Predictors of Cognition in Adults With HIV: Implications for Nursing Practice and Research
Open accessAbstract
The objective of this study was to identify predictors of cognitive performance among adults with HIV. Participants completed demographic, psychosocial, and mental and physical health questionnaires as well as cognitive measures of speed of processing, psychomotor ability and visuomotor coordination, attention and working memory, reasoning, and executive function. Hierarchical regression analyses were used to examine predictors of cognitive performance for each cognitive measure. Possible predictors included age, gender, socioeconomic status, Wide Range Achievement Test 3 Reading score (quality of education), social networks score, hardiness score, mood disturbance score, medical problems composite score, psychoactive drug use composite score, HIV chronicity, CD4+ lymphocyte cell count, and HIV medication usage. Model 1 examined demographic factors, and model 2 examined the contribution of the remaining variables on cognitive performance. Results revealed that several factors were predictive of cognitive functioning, with the individual regression models for each measure explaining 8% to 48% of the variability in performance. Overall, this study posits that among adults with HIV, the most consistent predictors of poorer cognition included older age, poorer reading ability, more depressed mood, CD4+ lymphocyte cell count less than 200, and lack of HIV medication usage. Results suggest that those aging with HIV are subject to decreases in cognitive functioning.
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Use of formal community-based services by older adults with HIV is complicated by frequent service barriers (knowledge/access, affordability) and cultural competency issues of mainstream providers.
“yet this is complicated by frequent service barriers (e.g., knowledge and access to services, ability to afford services) as well as cultural competency issues of mainstream service providers interacting with an HIV-infected population (77).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [77]
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- Authors
- Fazeli, P. L., Marceaux, J. C., Vance, D. E., Slater, L., & Long, C. A.
- Affiliations
- University of Alabama at Birmingham (US)
- Venue
- Journal of Neuroscience Nursing
- Published
- 2011-02
- Volume
- 43
- Issue
- 1
- Pages
- 36-50
- ISSN
- 0888-0395 (ISSN-L)
- PMC
- PMC3039887
- OpenAlex
- W2047717558
- Cited by
- 29
- References
- 26
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 8 · 2012: 2
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroscience Nursing (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Center for AIDS Research, University of Washington
- National Institute on Aging (P30AG022838)
- National Institute of Allergy and Infectious Diseases (P30AI027767)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- HIV, cognitive performance, cognitive predictors, aging with HIV, CD4 count, HIV treatment adherence, depression, reading skills, socioeconomic status, hardiness, psychosocial factors, executive function, working memory
- MeSH terms
- Adult, Aged, Aging, Attention, Cognition Disorders, Cross-Sectional Studies, Female, Health Status, Humans, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Surveys and Questionnaires, Clinical Nursing Research, AIDS Dementia Complex, Young Adult, Executive Function
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