Cited by 51Neurological Disease Mechanisms and TreatmentsNeurological Disorders and TreatmentsBarrier Structure and Function Studies

Osthole, a natural coumarin improves cognitive impairments and BBB dysfunction after transient global brain ischemia in C57 BL/6J mice: Involvement of Nrf2 pathway

Chen, ZiWei, Mao, XueXuan, Liu, AnMin, Gao, XiaoYun, Chen, XiaoHong, Ye, MinZhong, Ye, JianTao, Liu, PeiQing +5 more·2015·Neurochemical Research

Abstract

Oxidative stress and blood-brain barrier (BBB) disruption play important roles in cerebral ischemic pathogenesis and may represent targets for treatment. Earlier studies have shown that osthole, a main active constituent isolated from Cnidium monnieri (L.) Cusson, could be considered as an attractive therapeutic agent in the treatment of ischemic stroke. However, the mechanism underlying the protective effect remains vague. In this study we aimed to investigate the effect of osthole on transient cerebral ischemia as well as its mechanism(s) in C57 BL/6 J mice. Mice were subjected to transient global cerebral ischemia induced by bilateral common carotid artery occlusion for 25 min. Behavioral test was performed at 4 days after ischemia, followed by assessment of neuronal loss in hippocampal CA1 region. Osthole significantly improved the cognitive ability and enhanced the survival of pyramidal neurons in the CA1 region of mice after lesion. Further studies showed that osthole attenuated the permeation of BBB, which may contribute to antioxidative effect by increasing the superoxide dismutase activity and decreasing the malondialdehyde level in model mice. Further studies revealed that osthole obviously up-regulated the protein levels of nuclear factor erythroid 2-related factor 2/heme oxygenase 1 in HT22 cells. In conclusion, our findings indicated that osthole exerts neuroprotective effects against global cerebral ischemia injury by reducing oxidative stress injury and reserving the disruption of BBB, which may be attributed to elevating the protein levels of Nrf2 and HO-1.

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Crossref · 10.1007/s11064-014-1483-z

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  • Phenolic and flavonoid contents, catechins, coumarin, resveratrol, quercetin, curcumin, ginkgolide, glycyrrhizin, monoterpenoid, and S-allylcysteine isolated from various medicinal plants have been identified to have the potency to prevent Alzheimer's disease.

    “Phenolic and flavonoid contents [91], catechins [92], coumarin [93], resveratrol [94], quercetin [95]; curcumin [96], ginkgolide [97], glycyrrhizin [98], monoterpenoid [99], and S-allylcysteine [100] which isolated from various medicinal plants have been identified to have the potency to prevent AD.”

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Authors
Chen, Z., Mao, X., Liu, A., Gao, X., Chen, X., Ye, M., Ye, J., Liu, P., Xu, S., Liu, J., He, W., Lian, Q., & Pi, R.
Affiliations
  • Sun Yat-sen University (CN)
  • Guangzhou University of Chinese Medicine (CN)
  • Gannan Medical University (CN)
Corresponding author
  • Lian, QiShen
  • Pi, RongBiao
Venue
Neurochemical Research
Published
2014-11-26
Volume
40
Issue
1
Pages
186-194
ISSN
  • 0364-3190 (ISSN-L)
  • 1573-6903
OpenAlex
W2020663182
Cited by
51
References
42
Citations by year
2026: 1 · 2024: 7 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 13 · 2017: 3 · 2016: 5 · 2015: 5
FWCI
2.26
Type
journal article
Language
en
Open access
closed
Locations
  • Neurochemical Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • Sun Yat-sen University
Topics
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
osthole, coumarins, transient global cerebral ischemia, ischemic stroke, blood-brain barrier disruption, Nrf2, heme oxygenase-1, oxidative stress, neuroprotection, cognitive impairment, CA1 pyramidal neurons, Cnidium monnieri, superoxide dismutase, malondialdehyde, HT22 cells
MeSH terms
Animals, Blood-Brain Barrier, Cells, Cultured, Ischemic Attack, Transient, Coumarins, Hippocampus, Male, Malondialdehyde, Mice, Inbred C57BL, Superoxide Dismutase, Neuroprotective Agents, Nootropic Agents, Maze Learning, NF-E2-Related Factor 2, Mice, Heme Oxygenase-1

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