Differential aging of the brain: Patterns, cognitive correlates and modifiers

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Whole Brain Segmentation

Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610 · see citing works

A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains

Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0786 · Cited by 4,561 · see citing works

Chronic back pain is associated with decreased prefrontal and thalamic gray matter density

Apkarian, A. V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., & Gitelman, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2541-04.2004 · Cited by 1,434 · see citing works

Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain

Resnick, S. M., Pham, D. L., Kraut, M. A., Zonderman, A. B., & Davatzikos, C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03295.2003 · Cited by 1,425 · see citing works

Dynamics of Gray Matter Loss in Alzheimer's Disease

Thompson, P. M., Hayashi, K. M., de Zubicaray, G., Janke, A. L., Rose, S. E., Semple, J., Herman, D., Hong, M. S., Dittmer, S. S., Doddrell, D. M., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00994.2003 · Cited by 1,132 · see citing works

Rates of hippocampal atrophy correlate with change in clinical status in aging and AD

Jack, C. R., Petersen, R. C., Xu, Y., O’Brien, P. C., Smith, G. E., Ivnik, R. J., Boeve, B. F., Tangalos, E. G., & Kokmen, E. (2000) · Neurology · doi:10.1212/wnl.55.4.484 · Cited by 937 · see citing works

Stress hormones and human memory function across the lifespan

Lupien, S. J., Fiocco, A., Wan, N., Maheu, F., Lord, C., Schramek, T., & Tu, M. T. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.08.003 · Cited by 562 · see citing works

Oligodendrocytes and Ischemic Brain Injury

Dewar, D., Underhill, S. M., & Goldberg, M. P. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000053472.41007.f9 · Cited by 335 · see citing works

Markers of Endothelial and Hemostatic Activation and Progression of Cerebral White Matter Hyperintensities: Longitudinal Results of the Austrian Stroke Prevention Study

Markus, H. S., Hunt, B., Palmer, K., Enzinger, C., Schmidt, H., & Schmidt, R. (2005) · Stroke · doi:10.1161/01.str.0000169924.60783.d4 · Cited by 193 · see citing works

Dehydration confounds the assessment of brain atrophy

Duning, T., Kloska, S., Steinsträter, O., Kugel, H., Heindel, W., & Knecht, S. (2005) · Neurology · doi:10.1212/01.wnl.0000150542.16969.cc · Cited by 190 · see citing works

Role of Dopamine Systems in Cognitive Aging

Bäckman, L., & Farde, L. (2004) · Cognitive Neuroscience of Aging · doi:10.1093/acprof:oso/9780195156744.003.0003 · Cited by 66 · see citing works

Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced?

Hertzog, C., Kramer, A. F., Wilson, R. S., & Lindenberger, U. (2008) · Psychological Science in the Public Interest · doi:10.1111/j.1539-6053.2009.01034.x · Cited by 1,495 · see citing works

Age-associated cognitive decline

Deary, I. J., Corley, J., Gow, A. J., Harris, S. E., Houlihan, L. M., Marioni, R. E., Penke, L., Rafnsson, S. B., & Starr, J. M. (2009) · British Medical Bulletin · doi:10.1093/bmb/ldp033 · Cited by 1,295 · see citing works

One-Year Brain Atrophy Evident in Healthy Aging

Fjell, A. M., Walhovd, K. B., Fennema-Notestine, C., McEvoy, L. K., Hagler, D. J., Holland, D., Brewer, J. B., & Dale, A. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3252-09.2009 · Cited by 692 · see citing works

Aging and functional brain networks

Tomasi, D., & Volkow, N. D. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.81 · Cited by 578 · see citing works

Alzheimer's Disease: Treatment Strategies and Their Limitations.

Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213954 · Cited by 592 · see citing works

Aging of cerebral white matter: a review of MRI findings

Gunning‐Dixon, F. M., Brickman, A. M., Cheng, J. C., & Alexopoulos, G. S. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2087 · Cited by 564 · see citing works

Consistent neuroanatomical age-related volume differences across multiple samples

Walhovd, K. B., Westlye, L. T., Amlien, I., Espeseth, T., Reinvang, I., Raz, N., Agartz, I., Salat, D. H., Greve, D. N., Fischl, B., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.013 · Cited by 506 · see citing works

Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive functions, and speed

Kennedy, K. M., & Raz, N. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.01.001 · Cited by 475 · see citing works

Human cognitive aging: <i>Corriger la fortune?</i>

Lindenberger, U. (2014) · Science · doi:10.1126/science.1254403 · Cited by 414 · see citing works

Proprioceptive sensibility in the elderly: degeneration, functional consequences and plastic-adaptive processes

Goble, D. J., Coxon, J. P., Wenderoth, N., Van Impe, A., & Swinnen, S. P. (2009) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.012 · Cited by 426 · see citing works

Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies

Tromp, D., Dufour, A., Lithfous, S., Pebayle, T., & Després, O. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.08.006 · Cited by 390 · see citing works

A General Factor of Brain White Matter Integrity Predicts Information Processing Speed in Healthy Older People

Penke, L., Maniega, S. M., Murray, C., Gow, A. J., Valdés Hernández, M. C., Clayden, J. D., Starr, J. M., Wardlaw, J. M., Bastin, M. E., & Deary, I. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1553-10.2010 · Cited by 336 · see citing works

A common brain network links development, aging, and vulnerability to disease

Douaud, G., Groves, A. R., Tamnes, C. K., Westlye, L. T., Duff, E. P., Engvig, A., Walhovd, K. B., James, A., Gass, A., Monsch, A. U., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410378111 · Cited by 317 · see citing works

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype: Astrocyte senescence in aging brain

Salminen, A., Ojala, J., Kaarniranta, K., Haapasalo, A., Hiltunen, M., & Soininen, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07738.x · Cited by 333 · see citing works

Variation in longitudinal trajectories of regional brain volumes of healthy men and women (ages 10 to 85years) measured with atlas-based parcellation of MRI

Pfefferbaum, A., Rohlfing, T., Rosenbloom, M. J., Chu, W., Colrain, I. M., & Sullivan, E. V. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.008 · Cited by 256 · see citing works

Neuroplasticity and cognitive aging: The scaffolding theory of aging and cognition

Goh, J. O., & Park, D. C. (2009) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2009-0493 · Cited by 253 · see citing works

Risk Factors for β-Amyloid Deposition in Healthy Aging: Vascular and Genetic Effects

Rodrigue, K. M., Rieck, J. R., Kennedy, K. M., Devous, M. D., Diaz-Arrastia, R., & Park, D. C. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1342 · Cited by 249 · see citing works

Beta‐amyloid deposition and the aging brain

Rodrigue, K. M., Kennedy, K. M., & Park, D. C. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9118-x · Cited by 230 · see citing works

Accelerated Gray and White Matter Deterioration With Age in Schizophrenia

Cropley, V. L., Klauser, P., Lenroot, R. K., Bruggemann, J., Sundram, S., Bousman, C., Pereira, A., Di Biase, M. A., Weickert, T. W., Weickert, C. S., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16050610 · Cited by 217 · see citing works

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208 · see citing works

Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia

Heller, C., Foiani, M. S., Moore, K., Convery, R., Bocchetta, M., Neason, M., Cash, D. M., Thomas, D., Greaves, C. V., Woollacott, I. O., et al. (2020) · Journal of Neurology, Neurosurgery &amp; Psychiatry · doi:10.1136/jnnp-2019-321954 · Cited by 182 · see citing works

Cardiovascular Disease Risk Factors and Cognition in the Elderly

Leritz, E. C., McGlinchey, R. E., Kellison, I., Rudolph, J. L., & Milberg, W. P. (2011) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-011-0189-x · Cited by 188 · see citing works

