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Cited by 174Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryRetinal Diseases and Treatments

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Investigating the Movement of Intravitreal Human Serum Albumin Nanoparticles in the Vitreous and Retina

Kim, Hyuncheol, Robinson, Shaun B., Csaky, Karl G.·2009·Pharmaceutical Research
DOI 10.1007/s11095-008-9745-6
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Abstract

Purpose To investigate the movement of intravitreally injected human serum albumin nanoparticles (HSA-NP) with respect to nanoparticle surface charge and retinal injury.Methods HSA-NPs were developed by a desolvation technique. HSA-NPs were cationized by covalent coupling of hexamethylenediamine on the particle surface. Either anionic or cationic HSA-NPs were injected to determine the effect of surface charge on intravitreal nanoparticle movement. HSA-NPs were injected intravitreally into both normal and laser photocoagulated eyes to examine the effect of the integrity of retinal tissue on the retinal penetration. The retinal penetration of fluorescence labeled anionic HSA-NPs was investigated by confocal microscopy.Results Anionic particles (-33.3+/-6.1 mV) more easily diffused through the 3-dimensional vitreal network of collagen fibrils than did their cationic counterparts (11.7+/-7.2 mV). In the laser photocoagulated retina, more HSA-NPs were detected in the choroidal space, compared to the normal retina. The immunohistochemical studies indicated that HSA-NPs were taken up into Müller cells.Conclusions The movement of intravitreal nanoparticles depended on both nanoparticles surface charge and retinal injury. The Müller cells might play an important role in the retinal penetration of nanoparticles. The anionic HSA-NP is a promising drug or gene delivery carrier to the sub-retinal space and RPE.

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Crossref · 10.1007/s11095-008-9745-6

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Metadata

Authors
Kim, H., Robinson, S. B., & Csaky, K. G.
Affiliations
  • Duke University (US)
  • Duke Medical Center (US)
Corresponding author
Kim, Hyuncheol
ORCID
Venue
Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Published
2008-10-29
Volume
26
Issue
2
Pages
329-337
ISSN
  • 0724-8741 (ISSN-L)
  • 1573-904X
DOI
10.1007/s11095-008-9745-6
OpenAlex
W2026741029
Cited by
174
References
38
Citations by year
2026: 3 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 15 · 2020: 9 · 2019: 14 · 2018: 15 · 2017: 15 · 2016: 9 · 2015: 14 · 2014: 10 · 2013: 9 · 2012: 5
FWCI
3.72
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Pharmaceutical Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Food and Drug Administration
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Keywords
human serum albumin nanoparticles, intravitreal injection, vitreous humor, surface charge, cationic nanoparticles, anionic nanoparticles, laser photocoagulation, retinal damage, Müller cells, choroid, retinal pigment epithelium
MeSH terms
Animals, Choroid, Diamines, Diffusion, Drug Carriers, Fluorescent Dyes, Humans, Immunohistochemistry, Particle Size, Retina, Serum Albumin, Surface Properties, Vitreous Body, Bruch Membrane, Microscopy, Confocal, Rats, Laser Therapy, Nanoparticles

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