Cited by 174Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryRetinal Diseases and Treatments

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Investigating the Movement of Intravitreal Human Serum Albumin Nanoparticles in the Vitreous and Retina

Kim, Hyuncheol, Robinson, Shaun B., Csaky, Karl G.·2009·Pharmaceutical Research

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Abstract

Purpose To investigate the movement of intravitreally injected human serum albumin nanoparticles (HSA-NP) with respect to nanoparticle surface charge and retinal injury.Methods HSA-NPs were developed by a desolvation technique. HSA-NPs were cationized by covalent coupling of hexamethylenediamine on the particle surface. Either anionic or cationic HSA-NPs were injected to determine the effect of surface charge on intravitreal nanoparticle movement. HSA-NPs were injected intravitreally into both normal and laser photocoagulated eyes to examine the effect of the integrity of retinal tissue on the retinal penetration. The retinal penetration of fluorescence labeled anionic HSA-NPs was investigated by confocal microscopy.Results Anionic particles (-33.3+/-6.1 mV) more easily diffused through the 3-dimensional vitreal network of collagen fibrils than did their cationic counterparts (11.7+/-7.2 mV). In the laser photocoagulated retina, more HSA-NPs were detected in the choroidal space, compared to the normal retina. The immunohistochemical studies indicated that HSA-NPs were taken up into Müller cells.Conclusions The movement of intravitreal nanoparticles depended on both nanoparticles surface charge and retinal injury. The Müller cells might play an important role in the retinal penetration of nanoparticles. The anionic HSA-NP is a promising drug or gene delivery carrier to the sub-retinal space and RPE.

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Self-citation

Authors: Kim, H., Robinson, S. B., & Csaky, K. G.
Affiliations: Duke University (US)
Duke Medical Center (US)
Corresponding author: Kim, Hyuncheol
ORCID: Kim, Hyuncheol
Csaky, Karl G.
Venue: Pharmaceutical Research
Publisher: Springer Science and Business Media LLC
Published: 2008-10-29
Volume: 26
Issue: 2
Pages: 329-337
ISSN: 0724-8741 (ISSN-L)
1573-904X
DOI: 10.1007/s11095-008-9745-6
OpenAlex: W2026741029
Cited by: 174
References: 38
Citations by year: 2026: 3 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 15 · 2020: 9 · 2019: 14 · 2018: 15 · 2017: 15 · 2016: 9 · 2015: 14 · 2014: 10 · 2013: 9 · 2012: 5
FWCI: 3.72
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Pharmaceutical Research (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Food and Drug Administration
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Keywords: human serum albumin nanoparticles, intravitreal injection, vitreous humor, surface charge, cationic nanoparticles, anionic nanoparticles, laser photocoagulation, retinal damage, Müller cells, choroid, retinal pigment epithelium
MeSH terms: Animals, Choroid, Diamines, Diffusion, Drug Carriers, Fluorescent Dyes, Humans, Immunohistochemistry, Particle Size, Retina, Serum Albumin, Surface Properties, Vitreous Body, Bruch Membrane, Microscopy, Confocal, Rats, Laser Therapy, Nanoparticles

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Investigating the Movement of Intravitreal Human Serum Albumin Nanoparticles in the Vitreous and Retina

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