Body mass index and magnetic resonance markers of brain integrity in adults

Gazdzinski, S., Kornak, J., Weiner, M. W., & Meyerhoff, D. J. (2008) · Annals of Neurology · doi:10.1002/ana.21377 · Cited by 191 · see citing works

The theory of bipolar disorder as an illness of accelerated aging: implications for clinical care and research

Rizzo, L. B., Costa, L. G., Mansur, R. B., Swardfager, W., Belangero, S. I., Grassi-Oliveira, R., McIntyre, R. S., Bauer, M. E., & Brietzke, E. (2014) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.004 · Cited by 183 · see citing works

Multisensory integration mechanisms during aging

Freiherr, J., Lundström, J. N., Habel, U., & Reetz, K. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00863 · Cited by 173 · see citing works

Slowing down: age-related neurobiological predictors of processing speed

Eckert, M. A. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00025 · Cited by 162 · see citing works

Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults

Burzynska, A. Z., Chaddock-Heyman, L., Voss, M. W., Wong, C. N., Gothe, N. P., Olson, E. A., Knecht, A., Lewis, A., Monti, J. M., Cooke, G. E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107413 · Cited by 161 · see citing works

Alzheimer's Disease Neurodegenerative Biomarkers Are Associated with Decreased Cognitive Function but Not β-Amyloid in Cognitively Normal Older Individuals

Wirth, M., Madison, C. M., Rabinovici, G. D., Oh, H., Landau, S. M., & Jagust, W. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4409-12.2013 · Cited by 151 · see citing works

White matter integrity declined over 6-months, but dance intervention improved integrity of the fornix of older adults

Burzynska, A. Z., Jiao, Y., Knecht, A. M., Fanning, J., Awick, E. A., Chen, T., Gothe, N., Voss, M. W., McAuley, E., & Kramer, A. F. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00059 · Cited by 150 · see citing works

The Brain Ages Optimally to Model Its Environment: Evidence from Sensory Learning over the Adult Lifespan

Moran, R. J., Symmonds, M., Dolan, R. J., & Friston, K. J. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003422 · Cited by 136 · see citing works

An epigenetic predictor of death captures multi-modal measures of brain health

Hillary, R. F., Stevenson, A. J., Cox, S. R., McCartney, D. L., Harris, S. E., Seeboth, A., Higham, J., Sproul, D., Taylor, A. M., Redmond, P., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0616-9 · Cited by 139 · see citing works

Cerebrovascular resistance: effects on cognitive decline, cortical atrophy, and progression to dementia

Yew, B., Nation, D. A., & Initiative, F. T. A. D. N. (2017) · Brain · doi:10.1093/brain/awx112 · Cited by 133 · see citing works

Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging

Giovanoli, S., Notter, T., Richetto, J., Labouesse, M. A., Vuillermot, S., Riva, M. A., & Meyer, U. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0437-y · Cited by 124 · see citing works

Brain Network Modularity Predicts Exercise-Related Executive Function Gains in Older Adults

Baniqued, P. L., Gallen, C. L., Voss, M. W., Burzynska, A. Z., Wong, C. N., Cooke, G. E., Duffy, K., Fanning, J., Ehlers, D. K., Salerno, E. A., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00426 · Cited by 112 · see citing works

Cardiorespiratory fitness, hippocampal volume, and frequency of forgetting in older adults.

Szabo, A. N., McAuley, E., Erickson, K. I., Voss, M., Prakash, R. S., Mailey, E. L., Wójcicki, T. R., White, S. M., Gothe, N., Olson, E. A., et al. (2011) · Neuropsychology · doi:10.1037/a0022733 · Cited by 110 · see citing works

The Neuropsychology of HIV/AIDS in Older Adults

Hardy, D. J., & Vance, D. E. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9087-0 · Cited by 97 · see citing works

At least eighty percent of brain grey matter is modifiable by physical activity: A review study

Batouli, S. A. H., & Saba, V. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.002 · Cited by 92 · see citing works

Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity

Chételat, G., Landeau, B., Salmon, E., Yakushev, I., Bahri, M. A., Mézenge, F., Perrotin, A., Bastin, C., Manrique, A., Scheurich, A., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.03.009 · Cited by 92 · see citing works

Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice

Gray, N. E., Zweig, J. A., Caruso, M., Zhu, J. Y., Wright, K. M., Quinn, J. F., & Soumyanath, A. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.09.002 · Cited by 85 · see citing works

Comparative Proteomic Analysis of Brains of Naturally Aging Mice

Yang, S., Liu, T., Li, S., Zhang, X., Ding, Q., Que, H., Yan, X., Wei, K., & Liu, S. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.012 · Cited by 82 · see citing works

<i>Centella asiatica</i> increases hippocampal synaptic density and improves memory and executive function in aged mice

Gray, N. E., Zweig, J. A., Caruso, M., Martin, M. D., Zhu, J. Y., Quinn, J. F., & Soumyanath, A. (2018) · Brain and Behavior · doi:10.1002/brb3.1024 · Cited by 76 · see citing works

The impact of age-related changes on working memory functional activity

Steffener, J., Brickman, A. M., Rakitin, B. C., Gazes, Y., & Stern, Y. (2009) · Brain Imaging and Behavior · doi:10.1007/s11682-008-9056-x · Cited by 75 · see citing works

Improved cerebral oxygenation response and executive performance as a function of cardiorespiratory fitness in older women: a fNIRS study

Albinet, C. T., Mandrick, K., Bernard, P. L., Perrey, S., & Blain, H. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00272 · Cited by 65 · see citing works

Cognitive and neural correlates of aerobic fitness in obese older adults.

Bugg, J. M., Shah, K., Villareal, D. T., & Head, D. (2012) · Experimental Aging Research · doi:10.1080/0361073x.2012.659995 · Cited by 47 · see citing works

Age-related white matter integrity differences in oldest-old without dementia

Bennett, I. J., Greenia, D. E., Maillard, P., Sajjadi, S. A., DeCarli, C., Corrada, M. M., & Kawas, C. H. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.04.013 · Cited by 41 · see citing works

Effects of illness duration on cognitive performances in bipolar depression are mediated by white matter microstructure

Melloni, E. M. T., Poletti, S., Vai, B., Bollettini, I., Colombo, C., & Benedetti, F. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.02.015 · Cited by 34 · see citing works

Relationship between amyloid-β positivity and progression to mild cognitive impairment or dementia over 8 years in cognitively normal older adults

Dang, C., Harrington, K. D., Lim, Y. Y., Ames, D., Hassenstab, J., Laws, S. M., Yassi, N., Hickey, M., Rainey-Smith, S., Robertson, J., et al. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-180507 · Cited by 31 · see citing works

The effects of high-speed resistance training on health outcomes in independent older adults: a systematic review and meta-analysis.

Martins, A. D., Fernandes, O., Pereira, A., Oliveira, R., Alderete Goñi, F. D., Leite, N. J. C., & Brito, J. P. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095390 · Cited by 24 · see citing works

Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort

Mareckova, K., Marecek, R., Andryskova, L., Brazdil, M., & Nikolova, Y. S. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa014 · Cited by 32 · see citing works

Diffusion MRI detects basal forebrain cholinergic abnormalities in the 3xTg‐AD mouse model of Alzheimer's disease

Falangola, M. F., Nie, X., Ward, R., Dhiman, S., Voltin, J., Nietert, P. J., & Jensen, J. H. (2021) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2021.06.022 · Cited by 25 · see citing works

The Effects of Amyloid and Tau on Functional Network Connectivity in Older Populations

Wales, R. M., & Leung, H.-C. (2021) · Brain Connectivity · doi:10.1089/brain.2020.0902 · Cited by 26 · see citing works

Age-related differences in interhemispheric visuomotor integration measured by the redundant target effect.

Linnet, E., & Roser, M. E. (2012) · Psychology and Aging · doi:10.1037/a0024905 · Cited by 14 · see citing works