399a023 · Cited by 1,166
Eliezer, D., Kutluay, E., Bussell, R., & Browne, G. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4538 · Cited by 1,110
The Lewy body variant of Alzheimer's disease: A clinical and pathologic entity
Hansen, L., Salmon, D., Galasko, D., Masliah, E., Katzman, R., DeTeresa, R., Thal, L., Pay, M. M., Hofstetter, R., Klauber, M., et al. (1990) · Neurology · doi:10.1212/wnl.40.1.1 · Cited by 1,068
Self-citationThe Pathogenesis of Senile Plaques
DICKSON, D. W. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199704000-00001 · Cited by 753
Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease
Selkoe, D. J. (1994) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.10.110194.002105 · Cited by 748
Garrett, D. S., Powers, R., Gronenborn, A. M., & Clore, G. M. (1991) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(91)90341-p · Cited by 682
Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., & Mucke, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211412398 · Cited by 607
Self-citationSenile dementia of Lewy body type
Perry, R. H., Irving, D., Blessed, G., FAIRBAIRN, A. F., & Perry, E. K. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90236-g · Cited by 575
A Broken α-Helix in Folded α-Synuclein
Chandra, S. S., Chen, X., Rizo, J., Jahn, R., & Südhof, T. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213128200 · Cited by 540
Coles, M. P., Bicknell, W., Watson, A. A., Fairlie, D. P., & Craik, D. J. (1998) · Biochemistry · doi:10.1021/bi972979f · Cited by 526
Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson's Disease Mutation
Jensen, P. H., Nielsen, M. S., Jakes, R., Dotti, C. G., & Goedert, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26292 · Cited by 521
Hashimoto, M., Rockenstein, E. M., Crews, L. A., & Masliah, E. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:4:1-2:21 · Cited by 508
Self-citationShults, C. W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509567103 · Cited by 495
Biophysical Properties of the Synucleins and Their Propensities to Fibrillate
Uversky, V. N., Li, J., Souillac, P. O., Millett, I. S., Doniach, S., Jakes, R., Goedert, M., & Fink, A. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109541200 · Cited by 473
Selkoe (1999) · doi:10.1038/19866 · Cited by 468
Lee, H.-J., Choi, C., & Lee, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107045200 · Cited by 462
The toxicity in vitro of β-amyloid protein
Iversen, L. L., Mortishire‐Smith, R. J., Pollack, S. J., & Shearman, M. S. (1995) · Biochemical Journal · doi:10.1042/bj3110001 · Cited by 428
Degradation of α-Synuclein by Proteasome
Bennett, M. C., Bishop, J. F., Leng, Y., Chock, P. B., Chase, T. N., & Mouradian, M. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.33855 · Cited by 417
Clinical-Neuropathological Correlations in Alzheimer's Disease and Related Dementias
Galasko, D., Hansen, L. A., Katzman, R., Wiederholt, W. C., Masliah, E., Terry, R. D., Hill, L. R., Lessin, P. J., & Thal, L. J. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540210060013 · Cited by 408
Self-citationKosaka, K., Yoshimura, M., Ikeda, K., & Budka, H. (1984) · PubMed · Cited by 401
Shao, H., Jao, S., Ma, K., & Zagorski, M. G. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2348 · Cited by 308
A Precipitating Role for Truncated α-Synuclein and the Proteasome in α-Synuclein Aggregation
Liu, C.-W., Giasson, B. I., Lewis, K. A., Lee, V. M., Demartino, G., & Thomas, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501508200 · Cited by 270
CLINICAL AND PATHOLOGICAL FEATURES OF DIFFUSE CORTICAL LEWY BODY DISEASE (LEWY BODY DEMENTIA)
Gibb, W. R. G., Esiri, M. M., & Lees, A. J. (1987) · Brain · doi:10.1093/brain/110.5.1131 · Cited by 263
George, J. M. (2001) · Genome biology · doi:10.1186/gb-2001-3-1-reviews3002 · Cited by 244
Arima, K., Uéda, K., Sunohara, N., Hirai, S., Izumiyama, Y., Tonozuka-Uehara, H., & Kawai, M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00734-3 · Cited by 243
Non-A.beta. Component of Alzheimer's Disease Amyloid (NAC) is Amyloidogenic
Iwai, A., Yoshimoto, M., Masliah, E., & Saitoh, T. (1995) · Biochemistry · doi:10.1021/bi00032a006 · Cited by 237
Self-citationSidhu, A., Wersinger, C., & Vernier, P. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.03.063 · Cited by 175
Membrane Binding and Self-Association of α-Synucleins
Narayanan, V. S., & Scarlata, S. (2001) · Biochemistry · doi:10.1021/bi002952n · Cited by 170
Cortical Lewy body dementia: clinical features and classification.
