The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Contributions of the Insula to Cognition and Emotion
Abstract
Historically, the insula was considered primary gustatory cortex. Now it is known to play a more comprehensive role in the processing of sensory information, including acting as primary cortex for interoceptive information, including autonomic nervous system mediated changes. As such, it is critical for emotional feeling in accord with the James-Lange theory, a role previously ascribed to the limbic system. Neuroimaged abnormal grey matter volumes or activity levels in the insula have been associated with schizophrenia, eating disorders, anxiety and mood disorders, conduct disorder, autism, addiction, and chronic pain. The significance of these abnormal activity patterns remains theoretical. Neuropsychological studies have linked dominant insula injury with various symptoms of aphasia, but its exact role in language processing remains uncertain as most cases involve lesions that extend into perisylvian language zones. Functional neuroimaging studies have found insula hyper-activations, typically in conjunction with anterior cingulate cortex, for all manner of experimental tasks including those involving perception, intentional action, and consciousness. Such neuroimaged activity is unlikely to be task-specific, but rather reflective of generic changes in autonomic activity in response to salience, homeostatic incongruence, or cognitive challenge.
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“Insula cortex is critical for integration of interoceptive and sensory information and regulating emotional response (Gasquoine, 2014).”
From Sensory, emotional and cognitive contributions to anxiety in autism spectrum disorders (2017) · cites this paper as Gasquoine, 2014
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Cites
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BackgroundBrain magnetic resonance imaging with contrast dependent on blood oxygenation.
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Understanding Emotions: Origins and Roles of the Amygdala
Šimić, G., Tkalčić, M., Vukić, V., Mulc, D., Španić, E., Šagud, M., Olucha-Bordonau, F. E., Vukšić, M., & Hof, P. R. (2021) · Biomolecules · doi:10.3390/biom11060823 · Cited by 631
Dynamic Resting-State Functional Connectivity in Major Depression
Kaiser, R. H., Whitfield-Gabrieli, S., Dillon, D. G., Goer, F., Beltzer, M., Minkel, J., Smoski, M., Dichter, G., & Pizzagalli, D. A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.352 · Cited by 438
Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies
Schmaal, L., van Harmelen, A.-L., Chatzi, V., Lippard, E. T. C., Toenders, Y. J., Averill, L. A., Mazure, C. M., & Blumberg, H. P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0587-x · Cited by 373
Brain default-mode network dysfunction in addiction
Zhang, R., & Volkow, N. D. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.06.036 · Cited by 386
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Metadata
- Authors
- Gasquoine, P. G.
- Affiliations
- The University of Texas System (US)
- Corresponding author
- Gasquoine, Philip Gerard
- Venue
- Neuropsychology Review
- Published
- 2014-01-18
- Volume
- 24
- Issue
- 2
- Pages
- 77-87
- ISSN
- 1040-7308 (ISSN-L)
- 1573-6660
- OpenAlex
- W1989986125
- Cited by
- 400
- References
- 136
- Citations by year
- 2026: 18 · 2025: 37 · 2024: 52 · 2023: 31 · 2022: 40 · 2021: 39 · 2020: 66 · 2019: 32 · 2018: 23 · 2017: 26 · 2016: 18 · 2015: 15 · 2014: 3
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychology Review (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- insula, interoception, emotions, James-Lange theory, autonomic nervous system, schizophrenia, eating disorders, mood and anxiety disorders, autism spectrum disorder, addiction, chronic pain, aphasia, language processing, anterior cingulate cortex, salience, consciousness, cognitive challenge
- MeSH terms
- Animals, Autonomic Nervous System, Brain Mapping, Cerebral Cortex, Cognition, Emotions, Humans
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