The Neuropsychology of HIV/AIDS in Older Adults
Abstract
Highly active antiretroviral therapy is allowing increasing numbers of adults to age with HIV. The neuropsychological effects of aging with HIV are reviewed through three types of studies. First, the separate effects of HIV and aging on cognition are examined in studies that compare younger adults with HIV with neurologically normal older adults. Second, studies examine the impact of aging within samples of adults with HIV only. Third, providing the most critical evidence, are studies that assess cognition in younger and older adults with HIV relative to younger and older adults without HIV. In general research findings are inconclusive. Large individual differences among older adults with HIV as well as co-factors (APOE4 and detectable viral load) may account for inconsistent findings in the literature. A subgroup of older adults with HIV may be at greater risk for cognitive impairment, especially in attention functioning.
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- Authors
- Hardy, D. J., & Vance, D. E.
- Affiliations
- University of California, Los Angeles (US)
- University of Alabama at Birmingham (US)
- Corresponding author
- Hardy, David J.
- Venue
- Neuropsychology Review
- Published
- 2009-02-27
- Volume
- 19
- Issue
- 2
- Pages
- 263-272
- ISSN
- 1040-7308 (ISSN-L)
- 1573-6660
- OpenAlex
- W2044542717
- Cited by
- 97
- References
- 84
- Citations by year
- 2025: 2 · 2024: 3 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 9 · 2016: 5 · 2015: 7 · 2014: 12 · 2013: 7 · 2012: 10
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychology Review (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- HIV/AIDS, older adults, aging with HIV, cognitive impairment, highly active antiretroviral therapy, age effects on cognition, APOE ε4, viral load, attention, individual differences
- MeSH terms
- Acquired Immunodeficiency Syndrome, Adult, Aged, Aged, 80 and over, Aging, Central Nervous System Diseases, Cognition, Cognition Disorders, Geriatric Psychiatry, Humans, Middle Aged, Neuropsychological Tests, HIV Infections, Antiretroviral Therapy, Highly Active, Anti-Retroviral Agents, Young Adult
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