Gibb, W. R. G., Luthert, P. J., Janota, I., & Lantos, P. L. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.2.185 · Cited by 152
Garrett, D. S., Powers, R., Gronenborn, A. M., & Clore, G. M. (2011) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2011.09.007 · Cited by 139
McKeith, I. G., Burn, D. J., Ballard, C. G., Collerton, D., Jaros, E., Morris, C. M., McLaren, A., Perry, E. K., Perry, R., Piggott, M. A., et al. (2003) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2003.50006 · Cited by 134
A comprehensive discussion of HSQC and HMQC pulse sequences
Mandal, P. K., & Majumdar, A. K. (2004) · Concepts in Magnetic Resonance Part A · doi:10.1002/cmr.a.10095 · Cited by 91
Self-citationMandal, P. K., & Pettegrew, J. W. (2004) · Neurochemical Research · doi:10.1007/s11064-004-7035-1 · Cited by 67
Self-citationYokota, O., Terada, S., Ishizu, H., Ujike, H., Ishihara, T., Nakashima, H., Yasuda, M., Kitamura, Y., Uéda, K., Checler, F., et al. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0596-7 · Cited by 42
Mandal, P. K., & Pettegrew, J. W. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000013750.80925.25 · Cited by 42
Self-citation
Cited by
Sorted by citations
Neuropathological alterations in Alzheimer disease
Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345
Self-citationThe neuropathological diagnosis of Alzheimer's disease
DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329
Nguyen, P. H., Ramamoorthy, A., Sahoo, B. R., Zheng, J., Faller, P., Straub, J. E., Domínguez, L., Shea, J., Dokholyan, N. V., Simone, A. D., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01122 · Cited by 680
Amyloid oligomers: formation and toxicity of Aβ oligomers
Sakono, M., & Zako, T. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07568.x · Cited by 633
Basic mechanisms of neurodegeneration: a critical update
Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01010.x · Cited by 640
Metadata
- Authors
- Mandal, P. K., Pettegrew, J. W., Masliah, E., Hamilton, R. L., & Mandal, R.
- Affiliations
- University of Pittsburgh Medical Center (US)
- University of California San Diego (US)
- University of Pittsburgh (US)
- Corresponding author
- Mandal, Pravat K.
- Venue
- Neurochemical Research
- Published
- 2006-09
- Volume
- 31
- Issue
- 9
- Pages
- 1153-1162
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W1965229261
- Cited by
- 219
- References
- 48
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 12 · 2021: 17 · 2020: 20 · 2019: 17 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 12 · 2014: 9 · 2013: 11 · 2012: 9
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid-beta, alpha-synuclein, dementia with Lewy bodies, Alzheimer's disease, Parkinson's disease, protein-protein interaction, Aβ40, amyloid-beta 42, amyloid plaques, protein aggregation, molecular pathogenesis
- MeSH terms
- Alzheimer Disease, Amino Acid Sequence, Brain, Humans, Molecular Sequence Data, Parkinson Disease, Peptide Fragments, Amyloid beta-Peptides, Nuclear Magnetic Resonance, Biomolecular, Lewy Body Disease, alpha-Synuclein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review